Epigenetic Regulation Targeting Osteogenesis (Control skull growth)

[Rigged]

Spoiler: The Stacks

Spoiler: EZH2

1. Tazemetostat - 800mg oral 2x a day
2. AI - aromasin or something
3. Finasteride - 1 mg daily
4. Aspirin - 81mg daily
5. Nac - 600mg daily
6. Coq10 - 100mg daily

Spoiler: 5-azac

1. 5-azac - 100mg/m2 subq/iv daily 7 days for 28 day cycle 4 cycles
2. B12 - 1000mcg IM 1x a week
3. Folic acid - 1mg daily
4. G-CSF - 5 mcg/kg daily
5. Allopurinol - 100mg daily
6. Omeprazole - 20mg daily
7. Normal saline - whenever needed

Spoiler: Works

1. Regular CBC
2. Liver and kidney function tests
3. Hormone panels
4. Bone density scans every 6 months

Spoiler: The boring stuff

Spoiler: AZH2

So to start EZH2 is a histone methyltransferase component of PRC2 that shows epigenetic control by trimethylating H3K27me3 which causes transcriptional repression of key osteogenic genes like RUNX2. Supressing EZH2 with small molecule inhibitors like Tazemetostat would lower H3K27me3 marks causing a derepression of osteogenic pathways. This would reactivate silenced osteoprogenitor genes in craniofacial mesenchyme boosting controlled/localized osteoblast differentiation and from that craniofacial bone

Spoiler: 5-Azac

Next is 5-Azacytidine, it works as a DNA methyltransferase inhibitor including into DNA and inhibiting the methylation of cytosine residues so by preventing hypermethylation it reactivates growth related genes that have become epigenetically silenced, reexpression of chondrocyte related genes in cranial cartilage is possible, influencing cranial suture activity and boosting selective bone expansion, the accurate temporal and spatial use of these epigenetic modulators would be important to prevent offtarget effects and any unwanted systemic exposure

Shout out to @Master for making this possible he does so much for us by keeping this forum opened

Shout out to @MA_ascender @4lt.Real and @oppastoppathe2nd

They have confirmed and stated they will be testing these out for us so lets give them a kiss on the tip to motivate them

 

[Rigged]

Idk where to buy these but good luck also yes the 5-azac is absolutely only possible in office unless u wanna get freaky and rob a hospital

 

[Rigged]

@AscendingHero @Youㅤ @PsychoDsk

Hoping u kind sirs would like to expirement

 

[Outerz14]

Spoiler: The boring stuff

Spoiler: AZH2

So to start EZH2 is a histone methyltransferase component of PRC2 that shows epigenetic control by trimethylating H3K27me3 which causes transcriptional repression of key osteogenic genes like RUNX2. Supressing EZH2 with small molecule inhibitors like Tazemetostat would lower H3K27me3 marks causing a derepression of osteogenic pathways. This would reactivate silenced osteoprogenitor genes in craniofacial mesenchyme boosting controlled/localized osteoblast differentiation and from that craniofacial bone

Spoiler: 5-Azac

Next is 5-Azacytidine, it works as a DNA methyltransferase inhibitor including into DNA and inhibiting the methylation of cytosine residues so by preventing hypermethylation it reactivates growth related genes that have become epigenetically silenced, reexpression of chondrocyte related genes in cranial cartilage is possible, influencing cranial suture activity and boosting selective bone expansion, the accurate temporal and spatial use of these epigenetic modulators would be important to prevent offtarget effects and systemic exposure thats unwanted

Spoiler: Low inhib drug fuel

Spoiler: EZH2

1. Tazemetostat - 800mg oral 2x a day
2. AI - aromasin or sum
3. Finasteride - 1 mg daily
4. Aspirin - 81mg daily
5. Nac - 600mg daily
6. Coq10 - 100mg daily

Spoiler: 5-azac

1. 5-azac - 100mg/m2 subq/iv daily 7 days for 28 day cycle 4 cycles
2. B12 - 1000mcg IM 1x a week
3. Folic acid - 1mg daily
4. G-CSF - 5 mcg/kg daily
5. Allopurinol - 100mg daily
6. Omeprazole - 20mg daily
7. Normal saline - whenever needed

