Cistanche

[Deleted member 21543]

For those taking cistanche for test boosting are you all aware of this?

Echinacoside Increases Sperm Quantity in Rats by Targeting the Hypothalamic Androgen Receptor - Scientific Reports

Male infertility is a major health issue with an estimated prevalence of 4.2% of male infertility worldwide. Our early work demonstrated that Cistanche extracts protect against sperm damage in mice and that echinacoside (ECH) is one of the major active components. Here we report an essential...

www.nature.com

Cistanche increases testosterone as a response to blockage of androgenic receptors, so the net effect may not necessarily be positive for muscle growth?

Can someone decipher this study? I don't understand what mechanism cistanche works in and heard it negatively affects the AR

 

[Deleted member 21543]

@Seth Walsh

 

[thereallegend]

Where are your hearing these things about Cistanche and Cordyceps?

 

[Deleted member 21543]

Where are your hearing these things about Cistanche and Cordyceps?

Reddit and those studies haha

 

[thereallegend]

Reddit and those studies haha

What subreddits

 

[Deleted member 21543]

What subreddits

I don't remember brooo why

 

[thereallegend]

I don't remember brooo why

i wanna investigate the sources

 

[Deleted member 21543]

i wanna investigate the sources

Well here's the main post.
Cistanche Tubulosa Negative Interaction with AR



What do you think

 

[Deleted member 21543]

bump

 

[Deleted member 21543]

Damn so no one kno

 

[Seth Walsh]

Thank goodness AI can do the work for me now.

@OP


The study titled "Echinacoside Increases Sperm Quantity in Rats by Targeting the Hypothalamic Androgen Receptor" published in Nature discusses the effects of Echinacoside (ECH), a bioactive component derived from the medicinal plant species of Echinacea and Cistanche, on sperm quantity and hormone levels. Here are the key takeaways:

1. ECH Enhances Sperm Quantity: The study found that treatment with ECH significantly increased the epididymal sperm counts in rats. However, there was no significant difference in sperm viability and sperm motility.
2. ECH Increases Testosterone and LH Levels: ECH treatment notably increased Luteinizing hormone (LH) levels in the serum, encephalon + pituitary, and testis. Testosterone was significantly increased in encephalon + pituitary and testis, but not in serum after ECH treatment.
3. ECH Increased Steroidogenic Enzyme Gene Expression: ECH significantly increased the expressions of key steroidogenic enzymes in the testis, which are involved in the production of testosterone.
4. ECH Reduces Hypothalamic AR Translocation to the Nucleus: ECH down-regulated Androgen receptor (AR) protein in hypothalamic nuclei, suggesting that ECH blocks AR transport from the cytoplasm to the nucleus in the hypothalamus.
5. ECH Increased the Expressions of HPG-axis Related Genes: ECH significantly increased the expressions of LHβ, LHr, Gnrh 1, and Gnrhr in the mixture pools of encephalon + pituitary.
6. ECH Attenuates BPA-induced Reproductive Damage: ECH administration prevented the decrease in sperm count and sperm motility caused by Bisphenol A (BPA), a widespread environmental contaminant that impacts male fertility.
7. ECH Targets AR: The study confirmed that ECH can bind to the AR protein, which is involved in the regulation of a negative feed loop and that a reduction in AR-Testosterone interactions in the brain results in increased LH secretion.

In conclusion, the study suggests that ECH can increase sperm quantity and hormone levels by targeting the hypothalamic androgen receptor and increasing the expression of key steroidogenic enzymes. It also suggests that ECH can protect against reproductive damage caused by environmental contaminants like BPA.