Big Breakthrough: Meclozine to grow taller

[Corpuscula]

Not gonna lie I lowkey wanted to gatekeep that one but here we are
What's Meclozine?

Meclozine is actually just a medication used to cure nausea, vomiting and diziness caused by stuff like vertigo and motion sickness.

How does it work?
It works by blocking H1 histamine receptors.

Why it can help us get taller:

Do you know what H1 histamine receptors do?
INHIBIT THE ACTIVITY OF CHONDROCYTES! (Chondrocytes are VERY IMPORTANT FOR HEIGHT GROWTH)
Studies show that Meclozine boosts longitudinal bone growth:

"In our previous study, we found that meclozine, an over-the-counter H1 receptor inhibitor used to treat motion sickness, inhibited elevated FGFR3 signaling and promoted chondrocyte proliferation and differentiation using various chondrocytic cell lines. We also confirmed that meclozine alleviates fibroblast growth factor 2 (FGF2)-mediated longitudinal growth inhibition of embryonic tibiae in bone explant cultures (18). "

"meclozine increased body length of Fgfr3ach mice by 5.4% in our study. If the same effect could be observed in patients with ACH, the patients could be expected to increase 6.7–7.1 cm in height"

Note: 5% on a 5'9 individual would be 6'0!

Now the best part is how CHEAP and EASY to get it is.
You can literally find it over the counter for 3$.

Now, I just made this post to train my expression skills and be a little more valuable to the world before I die, rep if you liked.

 

[looksmaxxing223]

@wastedspermcel

 

[craven]

 

[JoChico]

so i dont need to get it prescribed by a doctor to get it? any downsides aswell???

 

[Corpuscula]

so i dont need to get it prescribed by a doctor to get it? any downsides aswell???

"No radical treatments for short stature in ACH are currently available." we don't know yet but 25mg is usually used when u have motion sickness so just try that prob

 

[Corpuscula]

what's so funny bud

 

[20/04/2008]

Not gonna lie I lowkey wanted to gatekeep that one but here we are
What's Meclozine?

Meclozine is actually just a medication used to cure nausea, vomiting and diziness caused by stuff like vertigo and motion sickness.
View attachment 3284040

How does it work?
It works by blocking H1 histamine receptors.

Why it can help us get taller:

Do you know what H1 histamine receptors do?
INHIBIT THE ACTIVITY OF CHONDROCYTES! (Chondrocytes are VERY IMPORTANT FOR HEIGHT GROWTH)
Studies show that Meclozine boosts longitudinal bone growth:

"In our previous study, we found that meclozine, an over-the-counter H1 receptor inhibitor used to treat motion sickness, inhibited elevated FGFR3 signaling and promoted chondrocyte proliferation and differentiation using various chondrocytic cell lines. We also confirmed that meclozine alleviates fibroblast growth factor 2 (FGF2)-mediated longitudinal growth inhibition of embryonic tibiae in bone explant cultures (18). "

"meclozine increased body length of Fgfr3ach mice by 5.4% in our study. If the same effect could be observed in patients with ACH, the patients could be expected to increase 6.7–7.1 cm in height"

Note: 5% on a 5'9 individual would be 6'0!

Now the best part is how CHEAP and EASY to get it is.
You can literally find it over the counter for 3$.

Now, I just made this post to train my expression skills and be a little more valuable to the world before I die, rep if you liked.

Your late

 

[Corpuscula]

Your late

wym...? ur growth plates have fused already or did someone already make a post about meclozine?

 

[20/04/2008]

wym...? ur growth plates have fused already or did someone already make a post about meclozine?

They already posted dozens of threads about it
Even i mentioned it long ago

 

[Corpuscula]

They already posted dozens of threads about it
Even i mentioned it long ago

oh damn i didnt know

 

[20/04/2008]

I like the way you write maybe we could write a thread together ????

 

[JoChico]

oh damn i didnt know

still w thread bhai, bookmarked + repped ignore the haters

 

[mog_or_be_mogged]

does this work for 50 year olds?

 

[Corpuscula]

I like the way you write maybe we could write a thread together ????

i dont think theres anything special about the way I write lol but sure

 

[Corpuscula]

does this work for 50 year olds?

idk prob not

 

[mog_or_be_mogged]

idk prob not

kill yourself

 

[mog_or_be_mogged]

whats the daily dose nigga

 

[Corpuscula]

kill yourself

omg he told me to kill myself, so edgy and dark

 

[Corpuscula]

whats the daily dose nigga

nobody knows

 

[JoChico]

nobody knows

just like @mog_or_be_mogged says, ascend or die

 

[Rigged]

Not gonna lie I lowkey wanted to gatekeep that one but here we are
What's Meclozine?

