Boosie’s_Build
Focus on improving yourself, not proving yourself
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Sarms guide
In this guide I prove that Sarm give gains and bone density. Ostarine actually has documented data about BMD and Volume being greater after giving rats osteoporosis and treatment.
TLDR: Sarm = muscle growth and bone density.
I had ChatGpt make me this cute little graph. I would say it’s kinda accurate but everybody’s body responds differently. Go ahead and pick out ur candy teenage Sarm goblin. Take the lbs with a grain of salt.
I would like to start by admitting the truth Sarms have subpar results when compared to roid cycles. However this post is going to be appreciated by the natty+ mindset. Or by those afraid of needles. Maybe gear heads looking for a more hair safe compound. Or maybe u genuinely have osteoporosis.
The difference between rat bones and human bones. Taken from rad-140 study.
TLDR you can come back to this later when I mention it in the article but tbh u don’t have to read it.
“These rates are also affected by age and growth stage. The rats used in the present study were ~400 g at the beginning of the study, which corresponds to ~9–10 weeks of age, which represents an age of continued growth. Bone formation rates normalized to bone volume (BFR/BV) have been reported to be several times higher in rats compared to humans (Rubin et al., 2001; Taguchi & Lopez, 2021; Tanizawa et al., 1999). Bone remodeling periods, which is the average total duration of a single cycle of bone remodeling at any point on a bone surface, have been reported to be ~6 days for rats and 6–9 months for humans (Taguchi & Lopez, 2021). These differences have an important role in the study design and interpretation of the study data”
https://pmc.ncbi.nlm.nih.gov/articles/PMC12274021/
3 Sarms that do put on more serious gains but more suppression: Lgd-4033, Rad-140, S23
Lgd-4033
Will it give me bigger muscles and bone growth?
Some report a much more watery muscle gain while other report lean. Some attribute watery gain to be from electrolyte imbalance. So increase potassium a lot. Also they say it’s like Dball
The phase 1 clinical trial shows promise,
(I linked it a bunch of hyperlinks, so that it can take u to where it says it in the articles. But I think it only works for 1 of the hyperlinks)
“In animal models, LGD-4033 has demonstrated anabolic activity in the muscle, anti-resorptive and anabolic activity in bone, and robust selectivity for muscle versus prostate.”
https://pmc.ncbi.nlm.nih.gov/articles/PMC4111291/
Breaking that down further I went to the linked study’s abstract which says,
“We demonstrated that LGD2226 is fully active in cell-based models of bone and muscle. LGD2226 exhibited anabolic activity on muscle and bone with reduced impact on prostate growth in rodent models. Biomechanical testing of bones from animals treated with LGD2226 showed strong enhancement of bone strength above sham levels.”
They say it again here in phase 1
“LGD-4033 is a novel nonsteroidal, oral SARM that binds to androgen receptor with high affinity (Ki of ∼1 nM) and selectivity. In animal models, LGD-4033 has demonstrated anabolic activity in the muscle, anti-resorptive and anabolic activity in bone, and robust selectivity for muscle versus prostate.”
https://pmc.ncbi.nlm.nih.gov/articles/PMC4111291/#:~:text=LGD-4033 is a novel,selectivity for muscle versus prostate.
Suppression at 1mg
“LGD-4033 administration was associated with dose-dependent suppression of total testosterone, sex hormone–binding globulin, high density lipoprotein cholesterol, and triglyceride levels. follicle-stimulating hormone and free testosterone showed significant suppression at 1.0-mg dose only. Lean body mass increased dose dependently, but fat mass did not change significantly. Hormone levels and lipids returned to baseline after treatment discontinuation”
(https://pmc.ncbi.nlm.nih.gov/articles/PMC4111291/)
So does that mean it’s not safe?
Well in the exact same study they say this it’s safe up to 22 mgs.
“We also evaluated the effects of graded doses of LGD-4033 on lean body mass (LBM), muscle strength, and physical function. LGD-4033 doses of 0.1, 0.3, and 1.0 mg were selected for multiple dosing over 21 days because a previous phase I single ascending-dose study had established the safety of up to 22 mg LGD-4033”
Was that dosed everyday over the 21 day study? Was it gradual as they infer in the study? How gradual was it? They really don’t say but many users who run minimal-no pct say they are fine at the 5-10mg dose. I personally do not take their word for it. They may feel better after 1-2 months off cycle after they have recovered a bit but please run pct if u care abt ur health if u don’t y are u here go blast tren.
