Extra Chromosome
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Preface
I will be writing a series of threads showcasing unknown but useful chemicals.
Abstract
-11KDHT is a potent androgen with a high AR-agonist activity, it also regulates the expression of more AR-regulated proteins than DHT.
-11KDHT and 11KT have a longer half-life than DHT and T due to the slower metabolism.[1] The half life of 11-KDHT is 36 hours.
DHT was completely eleminated from the body in 48 hours, while 21% of 11-KDHT remained after 72 hours
-11KT and 11KDHT bind to the AR with affinities similar to that of T and DHT[1]
-11KT and 11KDHT are full AR agonists.[1]
-11KT and 11KDHT induce AR-regulated gene expression.[1]
-11KT and 11KDHT induce androgen dependent cellular proliferation.[1]
11-KDHT plays a vital role in castration-resistant prostate cancer. Also, prostate cancer patients were noted to have low prolactin levels.[3]
As we have said before, 11-KDHT is as potent as DHT which has anti-prolactin properties[2]. This may be a benefit for users here looking to lower their prolactin level with longer inter-dose intervals (due to longer 11-KDHT half-life). This can be used as a substitute to other prolactin-inducing steroids. This property may also improve sexual experiences by decreasing recovery time forced by prolactin.
Moreover, 11-KDHT can also be used as an aromatase inhibitor with longer inter-dose intervals. Due to it being similar to DHT for its anti-estrogenic properties.[4]
This may be useful to @axe624 @Madness @Coping @Wincel to keep their plates open while promoting cell proliferation and skipping the horrendous side effects of AIs like aromasin or letrozole.
11-KT and 11-KDHT are also non-aromatizable, meaning that they won't get converted into estrogen, meaning they have no gyno side effects like other steroids.[7]
To add, there are also anecdotal evidence in DHT and 11-KDHT elimating bloat and promoting a "dry" look. @Zyros
Finally, 11-KT has anti-cortisol properties, which promotes "alpha" personality and inhibition, less stress, and better motivation. And so does its anti-prolactin properties.[5] 11-KDHT also has this property[6]
TLDR:
11KDHT and 11KT do the following:
-Increase NT
-lower inhibition
-Increase aggression
-lower stress
-enhance sexual experience
-decrease refractory period (time it take for a male to recover after orgasm.)
-Decrease estrogen
-Build muscle
-Burn fat
-Increase height in open platecels
-doesn't need AI
-Increase energy
-Eliminate bloat
-Decrease fatigue
Now, for the autists who want more in-depth detail.
Biosynthesis from the precursor 11OHA4[1]:
This shows that 11-oxo-andrenosterone could be used as a prohormone for 11-KT and 11-KDHT.
Binding of DHT, T, 11KDHT and 11KT to the human AR (A) and transactivation via an ARE (B and C).
Regulation of AR-regulated proteins by DHT, 11KDHT, T and 11KT in VCaP cells
Metabolism:
[1]https://www.researchgate.net/public...tent_Androgens_Which_Can_No_Longer_Be_Ignored
[2]https://www.ncbi.nlm.nih.gov/pubmed/2775814
[3]https://www.ncbi.nlm.nih.gov/pubmed/30763940
[4]https://www.ncbi.nlm.nih.gov/pubmed/6645492
[5]https://www.researchgate.net/public...tent_Androgens_Which_Can_No_Longer_Be_Ignored
[6]http://press.endocrine.org/doi/10.1210/endo-meetings.2015.NRSHA.6.SAT-276
[7]https://academic.oup.com/jcem/article/101/10/3582/2764896
This may be of interest to @jefferson and @Intel.Imperitive @The Dude Abides
Requested tags:
@Coping @HorseFace @Wincel @mido the slayer @Autist
(tell me if anyone wants to get tagged in future threads)
Disclaimer:
I am by no means an expert on the topic, so please correct me if I made any mistake in this thread. No misinformation intended.
