night dream
erm idk
- Joined
- Oct 20, 2025
- Posts
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Some of you might not understand the difference between epidermal turnover and dermal remodeling.
Thats why im making this thread
See...
Tretinoin is a mid-tier cope because it focuses solely on the surface, while GHK-Cu targets the actual architecture of the skin.
If you have severe acne, you hop on Accutane (Isotretinoin) first to nuke the sebaceous glands and force massive cellular turnover.
Accutane handles the "cleaning" phase by clearing the pores and accelerating keratinocyte replacement.
You do NOT microneedle while on the pill. You wait until the course is finished and the skin barrier is no longer compromised.
Once the Accutane course is done, your skin is clear but usually thinned out and fragile from the systemic toxicity.
This is where the GHK-Cu + 0.5mm dermastamp synergy comes in for the post-accutane recovery phase.
While Accutane handled the cellular turnover, GHK-Cu now handles the dermal renewal by upregulating Type III collagen and GAGs.
Using a 0.5mm stamp creates the necessary micro-channels to deliver the copper peptides directly to the fibroblasts.
At this depth, you trigger the release of copper-dependent enzymes like Lysyl Oxidase, which is the key for collagen cross-linking.
Systemic (injectable) GHK-Cu is good for internal healing but has poor localized bioavailability for facial aesthetics compared to MN delivery.
Injectables get degraded by plasma proteases too fast; topical application after 0.5mm MN ensures the peptide sits exactly where the remodeling happens.
You are basically using Accutane to clear the "canvas" and GHK-Cu to "rebuild" the density that the treatment stripped away.
This combo is superior to any Retinoid-only protocol because you avoid chronic inflammation while maximizing dermal matrix density.
Stop wasting time with 1.5mm needles that cause fibrosis; 0.5mm + GHK-Cu is the regenerative grail for best possible skin texture.
Thats why im making this thread
See...
Tretinoin is a mid-tier cope because it focuses solely on the surface, while GHK-Cu targets the actual architecture of the skin.
If you have severe acne, you hop on Accutane (Isotretinoin) first to nuke the sebaceous glands and force massive cellular turnover.
Accutane handles the "cleaning" phase by clearing the pores and accelerating keratinocyte replacement.
You do NOT microneedle while on the pill. You wait until the course is finished and the skin barrier is no longer compromised.
Once the Accutane course is done, your skin is clear but usually thinned out and fragile from the systemic toxicity.
This is where the GHK-Cu + 0.5mm dermastamp synergy comes in for the post-accutane recovery phase.
While Accutane handled the cellular turnover, GHK-Cu now handles the dermal renewal by upregulating Type III collagen and GAGs.
Using a 0.5mm stamp creates the necessary micro-channels to deliver the copper peptides directly to the fibroblasts.
At this depth, you trigger the release of copper-dependent enzymes like Lysyl Oxidase, which is the key for collagen cross-linking.
Systemic (injectable) GHK-Cu is good for internal healing but has poor localized bioavailability for facial aesthetics compared to MN delivery.
Injectables get degraded by plasma proteases too fast; topical application after 0.5mm MN ensures the peptide sits exactly where the remodeling happens.
You are basically using Accutane to clear the "canvas" and GHK-Cu to "rebuild" the density that the treatment stripped away.
This combo is superior to any Retinoid-only protocol because you avoid chronic inflammation while maximizing dermal matrix density.
Stop wasting time with 1.5mm needles that cause fibrosis; 0.5mm + GHK-Cu is the regenerative grail for best possible skin texture.
