orbicularis
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How hairloss occurs (dht)
Before we can stop our hairloss we must first understand how it occurs in the first place. Testosterone is converted into Dihydrotestosterone (dht) via the 5 a reductase enzyme. Dht then binds to the Hair Follicle Androgen Receptors which over time miniaturizes the hair follicle and shortens the anagen phase (Growth phase) and lengthens the telogen phase (resting phase).
Dht also reduces the production of growth factors such as VEGF and igf-1 in the hair follicle. Over time this leads hairloss.
5-ARIs(stop coping )
5 a reductase inhibitors bind the 5 a reductase enzyme preventing the conversion of testosterone into (DHT) Dihydrotestosterone stopping your hair folicles from getting raped.
These are absolutely essential for a solid hairloss protocol because without blocking dht you will not stop thinning.
There are 2 oral dht blockers you can take: finasteride and Dutustride
finasteride
(ru-58841)
)
Sides
Now that we have covered how to stop hairloss we need to introduce growth agents to actually regrow our hair
Topical/Oral minoxidil (oral mogs)
Microneedling ( dont use a derma roller)
2.5mg dut
50-100mg ru-58841 (may be needed if running androgens)
2.5mg oral min
5mg ghk-cu
ketoconazole shampoo 2-3x a week
Microneedling 1x a week
First guide
Before we can stop our hairloss we must first understand how it occurs in the first place. Testosterone is converted into Dihydrotestosterone (dht) via the 5 a reductase enzyme. Dht then binds to the Hair Follicle Androgen Receptors which over time miniaturizes the hair follicle and shortens the anagen phase (Growth phase) and lengthens the telogen phase (resting phase).
Dht also reduces the production of growth factors such as VEGF and igf-1 in the hair follicle. Over time this leads hairloss.
5-ARIs(stop coping )
5 a reductase inhibitors bind the 5 a reductase enzyme preventing the conversion of testosterone into (DHT) Dihydrotestosterone stopping your hair folicles from getting raped.
These are absolutely essential for a solid hairloss protocol because without blocking dht you will not stop thinning.
There are 2 oral dht blockers you can take: finasteride and Dutustride
finasteride
- Finasteride selectively inhibits Type 2 dht
- Its been shown in clinical trials to reduce serum dht level by 60-70% PubMed :https://pubmed.ncbi.nlm.nih.gov/10495374/
- Half life: Short half life of 5 to 8 hours
- You should always start with finastride first over dutasteride because of the shorter halflife. Finastride will leave your blood stream much faster if you need to stop taking it compared to dutustride
- Overall a very effective treatment for blocking dht
- use 1mg of finasteride daily
- Decreased libido
- Erectile dysfunction
- Reduced ejaculatory volume
- Mood changes / depression / brain fog (rare)
- Gynecomastia (rare)
- Fatigue (rare)
- Post-Finasteride Syndrome (very rare)
- Dutasteride inhibits both Type 1 and Type 2 dht, making it a more complete DHT suppressor than finasteride
- It has been shown in clinical trials to reduce serum DHT levels by 90-95% PubMed:https://pubmed.ncbi.nlm.nih.gov/17189955/
- Extremely long half-life 4–5 weeks
- Stays in the body for months after your last dose
- DHT increases sebum production and enlarges sebaceous glands which causes acne, blocking type 1 dht stops dht from raping your skin
- Start at .5mg and work your way up to 2.5 mg if tolerated
- Why 2.5 mg? 2.5 mg dutasteride has been shown in studies to be superior to .5mg (no shit taking more leads to stronger dht suppression)
- Decreased libido (slightly higher rate than finasteride)
- Erectile dysfunction
- Reduced ejaculatory volume
- Mood changes / depression / brain fog (rare)
- Gynecomastia (rare but more common than finasteride)
- Fatigue (rare)
- Long-lasting sides due to long half-life
(ru-58841)- Dht is essential during puberty and its a great looksmin to block dht during development, however there is a way to stop dht from raping your hair follicles
- Ru-58841 is a topical anti-androgen which competes with dht at the hair folicle to stop dht from binding to your follicles and raping it
- This is an effective treatment if you are too young to take dht blockers
- 50-100mg daily
)Sides
- Mild scalp irritation
- Systemic Side Effects (uncommon but definitely possible)
- Unknown / Long-Term Effects
- Your good unless ts gets absorbed systemically
- ketoconazole shampoo (2%) has been shown to slightly reduce scalp dht levels, it won't make a huge difference but i think it is definitely worth adding in a hairloss protocol
- ketoconazole also reduces sebum production, inflammation and has antifungal properties
- Use 2-3x a week
Now that we have covered how to stop hairloss we need to introduce growth agents to actually regrow our hair
Topical/Oral minoxidil (oral mogs)
- Widens blood vessels in the scalp leading to better nutrient and oxygen delivery to follicles
- Prolongs the anagen (growth) phase of hair
- 2.5-5mg (2.5 mg is usually sufficient)
- Topical apply once a day and use 5-10% minoxidil
- Upregulates VEGF
- Promotes more blood flow to follicles
- Better nutrient and oxygen delivery
- Increase collagen and elastin production
- 2-5mg a day, also make sure to supplement zinc to avoid copper toxicity
Microneedling ( dont use a derma roller)
- Creates tiny micro trauma in the scalp which triggers the body's natural healing process and growth factors
- Needle length: 1mm-1.5mm (i prefer 1mm needle length)
- Frequency: 1x a week
- Wait 24-48 hours after treatment to apply topicals like ru-58841 and topical minoxidil
2.5mg dut
50-100mg ru-58841 (may be needed if running androgens)
2.5mg oral min
5mg ghk-cu
ketoconazole shampoo 2-3x a week
Microneedling 1x a week
First guide
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