birthdefect
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just gonna make this a rapid fire thread, please correct me if im wrong on this
from: https://www.ncbi.nlm.nih.gov/books/...nging from 0.24 mg/kg/week to 0.47 mg/kg/week
this dosing is whats needed to treat short niggas
assume a patient is 60kgs for this
0.24 x 60 / 7 = ~2 mg daily dose
1mg = 3iu hgh thus the minimum STARTING DOSE is 6iu for 60kg patient. massive trvth nvke on niggas who spend like 2 months titrating up to 6iu and stopping there jfl
repeating this process for the highest dose recommended (0.47mg/kg/week) gives us ~4mg daily. 4 x 3 = 12iu daily
so just for a 60kg patient, you need minimum 6iu and max 12iu to make a significant difference
the average negro on here cannot afford 12iu daily for years on end, so a potential way to make up for this is with ghrfs and hgh combined
when i refer to ghrf (growth hormone releasing factor) im referring specifically to a ghrp+ghrh combo e.g mod-grf and ipamorelin. the shit greys dream of but does barely anything on its own. technically it can be any ghrp+ghrh but im gonna stick with mod-grf and ipamorelin just out of common familiarity.
an objective benefit of secretagogues over exogenous gh is pulsatile secretion, which we know increases localised igf1 in the growth plate chondrocytes more than the continuous exposure one would receive from hgh. while this is a benefit, ghrfs are simply not potent enough for this benefit to make up for the sheer magnitude of gh which can be delivered exogenously. why not combine them to get both benefits?
in general, we can assume exogenous gh to produce serum levels similar to the quick graph i just cooked up (not precise)
exogenous gh shuts down natural production almost entirely even at small doses so we dont need to factor that in for this
comparatively, this is the ghrf combo's assumed graph alongside the gh graph
it is known to be far smaller than exogenous gh can be (again, this is imprecise and im not using any known doses in my head, couldnt find graphs like this in studies)
if we simply add both graphs to each other, we get this result
in theory this should give you a spike in gh while simultaneously offering pseudo-pulsatile exposure, which could potentially have a more beneficial impact compared to just increasing the gh dose(although both could be done ofc)
i know the graphs are turbo-imprecise, but its just to get the point across
from: https://www.ncbi.nlm.nih.gov/books/...nging from 0.24 mg/kg/week to 0.47 mg/kg/week
this dosing is whats needed to treat short niggas
assume a patient is 60kgs for this
0.24 x 60 / 7 = ~2 mg daily dose
1mg = 3iu hgh thus the minimum STARTING DOSE is 6iu for 60kg patient. massive trvth nvke on niggas who spend like 2 months titrating up to 6iu and stopping there jfl
repeating this process for the highest dose recommended (0.47mg/kg/week) gives us ~4mg daily. 4 x 3 = 12iu daily
so just for a 60kg patient, you need minimum 6iu and max 12iu to make a significant difference
the average negro on here cannot afford 12iu daily for years on end, so a potential way to make up for this is with ghrfs and hgh combined
when i refer to ghrf (growth hormone releasing factor) im referring specifically to a ghrp+ghrh combo e.g mod-grf and ipamorelin. the shit greys dream of but does barely anything on its own. technically it can be any ghrp+ghrh but im gonna stick with mod-grf and ipamorelin just out of common familiarity.
an objective benefit of secretagogues over exogenous gh is pulsatile secretion, which we know increases localised igf1 in the growth plate chondrocytes more than the continuous exposure one would receive from hgh. while this is a benefit, ghrfs are simply not potent enough for this benefit to make up for the sheer magnitude of gh which can be delivered exogenously. why not combine them to get both benefits?
in general, we can assume exogenous gh to produce serum levels similar to the quick graph i just cooked up (not precise)
exogenous gh shuts down natural production almost entirely even at small doses so we dont need to factor that in for this
comparatively, this is the ghrf combo's assumed graph alongside the gh graph
it is known to be far smaller than exogenous gh can be (again, this is imprecise and im not using any known doses in my head, couldnt find graphs like this in studies)
if we simply add both graphs to each other, we get this result
in theory this should give you a spike in gh while simultaneously offering pseudo-pulsatile exposure, which could potentially have a more beneficial impact compared to just increasing the gh dose(although both could be done ofc)
i know the graphs are turbo-imprecise, but its just to get the point across
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