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Iron
- Joined
- May 11, 2025
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Drives growth of facial, pubic, axillary, and body hair
Contributes to male pattern facial acne and voice deepening through its powerful androgen activity
In boys born with 5α‑reductase deficiency external genitalia, facial hair, and prostate growth are impaired, reinforcing DHT's unique role during puberty
Male mice lacking the 5α‑reductase type 1 enzyme which is responsible for converting testosterone into DHT locally in bone, exhibit 36% lower trabecular bone mineral density, 15% reduction in cortical bone content, Decreased cortical bone size, and Weaker bone strength and reduced forelimb grip strength
Lower serum DHT was significantly associated with decreased bone mineral density in the heel bone (in men.)
DHT levels correlated positively with BMD even after adjusting for age, whereas total testosterone and estrogen levels did not
DHT Stimulates Cranial Osteoblasts & Suture Fusion (moderately in teens, in adulthood sutures are fused.)
In cultured human osteoblast-like cells, DHT was shown to increase mineralization in a dose- and time-dependent manner. It even upregulated AR expression, strengthening its own osteogenic effects
DHT promotes alkaline phosphatase activity, collagen production, and extracellular matrix mineralization via AR and PI3K/AKT signaling pathways—a hallmark of enhanced bone formation Nerdspeak for, "it makes your bones grow." In adulthood, DHT maintains and remodels bones, Which is good for face. you want increased bone mineral density in things like the brow ridge and mandible.
DHT post puberty makes your dick work.
Transdermal DHT gel (125–250 mg/day) administered in people with low T and ED resulted in significant improvement of early morning erections and the ability to maintain them
sexual performance was maintained and improved following the administration of DHT in older men
Transdermal DHT gel maintained sexual health in men with complete suppression of endogenous testosterone and estrogen
DHT is a downstream of Testosterone. If you are doing exogenous testosterone, DHT will increase, and you will lose hair.
SO.
Type 1 and type 5α-Reductase enzymes (nerdspeak for DHT.)
Type 1 deals with skin and bones in adulthood. It deals with more but we only really care about skin and bones. Increased DHT upregulates sebaceous glands which means more acne.
Type 2 is important for puberty. Makes your dick bigger, drives facial and body hair growth.
The primary enzyme responsible for scalp hairloss is type 2.
Dutasteride blocks both 1 & 2 enzymes. Which are responsible for converting T into DHT.
Finasteride blocks type 2 ONLY.
we want DHT in our body for our bones and erectile health so systematically suppressing either enzyme via oral administration is undesirable.
Use topical solutions. They aren't difficult to source.
Contributes to male pattern facial acne and voice deepening through its powerful androgen activity
In boys born with 5α‑reductase deficiency external genitalia, facial hair, and prostate growth are impaired, reinforcing DHT's unique role during puberty
Male mice lacking the 5α‑reductase type 1 enzyme which is responsible for converting testosterone into DHT locally in bone, exhibit 36% lower trabecular bone mineral density, 15% reduction in cortical bone content, Decreased cortical bone size, and Weaker bone strength and reduced forelimb grip strength
Lower serum DHT was significantly associated with decreased bone mineral density in the heel bone (in men.)
DHT levels correlated positively with BMD even after adjusting for age, whereas total testosterone and estrogen levels did not
DHT Stimulates Cranial Osteoblasts & Suture Fusion (moderately in teens, in adulthood sutures are fused.)
In cultured human osteoblast-like cells, DHT was shown to increase mineralization in a dose- and time-dependent manner. It even upregulated AR expression, strengthening its own osteogenic effects
DHT promotes alkaline phosphatase activity, collagen production, and extracellular matrix mineralization via AR and PI3K/AKT signaling pathways—a hallmark of enhanced bone formation Nerdspeak for, "it makes your bones grow." In adulthood, DHT maintains and remodels bones, Which is good for face. you want increased bone mineral density in things like the brow ridge and mandible.
DHT post puberty makes your dick work.
Transdermal DHT gel (125–250 mg/day) administered in people with low T and ED resulted in significant improvement of early morning erections and the ability to maintain them
sexual performance was maintained and improved following the administration of DHT in older men
Transdermal DHT gel maintained sexual health in men with complete suppression of endogenous testosterone and estrogen
DHT is a downstream of Testosterone. If you are doing exogenous testosterone, DHT will increase, and you will lose hair.
SO.
Type 1 and type 5α-Reductase enzymes (nerdspeak for DHT.)
Type 1 deals with skin and bones in adulthood. It deals with more but we only really care about skin and bones. Increased DHT upregulates sebaceous glands which means more acne.
Type 2 is important for puberty. Makes your dick bigger, drives facial and body hair growth.
The primary enzyme responsible for scalp hairloss is type 2.
Dutasteride blocks both 1 & 2 enzymes. Which are responsible for converting T into DHT.
Finasteride blocks type 2 ONLY.
we want DHT in our body for our bones and erectile health so systematically suppressing either enzyme via oral administration is undesirable.
Use topical solutions. They aren't difficult to source.
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