Best compound for Eye area
Oxymetazoline for saggy lids, Bimatoprost for lashes latisse
No surgery needed for these two specific eye area problems. If you have heavy upper lids or sparse lashes, these are the actual solutions with the use of pharmacology.
Oxymetazoline lifts the lid by stimulating the small Muller muscle. Bimatoprost grows lashes by extending their growth phase, like minoxodil does for all hair. Both are FDA approved for other things so you can get them at your pharmacy but you need prescription.
Oxymetazoline lifts the lid by stimulating the small Muller muscle. Bimatoprost grows lashes by extending their growth phase, like minoxodil does for all hair. Both are FDA approved for other things so you can get them at your pharmacy but you need prescription.
Upper eyelid ptosis happens when the levator palpebrae superioris or the sympathetically innervated Muller muscle weaken. Age, genetics, or nerve issues. The lid margin drops, covers the iris, makes you look tired or asymmetrical.
Lash hypotrichosis is just sparse thin lashes. Aging, genetics, overuse of extensions, alopecia. The follicles miniaturize or spend too long in resting phase.
Neither responds well to fillers. Surgery works but costs a shitton
Lash hypotrichosis is just sparse thin lashes. Aging, genetics, overuse of extensions, alopecia. The follicles miniaturize or spend too long in resting phase.
Neither responds well to fillers. Surgery works but costs a shitton
Oxymetazoline is an alpha I and alpha II adrenergic agonist, In the upper eyelid it targets Muller muscle, a small muscle that attaches to the tarsal plate and lifts the lid by about two millimeters when contracted.
Oxymetazoline binds alpha 1 receptors on Muller muscle smooth muscle fibers. Gq coupled signaling activates phospholipase C, meaning increased IP3 and DAG, raising intracellular calcium causing contraction. The lid margin rises.
Alpha II activation works throughout presynaptic modulation but the net effect is vasoconstriction and smooth muscle contraction.
Oxymetazoline binds alpha 1 receptors on Muller muscle smooth muscle fibers. Gq coupled signaling activates phospholipase C, meaning increased IP3 and DAG, raising intracellular calcium causing contraction. The lid margin rises.
Alpha II activation works throughout presynaptic modulation but the net effect is vasoconstriction and smooth muscle contraction.
Onset is 5-15 minutes. Duration is six to ten hours.
Rebound redness can occur with overuse. Blood pressure elevation is possible in susceptible individuals. Contraindicated in untreated narrow angle glaucoma due to potential for acute angle closure.
normal use is one drop in each eye daily, morning dosing for daytime lift. although i said it replaces surgery it depends on the gravity of the situation, does not replace surgery for severe ptosis but offers temporary improvement for events or mild cases.
Bimatoprost is a prostamide, a prostaglandin ethanolamide analog. It acts on FP prostaglandin receptors and possibly distinct prostamide sensitive receptors not fully characterized.
For lashes the mechanism is follicular. Bimatoprost binds receptors in the dermal papilla of eyelash follicles. This prolongs anagen phase, the active growth period, from weeks to months. It also increases melanogenesis, producing darker pigment.
The cellular cascade involves
FP or prostamide receptor activation
Gq coupled signaling
increased intracellular calcium
upregulation of matrix metalloproteinases remodeling of extracellular matrix around the follicle
sustained anagen signaling
Melanocyte activity increases through parallel pathways
For lashes the mechanism is follicular. Bimatoprost binds receptors in the dermal papilla of eyelash follicles. This prolongs anagen phase, the active growth period, from weeks to months. It also increases melanogenesis, producing darker pigment.
The cellular cascade involves
FP or prostamide receptor activation
Gq coupled signaling
increased intracellular calcium
upregulation of matrix metalloproteinases remodeling of extracellular matrix around the follicle
sustained anagen signaling
Melanocyte activity increases through parallel pathways
FDA approved as Latisse 0.03 percent solution. Originally developed for glaucoma where lash growth was noted as side effect just like minoxodil was discovered as a side effect for general hair growth
effects you can experience are periorbital skin darkening if solution runs off lash line, possible iris pigmentation changes with intraocular exposure, conjunctival hyperemia, and rarely periorbital fat atrophy with long term use. Most effects can be reverse on discontinuation (unlike Prostaglandin glaucoma drops.)
typical use is nightly application to upper lash line only. Lower lashes receive sufficient transfer from blinking jfl. Results visible at 4 weeks, maximal at 16 weeks. Maintenance dosing required to sustain.
Oxymetazoline works immediately, lasts hours, requires daily dosing, addresses lid position. Bimatoprost works by the time, lasts with maintenance, requires nightly application, addresses lash prominence.
i'd combine them personally, mine are long enough but u want them way longer
i'd combine them personally, mine are long enough but u want them way longer
Oxymetazoline is prescription only in most jurisdictions, marketed as Upneeq. Cost is approximately one hundred to two hundred dollars monthly without insurance.(PHARMA)
Bimatoprost is prescription only as Latisse, generic versions exist. Cost is approximately one hundred to one hundred fifty dollars monthly.
both pricy if gotten in a pharmacy, i consider geyting them elsewhere for the sake of your wallet.
Oxymetazoline limits which can cause for some users : rebound redness possible
systemic blood pressure effects
contraindication in narrow angle glaucoma
no effect on brow ptosis or dermatochalasis excess skin.
same for Bimatoprost limits:
periorbital pigmentation
possible iris color change
need for maintenance
no effect on lid position or skin laxity
Both require ongoing use for sustained effect. Neither is permanent. Surgery mogs and remains the solution for structural problems.
systemic blood pressure effects
contraindication in narrow angle glaucoma
no effect on brow ptosis or dermatochalasis excess skin.
same for Bimatoprost limits:
periorbital pigmentation
possible iris color change
need for maintenance
no effect on lid position or skin laxity
Both require ongoing use for sustained effect. Neither is permanent. Surgery mogs and remains the solution for structural problems.
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