So running this with pct is required. To what degree is up to you, some people also run lower doses (5-10mgs) which has lower suppression compared to the 20-50mgs taken for bodybuilding.
Recommend Pct
Hcg on cycle 500-1200mcg per week would be good to synthetically increase ur LH. (Get ur balls producing some test) and will act as our pct. Enclomiphene for 4 weeks pct as well.
Minimal pct
Serm of choice.
Enclomiphene 4-6 weeks pct.
Enclomiphene as “test base”
To get around injections some users will use anywhere from 6mgs-100mgs of Enclomiphene on cycle to keep test levels up. 6-12mgs is reportedly enough for some users taking 5-10mgs lgd ED.
Some have reported taking 25mg Enclomiphene ED on cycle with 10-20mgs lgd.
You can see how it exponentially increases from there.
Taking the Enclomiphene “test base” route comes with risks and effects. The most common being feeling like ur on your period everyday and gyno. The worst being Eye damage/blindness, and or eye floaters. Users report these effects around 50mgs ED.
Rad-140: muscle hardener, increase strength. Mega dose tested on grandmas with cancer?
This Sarm is more suppressive than lgd-4033. But u said it was tested on grandmas with cancer. Yes and they all survived. By suppressive I mean less suppressive than typical roids. To put it into perspective ostarine could be compared to 1-2 drinks of alcohol a day. Rad is more similar to “binge drinking” 4-6 drinks.
Cool. What abt the mega dosed grandmas man? Here’s the study.
https://www.annalsofoncology.org/article/S0923-7534(19)58565-9/fulltext
They gave these bitches 50-150mg of RAD for an avg of 8 weeks. And these woman had to be inoperable meaning stage 4 breast cancer to be apart of the study. And none of them died. Maybe Sarms arnt as bad as we thought.
Also these are woman their body’s respond differently than men. I just thought this shit was a crazy tolerance study so I included it.
Now here’s a study on something much more similar to the male bipedal Homosapien; rats and monkeys. shows how selective rad is on rats and monkeys at what would be 0.8mg per day for a 170lbs man. TLDR
“Clinical chemistry indicated the expected lowering of lipids (LDL, HDL, triglycerides).28 Despite the rather dramatic increases in body weight over such a short time, there was no elevation of liver enzyme transaminase levels in any animal at any dose >2 fold over its baseline value.29,30 Given the well-established relationship between oral androgen use and liver stress indicators, we were quite pleased that at a dose 10-fold greater than the fully effective dose we saw minimal liver enzyme elevations.31Taken in sum, RAD140 has all the hallmarks of a SARM. It is potency selective, since it stimulates muscle weight increases at a lower dose than that required to stimulate prostate weight increases. Moreover, it is also efficacy selective, because it is fully anabolic on muscle but demonstrates less than complete efficacy on the prostate and seminal vesicles and, in fact, can partially antagonize the stimulation of the seminal vesicles induced by testosterone.”
Whats funny is how set up to succeed this study was.
“One area of interest for the clinical use of SARMs involves the combination of their pharmaceutical use with resistance exercise aimed at increasing skeletal muscle size and strength. The current research sought to determine if RAD140 improves muscle growth and bone mineral density/microarchitecture in combination with a resistance exercise model. These results may serve as a basis for this approach to be applied in a clinical setting to combine a training program with RAD140 supplementation treatments (e.g., prehabilitation and rehabilitation). In preclinical models, FO is a resistance training model that induces animal muscular hypertrophy. This model works to achieve mechanical overload by chronically increasing the load on an animal's muscle group(s) by surgical intervention through removing critical synergist muscle(s) (or distal portions of muscle(s)), leaving the remaining muscle(s) to maintain the animal's posture and mobility (Terada et al., 2012; Terena et al., 2017). The FO model, combined with testosterone treatments, has been proven to significantly increase muscle mass and the cross‐sectional area of myofibers. Previous research has reported that the SARMs MK‐0773, GTx‐024, and LGD‐4033 can increase lean body mass and bone mineral density (BMD). There is also a link between resistance training and the FO model to bone remodeling. Resistance training in humans and FO in rodents are known to cause increases in various circulating factors, including IGF‐I, growth hormone, and testosterone (Zouhal et al., 2022).”
