Gatekept bone growth potential compound (no masai jumps, no cjc + ipamorelin) short thread

TrueLabRat

TrueLabRat

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To start off, im sorry that this thread is an eye-sore. no this is not chat GPT.
many of you have probably heard of BMP's in the context of bone growth.
BMPs or Bone Morphogenetic Proteins are a group of proteins that play a crucial role in bone and tissue formation, they are the signals that tell stemcells to become osteoblasts. stem cells are cells that have the ability to turn into multible types of cells, and osteoblasts are the cells in your body that build new bone. unlike GH or other groups that are reliant on growth plates, BMP's can grow new bone tissue from zero. although stem cell get limited to what cells they can become after puberty, they can always turn to osteoblasts throughout the life.
yet we still dont seem to have an easy way to activate them directly. the current medical treatment with BMP's activation used for osteoprosis and injuries is a rhBMP-2 protein scaffold/collagen sponge delivery which requires a full lab set up and thousands of dollars just for the protein itself, which most of us probably dont have:forcedsmile:
so it seems as if there's no hope for BMP's exogenous activations in the looksmaxxing community..:feelsbadman:
or atleast thats what they want you to think....:feelshah:
the compound that Im talking about is Simvastatin


simvastatin is a well-known anti LDL cholesterol drug founded in 1988 and since then it is mostly only recognised as a cardiovascular drug.
but in the early 2000s researchers noticed that it boosts BMP-2 expression and since then there were plenty of studies showing consistent results in local delivery in rats.
so what's the reason for it not being an approved treatment for oesteoprosis or to heal injuries? BIG PHARMA MONEY-GOYS FBI OPEN UP.
simvastatin is a dirt cheap generic drug, and because the current treatment with BMP for these conditions is very expansive and profitable, no company wants to invest tens of milions of dollars just to get an FDA approval for a new use for simvastatin and there is no way for them to charge shit load of money for a treatment that is already known worldwide for being a cheap cardiovascular medicine.
the studies done in rats show a significant rise in bone formation from plenty ways of delivery:
10-100 mcg per Subperioteal injection - showing signifcant rise in mineralization altough a precise number isnt reported.

10 - 100 mcg per PLGA microsphere scafolld - showing 40% bone formation in 12 weeks.

0.5 - 2 mg in gel near bone surface per site - showing the best results at a 30-50% increase in bone formation in a few weeks.

though reported to be ineffective in oral systematic delivery.

simvastatin was even used in clinical trials in the 1-10mg range on humans and the results were increased bone regeneration in local delivery in almost of the cases. i do belive that further results on humans and more trials are not shown and done to limit the exposure of it to the public.
and the price of 500mg raw high purity powder is about 300$ at research lab-grade chemicals suppliers websites

this is my first thread on the forum and I can make another one where ill explain the actual mechanisms of it and link the studies that i based my information from if it will be requested.
today Im a bit lazy so I chose to only write a short family friendly introduction anf feel free to correct me if im wrong. hope you enjoyed :feelspanties:
 
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your a retard bro
 
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Tl;dr or dnr
 
read purple word, it has potential to cause bone growth
 
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bump :feelsbadman:
 
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Interesting, do you have the studies that prove this
 
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Napoleon1800 said:
Interesting, do you have the studies that prove this
Click to expand...
There are only on rats from what I know


Also the only good BMP are 2,7 and 9 or something like that

Kaliyuga I think was talking about them and even found an source expensive asf tho
 
TrueLabRat said:
To start off, im sorry that this thread is an eye-sore. no this is not chat GPT.
many of you have probably heard of BMP's in the context of bone growth.
BMPs or Bone Morphogenetic Proteins are a group of proteins that play a crucial role in bone and tissue formation, they are the signals that tell stemcells to become osteoblasts. stem cells are cells that have the ability to turn into multible types of cells, and osteoblasts are the cells in your body that build new bone. unlike GH or other groups that are reliant on growth plates, BMP's can grow new bone tissue from zero. although stem cell get limited to what cells they can become after puberty, they can always turn to osteoblasts throughout the life.
yet we still dont seem to have an easy way to activate them directly. the current medical treatment with BMP's activation used for osteoprosis and injuries is a rhBMP-2 protein scaffold/collagen sponge delivery which requires a full lab set up and thousands of dollars just for the protein itself, which most of us probably dont have:forcedsmile:
so it seems as if there's no hope for BMP's exogenous activations in the looksmaxxing community..:feelsbadman:
or atleast thats what they want you to think....:feelshah:
the compound that Im talking about is Simvastatin


