![axm](/data/avatars/l/73/73728.jpg?1720767204)
axm
never give up <3
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https://aacrjournals.org/clincancer.../Caffeine-and-Caffeic-Acid-Inhibit-Growth-and
https://www.mdpi.com/2077-0383/9/4/1163
sorry for low effort lol
over for peaters
(in breast cancer)Caffeine also reduced the insulin-like growth factor-I receptor (IGFIR) and pAkt levels in both ER+ and ER− cells
https://www.mdpi.com/2077-0383/9/4/1163
Caffeine consumption has been related to growth retardation due to its impact on the growth plate cartilage. It has a negative impact on the main components of the ECM, as well as in some crucial transcription factors involved in chondrocyte differentiation. Caffeine also interacts with the GH/IGF-1 axis, leading to a reduction in IGF-1 signaling. Additionally, caffeine decreases intracellular calcium concentration (Ca2+), as well as chondrocyte apoptosis. Among the morphologic changes induced by caffeine intake, a wider hypertrophic zone and a reduction of mineralization stand out.
sorry for low effort lol
over for peaters