dihexa + nsi 189 (nootropics)

[NorwoodAscender]

any thoughts/anecdotes on these two nootropics (dihexa and nsi-189) before i splurge on them?

buying from swisschems btw alongside enclo

 

[castizo]

dihexa is worth it

 

[NorwoodAscender]

dihexa is worth it

don’t know how much info u know on it but i see people just taking high doses once a week because of its long half-life. is this something u have heard/tried?

 

[castizo]

don’t know how much info u know on it but i see people just taking high doses once a week because of its long half-life. is this something u have heard/tried?

Don't know enough to comment about any of that tbh, i just know its good because i have only heard people say good things about it sorry

 

[NorwoodAscender]

Don't know enough to comment about any of that tbh, i just know its good because i have only heard people say good things about it sorry

no worries, thanks.

 

[NorwoodAscender]

bump

 

[Alexanderr]

any thoughts/anecdotes on these two nootropics (dihexa and nsi-189) before i splurge on them?

buying from swisschems btw alongside enclo

I've tried both of them, dihexa I don't really think I felt terribly much. I still got it though, I think I only took it for some 2-3 weeks. First week I took it every day, 20mg, if I recall. After then once every 3-5 days. Via DMSO 99% on my forearms. NSI-189, I also took for about the same period, with an occasional day or two that I missed. I think I'll need to retry that one, I heard it takes a couple weeks of consistent use to feel that one.

 

[NorwoodAscender]

I've tried both of them, dihexa I don't really think I felt terribly much. I still got it though, I think I only took it for some 2-3 weeks. First week I took it every day, 20mg, if I recall. After then once every 3-5 days. Via DMSO 99% on my forearms. NSI-189, I also took for about the same period, with an occasional day or two that I missed. I think I'll need to retry that one, I heard it takes a couple weeks of consistent use to feel that one.

what would u say would be the ideal nootropic stack for cognitive function/working memory?

 

[Alexanderr]

what would u say would be the ideal nootropic stack for cognitive function/working memory?

Impossible to answer, as it's entirely dependent on what neurochemicals each person lacks, either due to poor diet, or genetics.
Nevertheless, he's a potential stack I had locked away in some old files

Spoiler

Acetylcholine Enhancement​

• CDP Choline
  • 1000 mg orally with a meal twice daily
  • Alternatives: IM injections to avoid TMAO
• Alpha GPC
  • 100-300 mg for cognitively taxing tasks
  • Re-dose: 3-4 hours later
  • Tips:
    • Move around in mouth for better absorption
    • Consider cycling: 1 day off per week
• Donepezil
  • 5-20 mg upon rising daily
• Uridine Monophosphate
  • 500 mg for cognitively taxing tasks
• Piracetam/Noopept
  • Piracetam: 1000-2000 mg, re-dose 1000 mg 3-4 hours later, max 5 days/week
  • Alternative: 10-30 mg Noopept
• Tip: Combine CDP-choline and Alpha-GPC

Dopamine Regulation​

• L-Tyrosine
  • 1000 mg upon rising
  • Enhances Adderall effects when taken on an empty stomach
• Adderall
  • 5-10 mg for taxing tasks, max 5x/week
• Alternatives
  • Safinamide, methylphenidate, or modafinil
• Low-dose Selegiline
  • For dopamine boost

Adrenaline Management​

• Propranolol
  • 10-40 mg in stressful circumstances

GABA Regulation​

• Diazepam
  • 2.5-5 mg for important social events, max 1x/week

Neuroplasticity Enhancement​

• Fluvoxamine/Amitriptyline
  • Fluvoxamine: Up to 50 mg before bed if genetics allow
  • Amitriptyline: Up to 25 mg otherwise
• Cerebrolysin
  • 5ml once a week if needed

Neuroinflammation Control​

• Low Dose Naltrexone
  • 5-10 mg upon rising
• Supplements
  • Butyric acid, EPA, NAC, TUDCA: 3x/day
  • Tips: Fasting for liver enzymes, Creatine and Betaine

Circadian Rhythms Optimization​

• Growth Hormone
  • 2-3 IU before bed
• Melatonin
  • 2.5-10 mg short release before bed
• SR9009
  • Injections upon rising, especially when traveling

Exercise Recommendations​

• Routine
  • 30 min aerobic + 20 min sauna, 4x/week
  • Tips: Morning cardio, Incorporate HIIT

Dietary Guidelines​

• Eating Window
  • Restrict to 6 hours daily
• Macronutrients
  • 150-200g protein, low carb
• Foods to Prioritize
  • Vegetables, fruits, nuts, beef liver, eggs

Genetic Considerations​

• BDNF Val66Met and 5-HTTLPR
  • Affect response to SSRIs
• MTHFR Polymorphisms
  • Implications for folate metabolism

Also found a list I'd stored of peptides relevant for cognition.

Spoiler

Neuroprotection and Recovery

• ARA-290: Enhances nerve fiber growth, reduces pain in various diseases.
• BPC-157: Repairs dopaminergic neurons, increases Nitric oxide.
• Cortagen: Aids posttraumatic recovery of peripheral nerve tissue.
• Cerebrolysin, N-PEP-12: Provides essential neurotrophic factors, enhances brain oxygen delivery.
• Cerluten: Regulates CNS, acts as antioxidant and adaptogen.
• Cortexin: Balances cortisol, boosts serotonin, GABA, and dopamine regulation.
• Dihexa: Stimulates synapse generation, potentially improving memory and motor functions.
• DNSP-5 & 11: Protects dopaminergic neurons, enhances motor performance.
• Glutathione: Combats oxidative stress in Parkinson’s disease.
• HAYED (5): Reduces oxidative damage in cells and brain.
• Humanin: Protects against neurotoxins, enhances neurological insulin sensitivity.
• Melanotan 1 & 2: Reduces neural inflammation, improves astrocyte function.
• Pinealon: Repairs neurologic and pituitary damage, improves circadian rhythms.
• Thymosin alpha-1, Thymosin Beta 4: Supports neuron growth and connectivity, reduces inflammation.
• WRW-4: Protects brain from amyloid β42 impairment.

