endogenous and exogenous substances that make you feel like that night before christmas when you were 9 again

[NoHoesinOhio]

. Phenylethylamine (can be raised through rasagiline)
. Piribedil (works by partial agonism of d2 and d3 w antagonism of d4)
. microdsed lsd (works through mglur5 coupled dopaminergic transmission)
. Sulbutiamine (works through upregulating d1)
.lisuride (agonises all 5 dopamine receptors)
. Semak/selank/ low dose naltrexone (antagonises melanocortin and is an enkephalinase inhibitor , enhances opiod signalling)
. Dihexa (Global upregulation of BDNF and other neurotrophic factors)
. baclofen (only use once in a while, gaba b agonism inhibtis serotonin release from brainsteam and dopamine modulation, increases impulsive behaviour and libido a ton although doesnt affect judgement like alcohol)
. microdsed salvia (seems to work for certain anhedonics through kappa opiod receptor downregulation)
.amantadine/bromantane (kir2 potassium channel inhibitor and upregulation of tyrosine hydroxylase plus confortmation change of postsynaptic dopamine receptors leading to enhanced signalling)
.certain cannabinoids (through mainly 5ht1a agonism although risk of downregulation)
.kratom (5 ht2a/2c antagonism and ht1a agonism , tolerance sets in quick just like with cannabis)
.amphetamine (enhances vesicular release of dopamine from the synaptic cleft, taar1 agonism, DAT inhibitor, DRI)

 

[NoHoesinOhio]

@CalulArgintiu59 @JeanneDArcAlter , I know theres a lot more but i think this stuff is available easier. I dont like rotigotine/ prami etc people think its the same but piribedil works and feels way different even though they all have mainly actions at d2 and d3

 

[JeanneDArcAlter]

@CalulArgintiu59 @JeanneDArcAlter , I know theres a lot more but i think this stuff is available easier. I dont like rotigotine/ prami etc people think its the same but piribedil works and feels way different even though they all have mainly actions at d2 and d3

Did not understand a single quark of this

 

[n9wiff]

High meat

 

[basedpheno88]

. Phenylethylamine (can be raised through rasagiline)
. Piribedil (works by partial agonism of d2 and d3 w antagonism of d4)
. microdsed lsd (works through mglur5 coupled dopaminergic transmission)
. Sulbutiamine (works through upregulating d1)
.lisuride (agonises all 5 dopamine receptors)
. Semak/selank/ low dose naltrexone (antagonises melanocortin and is an enkephalinase inhibitor , enhances opiod signalling)
. Dihexa (Global upregulation of BDNF and other neurotrophic factors)
. baclofen (only use once in a while, gaba b agonism inhibtis serotonin release from brainsteam and dopamine modulation, increases impulsive behaviour and libido a ton although doesnt affect judgement like alcohol)
. microdsed salvia (seems to work for certain anhedonics through kappa opiod receptor downregulation)
.amantadine/bromantane (kir2 potassium channel inhibitor and upregulation of tyrosine hydroxylase plus confortmation change of postsynaptic dopamine receptors leading to enhanced signalling)
.certain cannabinoids (through mainly 5ht1a agonism although risk of downregulation)
.kratom (5 ht2a/2c antagonism and ht1a agonism , tolerance sets in quick just like with cannabis)
.amphetamine (enhances vesicular release of dopamine from the synaptic cleft, taar1 agonism, DAT inhibitor, DRI)

wtf are these
only recognised kratom amphetamine and lsd
just smoke a joint bro

 

[NoHoesinOhio]

wtf are these
only recognised kratom amphetamine and lsd
just smoke a joint bro

naw im in the endgame son

 

[basedpheno88]

naw im in the endgame son

View attachment 3435029

do meth

 

[CalulArgintiu59]

. baclofen (only use once in a while, gaba b agonism inhibtis serotonin release from brainsteam and dopamine modulation, increases impulsive behaviour and libido a ton although doesnt affect judgement like alcohol)

Baclofen alone is kind of shitty, at least for me, it gives you like a shitty high, Clavicular was quite right about combining baclofen and lyrica, they synergize very good and adding a stimulant to this is like the best mood ever+more low inhib

 

[NoHoesinOhio]

do meth

Baclofen alone is kind of shitty, at least for me, it gives you like a shitty high, Clavicular was quite right about combining baclofen and lyrica, they synergize very good and adding a stimulant to this is like the best mood ever+more low inhib

Lyrica kills iq not interested in that stuff

 

[NoHoesinOhio]

@kyrre

 

[sauceboss]

Add steroids then it's a party

 

[kyrre]

@kyrre

modafinil with redbull and a blunt

 

[NoHoesinOhio]

modafinil with redbull and a blunt

Kill modafinil roundhouse kick into sewer bury it in cement vapourise modafinil w flamethrower

 

[kyrre]

Kill modafinil roundhouse kick into sewer bury it in cement vapourise modafinil w flamethrower

 

[CalulArgintiu59]

Lyrica kills iq not interested in that stuff

It can mess up with memory and shit, but I doubt that if used responsible and not frequently it will have much of an impact and bacofen is neuroprotective

 

[love_enforcer]

i get that just by looking at the mirror