Could FOXO4-DRI in theory help growth plates to stay open for longer?

[thuuk]

So, I'm not really educated on growth plate closure delaying, but I've been getting into it more and more as of recently, due to me being 172cm and not growing in well over a year, I will get them checked in 3 days (currently 15) and if theyre still open, or atleast partly open, I'd like them to stay open. So, what I've come up with is, that FOXO4-DRI kills senescent cells (through disruption of the FOXO4-p53 interaction). And senescent cells can be a factor in growth plate closure due to senescent chondrocytes playing a role in growth plate aging and eventual closure. So, in theory, could FOXO4 help with keeping them open for longer? Maybe if we combine this with fgfr3 inhibition (Infigratinib, Fexagratinib, etc) and Aromatase Inhibition? Idk how this would work in practice, but its a interesting thought in my opinion. Is there anyone that is high iq in this field and could help me?

BUT: In every source I've found, FOXO4 is expensive as hell (10mg*10vials for over 300€) thats one of the main problems.

 

[birthdefect]

So, I'm not really educated on growth plate closure delaying, but I've been getting into it more and more as of recently, due to me being 172cm and not growing in well over a year, I will get them checked in 3 days (currently 15) and if theyre still open, or atleast partly open, I'd like them to stay open. So, what I've come up with is, that FOXO4-DRI kills senescent cells (through disruption of the FOXO4-p53 interaction). And senescent cells can be a factor in growth plate closure due to senescent chondrocytes playing a role in growth plate aging and eventual closure. So, in theory, could FOXO4 help with keeping them open for longer? Maybe if we combine this with fgfr3 inhibition (Infigratinib, Fexagratinib, etc) and Aromatase Inhibition? Idk how this would work in practice, but its a interesting thought in my opinion. Is there anyone that is high iq in this field and could help me?

BUT: In every source I've found, FOXO4 is expensive as hell (10mg*10vials for over 300€) thats one of the main problems.

mechanistically yes it can, try it if you want

 

[thuuk]

mechanistically yes it can, try it if you want

I will definetly try it, if I get the money lmao in my country you cant really work anywhere except in the holidays when youre under 16

 

[birthdefect]

I will definetly try it, if I get the money lmao in my country you cant really work anywhere except in the holidays when youre under 16

im not sure how selective it is so this could be wrong but if its not that specific on inducing apoptosis in senescent cells its probably wise to use something to promote chondrocyte proliferation (igf1)

 

[thuuk]

im not sure how selective it is so this could be wrong but if its not that specific on inducing apoptosis in senescent cells its probably wise to use something to promote chondrocyte proliferation (igf1)

Obv I'd stack it with high dose hgh. Otherwise I wont even have anything to promote the actual growth. But by what I've found, it only kills specifc cells that are senescent and FOXO4-p53 dependent and I dont think igf-1 is

 

[Sachlichkeit]

So, I'm not really educated on growth plate closure delaying, but I've been getting into it more and more as of recently, due to me being 172cm and not growing in well over a year, I will get them checked in 3 days (currently 15) and if theyre still open, or atleast partly open, I'd like them to stay open. So, what I've come up with is, that FOXO4-DRI kills senescent cells (through disruption of the FOXO4-p53 interaction). And senescent cells can be a factor in growth plate closure due to senescent chondrocytes playing a role in growth plate aging and eventual closure. So, in theory, could FOXO4 help with keeping them open for longer? Maybe if we combine this with fgfr3 inhibition (Infigratinib, Fexagratinib, etc) and Aromatase Inhibition? Idk how this would work in practice, but its a interesting thought in my opinion. Is there anyone that is high iq in this field and could help me?

BUT: In every source I've found, FOXO4 is expensive as hell (10mg*10vials for over 300€) thats one of the main problems.

how about 30 sets of thoughts and prayers