GH SECRETAGOGUES (MK-677) VS HGH

[DORIAN]

I was recently asked on my profile

What are your thoughts on mk677 honestly?

So I am going to post this, as I think it's an interesting question and can save a lot of money to those who are not familiar with either.

GH SECRETAGOGUES (MK-677) VS HGH​

Not needed (money can be better spent on other things). Only somewhat unique benefit is stimulating appetite, which would just naturally increase anyway if you just force yourself to eat the right things. For all the other growth-related benefits, I would just stick to real HGH, which has the potential to be far more powerful and useful. There’s no reason to stick to an inferior compound if you have access to real HGH (information can be found at https://www.enhancedbb.com/index/ SOURCES).

Not necessary reading:

Saying all that, there are probably some cases where MK-677 use could be beneficial but that’s going to be mainly due to preference reasons (aversion to needles or something of that nature), legal reasons (countries where HGH for personal use is illegal but MK-677 isn’t), or an actual inability to eat more (before bodybuilding I was eating around if not less than 2000kcals, and now I’m eating a bit under 6000 kcals depending on whether it’s a training day or not without really forcing myself (highest I’ve eaten consistently was probably a bit over 6500 but I put on more fat than I wanted to), as you continue increasing food, etc, you will naturally increase your appetite, in almost all cases). Dorian said he was eating about 7000 in his off-season in 1997; taller guys have been reported to be eating well over 10,000. None of these people started off with the appetites or ability to probably eat half as much consistently.

Almost all of the other benefits of MK-677 are better taken care of with HGH.

Not necessary reading:

Of course, if you had an unlimited budget, there would be nothing wrong with taking MK-677 and HGH together, and there might be some other somewhat technical applications for both together. However, in the practical world, MK-677 is just an inferior compound.

The injectable HGH tends to release one type of growth hormone and suppresses the pituitary releasing its own gh (of multiple types); I think Russo talked about running a secretagogue such as MK-677 to stimulate the pituitary to benefit from multiple types of growth hormones being released as well as the massive amount of injectable HGH. However, I don’t know if this is actually something worthwhile or investigated or leads to any substantial practical differences. There are also reported sleep-related benefits from MK-677.

It is true that endogenous production of gh consists of multiple isoforms (so Russo is correct about that), whilst synthetic HGH is just the 22 kDa isoform (as far as I’m aware).

These other naturally produced isoforms, in addition to naturally produced 22 kDa might have some benefit we are overlooking or are unaware of, and there might be some synergistic benefits of running both due to the synthetic HGH feedback suppression. However, there is no evidence of this being true, nor of the fact that MK-677 would be able to reverse the suppression completely (as far as I’m aware), hence the only other reason running it other than the aforementioned ones being a technical reason/experiment on a higher budget.

MK-677 may provide IGF-1 level boosts equivalent to a few or more iu of HGH; however, just taking the HGH is going to be far more scalable and has the potential to be far more powerful. However, these levels tend not to be high enough for most people's expectations of proper enhancement via PEDs.

POSTED: https://www.enhancedbb.com/gh-secretagogues-mk-677-vs-hgh/

 

[DORIAN]

@halloweed.

 

[halloweed]

@halloweed.

Thank you for the comprehensive answer.

 

[sb23]

Read later. Bookmarked.

 

[halloweed]

I’ve read everything, so essentially mk677 is only good for a caloric surplus and increased IGF-1 levels.

I was recently asked on my profile

So I am going to post this, as I think it's an interesting question and can save a lot of money to those who are not familiar with either.

GH SECRETAGOGUES (MK-677) VS HGH​

Not needed (money can be better spent on other things). Only somewhat unique benefit is stimulating appetite, which would just naturally increase anyway if you just force yourself to eat the right things. For all the other growth-related benefits, I would just stick to real HGH, which has the potential to be far more powerful and useful. There’s no reason to stick to an inferior compound if you have access to real HGH (information can be found at https://www.enhancedbb.com/index/ SOURCES).

Not necessary reading:

Saying all that, there are probably some cases where MK-677 use could be beneficial but that’s going to be mainly due to preference reasons (aversion to needles or something of that nature), legal reasons (countries where HGH for personal use is illegal but MK-677 isn’t), or an actual inability to eat more (before bodybuilding I was eating around if not less than 2000kcals, and now I’m eating a bit under 6000 kcals depending on whether it’s a training day or not without really forcing myself (highest I’ve eaten consistently was probably a bit over 6500 but I put on more fat than I wanted to), as you continue increasing food, etc, you will naturally increase your appetite, in almost all cases). Dorian said he was eating about 7000 in his off-season in 1997; taller guys have been reported to be eating well over 10,000. None of these people started off with the appetites or ability to probably eat half as much consistently.

Almost all of the other benefits of MK-677 are better taken care of with HGH.

Not necessary reading:

Of course, if you had an unlimited budget, there would be nothing wrong with taking MK-677 and HGH together, and there might be some other somewhat technical applications for both together. However, in the practical world, MK-677 is just an inferior compound.

The injectable HGH tends to release one type of growth hormone and suppresses the pituitary releasing its own gh (of multiple types); I think Russo talked about running a secretagogue such as MK-677 to stimulate the pituitary to benefit from multiple types of growth hormones being released as well as the massive amount of injectable HGH. However, I don’t know if this is actually something worthwhile or investigated or leads to any substantial practical differences. There are also reported sleep-related benefits from MK-677.

It is true that endogenous production of gh consists of multiple isoforms (so Russo is correct about that), whilst synthetic HGH is just the 22 kDa isoform (as far as I’m aware).

