chinkcel
surgical chang soon
- Joined
- Jul 27, 2023
- Posts
- 164
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We want a leaner, denser appearance while still maintaing muscle size, we can do this by minimizing subQ water while maintaining IM fullness.
Concept Breakdown:
EC Water (Extracellular) → mostly controlled by sodium and aldosterone.
↑ Sodium / aldosterone → ↑ subQ water retention.
↓ Sodium / aldosterone → ↓ subQ water, sharper look.
IC Water (Intracellular) → regulated by potassium and glycogen.
↑ Glycogen + potassium → pulls water inside muscle cells → fuller, rounder look.
↓ Glycogen / K⁺ → muscles flatten, “dry but soft” appearance.
→ Goal here: shift water from EC → IC via controlled sodium, adequate potassium, glycogen maintenance, and mineralocorticoid blockade.
Lantus (long-acting insulin) : (common dose is 1iu/10g of carbs) – promotes steady glycogen storage within muscle tissue.
→ More glycogen = more intracellular (IC) water, supporting fuller muscle density while staying dry subcutaneously.
Eplerenone : 25–50mg/day (Mineralocorticoid receptor antagonist) - Divide your dose in 2-3 daily dosing.
→ Reduces subcutaneous (subQ) water without flattening muscles.
→ Unlike spironolactone, it spares androgen binding and keeps IM water stable.
→ Keep potassium intake controlled due to natural retention under eplerenone.
Hydration : +4 liters of water daily (clear urine = balanced hydration)
→ Consistent hydration ensures proper osmotic balance and limits rebound retention.
Sodium (NaCl) : ≤5g of table salt daily (≈2–3g sodium)
→ Sodium directly influences extracellular (EC) water.
→ Restricting sodium lowers subQ retention but too low = flat look and cramps.
Potassium (K⁺) : ~3g/day total (split AM + PM)
→ Balances intracellular hydration — K⁺ pulls water into cells, supporting muscle tone.
→ Do not exceed 3g/day, since eplerenone already increases serum potassium retention.
Concept Breakdown:
EC Water (Extracellular) → mostly controlled by sodium and aldosterone.
↑ Sodium / aldosterone → ↑ subQ water retention.
↓ Sodium / aldosterone → ↓ subQ water, sharper look.
IC Water (Intracellular) → regulated by potassium and glycogen.
↑ Glycogen + potassium → pulls water inside muscle cells → fuller, rounder look.
↓ Glycogen / K⁺ → muscles flatten, “dry but soft” appearance.
→ Goal here: shift water from EC → IC via controlled sodium, adequate potassium, glycogen maintenance, and mineralocorticoid blockade.
Lantus (long-acting insulin) : (common dose is 1iu/10g of carbs) – promotes steady glycogen storage within muscle tissue.
→ More glycogen = more intracellular (IC) water, supporting fuller muscle density while staying dry subcutaneously.
Eplerenone : 25–50mg/day (Mineralocorticoid receptor antagonist) - Divide your dose in 2-3 daily dosing.
→ Reduces subcutaneous (subQ) water without flattening muscles.
→ Unlike spironolactone, it spares androgen binding and keeps IM water stable.
→ Keep potassium intake controlled due to natural retention under eplerenone.
Hydration : +4 liters of water daily (clear urine = balanced hydration)
→ Consistent hydration ensures proper osmotic balance and limits rebound retention.
Sodium (NaCl) : ≤5g of table salt daily (≈2–3g sodium)
→ Sodium directly influences extracellular (EC) water.
→ Restricting sodium lowers subQ retention but too low = flat look and cramps.
Potassium (K⁺) : ~3g/day total (split AM + PM)
→ Balances intracellular hydration — K⁺ pulls water into cells, supporting muscle tone.
→ Do not exceed 3g/day, since eplerenone already increases serum potassium retention.