Neurogenesis and Cognitive Enhancement

• FGLL/HA-FGL: Stimulates neurite outgrowth, reduces oxidative stress-induced neuronal death.
• GHK-Cu: Enhances angiogenesis and nerve growth, reduces CNS inflammation.
• IGF-2: Involved in myelinogenesis, neuronal growth, and memory improvement.
• P21: Mimics LIF, inhibits tau hyperphosphorylation, enhances neurogenesis.
• Rubiscolin-6, Semax: Stimulates memory consolidation, induces neurotrophic factors.
• Tesamorelin: Increases NAAG levels, potentially enhancing cognitive function.

Regulatory and Signaling Pathways

• Epitalon (Epithalamin): Increases stress resistance, acts as antioxidant.
• Fermented rice peptide (FRP): Regulates ERK/CREB/BDNF signaling, memory function.
• GLP-1: Protects neurons, stimulates neurite outgrowth, reduces amyloid-beta levels.
• Gly-Pro-Glu (GPE): Modulates signaling pathways, facilitates dopamine release.
• Gonadorelin: Modulates testosterone levels, affecting neuroprotection.
• Mots-C: Sensitizes endothelial cells to signaling molecules.
• Noopept: Affects NGF and BDNF expression, enhances adaptation to environmental stress.
• Orexin-A: Improves memory tasks performance in sleep-deprived subjects.
• Phoenixin: Involved in regulation of memory, anxiety, and reproductive function.
• VGVAPG (pal-VGVAPG): Modulates astrocyte and neuroblastoma cell functions.
• VIP: Neuroprotective against inflammatory conditions, promotes repair and BDNF production.

Specialized Functions and Conditions

• Thyrotropin TRH: Facilitates motor learning, decreases ataxia in degenerative diseases.

---

Full list

• ARA-290 increases the number of small nerve fibers and reduces pain significantly, offering effective treatment for nerve damage seen in diseases like sarcoidosis, diabetes, thyroid dysfunction, celiac disease, HIV, and more. Dr. Daniel Culver states, "ARA 290 offers new hope for patients suffering debilitating pain and severe dysautonomia."
• BPC-157 repairs dopaminergic neurons and raises Nitric oxide levels.
• Cortagen demonstrated a pronounced therapeutic effect upon the structural and functional posttraumatic recovery of peripheral nerve tissue.
• Cerebrolysin (to a weaker extent N-PEP-12) contains GDNF, NGF, BDNF, CTNF, and many essential amino acids, encouraging more oxygen delivery into the brain.
• Cerluten helps regulate the CNS and cortex, acting as a neural antioxidant and perhaps as an adaptogen.
• Cortexin comprises BDNF and NGF peptides, reduces excessive levels of cortisol, and enhances serotonin and GABA production. Stimulates dopamine liberation and suppresses dopamine action on receptors.
• Dihexa is a hepatocyte growth factor agonist that stimulates nerve synapse generation, potentially overcoming memory and motor dysfunctions.
• DNSP-5 & 11 increase tyrosine hydroxylase positive neuronal sparing, enhance motor performance, and induce neurological GDNF(?), protecting dopaminergic neurons.
• Epitalon (A.K.A. Epithalamin) increases resistance to emotional stress and acts as an antioxidant.
• Fermented rice peptide (FRP) prevents memory impairment through regulation of the ERK/CREB/BDNF signaling pathway, decreasing acetylcholine levels and increasing acetylcholinesterase activity.
• FGLL/HA-FGL activates NCAM–FGFR signaling pathways, resulting in increased neurite outgrowth and survival, effects in memory, and decreased oxidative stress-induced neuronal cell death.
• GHK-Cu improves angiogenesis in the nervous system, boosts nerve outgrowth, and reduces inflammation in the central nervous system.
• GLP-1 protects against excitotoxic neuron damage and stimulates neurite outgrowth, reducing levels of amyloid-beta and the beta-amyloid precursor protein.
• Glutathione may combat oxidative stress that damages dopamine neurons in Parkinson’s disease.
• Gly-Pro-Glu (GPE) is neuroprotective, modulating calcium and GSK-3β signaling, facilitating dopamine release through NMDA receptor interaction.
• Gonadorelin raises LH, converting into testosterone, which contains neuroprotective effects against Dementia. Continuous use requires cycling due to natural testosterone shutdown.
• HAYED (5) decreases iron and radical levels, preventing cell and brain damage.
• Humanin protects the brain from neurotoxins like amyloid β, improves neurological insulin sensitivity, regulates IRS-1/mTOR signaling, and acts like an antioxidant to excitotoxins.
• IGF-2 plays a role in myelinogenesis, regulating growth, differentiation, survival of neurons, calcium homeostasis, and acetylcholinesterase enhancement.
• Melanotan 1 & 2 assist with neural inflammation and improve astrocyte functioning by increasing levels of BDNF.
• Mots-C sensitizes endothelial cells to effects of other signaling molecules like acetylcholine.
• Noopept positively affects psychological components for rapid climate adaptation, expression of NGF and BDNF mRNA, and increases DNA-binding activity of HIF-1.
• Orexin-A significantly improves performance in sleep-deprived subjects on short-term memory tasks.
• P21 is a LIF mimetic, inhibiting tau abnormal hyperphosphorylation, enhancing adult hippocampal progenitors proliferation and differentiation, and improving cognition.
• Phoenixin plays a role in reproductive function, memory, and anxiety regulation in the brain and periphery.
• Pinealon mends dopaminergic/serotonergic and pituitary damage caused by aging, may improve circadian rhythm disorders, and limits excitotoxic effects of NMDA activity.
• Rubiscolin-6 had an analgesic effect and stimulated memory consolidation.
• Semax, induces BDNF in the CNS, and improves gene expression for the hippocampus and frontal cortex, preventing long-term potentiation impairment.
• Tesamorelin raises NAAG levels.
• Thymosin alpha-1 advances neuron growth and development connections between neurons, protective for inflammation and neuron dysfunction.
• Thymosin Beta 4 might improve spinal cord wounds, promoting angiogenesis, neurogenesis, synaptogenesis, and oligodendrogenesis.
• Thyrotropin TRH enhances motor learning speed via exogenous administration, active in the cerebellum, and decreases ataxia in cerebellar degenerative disease models.
• VIP has a neuroprotective effect on inflammatory conditions, inhibiting production of microglia-derived proinflammatory factors and promoting axonal regrowth and BDNF production through the VPAC2 receptor.
• VGVAPG (sold as pal-VGVAPG) decreases secretion of P4 by astrocytes and SH-SY5Y Neuroblastoma cells proliferation, which is prevented by ROS scavenger N-acetyl-L-cysteine.
• WRW-4 protests the brain from amyloid β42 impairment, acting as a FPR2 antagonist.