These other naturally produced isoforms, in addition to naturally produced 22 kDa might have some benefit we are overlooking or are unaware of, and there might be some synergistic benefits of running both due to the synthetic HGH feedback suppression. However, there is no evidence of this being true, nor of the fact that MK-677 would be able to reverse the suppression completely (as far as I’m aware), hence the only other reason running it other than the aforementioned ones being a technical reason/experiment on a higher budget.

MK-677 may provide IGF-1 level boosts equivalent to a few or more iu of HGH; however, just taking the HGH is going to be far more scalable and has the potential to be far more powerful. However, these levels tend not to be high enough for most people's expectations of proper enhancement via PEDs.

POSTED: https://www.enhancedbb.com/gh-secretagogues-mk-677-vs-hgh/

 

[DORIAN]

caloric surplus

Increasing appetite if you can't manage it without, yes.

increased IGF-1 levels

HGH does a better job of this. MK-677 only does this to the equivalent level of a few or so iu of HGH, whereas you can run several iu a day or even run several iu of HGH every 4-5 hours and get much higher IGF-1 elevation. Also, the types of HGH produced by both methods differ slightly (but this is the technical part, which shouldn't really be too significant here and is explained in more detail in the post).

 

[inkile]

I was recently asked on my profile

So I am going to post this, as I think it's an interesting question and can save a lot of money to those who are not familiar with either.

GH SECRETAGOGUES (MK-677) VS HGH​

Not needed (money can be better spent on other things). Only somewhat unique benefit is stimulating appetite, which would just naturally increase anyway if you just force yourself to eat the right things. For all the other growth-related benefits, I would just stick to real HGH, which has the potential to be far more powerful and useful. There’s no reason to stick to an inferior compound if you have access to real HGH (information can be found at https://www.enhancedbb.com/index/ SOURCES).

Not necessary reading:

Saying all that, there are probably some cases where MK-677 use could be beneficial but that’s going to be mainly due to preference reasons (aversion to needles or something of that nature), legal reasons (countries where HGH for personal use is illegal but MK-677 isn’t), or an actual inability to eat more (before bodybuilding I was eating around if not less than 2000kcals, and now I’m eating a bit under 6000 kcals depending on whether it’s a training day or not without really forcing myself (highest I’ve eaten consistently was probably a bit over 6500 but I put on more fat than I wanted to), as you continue increasing food, etc, you will naturally increase your appetite, in almost all cases). Dorian said he was eating about 7000 in his off-season in 1997; taller guys have been reported to be eating well over 10,000. None of these people started off with the appetites or ability to probably eat half as much consistently.

Almost all of the other benefits of MK-677 are better taken care of with HGH.

Not necessary reading:

Of course, if you had an unlimited budget, there would be nothing wrong with taking MK-677 and HGH together, and there might be some other somewhat technical applications for both together. However, in the practical world, MK-677 is just an inferior compound.

The injectable HGH tends to release one type of growth hormone and suppresses the pituitary releasing its own gh (of multiple types); I think Russo talked about running a secretagogue such as MK-677 to stimulate the pituitary to benefit from multiple types of growth hormones being released as well as the massive amount of injectable HGH. However, I don’t know if this is actually something worthwhile or investigated or leads to any substantial practical differences. There are also reported sleep-related benefits from MK-677.

It is true that endogenous production of gh consists of multiple isoforms (so Russo is correct about that), whilst synthetic HGH is just the 22 kDa isoform (as far as I’m aware).

These other naturally produced isoforms, in addition to naturally produced 22 kDa might have some benefit we are overlooking or are unaware of, and there might be some synergistic benefits of running both due to the synthetic HGH feedback suppression. However, there is no evidence of this being true, nor of the fact that MK-677 would be able to reverse the suppression completely (as far as I’m aware), hence the only other reason running it other than the aforementioned ones being a technical reason/experiment on a higher budget.

MK-677 may provide IGF-1 level boosts equivalent to a few or more iu of HGH; however, just taking the HGH is going to be far more scalable and has the potential to be far more powerful. However, these levels tend not to be high enough for most people's expectations of proper enhancement via PEDs.

POSTED: https://www.enhancedbb.com/gh-secretagogues-mk-677-vs-hgh/

What are the downsides of MK-677? And can I use at 14

 

[halloweed]

What are the downsides of MK-677? And can I use at 14

Diabetes, cancer/tumour growth, heart enlargement, insulin resistance and yeah u can take it at 14, these aren’t guaranteed btw.

 

[moreplatesmoreweigh]

What abt other secretagogues like GHRPs and Cjc ?

 

[fatweewee123]

what would high dose mk677 be equivalent to in hgh ius

 

[DORIAN]

what would high dose mk677 be equivalent to in hgh ius

MK-677 may provide IGF-1 level boosts equivalent to a few or more iu of HGH

 

[truecel12]

Increasing appetite if you can't manage it without, yes.

HGH does a better job of this. MK-677 only does this to the equivalent level of a few or so iu of HGH, whereas you can run several iu a day or even run several iu of HGH every 4-5 hours and get much higher IGF-1 elevation. Also, the types of HGH produced by both methods differ slightly (but this is the technical part, which shouldn't really be too significant here and is explained in more detail in the post).

bumped. im using 13.33iu a day rn

 

[DORIAN]

What abt other secretagogues like GHRPs and Cjc ?

Secretagogues stimulate endogenous GH production via the pituitary, which is limited to a few IU equivalent of HGH because the pituitary isn’t going to produce more.

Injecting actual HGH, you can inject hundreds of IU (don’t go into high doses quickly, though and make sure to monitor properly) if you want as you are injecting actual HGH instead of telling your pituitary to make a bit more.

equivalent level of a few or so iu of HGH, whereas you can run several iu a day or even run several iu of HGH every 4-5 hours and get much higher IGF-1 elevation