
pharmatropics
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This thread is a deep dive about ultrasound being used as stimulation for localized bone growth. This thread will be more about height, but I'm interested to find out if it also stimulates facial / clavicular bone growth in the future as well.
A specific kind of ultrasound, LIPUS (Low-Intensity Pulsed Ultrasound) is commonly used in orthopedics to accelerate the healing of fractures. It works by stimulating bone tissue through sound (vibration) to trigger mechanical stimulation at the cellular level. This therefore increases osteoblast activity, which releases localized growth factor hormones (IGF-1 & VEGF).

Theoretically speaking this could be used universally on all hard tissues, including growth plates.
What initially piqued my interest in local IGF-1 stimulation, was the fact that multiple studies suggest that the majority of longitudinal bone growth is driven by local IGF-1 within the growth plate itself, and that circulating IGF-1 doesn't matter as much. Kinda made me sad thinking that all of my suspicious, totally not somatropin shipments from China might have been cope.
- (1993, Proceedings of the National Academy of Sciences) showed that mice with near-zero IGF-1 in their bloodstreams still maintained near-normal growth as long as the growth plate itself was producing IGF-1 locally
- (2004, Journal of Bone and Mineral Research) found that even when systemic IGF-1 levels were normal, growth failed if growth plates couldn’t receive signals due to missing IGF-1 receptors
- (2009, Endocrine Reviews) estimated that around 70–80% of bone growth effects come from local IGF-1 signaling, not systemic hormones.
Back to ultrasound therapy, LIPUS has already been tested on animal growth plates.
Rabbits and rodent trials reported:
- Increased thickness in the proliferative zone of the physis
- Higher chondrocyte division rate
- More organized hypertrophic cartilage columns
- Slight increases in longitudinal bone growth when compared to untreated control limbs

If translated to humans, the most effective targets would be:
- Distal Femur, right above the knee, ~70% of naturally occuring femur growth
- Proximal Tibia, just below the knee, ~ 55% of naturally occuring tibia growth
Conclusion:
LIPUS shows clear stimulatory effects on bone and cartilage in medical contexts.

You can get an EXOGEN LIPUS device, or be like me and try to build your own rig. EXOGEN, the company, they're fucking scammers because they limit the amount of times you can use their device. I think the software deletes itself after 150 uses.
There will be more details about the rig I'm building soon, which will have more than one probe to simulate all my bones at the same time. I'm interested to see if the same idea applies to clavicles and facial bones, because I would blast the fuck out of them if the theory held true.
Note: I just got accepted to org, I hope this is a good rookie debut. I've been keeping this one in the chamber for a while now because org takes a long ass time to accept new people