 

[NorwoodAscender]

Impossible to answer, as it's entirely dependent on what neurochemicals each person lacks, either due to poor diet, or genetics.
Nevertheless, he's a potential stack I had locked away in some old files

Spoiler

Acetylcholine Enhancement​

• CDP Choline
  • 1000 mg orally with a meal twice daily
  • Alternatives: IM injections to avoid TMAO
• Alpha GPC
  • 100-300 mg for cognitively taxing tasks
  • Re-dose: 3-4 hours later
  • Tips:
    • Move around in mouth for better absorption
    • Consider cycling: 1 day off per week
• Donepezil
  • 5-20 mg upon rising daily
• Uridine Monophosphate
  • 500 mg for cognitively taxing tasks
• Piracetam/Noopept
  • Piracetam: 1000-2000 mg, re-dose 1000 mg 3-4 hours later, max 5 days/week
  • Alternative: 10-30 mg Noopept
• Tip: Combine CDP-choline and Alpha-GPC

Dopamine Regulation​

• L-Tyrosine
  • 1000 mg upon rising
  • Enhances Adderall effects when taken on an empty stomach
• Adderall
  • 5-10 mg for taxing tasks, max 5x/week
• Alternatives
  • Safinamide, methylphenidate, or modafinil
• Low-dose Selegiline
  • For dopamine boost

Adrenaline Management​

• Propranolol
  • 10-40 mg in stressful circumstances

GABA Regulation​

• Diazepam
  • 2.5-5 mg for important social events, max 1x/week

Neuroplasticity Enhancement​

• Fluvoxamine/Amitriptyline
  • Fluvoxamine: Up to 50 mg before bed if genetics allow
  • Amitriptyline: Up to 25 mg otherwise
• Cerebrolysin
  • 5ml once a week if needed

Neuroinflammation Control​

• Low Dose Naltrexone
  • 5-10 mg upon rising
• Supplements
  • Butyric acid, EPA, NAC, TUDCA: 3x/day
  • Tips: Fasting for liver enzymes, Creatine and Betaine

Circadian Rhythms Optimization​

• Growth Hormone
  • 2-3 IU before bed
• Melatonin
  • 2.5-10 mg short release before bed
• SR9009
  • Injections upon rising, especially when traveling

Exercise Recommendations​

• Routine
  • 30 min aerobic + 20 min sauna, 4x/week
  • Tips: Morning cardio, Incorporate HIIT

Dietary Guidelines​

• Eating Window
  • Restrict to 6 hours daily
• Macronutrients
  • 150-200g protein, low carb
• Foods to Prioritize
  • Vegetables, fruits, nuts, beef liver, eggs

Genetic Considerations​

• BDNF Val66Met and 5-HTTLPR
  • Affect response to SSRIs
• MTHFR Polymorphisms
  • Implications for folate metabolism

Also found a list I'd stored of peptides relevant for cognition.

Spoiler

Neuroprotection and Recovery

• ARA-290: Enhances nerve fiber growth, reduces pain in various diseases.
• BPC-157: Repairs dopaminergic neurons, increases Nitric oxide.
• Cortagen: Aids posttraumatic recovery of peripheral nerve tissue.
• Cerebrolysin, N-PEP-12: Provides essential neurotrophic factors, enhances brain oxygen delivery.
• Cerluten: Regulates CNS, acts as antioxidant and adaptogen.
• Cortexin: Balances cortisol, boosts serotonin, GABA, and dopamine regulation.
• Dihexa: Stimulates synapse generation, potentially improving memory and motor functions.
• DNSP-5 & 11: Protects dopaminergic neurons, enhances motor performance.
• Glutathione: Combats oxidative stress in Parkinson’s disease.
• HAYED (5): Reduces oxidative damage in cells and brain.
• Humanin: Protects against neurotoxins, enhances neurological insulin sensitivity.
• Melanotan 1 & 2: Reduces neural inflammation, improves astrocyte function.
• Pinealon: Repairs neurologic and pituitary damage, improves circadian rhythms.
• Thymosin alpha-1, Thymosin Beta 4: Supports neuron growth and connectivity, reduces inflammation.
• WRW-4: Protects brain from amyloid β42 impairment.

Neurogenesis and Cognitive Enhancement

• FGLL/HA-FGL: Stimulates neurite outgrowth, reduces oxidative stress-induced neuronal death.
• GHK-Cu: Enhances angiogenesis and nerve growth, reduces CNS inflammation.
• IGF-2: Involved in myelinogenesis, neuronal growth, and memory improvement.
• P21: Mimics LIF, inhibits tau hyperphosphorylation, enhances neurogenesis.
• Rubiscolin-6, Semax: Stimulates memory consolidation, induces neurotrophic factors.
• Tesamorelin: Increases NAAG levels, potentially enhancing cognitive function.