Meclozine is actually just a medication used to cure nausea, vomiting and diziness caused by stuff like vertigo and motion sickness.
View attachment 3284040

How does it work?
It works by blocking H1 histamine receptors.

Why it can help us get taller:

Do you know what H1 histamine receptors do?
INHIBIT THE ACTIVITY OF CHONDROCYTES! (Chondrocytes are VERY IMPORTANT FOR HEIGHT GROWTH)
Studies show that Meclozine boosts longitudinal bone growth:

"In our previous study, we found that meclozine, an over-the-counter H1 receptor inhibitor used to treat motion sickness, inhibited elevated FGFR3 signaling and promoted chondrocyte proliferation and differentiation using various chondrocytic cell lines. We also confirmed that meclozine alleviates fibroblast growth factor 2 (FGF2)-mediated longitudinal growth inhibition of embryonic tibiae in bone explant cultures (18). "

"meclozine increased body length of Fgfr3ach mice by 5.4% in our study. If the same effect could be observed in patients with ACH, the patients could be expected to increase 6.7–7.1 cm in height"

Note: 5% on a 5'9 individual would be 6'0!

Now the best part is how CHEAP and EASY to get it is.
You can literally find it over the counter for 3$.

Now, I just made this post to train my expression skills and be a little more valuable to the world before I die, rep if you liked.

They already posted dozens of threads about it
Even i mentioned it long ago

FGFR3 modified models (achondroplasia) is NOT the same as normal human growth physiology in normal models H1 receptors inhib doesnt stimulate chondrocyte growth at a relevant level

Meclozine doesnt work for height

 

[Corpuscula]

FGFR3 modified models, close to achondroplasia, is different from normal human growth physiology in normal models H1 receptors inhib doesnt stimulate chondrocyte growth at a relevant level

Meclozine doesnt work for height

explain this then: In contrast, loss-of-function mutations in FGFR3 lead to camptodactyly, tall stature, and hearing loss syndrome

Note: The people with tall stature due to loss of function in FGFR3 never had achondroplasia to begin with

 

[Rigged]

explain this then: In contrast, loss-of-function mutations in FGFR3 lead to camptodactyly, tall stature, and hearing loss syndrome

Note: The people with tall stature due to loss of function in FGFR3 never had achondroplasia to begin with

Thats based on a genetic distinction, LOF mutations lower FGFR3s normal inhibitory signals which is the reason for unchecked chondrocyte proliferation and thats what causes the height growth, meclozines effect is from targeting an excessive amount of FGFR3 activity (like i said b4 achondroplasia) and not base FGFR3 signaling which in a normal person who already has balanced FGFR3 (great majority of people) blocking it with meclo has no target, so it doesnt cause the height growth effect u grt with genetic FGFR3 issues


Edit: doesnt matter if they have achondroplasia that was just one example

 

[Corpuscula]

Thats based on a genetic distinction, LOF mutations lower FGFR3s normal inhibitory signals which is the reason for unchecked chondrocyte proliferation and thats what causes the height growth, meclozines effect is from targeting an excessive amount of FGFR3 activity (like i said b4 achondroplasia) and not base FGFR3 signaling which in a normal person who already has balanced FGFR3 (great majority of people) blocking it with meclo has no target, so it doesnt cause the height growth effect u grt with genetic FGFR3 issues


Edit: doesnt matter if they have achondroplasia that was just one example

bro stop baffling nonsense and just admit u wanna keep them short, theres nothing that ONLY works on people with certain issues, shit wont say "oh he has normal levels so we're not gonna do anything" and then just disappear into thin air; you literally did not back up anything at all

 

[Rigged]

bro stop baffling nonsense and just admit u wanna keep them short, theres nothing that ONLY works on people with certain issues, shit wont say "oh he has normal levels so we're not gonna do anything" and then just disappear into thin air; you literally did not back up anything at all

R u this ignorant ur reply was the equivalent of saying “no ur wrong idc” jts not nonsense what i stated is the facts, the proof and studies i was referencing were the ones u quoted i was only pointing out ur missunderstanding

 

[Corpuscula]

R u this ignorant ur reply was the equivalent of saying “no ur wrong idc” jts not nonsense what i stated is the facts, the proof and studies i was referencing were the ones u quoted i was only pointing out ur missunderstanding

ight mb

 

[Vista]

this is kind of a double edged sword, using anti-histamine's also down regulates the adrenal cortex, therby inhibiting a fuckton of enzymes like 21-Hydroxylase (and therby it's products - i.e mineralocorticoids). If you've ever actually used any anti- histamines you would also know that they turn you into a literal narcoleptic, emotionless zombie. Interesting study but really not feasible in practice.

