T
TrueLabRat
Iron
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- Oct 22, 2025
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To start off, im sorry that this thread is an eye-sore. no this is not chat GPT.
many of you have probably heard of BMP's in the context of bone growth.
yet we still dont seem to have an easy way to activate them directly. the current medical treatment with BMP's activation used for osteoprosis and injuries is a rhBMP-2 protein scaffold/collagen sponge delivery which requires a full lab set up and thousands of dollars just for the protein itself, which most of us probably dont have
so it seems as if there's no hope for BMP's exogenous activations in the looksmaxxing community..
or atleast thats what they want you to think....
the compound that Im talking about is Simvastatin
simvastatin is a well-known anti LDL cholesterol drug founded in 1988 and since then it is mostly only recognised as a cardiovascular drug.
but in the early 2000s researchers noticed that it boosts BMP-2 expression and since then there were plenty of studies showing consistent results in local delivery in rats.
so what's the reason for it not being an approved treatment for oesteoprosis or to heal injuries? BIG PHARMA MONEY-GOYS FBI OPEN UP.
simvastatin is a dirt cheap generic drug, and because the current treatment with BMP for these conditions is very expansive and profitable, no company wants to invest tens of milions of dollars just to get an FDA approval for a new use for simvastatin and there is no way for them to charge shit load of money for a treatment that is already known worldwide for being a cheap cardiovascular medicine.
the studies done in rats show a significant rise in bone formation from plenty ways of delivery:
10-100 mcg per Subperioteal injection - showing signifcant rise in mineralization altough a precise number isnt reported.
10 - 100 mcg per PLGA microsphere scafolld - showing 40% bone formation in 12 weeks.
0.5 - 2 mg in gel near bone surface per site - showing the best results at a 30-50% increase in bone formation in a few weeks.
though reported to be ineffective in oral systematic delivery.
simvastatin was even used in clinical trials in the 1-10mg range on humans and the results were increased bone regeneration in local delivery in almost of the cases. i do belive that further results on humans and more trials are not shown and done to limit the exposure of it to the public.
and the price of 500mg raw high purity powder is about 300$ at research lab-grade chemicals suppliers websites
this is my first thread on the forum and I can make another one where ill explain the actual mechanisms of it and link the studies that i based my information from if it will be requested.
today Im a bit lazy so I chose to only write a short family friendly introduction anf feel free to correct me if im wrong. hope you enjoyed
many of you have probably heard of BMP's in the context of bone growth.
BMPs or Bone Morphogenetic Proteins are a group of proteins that play a crucial role in bone and tissue formation, they are the signals that tell stemcells to become osteoblasts. stem cells are cells that have the ability to turn into multible types of cells, and osteoblasts are the cells in your body that build new bone. unlike GH or other groups that are reliant on growth plates, BMP's can grow new bone tissue from zero. although stem cell get limited to what cells they can become after puberty, they can always turn to osteoblasts throughout the life.
so it seems as if there's no hope for BMP's exogenous activations in the looksmaxxing community..
or atleast thats what they want you to think....
the compound that Im talking about is Simvastatin
simvastatin is a well-known anti LDL cholesterol drug founded in 1988 and since then it is mostly only recognised as a cardiovascular drug.
but in the early 2000s researchers noticed that it boosts BMP-2 expression and since then there were plenty of studies showing consistent results in local delivery in rats.
so what's the reason for it not being an approved treatment for oesteoprosis or to heal injuries? BIG PHARMA MONEY-GOYS FBI OPEN UP.
simvastatin is a dirt cheap generic drug, and because the current treatment with BMP for these conditions is very expansive and profitable, no company wants to invest tens of milions of dollars just to get an FDA approval for a new use for simvastatin and there is no way for them to charge shit load of money for a treatment that is already known worldwide for being a cheap cardiovascular medicine.
the studies done in rats show a significant rise in bone formation from plenty ways of delivery:
10-100 mcg per Subperioteal injection - showing signifcant rise in mineralization altough a precise number isnt reported.
10 - 100 mcg per PLGA microsphere scafolld - showing 40% bone formation in 12 weeks.
0.5 - 2 mg in gel near bone surface per site - showing the best results at a 30-50% increase in bone formation in a few weeks.
though reported to be ineffective in oral systematic delivery.
simvastatin was even used in clinical trials in the 1-10mg range on humans and the results were increased bone regeneration in local delivery in almost of the cases. i do belive that further results on humans and more trials are not shown and done to limit the exposure of it to the public.
and the price of 500mg raw high purity powder is about 300$ at research lab-grade chemicals suppliers websites
this is my first thread on the forum and I can make another one where ill explain the actual mechanisms of it and link the studies that i based my information from if it will be requested.
today Im a bit lazy so I chose to only write a short family friendly introduction anf feel free to correct me if im wrong. hope you enjoyed