Regulatory and Signaling Pathways

• Epitalon (Epithalamin): Increases stress resistance, acts as antioxidant.
• Fermented rice peptide (FRP): Regulates ERK/CREB/BDNF signaling, memory function.
• GLP-1: Protects neurons, stimulates neurite outgrowth, reduces amyloid-beta levels.
• Gly-Pro-Glu (GPE): Modulates signaling pathways, facilitates dopamine release.
• Gonadorelin: Modulates testosterone levels, affecting neuroprotection.
• Mots-C: Sensitizes endothelial cells to signaling molecules.
• Noopept: Affects NGF and BDNF expression, enhances adaptation to environmental stress.
• Orexin-A: Improves memory tasks performance in sleep-deprived subjects.
• Phoenixin: Involved in regulation of memory, anxiety, and reproductive function.
• VGVAPG (pal-VGVAPG): Modulates astrocyte and neuroblastoma cell functions.
• VIP: Neuroprotective against inflammatory conditions, promotes repair and BDNF production.

Specialized Functions and Conditions

• Thyrotropin TRH: Facilitates motor learning, decreases ataxia in degenerative diseases.

---

Full list

• ARA-290 increases the number of small nerve fibers and reduces pain significantly, offering effective treatment for nerve damage seen in diseases like sarcoidosis, diabetes, thyroid dysfunction, celiac disease, HIV, and more. Dr. Daniel Culver states, "ARA 290 offers new hope for patients suffering debilitating pain and severe dysautonomia."
• BPC-157 repairs dopaminergic neurons and raises Nitric oxide levels.
• Cortagen demonstrated a pronounced therapeutic effect upon the structural and functional posttraumatic recovery of peripheral nerve tissue.
• Cerebrolysin (to a weaker extent N-PEP-12) contains GDNF, NGF, BDNF, CTNF, and many essential amino acids, encouraging more oxygen delivery into the brain.
• Cerluten helps regulate the CNS and cortex, acting as a neural antioxidant and perhaps as an adaptogen.
• Cortexin comprises BDNF and NGF peptides, reduces excessive levels of cortisol, and enhances serotonin and GABA production. Stimulates dopamine liberation and suppresses dopamine action on receptors.
• Dihexa is a hepatocyte growth factor agonist that stimulates nerve synapse generation, potentially overcoming memory and motor dysfunctions.
• DNSP-5 & 11 increase tyrosine hydroxylase positive neuronal sparing, enhance motor performance, and induce neurological GDNF(?), protecting dopaminergic neurons.
• Epitalon (A.K.A. Epithalamin) increases resistance to emotional stress and acts as an antioxidant.
• Fermented rice peptide (FRP) prevents memory impairment through regulation of the ERK/CREB/BDNF signaling pathway, decreasing acetylcholine levels and increasing acetylcholinesterase activity.
• FGLL/HA-FGL activates NCAM–FGFR signaling pathways, resulting in increased neurite outgrowth and survival, effects in memory, and decreased oxidative stress-induced neuronal cell death.
• GHK-Cu improves angiogenesis in the nervous system, boosts nerve outgrowth, and reduces inflammation in the central nervous system.
• GLP-1 protects against excitotoxic neuron damage and stimulates neurite outgrowth, reducing levels of amyloid-beta and the beta-amyloid precursor protein.
• Glutathione may combat oxidative stress that damages dopamine neurons in Parkinson’s disease.
• Gly-Pro-Glu (GPE) is neuroprotective, modulating calcium and GSK-3β signaling, facilitating dopamine release through NMDA receptor interaction.
• Gonadorelin raises LH, converting into testosterone, which contains neuroprotective effects against Dementia. Continuous use requires cycling due to natural testosterone shutdown.
• HAYED (5) decreases iron and radical levels, preventing cell and brain damage.
• Humanin protects the brain from neurotoxins like amyloid β, improves neurological insulin sensitivity, regulates IRS-1/mTOR signaling, and acts like an antioxidant to excitotoxins.
• IGF-2 plays a role in myelinogenesis, regulating growth, differentiation, survival of neurons, calcium homeostasis, and acetylcholinesterase enhancement.
• Melanotan 1 & 2 assist with neural inflammation and improve astrocyte functioning by increasing levels of BDNF.
• Mots-C sensitizes endothelial cells to effects of other signaling molecules like acetylcholine.
• Noopept positively affects psychological components for rapid climate adaptation, expression of NGF and BDNF mRNA, and increases DNA-binding activity of HIF-1.
• Orexin-A significantly improves performance in sleep-deprived subjects on short-term memory tasks.
• P21 is a LIF mimetic, inhibiting tau abnormal hyperphosphorylation, enhancing adult hippocampal progenitors proliferation and differentiation, and improving cognition.
• Phoenixin plays a role in reproductive function, memory, and anxiety regulation in the brain and periphery.
• Pinealon mends dopaminergic/serotonergic and pituitary damage caused by aging, may improve circadian rhythm disorders, and limits excitotoxic effects of NMDA activity.
• Rubiscolin-6 had an analgesic effect and stimulated memory consolidation.
• Semax, induces BDNF in the CNS, and improves gene expression for the hippocampus and frontal cortex, preventing long-term potentiation impairment.
• Tesamorelin raises NAAG levels.
• Thymosin alpha-1 advances neuron growth and development connections between neurons, protective for inflammation and neuron dysfunction.
• Thymosin Beta 4 might improve spinal cord wounds, promoting angiogenesis, neurogenesis, synaptogenesis, and oligodendrogenesis.
• Thyrotropin TRH enhances motor learning speed via exogenous administration, active in the cerebellum, and decreases ataxia in cerebellar degenerative disease models.
• VIP has a neuroprotective effect on inflammatory conditions, inhibiting production of microglia-derived proinflammatory factors and promoting axonal regrowth and BDNF production through the VPAC2 receptor.
• VGVAPG (sold as pal-VGVAPG) decreases secretion of P4 by astrocytes and SH-SY5Y Neuroblastoma cells proliferation, which is prevented by ROS scavenger N-acetyl-L-cysteine.
• WRW-4 protests the brain from amyloid β42 impairment, acting as a FPR2 antagonist.

absolute legend. appreciate it brother

 

[9898]

I've tried both of them, dihexa I don't really think I felt terribly much. I still got it though, I think I only took it for some 2-3 weeks. First week I took it every day, 20mg, if I recall. After then once every 3-5 days. Via DMSO 99% on my forearms. NSI-189, I also took for about the same period, with an occasional day or two that I missed. I think I'll need to retry that one, I heard it takes a couple weeks of consistent use to feel that one.