https://pmc.ncbi.nlm.nih.gov/articles/PMC12274021/
This study goes over how rad increases muscle growth in rats and bone growth.
https://pmc.ncbi.nlm.nih.gov/articles/PMC12274021/
TLDR:
That shit was depressing to read all of it just to find out what I knew already. Rad can grow muscle but failed to show promise in bones. However they do say they didn’t get the rats the 3mg/per/day and only 1.8-2.whatever it was. And that rats bones are vastly different than humans. The rat bone stuff said at the beginning is from this study.
Also they do say,
“Previous research has reported that the SARMs MK‐0773, GTx‐024, and LGD‐4033 can increase lean body mass and bone mineral density (BMD).”
So I’m glad I don’t have to go research that and put it down here for yall.
With what we already know about Sarms it’s still quite possible that rad does increase bone density in humans. According to the next studies.
https://cellbiopharm.com/ojs/index.php/MCBS/article/view/536#:~:text=SARM%20Rad140%20Increases%20Osteoblasts%2C%20Muscle,Molecular%20and%20Cellular%20Biomedical%20Sciences
https://pdfs.semanticscholar.org/5787/e5815292beba3f3ff294a3730f00ce08cb63.pdf
SARM Rad140 significantly increased the number of osteoblasts, muscle fiber CSA, and gastrocnemius muscle myonuclei, as well as decreased the number of osteoclasts.
SARM Rad140 may offer potential benefits as a therapy for osteoporosis and muscle weakening due to ADT, as the treatment has been shown to increase bone density.
TLDR
Bone density and lean muscle increase.
How does it feel
Many say they feel aggressive on it. Huh, weird I thought it was a Sarm, not riods. Sarms are not exactly what they are on paper. They are still being researched but this alone is proof they are not as selective as the Name Sarm interprets.
I would also like you to run this with a test base but if you don’t want to the same can be done as lgd to mitigate while on cycle and pct to get u back on the rail road .
S23
If your thinking about taking this you should have already tried a few others Sarms. As this one take more experience to deal with and honestly I don’t even think ima do it justice here this thread is more of an intro/guild into the Sarm world trying to make less ppl hate them.
This shit was developed as a male contraceptive. Many of u have never heard of male contraception due to the fact u don’t get hoes.
Is this an effective contraceptive; yes. But I still wouldn’t bet 18 years of pay checks on it. (Jfl I’m a pull and pray type of guy tbh I wish I ran this in hs would have saved me so many cortisol spikes and boosted growth)
“four of six animals showed no sperm in the testis and zero pregnancies (none of six) in mating trials. After termination of treatment, infertility was fully reversible, with a 100% pregnancy rate observed after 100 d of recovery”
“In intact male rats treated for 14 d, S-23 alone suppressed LH levels by greater than 50% at doses greater than 0.1 mg/d, with corresponding decreases in the size of the prostate but increases in the size of levator ani muscle.” Suppression is 100% going to happen on this shit it is reported by users to basically be a riod.
“S-23 increased bone mineral density and lean mass but reduced fat mass in a dose-dependent manner. This is the first study to show that a selective androgen receptor modulator combined with EB is an effective and reversible regimen for hormonal male contraception in rats.”
https://pmc.ncbi.nlm.nih.gov/articles/PMC2630904/#:~:text=S-23 increased bone mineral,hormonal male contraception in rats.
S4
This is the Sarm known for scary vision coloring; a yellow or at high doses green tint. Not that scary after stopping people report vision returning to normal. Night blindness starts around 50mgs some people take this up to 200mg
100mgs of S4 is still more hair safe than 10mg of rad-140.
A guy named Alek.performance took 175mg everyday for like a year or 2 and after he stopped taking it his green vision stopped.
