Does megadosing d3 help with skin

[Deleted member 9670]

Q

 

[Deleted member 14160]

perhaps

 

[Deleted member 9670]

perhaps

I've seen ppl say it does but no proof

 

[Clark69]

it depends if you're deficient or not. people deficient in vit D have skin rashes, acne bc of shit hormones, and age faster in skin and hair loss.

Furthermore, sebocytes were identified as 1,25OH2D responsive target cells, indicating that vitamin D analogs may be effective in the treatment of acne.

The role of vitamin D in hair might be explained by the fact that an optimal concentration of vitamin D has been suggested to be necessary to delay the aging phenomena, including hair loss [130]. Recently it has been shown that 1,25OH2D/VDR promotes the ability of β-catenin to stimulate hair follicle differentiation [131]. Moreover extensive data from animal models clearly show that the VDR activation plays an important role in the hair follicle cycle, specifically anagen initiation [132]. Interestingly, in VDR ablated mice it did not seem that normalization of mineral ion homeostasis by a diet high in calcium and phosphorous prevented alopecia suggesting that the mechanism for alopecia is unrelated to mineral levels but rather to the vitamin D levels [133]. Furthermore, recent data suggested that VDR regulates directly or indirectly the expression of genes required for hair follicle cycling, including the hedgehog signaling pathway [134].

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642156/

 

[Deleted member 9670]

it depends if you're deficient or not. people deficient in vit D have skin rashes, acne bc of shit hormones, and age faster in skin and hair loss.


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642156/

ye I think vit D deficiency made my hairloss worse

not deficient now but haven't noticed skin improvement