Spoiler: Works

1. Regular CBC
2. Liver and kidney function tests
3. Hormone panels
4. Bone density scans every 6 months

Shout out to @Master for making this possible he does so much for us by keeping this forum opened

Shout out to @MA_ascender @4lt.Real and @oppastoppathe2nd

They have confirmed and stated they will be testing these out for us so lets give them a kiss on the tip to motivate them

Tf is that nigga

 

[Rigged]

@Donkeyballs

You also try it pls and thank u

 

[Rigged]

Tf is that nigga

Ignore the words just take the drugs embrace the skull fuel

 

[Donkeyballs]

999999IQ thread.
A relative I know has non-Hodgkin lymphoma and I think he has Tazverik (Tazemetostat)
of course I can not just rob them but I can figure something out

 

[Donkeyballs]

If this dosent work then I will try last resort:
DIY cranial vault distraction osteogenesis

 

[slavicpsycho]

Finasteride faggot hahaha

 

[Rigged]

2nd one is possible outside of office if u can afford the equipment

 

[Rigged]

Finasteride faggot hahaha

Its taken for a reason here my guy, im aware how finasteride works

 

[4lt.Real]

999999IQ thread.
A relative I know has non-Hodgkin lymphoma and I think he has Tazverik (Tazemetostat)
of course I can not just rob them but I can figure something out

does he have Chad bones/skull?

 

[mathis]

Spoiler: The Stacks

Spoiler: EZH2

1. Tazemetostat - 800mg oral 2x a day
2. AI - aromasin or something
3. Finasteride - 1 mg daily
4. Aspirin - 81mg daily
5. Nac - 600mg daily
6. Coq10 - 100mg daily

Spoiler: 5-azac

1. 5-azac - 100mg/m2 subq/iv daily 7 days for 28 day cycle 4 cycles
2. B12 - 1000mcg IM 1x a week
3. Folic acid - 1mg daily
4. G-CSF - 5 mcg/kg daily
5. Allopurinol - 100mg daily
6. Omeprazole - 20mg daily
7. Normal saline - whenever needed

Spoiler: Works

1. Regular CBC
2. Liver and kidney function tests
3. Hormone panels
4. Bone density scans every 6 months

Spoiler: The boring stuff

Spoiler: AZH2

So to start EZH2 is a histone methyltransferase component of PRC2 that shows epigenetic control by trimethylating H3K27me3 which causes transcriptional repression of key osteogenic genes like RUNX2. Supressing EZH2 with small molecule inhibitors like Tazemetostat would lower H3K27me3 marks causing a derepression of osteogenic pathways. This would reactivate silenced osteoprogenitor genes in craniofacial mesenchyme boosting controlled/localized osteoblast differentiation and from that craniofacial bone

Spoiler: 5-Azac

Next is 5-Azacytidine, it works as a DNA methyltransferase inhibitor including into DNA and inhibiting the methylation of cytosine residues so by preventing hypermethylation it reactivates growth related genes that have become epigenetically silenced, reexpression of chondrocyte related genes in cranial cartilage is possible, influencing cranial suture activity and boosting selective bone expansion, the accurate temporal and spatial use of these epigenetic modulators would be important to prevent offtarget effects and any unwanted systemic exposure

Shout out to @Master for making this possible he does so much for us by keeping this forum opened

Shout out to @MA_ascender @4lt.Real and @oppastoppathe2nd

They have confirmed and stated they will be testing these out for us so lets give them a kiss on the tip to motivate them

Just give yourself cancer for a 10% chance of getting barely visible results theory ( if you are the luckiest mf on earth and dont get unwanted growth )
Mirin getting rid of the concurrence

 

[DR. NICKGA]

Just give yourself cancer for a 10% chance of getting barely visible results theory ( if you are the luckiest mf on earth and dont get unwanted growth )
Mirin getting rid of the concurrence
View attachment 3127535

This will not happend

 

[CD34]

Spoiler: The Stacks

Spoiler: EZH2

1. Tazemetostat - 800mg oral 2x a day
2. AI - aromasin or something
3. Finasteride - 1 mg daily
4. Aspirin - 81mg daily
5. Nac - 600mg daily
6. Coq10 - 100mg daily

