Does accutane have any side effects

[ingush_slayer]

I’m 16 and had acne since like 14 I wanna take accutane but does it have any bad side effects like to my hormones

 

[SDPmaggot]

I’m 16 and had acne since like 14 I wanna take accutane but does it have any bad side effects like to my hormones

I don't know but I microdosed it and it nuked my acne, I just had dry lips.

 

[LLcel]

sudden death

 

[Mushroom]

I’m 16 and had acne since like 14 I wanna take accutane but does it have any bad side effects like to my hormones

the only reason that isotretinoin shit works is because it lowers your DHT levels, and DHT is needed at yo age

 

[ingush_slayer]

the only reason that isotretinoin shit works is because it lowers your DHT levels, and DHT is needed at yo age

So what do u think I should do to fix skin

 

[Mushroom]

So what do u think I should do to fix skin

The only way to fix acne is by lowering the conversion of your testosterone to DHT, and DHT is mandatory for bonemass, so the strategy is to lower DHT just a little bit and not nuke it and the only way to do this is by a natural supplement named SAW PALMETTO, take 500 to 800mg of that shit daily

 

[PainfulProportions]

I’m 16 and had acne since like 14 I wanna take accutane but does it have any bad side effects like to my hormones

take the accutane, approx 6 months, ive been on it for 1 week. current symptoms are dry skin, my face started being less oily and dry lips, with some joint pain if i go on long walks.

 

[LTN psl god]

I’m 16 and had acne since like 14 I wanna take accutane but does it have any bad side effects like to my hormones

You will get dry ass lips thats 100% but you could also get more acne at the beggining of the treatment and its a small chance you coul end up with depression. If you have big acne like big ass pimpels you will get scars

 

[PainfulProportions]

I’m 16 and had acne since like 14 I wanna take accutane but does it have any bad side effects like to my hormones

Also its not just DHT, i havent heard much abt DHT being involved. Accutane just makes your sebaceous glands shrink significantly which reduces oil and oil is what causes the bacteria to mix and clog pores. so pretty much a retinoid that targets oil glands.

 

[Mushroom]

Also its not just DHT, i havent heard much abt DHT being involved. Accutane just makes your sebaceous glands shrink significantly which reduces oil and oil is what causes the bacteria to mix and clog pores. so pretty much a retinoid that targets oil glands.

Accutane is basically a vitamin A overdose, and Yes it lowers DHT a shit ton, which helps with stopping sebaceous glands too, with also a direct hit to the glands themselves

 

[PainfulProportions]

nvm haha DHT is significantly reduced. but i believe you dont need to worry if its just low dose 20mg or below and 6 months usage.

 

[PainfulProportions]

Accutane is basically a vitamin A overdose, and Yes it lowers DHT a shit ton, which helps with stopping sebaceous glands too, with also a direct hit to the glands themselves

ur right

 

[new psl]

Permanent dryness , nose bleed , stunts growth , permanent dry eyes which i have

 

[PainfulProportions]

a direct hit to the glands themselves

i believe this is why accutane is such an effective option. bro i burnt my skin with topical products so i say go for it.

 

[Mushroom]

ur right

try lowering DHT just a little with a saw palmetto supplement instead of stunting your growth at a young age and test if it works if not then hop on Vitamin a overdose again

 

[swagdicerrr]

I recommend it even if it has side effects i was on it for a couple months and it completely cleared my skin

 

[PainfulProportions]

I recommend it even if it has side effects i was on it for a couple months and it completely cleared my skin

Guarantee when he says 'cleared', its cleared. accutane is very helpful. DHT isnt even an issue, and ppl at gym doing peptides etc find it useful for their pct

 

[ingush_slayer]

try lowering DHT just a little with a saw palmetto supplement instead of stunting your growth at a young age and test if it works if not then hop on Vitamin a overdose again

Guarantee when he says 'cleared', it’s cleared. accutane is very helpful. DHT isnt even an issue, and ppl at gym doing peptides etc find it useful for their pct

Wait I also have another question would I have to stay on it like if I stop will it come back

 

[PainfulProportions]

Wait I also have another question would I have to stay on it like if I stop will it come back

its results are long term so i doubt it would come back. unlike topical products

 

[Ogionth]

Accutane is basically a vitamin A overdose, and Yes it lowers DHT a shit ton, which helps with stopping sebaceous glands too, with also a direct hit to the glands themselves

Do you have a study to back up this claim?

I couldn't find any study that stated what you just said, this study (at the end of the thread) says that DHT levels were unchanged in men, however reduced in women.

3 alpha diol reduction doesn't have correlation with other bone related, penile length related etc effects of DHT.

Not only did you claim that it lowers DHT but by a "shit ton", so would you like to provide proof?

Effect of isotretinoin on serum levels of precursor and peripherally derived androgens in patients with acne
D P Lookingbill et al. Arch Dermatol. 1988 Apr.