Dihexa alone is seven orders of magnitude stronger than BDNF at inducing neurogenesis. 2-3 weeks is not nearly long enough to gauge the effects especially considering Dihexa's half life is about 13 days long

 

[NorwoodAscender]

Dihexa alone is seven orders of magnitude stronger than BDNF at inducing neurogenesis. 2-3 weeks is not nearly long enough to gauge the effects especially considering Dihexa's half life is about 13 days long

i think i remember u mentioning your stack somewhere and saying to cycle on and cycle off. how long would u cycle for, and how long of a break between cycles.

 

[9898]

i think i remember u mentioning your stack somewhere and saying to cycle on and cycle off. how long would u cycle for, and how long if a break between cycles.

I'm building a new stack at the moment to recover from pregabalin abuse. I have an essential tremor now which makes me seem like I a high inhib geriatric with parkinson's disease

I haven't got everything yet but this'll be the stack:

• Dihexa: HGF positive allosteric modulator which is by far the strongest neurogenic compound currently available
• ISRIB: Integrated stress response inhibitor: inhibits the stress response which is responsible for globally halting protein synthesis after traumatic brain injuries and viruses. I'm hoping this will revert any damage that occurred with sustained pregabalin abuse
• SR9009: legitimately a godsend and the more I research it the better it seems. Basically abolishes LDL entirely, decreases lipogenesis, increases bile synthesis in the liver, strongly hepatoprotective, decreases fibrosis in the heart, reverts LVH, increases insulin sensitivity, increases glucose uptake into skeletal muscle, increases mitogenesis and mitochondrial density, increases muscle mass, resets circadian rhythm, promotes nautral wakefullness without feeling stimmy, anxioylsis equivalent to benzodiazpines without dependence/withdrawal, it selectively eviscerates certain cancers and is apopototic toward tumours without causing apoptosis to regular cells. It's probably the healthiest thing you could ever give yourself
• MOTS-C: increases mitochondrial function, increases insulin sensivity, increases glucose uptake into myocytes, crushes LDL, increases energy expenditure, decreases expression of myostatin (higher myostatin = lower endogenous MOTS-c and the inverse is also true).
• ITPP: membrane-permeant allosteric regulator of hemoglobin which slightly reduces oxygen's affinity towards Hb and therefore increases the uptake of oxygen by the body by over 30%. This is by far the most potent endurance enhancer ever. It's deeply anti-cancer as well because oxygen kills tumors and one of the defining features of metastasis is lack of oxygen being provided to cancerous tissue. It's nootropic because it increases oxygen uptake into the brain also.
• Inj L-carnitine: I take this because combined with pantothenic acid it increases production of co-enzyme-A which decreases lipogenesis in sebaceous glands and increases fatty acid oxidation.
• BPC157: just because it increases GH receptor density and is overall a miracle compound for healing
• GH: 4iu before bed for circadian rhythm, recovery and also because it synergises with Dihexa to produce stronger neurogenesis

I'll probably start introducing things like Bromantane, Cyclazodone and selegiline to optimize dopamine but for now this is what I'll use

 

[NorwoodAscender]

pregabalin abuse

brutal… my pregab arrives tomorrow

should i be okay if i only use it on special occasions? (presentations and going out)

and holy shit i need to look into SR9009

 

[9898]

should i be okay if i only use it on special occasions? (presentations and going out)

Yeah use it sparingly and you'll be fine.

It legitimately reduces synaptogenesis like nothing else. It's doing the opposite of what Dihexa is longterm

 

[NorwoodAscender]

Yeah use it sparingly and you'll be fine.

It legitimately reduces synaptogenesis like nothing else. It's doing the opposite of what Dihexa is longterm

i’m currently on adderall 5 days on 2 off.

is there anything you would recommend adding to it mainly to improve working memory, verbal fluency, and cognition?

 

[9898]

i’m currently on adderall 5 days on 2 off.

is there anything you would recommend adding to it mainly to improve working memory, verbal fluency, and cognition?

Dihexa

 

[NorwoodAscender]

Dihexa

all i needed to hear. appreciate it. and nothing else? is nsi not worth it ROI wise in your opinion?

 

[9898]

all i needed to hear. appreciate it. and nothing else? is nsi not worth it ROI wise in your opinion?

NSI is garbage jfl

yeah don't touch that worthless poison. Dihexa will induce all the neurogenesis you need

the rest of my stack is to provide bullet-proof physical/mental energy

 

[Clavicular]

Impossible to answer, as it's entirely dependent on what neurochemicals each person lacks, either due to poor diet, or genetics.
Nevertheless, he's a potential stack I had locked away in some old files

Spoiler

Acetylcholine Enhancement​

• CDP Choline
  • 1000 mg orally with a meal twice daily
  • Alternatives: IM injections to avoid TMAO
• Alpha GPC
  • 100-300 mg for cognitively taxing tasks
  • Re-dose: 3-4 hours later
  • Tips:
    • Move around in mouth for better absorption
    • Consider cycling: 1 day off per week
• Donepezil
  • 5-20 mg upon rising daily
• Uridine Monophosphate
  • 500 mg for cognitively taxing tasks
• Piracetam/Noopept
  • Piracetam: 1000-2000 mg, re-dose 1000 mg 3-4 hours later, max 5 days/week
  • Alternative: 10-30 mg Noopept
• Tip: Combine CDP-choline and Alpha-GPC

