D-Chiro Inositol, a potent natural aromatase inhibitor

[Inosebreathonly]

D-chiro-inositol, an aromatase down-modulator, increases androgens and reduces estrogens in male volunteers
(https://www.researchgate.net/figure...reatment-on-testosterone-estradiol-T-E2-ratio)

20% decrease in estrogen and 25% increase in testosterone.. Seems good for me


DCI contributes to an androgenic environment, either by stimulating the biosynthesis of testosterone or by reducing its conversion to estradiol
PMID: 37111094


D-Chiro-Inositol’s action as "aromatase inhibitor": rationale and potential clinical targets

Increased androgens and decreased estrogens seem to confirm that D-chiro-inositol acts as an aromatase down-modulator

D-chiro-inositol, an aromatase down-modulator, increases androgens and reduces estrogens in male volunteers: a pilot study - PubMed

NCT04615767 (registry: ClinicalTrials.gov) Date of registration: November 3, 2020.

pubmed.ncbi.nlm.nih.gov

But you either gotta take Myo and D-Chiro Inositol mix at 3.6 or lower ratios or find pure D-Chiro Inositol (Chirositol) to actually get the androgenic benefits coz myo-inositol is actually estrogenic
40:1 ratio and supplementing with just myo-inositol also showed increases in estrogen



Btw I am taking 12.5 mg aromasin this is just to decrease estrogen a bit more, preventing any bone aging without getting side effects or spending too much money on aromasin

 

[MA_ascender]

DNR cope

 

[Inosebreathonly]

DNR cope

What does dnr mean

 

[Roninotrolling]

how much d chloro insoitol need to observe the anti estrogen effect?

 

[Inosebreathonly]

how much d chloro insoitol need to observe the anti estrogen effect?

Probably between 400 and 1500 mg

 

[Roninotrolling]

Probably between 400 and 1500 mg

i thought myo inositol only increased estrogen in women, ig not. It seems to be progestogenic though, that can decrease testosterone as well

 

[Inosebreathonly]

i thought myo inositol only increased estrogen in women, ig not. It seems to be progestogenic though, that can decrease testosterone as well

Myo inositol slightly increases aromatase activity and estrogen levels in men, can slightly increase testosterone too but due to the down regulation of 5-ar, resulting in lower DHT levels

 

[Roninotrolling]

cant find any pure dci or less than 20 :1 d chloro to myo insoitol stuff, its over

 

[Inosebreathonly]

cant find any pure dci or less than 20 :1 d chloro to myo insoitol stuff, its over

Did you search with 3.6:1 ratio that is a very popular version
Also found this on E-bay: https://www.ebay.com/itm/353413666037
And some others on chinese websites
Also buckwheat seems to have naturally high levels

 

[Inosebreathonly]

cant find any pure dci or less than 20 :1 d chloro to myo insoitol stuff, its over

D-Chiro-Inositol

The world's first and only dosage of 600 mg PURE D-chiro-inositol made from carob, not soy.

chiralbalance.com

A bit pricey

Also found that carob pods contain between 4-5.5 grams of D-Chiro Inositol per 100 g which is crazy and almost 0 myo-inositol, mogs all other alternatives
With just 20-25 g of carob pods almost 20% decrease in estrogen and 25% increase in testosterone

 

[oppastoppathe2nd]

Did you search with 3.6:1 ratio that is a very popular version
Also found this on E-bay: https://www.ebay.com/itm/353413666037
And some others on chinese websites
Also buckwheat seems to have naturally high levels

is there any info about if this is a reversible or irreversible inhibitor? if it is reversible we would have to be very consistent or else estradiol will spike

 

[Roninotrolling]

D-Chiro-Inositol

The world's first and only dosage of 600 mg PURE D-chiro-inositol made from carob, not soy.

chiralbalance.com

A bit pricey

Also found that carob pods contain between 4-8 grams of D-Chiro Inositol per 100 g which is crazy and almost 0 myo-inositol mogs all other alternatives
With just 20 g of carob pods almost 20% decrease in estrogen and 25% increase in testosterone

do u have any source in india or ships to india

carob pods are these good?

Carob Powder (Medium Roast) | Caffeine-Free

Discover Sattvic Foods' Medium Roast Carob Powder from Switzerland. Naturally sweet, caffeine-free, and rich in fibre—perfect for baking and beverages.

www.sattvicfoods.in

 

[Inosebreathonly]

do u have any source in india or ships to india

carob pods are these good?