Sebaceous glands are stimulated by androgens and can convert them to more active forms. Isotretinoin, however, has a profound inhibitory effect on sebaceous gland size and function. This study evaluated the effect of isotretinoin on serum levels of precursor and tissue-derived androgens. Twenty-four subjects (15 men and nine women) were treated for 20 weeks with 1 mg/kg/d of isotretinoin. Serum samples were obtained at baseline, 8, 16, and 24 weeks, and assayed for precursor androgens--total testosterone (TT), free testosterone (free T), dehydroepiandrosterone (DHEA), dehydroepiandrosterone-sulfate (DHEA-S); and tissue androgens--dihydrotestosterone (DHT), and its metabolite, 3 alpha-androstanediol glucuronide (3 alpha-diol G). Isotretinoin had no meaningful effects on precursor androgens, except for producing an elevation of free T in women. In contrast, isotretinoin produced depressions in the serum levels of DHT and 3 alpha-diol G in women and in 3 alpha-diol G in men. These decreases are believed to be the result, rather than the cause, of a reduction in the size of the sebaceous glands: The magnitude of the observed decreases may represent the amount of tissue-derived androgens that sebaceous glands normally contribute to the circulating pool.

 

[babel1]

dry lips and made depression worse but acne went forever. It's a magic pill for acne

 

[Rice and Chicken]

nose bleeding=closed nose all the time
super dry lips
and I heard it close growth plates

 

[szmyuss]

I’m 16 and had acne since like 14 I wanna take accutane but does it have any bad side effects like to my hormones

yes it can be mood swings dry skin and etc

 

[Mushroom]

Do you have a study to back up this claim?

I couldn't find any study that stated what you just said, this study (at the end of the thread) says that DHT levels were unchanged in men, however reduced in women.

3 alpha diol reduction doesn't have correlation with other bone related, penile length related etc effects of DHT.

Not only did you claim that it lowers DHT but by a "shit ton", so would you like to provide proof?

Effect of isotretinoin on serum levels of precursor and peripherally derived androgens in patients with acne
D P Lookingbill et al. Arch Dermatol. 1988 Apr.


Sebaceous glands are stimulated by androgens and can convert them to more active forms. Isotretinoin, however, has a profound inhibitory effect on sebaceous gland size and function. This study evaluated the effect of isotretinoin on serum levels of precursor and tissue-derived androgens. Twenty-four subjects (15 men and nine women) were treated for 20 weeks with 1 mg/kg/d of isotretinoin. Serum samples were obtained at baseline, 8, 16, and 24 weeks, and assayed for precursor androgens--total testosterone (TT), free testosterone (free T), dehydroepiandrosterone (DHEA), dehydroepiandrosterone-sulfate (DHEA-S); and tissue androgens--dihydrotestosterone (DHT), and its metabolite, 3 alpha-androstanediol glucuronide (3 alpha-diol G). Isotretinoin had no meaningful effects on precursor androgens, except for producing an elevation of free T in women. In contrast, isotretinoin produced depressions in the serum levels of DHT and 3 alpha-diol G in women and in 3 alpha-diol G in men. These decreases are believed to be the result, rather than the cause, of a reduction in the size of the sebaceous glands: The magnitude of the observed decreases may represent the amount of tissue-derived androgens that sebaceous glands normally contribute to the circulating pool.

i said one of the reasons it's good at stopping acne, is because it lowers the androgen that is responsible for the most sebaceous glands stimulation which is Mister DHT

 

[Deleted member 142159]

Not any I have heard. It could lead to blindness if taken with some other supplement whose name I forgot.

 

[duplybones]

I’m 16 and had acne since like 14 I wanna take accutane but does it have any bad side effects like to my hormones

helped my acne massively, can stun your growth though

 

[Zeekie]

I’m 16 and had acne since like 14 I wanna take accutane but does it have any bad side effects like to my hormones

At higher doses it can be hepatoxic, but it will not affect my hormones. It requires prescription though. If you can't get a prescription for it then buy it illegally. If you can't do that, then get a prescription for tretinoin, if you can't get it then buy it illegally. If you can't buy tretinoin then do adapalene, which is over-the-counter.

 

[Ogionth]

View attachment 3734994
i said one of the reasons it's good at stopping acne, is because it lowers the androgen that is responsible for the most sebaceous glands stimulation which is Mister DHT

It says

"The decrease in skin androgen receptor levels (this study) and the recently reported suppression of skin 5 alpha-dihydrotestosterone production by isotretinoin treatment appeared consistent with the involvement of androgen receptor and 5 alpha-dihydrotestosterone in the pathogenesis of acne"

Skin DHT ≠ whole of serum DHT, which is what one refers to by saying "It lowers DHT levels in the body" because skin DHT is not necessarily as important for most functions, so lowering it has little to no side effects.

Systemic DHT could remain the same even if skin, reduced.

I could be wrong, I've not looked into other studies but I just wanna know the truth and the study you stated does not support what you claimed.

 

[Mushroom]

It says

"The decrease in skin androgen receptor levels (this study) and the recently reported suppression of skin 5 alpha-dihydrotestosterone production by isotretinoin treatment appeared consistent with the involvement of androgen receptor and 5 alpha-dihydrotestosterone in the pathogenesis of acne"

Skin DHT ≠ whole of serum DHT, which is what one refers to by saying "It lowers DHT levels in the body" because skin DHT is not necessarily as important for most functions, so lowering it has little to no side effects.