simvastatin is a well-known anti LDL cholesterol drug founded in 1988 and since then it is mostly only recognised as a cardiovascular drug.
but in the early 2000s researchers noticed that it boosts BMP-2 expression and since then there were plenty of studies showing consistent results in local delivery in rats.
so what's the reason for it not being an approved treatment for oesteoprosis or to heal injuries? BIG PHARMA MONEY-GOYS FBI OPEN UP.
simvastatin is a dirt cheap generic drug, and because the current treatment with BMP for these conditions is very expansive and profitable, no company wants to invest tens of milions of dollars just to get an FDA approval for a new use for simvastatin and there is no way for them to charge shit load of money for a treatment that is already known worldwide for being a cheap cardiovascular medicine.
the studies done in rats show a significant rise in bone formation from plenty ways of delivery:
10-100 mcg per Subperioteal injection - showing signifcant rise in mineralization altough a precise number isnt reported.

10 - 100 mcg per PLGA microsphere scafolld - showing 40% bone formation in 12 weeks.

0.5 - 2 mg in gel near bone surface per site - showing the best results at a 30-50% increase in bone formation in a few weeks.

though reported to be ineffective in oral systematic delivery.

simvastatin was even used in clinical trials in the 1-10mg range on humans and the results were increased bone regeneration in local delivery in almost of the cases. i do belive that further results on humans and more trials are not shown and done to limit the exposure of it to the public.
and the price of 500mg raw high purity powder is about 300$ at research lab-grade chemicals suppliers websites

this is my first thread on the forum and I can make another one where ill explain the actual mechanisms of it and link the studies that i based my information from if it will be requested.
today Im a bit lazy so I chose to only write a short family friendly introduction anf feel free to correct me if im wrong. hope you enjoyed :feelspanties:
Click to expand...
it’s ONLY EVER bone density!!!!
didn’t read btw
 
Mike456 said:
There are only on rats from what I know


Also the only good BMP are 2,7 and 9 or something like that

Kaliyuga I think was talking about them and even found an source expensive asf tho
Click to expand...
there is no reason for medicine companies to perform human trials, it isn’t profitable for them
 
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not reading just tell me what drugs to use
 
TrueLabRat said:
Simvastatin, easy to get, dont use orally
Click to expand...
okay interesting have looked at it. You're going to inject it locally? in cheekbone for exmaple? what are you pairing it with?
 
What do you think of local PTH analog injection?
 
ynns said:
What do you think of local PTH analog injection?
Click to expand...
no reason to perform them if you could easily and more effectively supply them systematically
 
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ynns said:
okay interesting have looked at it. You're going to inject it locally? in cheekbone for exmaple? what are you pairing it with?
Click to expand...
it can be used in pretty much every bone, the injection depth and type differs from each tho, its magically fucking effective for height purposes becuase an intra atricular injection of it lets the BMP increase reach the early Hypertrophic Zones and the Proliferative Zones but NOT the Late hypertrophic zones and the Resting zones if supplied via intra articular injection (not that complicated to perform) meaning it hits the parts that actually produce growth but mostly skips the parts that accelerates plate closure insane biological luck. if you want to use it for height purposes i would recommend to pair it with a mild VEGF inhibitor to further prevent early closure and if you want to use it for facial bone mass i would reccomend to pair it with a WNT activator (optional) and mechanical tension (mandatory), hard clinching most of the day + mewing (yes im not joking lol) the injection itself needs to be in the periosteum surface which is a bit rougher and more complicated to perform but still worth it imo
 
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ye idk lmk when u try it out
 
TrueLabRat said:
To start off, im sorry that this thread is an eye-sore. no this is not chat GPT.
many of you have probably heard of BMP's in the context of bone growth.
BMPs or Bone Morphogenetic Proteins are a group of proteins that play a crucial role in bone and tissue formation, they are the signals that tell stemcells to become osteoblasts. stem cells are cells that have the ability to turn into multible types of cells, and osteoblasts are the cells in your body that build new bone. unlike GH or other groups that are reliant on growth plates, BMP's can grow new bone tissue from zero. although stem cell get limited to what cells they can become after puberty, they can always turn to osteoblasts throughout the life.
yet we still dont seem to have an easy way to activate them directly. the current medical treatment with BMP's activation used for osteoprosis and injuries is a rhBMP-2 protein scaffold/collagen sponge delivery which requires a full lab set up and thousands of dollars just for the protein itself, which most of us probably dont have:forcedsmile:
so it seems as if there's no hope for BMP's exogenous activations in the looksmaxxing community..:feelsbadman:
or atleast thats what they want you to think....:feelshah:
the compound that Im talking about is Simvastatin