Carob Powder (Medium Roast) | Caffeine-Free

Discover Sattvic Foods' Medium Roast Carob Powder from Switzerland. Naturally sweet, caffeine-free, and rich in fibre—perfect for baking and beverages.

www.sattvicfoods.in

Carob pods seems like the best source tbh and their D-Chiro Inositol content may explain why they consistently increase testosterone levels in males in studies

 

[Inosebreathonly]

is there any info about if this is a reversible or irreversible inhibitor? if it is reversible we would have to be very consistent or else estradiol will spike

I don't think there are any natural irreversible aromatase inhibitors and I don't think these type of supplements will cause a big rebound effect but being consistent would still be a good idea

 

[Roninotrolling]

iodine also has certain anti estrogenic effects, what are your thoughts on DIM and calcium d glucornate? those also seem to have anti estrogenic prop. DHT gel is aslo potently anti estrogenic

 

[Inosebreathonly]

iodine also has certain anti estrogenic effects, what are your thoughts on DIM and calcium d glucornate? those also seem to have anti estrogenic prop. DHT gel is aslo potently anti estrogenic

Increasing thyroid hormones and reducing cortisol will decrease estrogen levels.
Iodine is also good for esteogen metabolism.

DIM and calcium d glucarate activate detox pathways of estrogen in the liver also a few studies saying DIM is also a weak aromatase inhibitor.
DIM and CDG are good if you have excess estrogen or constantly exposed to xenoestrogens.

Yeah DHT is unaromatazible and opposes estrogen but naturally increasing DHT by increasing the activity of 5-ar could be even better because it's reduces free testosterone which in turn decreases the aromatisation rates while exerting even more androgenic effects because of the conversion to DHT
Butea superba seems to be the best supplement for that it has tons of phytoandrogens and you can at least double your DHT levels with regular use

 

[Delons]

D-Chiro-Inositol

The world's first and only dosage of 600 mg PURE D-chiro-inositol made from carob, not soy.

chiralbalance.com

A bit pricey

Also found that carob pods contain between 4-5.5 grams of D-Chiro Inositol per 100 g which is crazy and almost 0 myo-inositol, mogs all other alternatives
With just 20-25 g of carob pods almost 20% decrease in estrogen and 25% increase in testosterone

Is this source legit? Did u try this sup

 

[20/04/2008]

D-chiro-inositol, an aromatase down-modulator, increases androgens and reduces estrogens in male volunteers
(https://www.researchgate.net/figure...reatment-on-testosterone-estradiol-T-E2-ratio)
View attachment 3205069
View attachment 3205067

20% decrease in estrogen and 25% increase in testosterone.. Seems good for me


DCI contributes to an androgenic environment, either by stimulating the biosynthesis of testosterone or by reducing its conversion to estradiol
PMID: 37111094


D-Chiro-Inositol’s action as "aromatase inhibitor": rationale and potential clinical targets

Increased androgens and decreased estrogens seem to confirm that D-chiro-inositol acts as an aromatase down-modulator

D-chiro-inositol, an aromatase down-modulator, increases androgens and reduces estrogens in male volunteers: a pilot study - PubMed

NCT04615767 (registry: ClinicalTrials.gov) Date of registration: November 3, 2020.

pubmed.ncbi.nlm.nih.gov

But you either gotta take Myo and D-Chiro Inositol mix at 3.6 or lower ratios or find pure D-Chiro Inositol (Chirositol) to actually get the androgenic benefits coz myo-inositol is actually estrogenic
40:1 ratio and supplementing with just myo-inositol also showed increases in estrogen



Btw I am taking 12.5 mg aromasin this is just to decrease estrogen a bit more, preventing any bone aging without getting side effects or spending too much money on aromasin

Best natty estrogenblocking stack
You could get your estrogen to the 15 range aslong you don’t toush estrogenic clothes
Dim 200 mg
Calcium D glucarate 1000 mg
Melatonin 3-100 mg
Tadalfil 5-10 mg
D chiro inositol 1.5g
Vitamin e 1500 iu
Zinc picolinate 100 mg

 

[Inosebreathonly]

Best natty estrogenblocking stack
You could get your estrogen to the 15 range aslong you don’t toush estrogenic clothes
Dim 200 mg
Calcium D glucarate 1000 mg
Melatonin 3-100 mg
Tadalfil 5-10 mg
D chiro inositol 1.5g
Vitamin e 1500 iu
Zinc picolinate 100 mg

Good picks but dosages look extreme and I'd also add some kind of polyphenol maybe hesperidin, trans resveratrol supplement or standardized 20% oleuropein olive leaf extract

 

[20/04/2008]

Good picks but dosages look extreme and I'd also add some kind of polyphenol maybe hesperidin, trans resveratrol supplement or standardized 20% oleuropein olive leaf extract

Reservatrol sucks
Hesperidn you can get food
Olivee leaf extract o forgot to put in swear
(I know from who you get that information)

 

[Inosebreathonly]

Reservatrol sucks
Hesperidn you can get food
Olivee leaf extract o forgot to put in swear
(I know from who you get that information)

The amount you get from food vs supplements is uncomparable
Resveratrol should be used a little bit more carefully than othersq