Spoiler: 5-azac

1. 5-azac - 100mg/m2 subq/iv daily 7 days for 28 day cycle 4 cycles
2. B12 - 1000mcg IM 1x a week
3. Folic acid - 1mg daily
4. G-CSF - 5 mcg/kg daily
5. Allopurinol - 100mg daily
6. Omeprazole - 20mg daily
7. Normal saline - whenever needed

Spoiler: Works

1. Regular CBC
2. Liver and kidney function tests
3. Hormone panels
4. Bone density scans every 6 months

Spoiler: The boring stuff

Spoiler: AZH2

So to start EZH2 is a histone methyltransferase component of PRC2 that shows epigenetic control by trimethylating H3K27me3 which causes transcriptional repression of key osteogenic genes like RUNX2. Supressing EZH2 with small molecule inhibitors like Tazemetostat would lower H3K27me3 marks causing a derepression of osteogenic pathways. This would reactivate silenced osteoprogenitor genes in craniofacial mesenchyme boosting controlled/localized osteoblast differentiation and from that craniofacial bone

Spoiler: 5-Azac

Next is 5-Azacytidine, it works as a DNA methyltransferase inhibitor including into DNA and inhibiting the methylation of cytosine residues so by preventing hypermethylation it reactivates growth related genes that have become epigenetically silenced, reexpression of chondrocyte related genes in cranial cartilage is possible, influencing cranial suture activity and boosting selective bone expansion, the accurate temporal and spatial use of these epigenetic modulators would be important to prevent offtarget effects and any unwanted systemic exposure

Shout out to @Master for making this possible he does so much for us by keeping this forum opened

Shout out to @MA_ascender @4lt.Real and @oppastoppathe2nd

They have confirmed and stated they will be testing these out for us so lets give them a kiss on the tip to motivate them

If this is executed before puberty it may stimulates also the condrocytes in the center of ossification to stimulate them to proliferate and synthesize new extracellular matrix? Long story short could it give you longitudinal bone growth?

 

[mathis]

This will not happend

In puberty yes. This stack will promote existing cancer cells and increase the chance of cancer. thats just one and not the worst thing that could happen
I mean idc abt you
do as you wish

 

[Rigged]

Just give yourself cancer for a 10% chance of getting barely visible results theory ( if you are the luckiest mf on earth and dont get unwanted growth )
Mirin getting rid of the concurrence
View attachment 3127535

In puberty yes. This stack will promote existing cancer cells and increase the chance of cancer. thats just one and not the worst thing that could happen
I mean idc abt you
do as you wish

ur a retard u dont even know what anything i said is, cancer can happen from literally any drug or food, if u take everything as i said properly and consitently with all the works ull be fine

 

[Rigged]

If this is executed before puberty it may stimulates also the condrocytes in the center of ossification to stimulate them to proliferate and synthesize new extracellular matrix? Long story short could it give you longitudinal bone growth?

Yes

 

[DR. NICKGA]

Explain why finasteride

 

[DR. NICKGA]

And any result pictures?

 

[Kelly Oubre Jr]

999999IQ thread.
A relative I know has non-Hodgkin lymphoma and I think he has Tazverik (Tazemetostat)
of course I can not just rob them but I can figure something out

if you were to steal it wouldnt they just go and tell the hospital it got stolen and get more

 

[Rigged]

Explain why finasteride

Its the best roi for countering all androgenic sides and min + ru cant

 

[Rigged]

And any result pictures?

No

 

[AscendingHero]

Spoiler: The Stacks

Spoiler: EZH2

1. Tazemetostat - 800mg oral 2x a day
2. AI - aromasin or something
3. Finasteride - 1 mg daily
4. Aspirin - 81mg daily
5. Nac - 600mg daily
6. Coq10 - 100mg daily

Spoiler: 5-azac

1. 5-azac - 100mg/m2 subq/iv daily 7 days for 28 day cycle 4 cycles
2. B12 - 1000mcg IM 1x a week
3. Folic acid - 1mg daily
4. G-CSF - 5 mcg/kg daily
5. Allopurinol - 100mg daily
6. Omeprazole - 20mg daily
7. Normal saline - whenever needed