Dopamine Regulation​

• L-Tyrosine
  • 1000 mg upon rising
  • Enhances Adderall effects when taken on an empty stomach
• Adderall
  • 5-10 mg for taxing tasks, max 5x/week
• Alternatives
  • Safinamide, methylphenidate, or modafinil
• Low-dose Selegiline
  • For dopamine boost

Adrenaline Management​

• Propranolol
  • 10-40 mg in stressful circumstances

GABA Regulation​

• Diazepam
  • 2.5-5 mg for important social events, max 1x/week

Neuroplasticity Enhancement​

• Fluvoxamine/Amitriptyline
  • Fluvoxamine: Up to 50 mg before bed if genetics allow
  • Amitriptyline: Up to 25 mg otherwise
• Cerebrolysin
  • 5ml once a week if needed

Neuroinflammation Control​

• Low Dose Naltrexone
  • 5-10 mg upon rising
• Supplements
  • Butyric acid, EPA, NAC, TUDCA: 3x/day
  • Tips: Fasting for liver enzymes, Creatine and Betaine

Circadian Rhythms Optimization​

• Growth Hormone
  • 2-3 IU before bed
• Melatonin
  • 2.5-10 mg short release before bed
• SR9009
  • Injections upon rising, especially when traveling

Exercise Recommendations​

• Routine
  • 30 min aerobic + 20 min sauna, 4x/week
  • Tips: Morning cardio, Incorporate HIIT

Dietary Guidelines​

• Eating Window
  • Restrict to 6 hours daily
• Macronutrients
  • 150-200g protein, low carb
• Foods to Prioritize
  • Vegetables, fruits, nuts, beef liver, eggs

Genetic Considerations​

• BDNF Val66Met and 5-HTTLPR
  • Affect response to SSRIs
• MTHFR Polymorphisms
  • Implications for folate metabolism

Also found a list I'd stored of peptides relevant for cognition.

Spoiler

Neuroprotection and Recovery

• ARA-290: Enhances nerve fiber growth, reduces pain in various diseases.
• BPC-157: Repairs dopaminergic neurons, increases Nitric oxide.
• Cortagen: Aids posttraumatic recovery of peripheral nerve tissue.
• Cerebrolysin, N-PEP-12: Provides essential neurotrophic factors, enhances brain oxygen delivery.
• Cerluten: Regulates CNS, acts as antioxidant and adaptogen.
• Cortexin: Balances cortisol, boosts serotonin, GABA, and dopamine regulation.
• Dihexa: Stimulates synapse generation, potentially improving memory and motor functions.
• DNSP-5 & 11: Protects dopaminergic neurons, enhances motor performance.
• Glutathione: Combats oxidative stress in Parkinson’s disease.
• HAYED (5): Reduces oxidative damage in cells and brain.
• Humanin: Protects against neurotoxins, enhances neurological insulin sensitivity.
• Melanotan 1 & 2: Reduces neural inflammation, improves astrocyte function.
• Pinealon: Repairs neurologic and pituitary damage, improves circadian rhythms.
• Thymosin alpha-1, Thymosin Beta 4: Supports neuron growth and connectivity, reduces inflammation.
• WRW-4: Protects brain from amyloid β42 impairment.

Neurogenesis and Cognitive Enhancement

• FGLL/HA-FGL: Stimulates neurite outgrowth, reduces oxidative stress-induced neuronal death.
• GHK-Cu: Enhances angiogenesis and nerve growth, reduces CNS inflammation.
• IGF-2: Involved in myelinogenesis, neuronal growth, and memory improvement.
• P21: Mimics LIF, inhibits tau hyperphosphorylation, enhances neurogenesis.
• Rubiscolin-6, Semax: Stimulates memory consolidation, induces neurotrophic factors.
• Tesamorelin: Increases NAAG levels, potentially enhancing cognitive function.

Regulatory and Signaling Pathways

• Epitalon (Epithalamin): Increases stress resistance, acts as antioxidant.
• Fermented rice peptide (FRP): Regulates ERK/CREB/BDNF signaling, memory function.
• GLP-1: Protects neurons, stimulates neurite outgrowth, reduces amyloid-beta levels.
• Gly-Pro-Glu (GPE): Modulates signaling pathways, facilitates dopamine release.
• Gonadorelin: Modulates testosterone levels, affecting neuroprotection.
• Mots-C: Sensitizes endothelial cells to signaling molecules.
• Noopept: Affects NGF and BDNF expression, enhances adaptation to environmental stress.
• Orexin-A: Improves memory tasks performance in sleep-deprived subjects.
• Phoenixin: Involved in regulation of memory, anxiety, and reproductive function.
• VGVAPG (pal-VGVAPG): Modulates astrocyte and neuroblastoma cell functions.
• VIP: Neuroprotective against inflammatory conditions, promotes repair and BDNF production.

Specialized Functions and Conditions

• Thyrotropin TRH: Facilitates motor learning, decreases ataxia in degenerative diseases.

