BPC-157 on HGH

[Faaska]

BPC 157, a pentadecapeptide derived from human gastric juice, has been demonstrated to promote the healing of different tissues, including skin, muscle, bone, ligament and tendon. The underlying mechanism has not been fully clarified. From the result of cDNA microarray analysis, growth hormone receptor was revealed as one of the most abundantly up-regulated genes in tendon fibroblasts by BPC 157. BPC 157 dose- and time-dependently increased the expression of growth hormone receptor in tendon fibroblasts at both the mRNA and protein levels as measured by RT/real-time PCR and Western blot, respectively. The addition of growth hormone to BPC 157-treated tendon fibroblasts dose- and time-dependently increased the cell proliferation as determined by MTT assay and PCNA expression by RT/real-time PCR. Janus kinase 2, the downstream signal pathway of growth hormone receptor, was activated time-dependently by stimulating the BPC 157-treated tendon fibroblasts with growth hormone. In conclusion, the BPC 157-induced increase of growth hormone receptor in tendon fibroblasts may potentiate the proliferation-promoting effect of growth hormone and contribute to the healing of tendon.

Genes up-regulated in tendon fibroblasts by BPC 157.

Gene	Fold Change
HP33	7.71
Potassium voltage gated channel, Shaw-related subfamily, member 2	3.57
Seminal vesicle antigen-like 1	3.47
Retinoblastoma-binding protein 9	3.03
cAMP-regulated guanine nucleotide exchange factor II	2.80
Putative pheromone receptor VN7	2.38
Solute carrier family 26	2.34
Growth hormone receptor	2.29

BPC 157 appears to be beneficial to almost all organ systems when in very low dosages (mostly ng/kg to μg/kg range) after ip, ig, and intramucosal application are used and no side effect or toxicity is found. Except the effects on various gastrointestinal lesions, the healing effects of BPC 157 have also been reported on pancreas, liver injuries, endothelium, heart damage and pseudoarthrosis.
BPC 157 actually has no direct effect on promoting the proliferation or the expression of PCNA gene in tendon fibroblasts, although it enhances the migratory ability of tendon fibroblasts

In conclusion BPC-157 increases the expression of growth hormone receptor to promote the beneficial effect of growth hormone in terms of enhanced proliferation. In addition, the amount of growth hormone used can theoretically be reduced and also the cost of therapy. BPC 157 may play an important role in promoting tendon healing and potential clinical usage in the future is expected.

 

[JohnDoe]

Except the effects on various gastrointestinal lesions

Does this mean a positive effect on G.I. lesions or negative? What are your thoughts on Oral BPC-157 @Rigged

 

[Faaska]

Does this mean a positive effect on G.I. lesions or negative? What are your thoughts on Oral BPC-157 @Rigged

it is a negative effect, oral intake would be worse than any form of injection due too problems with peptides being absorbed into circulation

 

[Faaska]

it is a negative effect, oral intake would be worse than any form of injection due too problems with peptides being absorbed into circulation

May also exacerbate side effects too if taken orally

 

[TheBonePilled]

thanks

 

[roider122]

test nandrolone ghk cu hgh BPC-157 + TB-500 (Blend) igf lr 3 should i add something else

 

[Faaska]

test nandrolone ghk cu hgh BPC-157 + TB-500 (Blend) igf lr 3 should i add something else

Igf l3 cant bind to binding proteins which carry the chemical around the body so it won’t really do as much as you think sadly you should just stick to your nice test stuff and the hgh bpc mix, you could maybe add some stuff to work on somatostatin but there are limited options there so you could just skip that.