Spoiler: Works

1. Regular CBC
2. Liver and kidney function tests
3. Hormone panels
4. Bone density scans every 6 months

Spoiler: The boring stuff

Spoiler: AZH2

So to start EZH2 is a histone methyltransferase component of PRC2 that shows epigenetic control by trimethylating H3K27me3 which causes transcriptional repression of key osteogenic genes like RUNX2. Supressing EZH2 with small molecule inhibitors like Tazemetostat would lower H3K27me3 marks causing a derepression of osteogenic pathways. This would reactivate silenced osteoprogenitor genes in craniofacial mesenchyme boosting controlled/localized osteoblast differentiation and from that craniofacial bone

Spoiler: 5-Azac

Next is 5-Azacytidine, it works as a DNA methyltransferase inhibitor including into DNA and inhibiting the methylation of cytosine residues so by preventing hypermethylation it reactivates growth related genes that have become epigenetically silenced, reexpression of chondrocyte related genes in cranial cartilage is possible, influencing cranial suture activity and boosting selective bone expansion, the accurate temporal and spatial use of these epigenetic modulators would be important to prevent offtarget effects and any unwanted systemic exposure

Shout out to @Master for making this possible he does so much for us by keeping this forum opened

Shout out to @MA_ascender @4lt.Real and @oppastoppathe2nd

They have confirmed and stated they will be testing these out for us so lets give them a kiss on the tip to motivate them

Good thread

Few Qs

the accurate temporal and spatial use of these epigenetic modulators would be important to prevent offtarget effects

Wdym by this, please elaborate

Spatial use as in localized effects?

Or temporal use as in time and spatial use as in space ye?

What could be some deadly off target effects of inaccurate temporal & spatial use of epigenetic modulators?

by preventing hypermethylation it reactivates growth related genes that have become epigenetically silenced, reexpression of chondrocyte related genes in cranial cartilage is possible

Is there anything there for this relating to limbs and the bones of the appendicular skeleton?

Spoiler: 5-Azac

So to start EZH2 is a histone methyltransferase component of PRC2 that shows epigenetic control by trimethylating H3K27me3 which causes transcriptional repression of key osteogenic genes like RUNX2. Supressing EZH2 with small molecule inhibitors like Tazemetostat would lower H3K27me3 marks causing a derepression of osteogenic pathways. This would reactivate silenced osteoprogenitor genes in craniofacial mesenchyme boosting controlled/localized osteoblast differentiation and from that craniofacial bone
Spoiler: 5-Azac Next is 5-Azacytidine, it works as a DNA methyltransferase inhibitor including into DNA and inhibiting the methylation of cytosine residues so by preventing hypermethylation it reactivates growth related genes that have become epigenetically silenced, reexpression of chondrocyte related genes in cranial cartilage is possible, influencing cranial suture activity and boosting selective bone expansion, the accurate temporal and spatial use of these epigenetic modulators would be important to prevent offtarget effects and any unwanted systemic exposure

After taking all this, what should one expect

Chad growth can be localized, holistic and above all it is aesthetic

How do we ensure we get aesthetic results from taking all of this?

Growth just for the sake of it , isn't always ideal (ie acromegalics)

 

[LVZZO]

They have confirmed and stated they will be testing these out for us so lets give them a kiss on the tip to motivate them

Rest in peace

 

[Rigged]

Good thread

Few Qs


Wdym by this, please elaborate

Spatial use as in localized effects?

Or temporal use as in time and spatial use as in space ye?
View attachment 3128345


What could be some deadly off target effects of inaccurate temporal & spatial use of epigenetic modulators?


Is there anything there for this relating to limbs and the bones of the appendicular skeleton?


After taking all this, what should one expect

Chad growth can be localized, holistic and above all it is aesthetic

How do we ensure we get aesthetic results from taking all of this?