 

[Corpuscula]

ight mb

Wait, https://www.naturalheightgrowth.com...breakthrough-otc-height-supplement-meclozine/

 

[Corpuscula]

Wait, https://www.naturalheightgrowth.com...breakthrough-otc-height-supplement-meclozine/

@Rigged

 

[Corpuscula]

R u this ignorant ur reply was the equivalent of saying “no ur wrong idc” jts not nonsense what i stated is the facts, the proof and studies i was referencing were the ones u quoted i was only pointing out ur missunderstanding

meclozine also increased bone growth in wild-type mice

 

[Rigged]

meclozine also increased bone growth in wild-type mice

Ill read what u sent in a minute, but thats tylers site, ive talked to tyler b4 unless hes directly quoting that from a study hes not an official source of info

 

[Corpuscula]

Ill read what u sent in a minute, but thats tylers site, ive talked to tyler b4 unless hes directly quoting that from a study hes not an official source of info

Ill read what u sent in a minute, but thats tylers site, ive talked to tyler b4 unless hes directly quoting that from a study hes not an official source of info

Interestingly, meclozine also increased bone growth in wild-type mice. The plasma concentration ofmeclozine during treatment was within the range that has been used in clinical settings for motionsickness. Increased longitudinal bone growth in Fgfr3ach mice by oral administration of meclozinein a growth period suggests potential clinical feasibility of meclozine for the improvement of shortstature in ACH.
from THIS STUDY: https://academic.oup.com/endo/article-pdf/156/2/548/8989945/endo0548.pdf

 

[mathis]

Won't work

 

[Corpuscula]

Won't work

https://academic.oup.com/endo/article-pdf/156/2/548/8989945/endo0548.pdf

"Interestingly, meclozine also increased bone growth in wild-type mice. The plasma concentration ofmeclozine during treatment was within the range that has been used in clinical settings for motionsickness. Increased longitudinal bone growth in Fgfr3ach mice by oral administration of meclozinein a growth period suggests potential clinical feasibility of meclozine for the improvement of shortstature in ACH."

 

[Rigged]

meclozine also increased bone growth in wild-type mice

Rats have higher plate plasticity than us and their chondrocytes are more sensitive to FGF3 cause of their receptor activation thresholds and postnatal skeletal growth windows so the increase in bone length isnt as simple to say itll work the same for humans since our chondrocyte are modulated by gh, igf, and thryoid
Which brings me back to my original post

Thats based on a genetic distinction, LOF mutations lower FGFR3s normal inhibitory signals which is the reason for unchecked chondrocyte proliferation and thats what causes the height growth, meclozines effect is from targeting an excessive amount of FGFR3 activity (like i said b4 achondroplasia) and not base FGFR3 signaling which in a normal person who already has balanced FGFR3 (great majority of people) blocking it with meclo has no target, so it doesnt cause the height growth effect u grt with genetic FGFR3 issues


Edit: doesnt matter if they have achondroplasia that was just one example

In the study u sent it says meclozine modultes the FGFR3-ERK axis
It modulating that means it weakens ERK phosphorylation in chondrocytes
The issue with that is ERK signaling in the plates work at a biphasic model and transient activation boosts proliferation while maintained activation inhibits it thru cyclin D1 mediated p21/p27 stabilization
This wont work in humans
Humans ERK signaling have tissue specific crosstalk with RAS-MAPK and PI3K-AKT paths which causes nonlinear feedback loops thatll js stop this from happening

 

[Corpuscula]

Ill read what u sent in a minute, but thats tylers site, ive talked to tyler b4 unless hes directly quoting that from a study hes not an official source of info

oh btw i found out that Meclozine increases CNP, so it could theorically increase bone growth even if it 'doesnt do shit' to FGF3 or wtv

 

[Rigged]

oh btw i found out that Meclozine increases CNP, so it could theorically increase bone growth even if it 'doesnt do shit' to FGF3 or wtv

CNP isnt a main growth factor, and the affect from meclo is irrelevant, if u look at my profile posts ive recommended CNP directly, saying meclo increases height cause of CNP is like saying playing basketball increases height cause of minor gh boosts