I will be writing a series of threads showcasing unknown but useful chemicals.
Abstract
-11KDHT is a potent androgen with a high AR-agonist activity, it also regulates the expression of more AR-regulated proteins than DHT.
-11KDHT and 11KT have a longer half-life than DHT and T due to the slower metabolism.[1] The half life of 11-KDHT is 36 hours.
DHT was completely eleminated from the body in 48 hours, while 21% of 11-KDHT remained after 72 hours
-11KT and 11KDHT bind to the AR with affinities similar to that of T and DHT[1]
-11KT and 11KDHT are full AR agonists.[1]
-11KT and 11KDHT induce AR-regulated gene expression.[1]
-11KT and 11KDHT induce androgen dependent cellular proliferation.[1]
11-KDHT plays a vital role in castration-resistant prostate cancer. Also, prostate cancer patients were noted to have low prolactin levels.[3]
As we have said before, 11-KDHT is as potent as DHT which has anti-prolactin properties[2]. This may be a benefit for users here looking to lower their prolactin level with longer inter-dose intervals (due to longer 11-KDHT half-life). This can be used as a substitute to other prolactin-inducing steroids. This property may also improve sexual experiences by decreasing recovery time forced by prolactin.
Moreover, 11-KDHT can also be used as an aromatase inhibitor with longer inter-dose intervals. Due to it being similar to DHT for its anti-estrogenic properties.[4]
This may be useful to @axe624 @Madness @Coping @Wincel to keep their plates open while promoting cell proliferation and skipping the horrendous side effects of AIs like aromasin or letrozole.
11-KT and 11-KDHT are also non-aromatizable, meaning that they won't get converted into estrogen, meaning they have no gyno side effects like other steroids.[7]
To add, there are also anecdotal evidence in DHT and 11-KDHT elimating bloat and promoting a "dry" look. @Zyros
Finally, 11-KT has anti-cortisol properties, which promotes "alpha" personality and inhibition, less stress, and better motivation. And so does its anti-prolactin properties.[5] 11-KDHT also has this property[6]
TLDR:
11KDHT and 11KT do the following:
-Increase NT
-lower inhibition
-Increase aggression
-lower stress
-enhance sexual experience
-decrease refractory period (time it take for a male to recover after orgasm.)
-Decrease estrogen
-Build muscle
-Burn fat
-Increase height in open platecels
-doesn't need AI
-Increase energy
-Eliminate bloat
-Decrease fatigue
Now, for the autists who want more in-depth detail.
Biosynthesis from the precursor 11OHA4[1]:
This shows that 11-oxo-andrenosterone could be used as a prohormone for 11-KT and 11-KDHT.
Binding of DHT, T, 11KDHT and 11KT to the human AR (A) and transactivation via an ARE (B and C).
Regulation of AR-regulated proteins by DHT, 11KDHT, T and 11KT in VCaP cells
Metabolism:
[1]https://www.researchgate.net/public...tent_Androgens_Which_Can_No_Longer_Be_Ignored
[2]https://www.ncbi.nlm.nih.gov/pubmed/2775814
[3]https://www.ncbi.nlm.nih.gov/pubmed/30763940
[4]https://www.ncbi.nlm.nih.gov/pubmed/6645492
[5]https://www.researchgate.net/public...tent_Androgens_Which_Can_No_Longer_Be_Ignored
[6]http://press.endocrine.org/doi/10.1210/endo-meetings.2015.NRSHA.6.SAT-276
[7]https://academic.oup.com/jcem/article/101/10/3582/2764896
This may be of interest to @jefferson and @Intel.Imperitive @The Dude Abides
Requested tags:
@Coping @HorseFace @Wincel @mido the slayer @Autist
(tell me if anyone wants to get tagged in future threads)
Disclaimer:
I am by no means an expert on the topic, so please correct me if I made any mistake in this thread. No misinformation intended.
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