Growth just for the sake of it , isn't always ideal (ie acromegalics)

1.Yes spatial as in localized and temporal as in timing and duration

2. Taking it wrong would probably cause similar issues to hgh, random bone growth, cancer risk, organ problems, neural development issues, but none of these sides would happen if the user is taking them correctly and on time + u could take ancillaries for these and i listed some

3. Yes this could be used for reactivating growth factors in in limb bones, and allow controlled growth

4. Id expect targeted growth ofc but getting the perfect results would need extreme control of epigenetic and hormonal modulators. So to make this happen ud need advanced imaging like 3D facial scanning and controlled dosing, now ofcourse its possible without if someone wanted to diy this, but it would be about as random as “bonesmashing” for volume, (if yk what ur doing u could diy it) acromegaly shouldnt happen if u do it right but incase it does ud probably have to monitor it with again some sort of imaging

 

[Rigged]

Good thread

Few Qs


Wdym by this, please elaborate

Spatial use as in localized effects?

Or temporal use as in time and spatial use as in space ye?
View attachment 3128345


What could be some deadly off target effects of inaccurate temporal & spatial use of epigenetic modulators?


Is there anything there for this relating to limbs and the bones of the appendicular skeleton?


After taking all this, what should one expect

Chad growth can be localized, holistic and above all it is aesthetic

How do we ensure we get aesthetic results from taking all of this?

Growth just for the sake of it , isn't always ideal (ie acromegalics)

To add when i say extremely precise i only mean dosing time and duration

 

[Rigged]

Rest in peace

Who is in ur pfp

 

[sb23]

Spoiler: The Stacks

Spoiler: EZH2

1. Tazemetostat - 800mg oral 2x a day
2. AI - aromasin or something
3. Finasteride - 1 mg daily
4. Aspirin - 81mg daily
5. Nac - 600mg daily
6. Coq10 - 100mg daily

Spoiler: 5-azac

1. 5-azac - 100mg/m2 subq/iv daily 7 days for 28 day cycle 4 cycles
2. B12 - 1000mcg IM 1x a week
3. Folic acid - 1mg daily
4. G-CSF - 5 mcg/kg daily
5. Allopurinol - 100mg daily
6. Omeprazole - 20mg daily
7. Normal saline - whenever needed

Spoiler: Works

1. Regular CBC
2. Liver and kidney function tests
3. Hormone panels
4. Bone density scans every 6 months

Spoiler: The boring stuff

Spoiler: AZH2

So to start EZH2 is a histone methyltransferase component of PRC2 that shows epigenetic control by trimethylating H3K27me3 which causes transcriptional repression of key osteogenic genes like RUNX2. Supressing EZH2 with small molecule inhibitors like Tazemetostat would lower H3K27me3 marks causing a derepression of osteogenic pathways. This would reactivate silenced osteoprogenitor genes in craniofacial mesenchyme boosting controlled/localized osteoblast differentiation and from that craniofacial bone

Spoiler: 5-Azac

Next is 5-Azacytidine, it works as a DNA methyltransferase inhibitor including into DNA and inhibiting the methylation of cytosine residues so by preventing hypermethylation it reactivates growth related genes that have become epigenetically silenced, reexpression of chondrocyte related genes in cranial cartilage is possible, influencing cranial suture activity and boosting selective bone expansion, the accurate temporal and spatial use of these epigenetic modulators would be important to prevent offtarget effects and any unwanted systemic exposure

Shout out to @Master for making this possible he does so much for us by keeping this forum opened

Shout out to @MA_ascender @4lt.Real and @oppastoppathe2nd

They have confirmed and stated they will be testing these out for us so lets give them a kiss on the tip to motivate them

I will read up on this further later. I just don’t get the point if we don’t have sourcing though. How did the people mentioned get theirs? How much would all of this cost per month aprox?

 

[Rigged]

I will read up on this further later. I just don’t get the point if we don’t have sourcing though. How did the people mentioned get theirs? How much would all of this cost per month aprox?

Ask them just @ them

 

[sb23]

@MA_ascender @4lt.Real @oppastoppathe2nd how is sourcing going so far?

 

[JohnDoe]

Nice thread, no threads for 28y oldcels like me

 

[oppastoppathe2nd]

how is sourcing going so far?

great i have all 13 substances going to be shipped in the next few days

 

[sb23]

great i have all 13 substances going to be shipped in the next few days

I found sourcing for everything other than the Tazemetostat and 5-azac. Mind helping in dms for the sourcing of these?

 

[LVZZO]

Who is in ur pfp

My boyfriend's sister