simvastatin is a well-known anti LDL cholesterol drug founded in 1988 and since then it is mostly only recognised as a cardiovascular drug.
but in the early 2000s researchers noticed that it boosts BMP-2 expression and since then there were plenty of studies showing consistent results in local delivery in rats.
so what's the reason for it not being an approved treatment for oesteoprosis or to heal injuries? BIG PHARMA MONEY-GOYS FBI OPEN UP.
simvastatin is a dirt cheap generic drug, and because the current treatment with BMP for these conditions is very expansive and profitable, no company wants to invest tens of milions of dollars just to get an FDA approval for a new use for simvastatin and there is no way for them to charge shit load of money for a treatment that is already known worldwide for being a cheap cardiovascular medicine.
the studies done in rats show a significant rise in bone formation from plenty ways of delivery:
10-100 mcg per Subperioteal injection - showing signifcant rise in mineralization altough a precise number isnt reported.

10 - 100 mcg per PLGA microsphere scafolld - showing 40% bone formation in 12 weeks.

0.5 - 2 mg in gel near bone surface per site - showing the best results at a 30-50% increase in bone formation in a few weeks.

though reported to be ineffective in oral systematic delivery.

simvastatin was even used in clinical trials in the 1-10mg range on humans and the results were increased bone regeneration in local delivery in almost of the cases. i do belive that further results on humans and more trials are not shown and done to limit the exposure of it to the public.
and the price of 500mg raw high purity powder is about 300$ at research lab-grade chemicals suppliers websites

this is my first thread on the forum and I can make another one where ill explain the actual mechanisms of it and link the studies that i based my information from if it will be requested.
today Im a bit lazy so I chose to only write a short family friendly introduction anf feel free to correct me if im wrong. hope you enjoyed :feelspanties:
Click to expand...
Had to put my site on light mode to read this lol
 
TrueLabRat said:
To start off, im sorry that this thread is an eye-sore. no this is not chat GPT.
many of you have probably heard of BMP's in the context of bone growth.
BMPs or Bone Morphogenetic Proteins are a group of proteins that play a crucial role in bone and tissue formation, they are the signals that tell stemcells to become osteoblasts. stem cells are cells that have the ability to turn into multible types of cells, and osteoblasts are the cells in your body that build new bone. unlike GH or other groups that are reliant on growth plates, BMP's can grow new bone tissue from zero. although stem cell get limited to what cells they can become after puberty, they can always turn to osteoblasts throughout the life.
yet we still dont seem to have an easy way to activate them directly. the current medical treatment with BMP's activation used for osteoprosis and injuries is a rhBMP-2 protein scaffold/collagen sponge delivery which requires a full lab set up and thousands of dollars just for the protein itself, which most of us probably dont have:forcedsmile:
so it seems as if there's no hope for BMP's exogenous activations in the looksmaxxing community..:feelsbadman:
or atleast thats what they want you to think....:feelshah:
the compound that Im talking about is Simvastatin


simvastatin is a well-known anti LDL cholesterol drug founded in 1988 and since then it is mostly only recognised as a cardiovascular drug.
but in the early 2000s researchers noticed that it boosts BMP-2 expression and since then there were plenty of studies showing consistent results in local delivery in rats.
so what's the reason for it not being an approved treatment for oesteoprosis or to heal injuries? BIG PHARMA MONEY-GOYS FBI OPEN UP.
simvastatin is a dirt cheap generic drug, and because the current treatment with BMP for these conditions is very expansive and profitable, no company wants to invest tens of milions of dollars just to get an FDA approval for a new use for simvastatin and there is no way for them to charge shit load of money for a treatment that is already known worldwide for being a cheap cardiovascular medicine.
the studies done in rats show a significant rise in bone formation from plenty ways of delivery:
10-100 mcg per Subperioteal injection - showing signifcant rise in mineralization altough a precise number isnt reported.

10 - 100 mcg per PLGA microsphere scafolld - showing 40% bone formation in 12 weeks.

