hej1377
Chad-affirming care is a right, not a privilege
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I recently made a thread about a similar drug. ASC-J9, a hairloss drug that works both differently from 5-alpha reductase inhibitors like dutasteride and also different from anti androgens like RU58841
Tl;dr it will topically cause your androgen receptors to actually break down and therefore not be able to cause shit like acne or hairloss as they do not exist
This compound is a PROTAC like the anticipated GT20029, this stands for proteolysis targeting chimera which means that it's able to selectively remove certain proteins. It binds to something called E3 ubiquitin which is what causes the selective removal and destruction of protein. At the same time it binds to an androgen receptor which in practise will make the eq ubiquitin steal proteins from the AR. Then in turn the androgen receptor becomes unstable and is destroyed,
this image shows how PROTAC's work visually. (poi) in the image stands fod point of interest, in the case the AR
this image shows how PROTAC's work visually. (poi) in the image stands fod point of interest, in the case the AR
Based on the mechanisms it might seem scary because of the worry that it might go systemic. But at its current stage which is phase 1 clinicals, this was released only 10 days ago. "The trial confirmed that AH-001 was safe and well-tolerated across all dose levels, with no drug-related adverse events." After they tested the drug at 4 diffrent % of the topical creams from 0,2%-2%
Its also by design unlikely to go systemic mechanistically since they designed it to be topical. Its a bit of a larger molecule than other PROTAC's so its hard to cross the layers it needs to get into the bloodstream, its also super polar.
The company, AnHorn medicines presented data and "effectively reverses dihydrotestosterone (DHT)-induced hair loss in preclinical studies."
Both of these should of course be taken with a grain of salt as they are presented by the developing company
Its also by design unlikely to go systemic mechanistically since they designed it to be topical. Its a bit of a larger molecule than other PROTAC's so its hard to cross the layers it needs to get into the bloodstream, its also super polar.
The company, AnHorn medicines presented data and "effectively reverses dihydrotestosterone (DHT)-induced hair loss in preclinical studies."
Both of these should of course be taken with a grain of salt as they are presented by the developing company
Now the only comparison that makes sense currently in my opinion is ASC-J9 as they are the only types of drugs i know decently well that currently are available on the market. Id actually go with AH-001 as its design seems to make it safer for topical use, while ASC-J9 seerms to have worked this far at also being used topically for acne and hairloss id still rather take the drug with the mechanisms of AH-001 as it seems a lot safer and safety would be important for this type of drug. I am unable to on the other hand compare how effecient they are at this stage of development.
I dont see a reason to even try to compare it to dutasteride or RU58841 for example as they are not redundant, i consider this an add on to dutasteride not primarily a replacement, so ill keep gobbling down my dutasteride.
GT20029 is very similar and the comparison will be highly relevant some time,but now now.
I dont see a reason to even try to compare it to dutasteride or RU58841 for example as they are not redundant, i consider this an add on to dutasteride not primarily a replacement, so ill keep gobbling down my dutasteride.
GT20029 is very similar and the comparison will be highly relevant some time,but now now.
