Could caffeine shampoo fix my norwooding hairline?

[DarknLost]

If I use it along with dermaroller.

 

[CupOfCoffee]

NO NO NO NO NO stop wasting your time and money

 

[x30001]

No. It's just a weak OR2AT4 receptor agonist.

 

[Deleted member 1106]

no, it might buy you time though, if you want to fix it combine it with dht blocker

 

[x30001]

lol no you beta faggot, stop being a pussy.

fin + RU in Minoxidil + Microneedling (Derminator)

Thats it, thats all you need. If you start early you'll keep your hairline and density FOREVER

You can't keep it perfect forever even if you start taking all those things before your hairline starts to recede. You'll just soften the blow or the effects of MPB.

 

[Deleted member 1106]

You can't keep it perfect forever even if you start taking all those things before your hairline starts to recede. You'll just soften the blow or the effects of MPB.

thats cope, androgenic apolecia just means your hair follicles are sensitive to androgens, no androgens to attach to them means you will not go bald

 

[x30001]

thats cope, androgenic apolecia just means your hair follicles are sensitive to androgens, no androgens to attach to them means you will not go bald

Lorsss said:
ryo_hazuki uses it.... I don't know wether it's better than topical fin and ru

Haven't heard about topical finasteride tbh. Ryo uses dut and fin lol. Why both? There's literally no point... To me, Ru58841 is like topical fin/dut except less potent and localised/non-systemic. Topical fin would still be systemic ie: if you absorb it dermally with dimethylsulfoxide. Spironolactone is some crazy shit. Doesn't even interact with the 5-alpha-reductase enzyme or any enzymes, just works at lowering androgen levels entirely. Possibly an androgen receptor antagonist or something similar. cb-03-01 (breezula) is the closest thing to topical spironolactone. Spironolactone is also a diuretic and good for treating female hormonal acne. Idk why ryo_hazuki uses all of those things at once. Maybe he was just trolling....

I've nw0 but among all these things, dutasteride will keep the reaper furthest away, and works on regrowth to a small extent unlike finasteride which is really just a weaker delayant and less potent. More sides with dut though incl sexual disfunction. sm04554 will be the saving grace. Or any mad scientist who can create a molecule to activate the Wnt/Beta Catenin signalling pathway like sm04554 does. But seems like no one except samumed have that molecule the moment. Creating it would be expensive/hard enough with all the R&D and cost.. Also keeping the molecule stable and pure is really difficult. But it's completely solved the root problem of Androgenic Alopecia.

If Androgenic Alopecia can only occur through androgens (primarily DHT), and unbound calclium ions, microplastics etc creating overactivity ie overdestruction during the Catagen phase of the hair cycle due to the MPB gene expression, then reducing DHT, or even reducing the amount of all androgens, calcification, and presence of all aggressors of AA won't do much except delay the process. Because MPB gene expression ensures that you will always have overactivity in the destructive phase(s) of the hair cycle in proportion to the constructive phase, the Anagen phase. MPB gene expression is such a bitch that it'll recruit anything that minaturasises hair follicules to rape the fuck out of your hair follicles during the Catagen phase. Everyones hair goes through Anagen (growth) -> Catagen (follicle minituarisation) -> Telogen (hair falling out). Difference is, those without the MPB gene don't experience an overly destructive Catagen phase and the Anagen phase is always proportionately more constructive than the Catagen phase is destructive. Therefore, we only can lose a small amount of hair when we reach the Telogen phase. And as the hair cycle continues, non MPB gene holders can keep their hair luckily.

sm04554 activates Wnt/Beta-Catenin pathway signalling which in turn prevents the transition from the Anagen phase to the Catagen phase. So they pause/halt the hair cycle and keep it in the phase responsible from hair growth and keratinocyte proliferation. DHT or anything capable of hair follicle miniturisation are completely useless in the Anagen phase as they can only attack hair follicles during the destructive Catagen phase. So that's how that works. It's pretty much a complete fix. Won't remove the MPB gene from carriers, but MPB gene expression will be completely redundant due to the inability to transition out of the Anagen phase.