0.5 - 2 mg in gel near bone surface per site - showing the best results at a 30-50% increase in bone formation in a few weeks.

though reported to be ineffective in oral systematic delivery.

simvastatin was even used in clinical trials in the 1-10mg range on humans and the results were increased bone regeneration in local delivery in almost of the cases. i do belive that further results on humans and more trials are not shown and done to limit the exposure of it to the public.
and the price of 500mg raw high purity powder is about 300$ at research lab-grade chemicals suppliers websites

this is my first thread on the forum and I can make another one where ill explain the actual mechanisms of it and link the studies that i based my information from if it will be requested.
today Im a bit lazy so I chose to only write a short family friendly introduction anf feel free to correct me if im wrong. hope you enjoyed :feelspanties:
Click to expand...
Oh brother... 😭
 
Mike456 said:
There are only on rats from what I know


Also the only good BMP are 2,7 and 9 or something like that

Kaliyuga I think was talking about them and even found an source expensive asf tho
Click to expand...
Brain dead
 
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TrueLabRat said:
no reason to perform them if you could easily and more effectively supply them systematically
Click to expand...
Studies show much greater bone growth when used locally. look it up.
 
ynns said:
Studies show much greater bone growth when used locally. look it up.
Click to expand...
The IHH-PTHrP loop works systematically rather than locally tho not sure how PTH analogs would benefit from being supplied locally, and also the molecular weight of Teriparatide and its brothers is fucking huge, pretty sure it won’t be able to reach any growth plates by joint injection or periosteum injection, the studies probably provided hydrogel with PTH analogs straight into the bones, not sure how possible it is to perform a DIY of this kind…
 
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TrueLabRat said:
To start off, im sorry that this thread is an eye-sore. no this is not chat GPT.
many of you have probably heard of BMP's in the context of bone growth.
BMPs or Bone Morphogenetic Proteins are a group of proteins that play a crucial role in bone and tissue formation, they are the signals that tell stemcells to become osteoblasts. stem cells are cells that have the ability to turn into multible types of cells, and osteoblasts are the cells in your body that build new bone. unlike GH or other groups that are reliant on growth plates, BMP's can grow new bone tissue from zero. although stem cell get limited to what cells they can become after puberty, they can always turn to osteoblasts throughout the life.
yet we still dont seem to have an easy way to activate them directly. the current medical treatment with BMP's activation used for osteoprosis and injuries is a rhBMP-2 protein scaffold/collagen sponge delivery which requires a full lab set up and thousands of dollars just for the protein itself, which most of us probably dont have:forcedsmile:
so it seems as if there's no hope for BMP's exogenous activations in the looksmaxxing community..:feelsbadman:
or atleast thats what they want you to think....:feelshah:
the compound that Im talking about is Simvastatin


simvastatin is a well-known anti LDL cholesterol drug founded in 1988 and since then it is mostly only recognised as a cardiovascular drug.
but in the early 2000s researchers noticed that it boosts BMP-2 expression and since then there were plenty of studies showing consistent results in local delivery in rats.
so what's the reason for it not being an approved treatment for oesteoprosis or to heal injuries? BIG PHARMA MONEY-GOYS FBI OPEN UP.
simvastatin is a dirt cheap generic drug, and because the current treatment with BMP for these conditions is very expansive and profitable, no company wants to invest tens of milions of dollars just to get an FDA approval for a new use for simvastatin and there is no way for them to charge shit load of money for a treatment that is already known worldwide for being a cheap cardiovascular medicine.
the studies done in rats show a significant rise in bone formation from plenty ways of delivery:
10-100 mcg per Subperioteal injection - showing signifcant rise in mineralization altough a precise number isnt reported.

10 - 100 mcg per PLGA microsphere scafolld - showing 40% bone formation in 12 weeks.

0.5 - 2 mg in gel near bone surface per site - showing the best results at a 30-50% increase in bone formation in a few weeks.

though reported to be ineffective in oral systematic delivery.

simvastatin was even used in clinical trials in the 1-10mg range on humans and the results were increased bone regeneration in local delivery in almost of the cases. i do belive that further results on humans and more trials are not shown and done to limit the exposure of it to the public.
and the price of 500mg raw high purity powder is about 300$ at research lab-grade chemicals suppliers websites

this is my first thread on the forum and I can make another one where ill explain the actual mechanisms of it and link the studies that i based my information from if it will be requested.
today Im a bit lazy so I chose to only write a short family friendly introduction anf feel free to correct me if im wrong. hope you enjoyed :feelspanties:
Click to expand...
The title suggests to me what your saying is gonna be cope
 
Hunter said:
The title suggests to me what your saying is gonna be cope
Click to expand...
You’re missing out, I put the title because I’ve seen plenty of users post long ass threads that they obviously put effort into and some retards are there to bark with AI aligations without reading the thread this thread is not a copy paste it’s completely original and based around my own research, I just don’t know how to make openings lol
 
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