---

Full list

• ARA-290 increases the number of small nerve fibers and reduces pain significantly, offering effective treatment for nerve damage seen in diseases like sarcoidosis, diabetes, thyroid dysfunction, celiac disease, HIV, and more. Dr. Daniel Culver states, "ARA 290 offers new hope for patients suffering debilitating pain and severe dysautonomia."
• BPC-157 repairs dopaminergic neurons and raises Nitric oxide levels.
• Cortagen demonstrated a pronounced therapeutic effect upon the structural and functional posttraumatic recovery of peripheral nerve tissue.
• Cerebrolysin (to a weaker extent N-PEP-12) contains GDNF, NGF, BDNF, CTNF, and many essential amino acids, encouraging more oxygen delivery into the brain.
• Cerluten helps regulate the CNS and cortex, acting as a neural antioxidant and perhaps as an adaptogen.
• Cortexin comprises BDNF and NGF peptides, reduces excessive levels of cortisol, and enhances serotonin and GABA production. Stimulates dopamine liberation and suppresses dopamine action on receptors.
• Dihexa is a hepatocyte growth factor agonist that stimulates nerve synapse generation, potentially overcoming memory and motor dysfunctions.
• DNSP-5 & 11 increase tyrosine hydroxylase positive neuronal sparing, enhance motor performance, and induce neurological GDNF(?), protecting dopaminergic neurons.
• Epitalon (A.K.A. Epithalamin) increases resistance to emotional stress and acts as an antioxidant.
• Fermented rice peptide (FRP) prevents memory impairment through regulation of the ERK/CREB/BDNF signaling pathway, decreasing acetylcholine levels and increasing acetylcholinesterase activity.
• FGLL/HA-FGL activates NCAM–FGFR signaling pathways, resulting in increased neurite outgrowth and survival, effects in memory, and decreased oxidative stress-induced neuronal cell death.
• GHK-Cu improves angiogenesis in the nervous system, boosts nerve outgrowth, and reduces inflammation in the central nervous system.
• GLP-1 protects against excitotoxic neuron damage and stimulates neurite outgrowth, reducing levels of amyloid-beta and the beta-amyloid precursor protein.
• Glutathione may combat oxidative stress that damages dopamine neurons in Parkinson’s disease.
• Gly-Pro-Glu (GPE) is neuroprotective, modulating calcium and GSK-3β signaling, facilitating dopamine release through NMDA receptor interaction.
• Gonadorelin raises LH, converting into testosterone, which contains neuroprotective effects against Dementia. Continuous use requires cycling due to natural testosterone shutdown.
• HAYED (5) decreases iron and radical levels, preventing cell and brain damage.
• Humanin protects the brain from neurotoxins like amyloid β, improves neurological insulin sensitivity, regulates IRS-1/mTOR signaling, and acts like an antioxidant to excitotoxins.
• IGF-2 plays a role in myelinogenesis, regulating growth, differentiation, survival of neurons, calcium homeostasis, and acetylcholinesterase enhancement.
• Melanotan 1 & 2 assist with neural inflammation and improve astrocyte functioning by increasing levels of BDNF.
• Mots-C sensitizes endothelial cells to effects of other signaling molecules like acetylcholine.
• Noopept positively affects psychological components for rapid climate adaptation, expression of NGF and BDNF mRNA, and increases DNA-binding activity of HIF-1.
• Orexin-A significantly improves performance in sleep-deprived subjects on short-term memory tasks.
• P21 is a LIF mimetic, inhibiting tau abnormal hyperphosphorylation, enhancing adult hippocampal progenitors proliferation and differentiation, and improving cognition.
• Phoenixin plays a role in reproductive function, memory, and anxiety regulation in the brain and periphery.
• Pinealon mends dopaminergic/serotonergic and pituitary damage caused by aging, may improve circadian rhythm disorders, and limits excitotoxic effects of NMDA activity.
• Rubiscolin-6 had an analgesic effect and stimulated memory consolidation.
• Semax, induces BDNF in the CNS, and improves gene expression for the hippocampus and frontal cortex, preventing long-term potentiation impairment.
• Tesamorelin raises NAAG levels.
• Thymosin alpha-1 advances neuron growth and development connections between neurons, protective for inflammation and neuron dysfunction.
• Thymosin Beta 4 might improve spinal cord wounds, promoting angiogenesis, neurogenesis, synaptogenesis, and oligodendrogenesis.
• Thyrotropin TRH enhances motor learning speed via exogenous administration, active in the cerebellum, and decreases ataxia in cerebellar degenerative disease models.
• VIP has a neuroprotective effect on inflammatory conditions, inhibiting production of microglia-derived proinflammatory factors and promoting axonal regrowth and BDNF production through the VPAC2 receptor.
• VGVAPG (sold as pal-VGVAPG) decreases secretion of P4 by astrocytes and SH-SY5Y Neuroblastoma cells proliferation, which is prevented by ROS scavenger N-acetyl-L-cysteine.
• WRW-4 protests the brain from amyloid β42 impairment, acting as a FPR2 antagonist.

@Alexanderr How'd you like dihexa, about to start using it with DMSO for transcrotal absorption (JFL)

Also donepezil seems utterly worthless to me, you like that stuff?

 

[Alexanderr]

@Alexanderr How'd you like dihexa, about to start using it with DMSO for transcrotal absorption (JFL)

Also donepezil seems utterly worthless to me, you like that stuff?

I haven't quite used it long enough to properly give it a review, I only took it for some 2-3 weeks. I wouldn't put it anywhere near my balls, that shit burns. It's odd, some people say they immediately felt a significant change, others it took weeks and some none at all.

Donepezil I haven't used my self, but its listed because it increases acetylcholine levels in the synapses and enhances cholinergic neurotransmission. It's just one of the possible options people can use to enhance acetylcholine levels, probably the most potent.

 

[Clavicular]

I haven't quite used it long enough to properly give it a review, I only took it for some 2-3 weeks. I wouldn't put it anywhere near my balls, that shit burns. It's odd, some people say they immediately felt a significant change, others it took weeks and some none at all.

Donepezil I haven't used my self, but its listed because it increases acetylcholine levels in the synapses and enhances cholinergic neurotransmission. It's just one of the possible options people can use to enhance acetylcholine levels, probably the most potent.