Systemic DHT could remain the same even if skin, reduced.

I could be wrong, I've not looked into other studies but I just wanna know the truth and the study you stated does not support what you claimed.

lowering systematic DHT lowers skin DHT and lowering skin DHT reduces sebaceous glands activity therefore less acne, so by lowering the systematic DHT you get the other snowball effect, lowering DHT has side effects that are far less and easier than isotretinoin side effects

 

[Ogionth]

It says

"The decrease in skin androgen receptor levels (this study) and the recently reported suppression of skin 5 alpha-dihydrotestosterone production by isotretinoin treatment appeared consistent with the involvement of androgen receptor and 5 alpha-dihydrotestosterone in the pathogenesis of acne"

Skin DHT ≠ whole of serum DHT, which is what one refers to by saying "It lowers DHT levels in the body" because skin DHT is not necessarily as important for most functions, so low

It says

"The decrease in skin androgen receptor levels (this study) and the recently reported suppression of skin 5 alpha-dihydrotestosterone production by isotretinoin treatment appeared consistent with the involvement of androgen receptor and 5 alpha-dihydrotestosterone in the pathogenesis of acne"

Skin DHT ≠ whole of serum DHT, which is what one refers to by saying "It lowers DHT levels in the body" because skin DHT is not necessarily as important for most functions, so low

lowering systematic DHT lowers skin DHT and lowering skin DHT reduces sebaceous glands activity therefore less acne, so by lowering the systematic DHT you get the other snowball effect, lowering DHT has side effects that are far less and easier than isotretinoin side effects

it doesn't say it lowered systemic DHT, lowering skin DHT does not have a significant or sometimes not even noticeable effect on systemic DHT, the study clearly says this, have you even read them?

 

[Mushroom]

it doesn't say it lowered systemic DHT, lowering skin DHT does not have a significant or sometimes not even noticeable effect on systemic DHT, the study clearly says this, have you even read them?

i just made a logic starting off from systematic DHT, the point is that lowering skin DHT results in less acne, so why not lowering systematic DHT that will eventually lower the skin DHT that isotret lowers and then you gain less acne and less hairloss too + less side effects than isotret

 

[Ogionth]

i just made a logic starting off from systematic DHT, the point is that lowering skin DHT results in less acne, so why not lowering systematic DHT that will eventually lower the skin DHT that isotret lowers and then you gain less acne and less hairloss too + less side effects than isotret

That logic could've been deduced only if the study didn't state "Serum DHT levels remained unaffected" and the other study didn't see any changes in men on Serum DHT.

Reducing Skin DHT does not NECESSARILY mean overall systemic DHt must be significantly reduced.

 

[Mushroom]

That logic could've been deduced only if the study didn't state "Serum DHT levels remained unaffected" and the other study didn't see any changes in men on Serum DHT.

Reducing Skin DHT does not NECESSARILY mean overall systemic DHt must be significantly reduced.

our goal here is to reduce acne AKA reducing skin DHT with the least side effects so reducing systematic DHT but dut is an alternative solution to reduce skin DHT with less side effects that accutane + hairloss gains

 

[Ogionth]

our goal here is to reduce acne AKA reducing skin DHT with the least side effects so reducing systematic DHT but dut is an alternative solution to reduce skin DHT with less side effects that accutane + hairloss gains

So?

Dutastride reduces systemic DHT by 90%, the original commentator didn't ask about that?

Accutane has less side effects while maintaining DHT because it is needed during puberty.

Why the fuck would you suggest Dutastride to a 16 year old?


JUST say that you were mistaken about accutane's effects on systemic DHT and move on.

No need to switch the topic to dutasride, no sane person should take dutastride at 16

 

[Mushroom]

So?

Dutastride reduces systemic DHT by 90%, the original commentator didn't ask about that?

Accutane has less side effects while maintaining DHT because it is needed during puberty.

Why the fuck would you suggest Dutastride to a 16 year old?


JUST say that you were mistaken about accutane's effects on systemic DHT and move on.

No need to switch the topic to dutasride, no sane person should take dutastride at 16

that's why i told him use a lite version of dut which is natural saw palmetto te slightly reduce the DHT if the acne still there hop on accutane what you think ?

 

[Ogionth]

that's why i told him use a lite version of dut which is natural saw palmetto te slightly reduce the DHT if the acne still there hop on accutane what you think ?

Accutane will fix any acne tbh once the term is completed, I don't really suggest DHT inhibitors on their own before puberty has completely ended.

At most, do a second term of accutane but never 5 aris before puberty end.

 

[Ogionth]

Accutane will fix any acne tbh once the term is completed, I don't really suggest DHT inhibitors on their own before puberty has completely ended.

At most, do a second term of accutane but never 5 aris before puberty end.

And it isn't even a good fix to acne.

Reducing DHT for a while would only reduce the sebaceous gland size for a while / temporarily during the dosage, as opposed to Accutane that permanently reduces it.

It also wouldn't effect the other pathways (bacterial etc).