Transcrotal has highest absorbtion, dyorotic does it aswell. I felt too foggy on 10mg of donepezil

 

[NorwoodAscender]

@Alexanderr How'd you like dihexa, about to start using it with DMSO for transcrotal absorption (JFL)

Also donepezil seems utterly worthless to me, you like that stuff?

don’t make any threads on it plz

already hard enough to source as is

 

[Clavicular]

don’t make any threads on it plz

already hard enough to source as is

Its easy to source if ur not retarded, also JFL if u think anyone on here actually drugmaxes

 

[dorian]

I'm building a new stack at the moment to recover from pregabalin abuse. I have an essential tremor now which makes me seem like I a high inhib geriatric with parkinson's disease

I haven't got everything yet but this'll be the stack:

• Dihexa: HGF positive allosteric modulator which is by far the strongest neurogenic compound currently available
• ISRIB: Integrated stress response inhibitor: inhibits the stress response which is responsible for globally halting protein synthesis after traumatic brain injuries and viruses. I'm hoping this will revert any damage that occurred with sustained pregabalin abuse
• SR9009: legitimately a godsend and the more I research it the better it seems. Basically abolishes LDL entirely, decreases lipogenesis, increases bile synthesis in the liver, strongly hepatoprotective, decreases fibrosis in the heart, reverts LVH, increases insulin sensitivity, increases glucose uptake into skeletal muscle, increases mitogenesis and mitochondrial density, increases muscle mass, resets circadian rhythm, promotes nautral wakefullness without feeling stimmy, anxioylsis equivalent to benzodiazpines without dependence/withdrawal, it selectively eviscerates certain cancers and is apopototic toward tumours without causing apoptosis to regular cells. It's probably the healthiest thing you could ever give yourself
• MOTS-C: increases mitochondrial function, increases insulin sensivity, increases glucose uptake into myocytes, crushes LDL, increases energy expenditure, decreases expression of myostatin (higher myostatin = lower endogenous MOTS-c and the inverse is also true).
• ITPP: membrane-permeant allosteric regulator of hemoglobin which slightly reduces oxygen's affinity towards Hb and therefore increases the uptake of oxygen by the body by over 30%. This is by far the most potent endurance enhancer ever. It's deeply anti-cancer as well because oxygen kills tumors and one of the defining features of metastasis is lack of oxygen being provided to cancerous tissue. It's nootropic because it increases oxygen uptake into the brain also.
• Inj L-carnitine: I take this because combined with pantothenic acid it increases production of co-enzyme-A which decreases lipogenesis in sebaceous glands and increases fatty acid oxidation.
• BPC157: just because it increases GH receptor density and is overall a miracle compound for healing
• GH: 4iu before bed for circadian rhythm, recovery and also because it synergises with Dihexa to produce stronger neurogenesis

I'll probably start introducing things like Bromantane, Cyclazodone and selegiline to optimize dopamine but for now this is what I'll use

I don't think inj l-carnitine is worth (for me, anyways) the injection spot occupation if you're pinning a lot of other stuff (I was doing 3cc of 500mg/ml), but you and @Alexanderr have posted some great stuff.

 

[9898]

I don't think inj l-carnitine is worth (for me, anyways) the injection spot occupation if you're pinning a lot of other stuff (I was doing 3cc of 500mg/ml), but you and @Alexanderr have posted some great stuff

In conjunction with oral pantothenic acid it can be useful for the creation of Co-enzyme-A which helps reduce sebaceous gland output. It's like an accutane-lite without the sides. Other than that it's pretty worthless

ITPP is the best chemical ever created for endurance, energy and wellbeing IMO.

 

[NorwoodAscender]

In conjunction with oral pantothenic acid it can be useful for the creation of Co-enzyme-A which helps reduce sebaceous gland output. It's like an accutane-lite without the sides. Other than that it's pretty worthless

ITPP is the best chemical ever created for endurance, energy and wellbeing IMO.

any tips on how to recover from months of adderall abuse? is just going cold turkey and cutting it out for a month or 2 enough?

 

[9898]

any tips on how to recover from months of adderall abuse? is just going cold turkey and cutting it out for a month or 2 enough?

Best thing to do is simply quit.

BPC157 heals dopaminergic neurons
DIHEXA in general is amazing for reversing brain damage after drug abuse
Bromantane + selegiliine to upregulate dopamine in general without causing aberrant signaling

 

[Clavicular]

I've tried both of them, dihexa I don't really think I felt terribly much. I still got it though, I think I only took it for some 2-3 weeks. First week I took it every day, 20mg, if I recall. After then once every 3-5 days. Via DMSO 99% on my forearms. NSI-189, I also took for about the same period, with an occasional day or two that I missed. I think I'll need to retry that one, I heard it takes a couple weeks of consistent use to feel that one.

It takes a while for it to work because your building new synapses overtime. Also, you dont need to use it daily, its a 13 day half life. Transcrotal absorbs far better than forearms (not a joke)

 

[Alexanderr]

It takes a while for it to work because your building new synapses overtime. Also, you dont need to use it daily, its a 13 day half life. Transcrotal absorbs far better than forearms (not a joke)

Yeah it might but having put that stuff on my forearms before, it burns so I don’t really see myself applying it via transcrotal.
Instead what I’ve done to increase absorption is to use my Derminator 2, on my forearms and to then apply the Dihexa afterward.

 

[TallDarkAndHandsome]

i’m currently on adderall 5 days on 2 off.

is there anything you would recommend adding to it mainly to improve working memory, verbal fluency, and cognition?

Instant release or extended? I can only get vyvanse (lisdexamphetamine) which is a prodrug to dexamphetamine with a half life of about 10-14 hrs although the usable effects for me feels like 8hrs or so. I'm trying to get instant release dex by switching psychiatrists but it might be hard.

 

[NorwoodAscender]

Instant release or extended? I can only get vyvanse (lisdexamphetamine) which is a prodrug to dexamphetamine with a half life of about 10-14 hrs although the usable effects for me feels like 8hrs or so. I'm trying to get instant release dex by switching psychiatrists but it might be hard.

i’m switching back to vyvanse im more productive on it. addy is too stimulating for me i got rot here for hours