Anyways bone density
“S-4 treatment caused a significantly larger increase in total body bone mineral density than DHT. S-4 (3 and 10 mg/kg) also demonstrated agonist activity in the pituitary and significantly decreased plasma LH and FSH levels in castrated animals in a dose-dependent manner. In summary, the strong anabolic effects of S-4 in skeletal muscle, bone, and pituitary were achieved with minimal pharmacologic effect in the prostate. The tissue-selective pharmacologic activity of SARMs provides obvious advantages over steroidal androgen therapy and demonstrates the promising therapeutic utility that this new class of drugs may hold.”
https://pmc.ncbi.nlm.nih.gov/articles/PMC2039881/#:~:text=Furthermore, S-4 treatment caused,class of drugs may hold.
S-4 does not interact with the ER and cannot be aromatized. Thus, the effects of S-4 on bone should be mediated only by direct action on the AR, providing a valid and direct comparison to DHT.
Considering the fact that both muscle and bone are DHT-independent tissues, we hypothesized that S-4 would have similar anabolic activity to DHT in these tissues, and both treatments would improve muscle strength and body composition and restore ORX-caused bone loss.
Total body BMD and BMC (n = 7–8) in different treatment groups. A, Total body BMD and BMC measured at 12 wk (before S-4 and DHT treatment) and 20 wk (after S-4 and DHT treatment). B, Changes in total body BMD and BMC during 8 wk treatment with S-4 and DHT (between 12 and 20 wk after ORX). Data are presented as mean ± sem. *, P < 0.05, compared with the intact control group. #, P< 0.05, compared with the vehicle (Veh)-treated ORX group.
“S-4 (3 or 10 mg/kg) treatment did not affect IGF-I levels. However, DHT (3 mg/kg) significantly decreased plasma IGF-I concentrations to 271 ng/ml, approximately 70% of the level observed in intact animals.”
I assume this igf suppression doesn’t really matter. Yall prolly run HGH with dht.
Ac-262:
Less data on this one
“Conclusion
Given AC-262's properties as a SARM, AC-262 holds potential for a range of medical applications. One of the most promising uses is in treating conditions like sarcopenia (age-related muscle loss) and osteoporosis, where patients could benefit from increased
muscle mass and bone density without the risks associated with traditional androgen therapy.”
Note worthy
“In prostate cancer cells, AC-262
was able to antagonize the effects of DHT, a strong natural androgen. The cancer cells react to DHT by multiplying and thus AC-262 was able to inhibit cancer growth in the presence of DHT.”
https://umbrellalabs.is/wp-content/uploads/2025/06/ULB-Article-10_2024-02-AC_262536-WMlinked.pdf
Ostarine (MK-2866)
This one is pretty much in stone it will grow ur bones. Not only fixed damage but actually made the bones BMD higher than what it was before making these rats have osteoporosis.
Bone analyses
In vivo pQCT of L4
Twelve weeks after Orx, total BMD was significantly lower in the Orx group as compared to the Non-Orx group, whereas ostarine and testosterone prophylaxis treatments prevented this bone loss and showed increased total BMD as compared with the Orx, Ostarine Therapy, and Test. Therapy groups (Table 1).
At the end of the experiment (week 18), the total BMD of Orx animals was lower as compared to those of the Non-Orx, Ostarine Proph., and Test. Proph. groups (Table 1). In ostarine prophylaxis animals, BMD was higher as compared to the ostarine therapy group, while testosterone-therapy animals had lower BMD as compared to ostarine-prophylaxis animals.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10403398/
“Short-term treatment of osteoporotic bone with ostarine leads to improvement of several microstructural bone indices.”
https://pubmed.ncbi.nlm.nih.gov/29785666/#:~:text=Short-term treatment of osteoporotic,of several microstructural bone indices.
TLDR: bone go big
“In our study, we present ostarine’s effects on structural and chemical parameters, biomechanical stability, and gene expression at two skeletal sites, the lumbar spine and femur. This study provides new insights into the important topic of male osteoporosis. In the present study, Ostarine Proph. treatment prevented bone deterioration in male rats after Orx by maintaining the BMD of L4 at a higher level than in Orx rats, as was determined via in vivo pQCT analysis at weeks 12 and 18 after Orx. After 18 weeks had passed since Orx, this treatment even improved BMD as comparing to Non-Orx rats. The favorable effect of Ostarine Proph. was supported by a detailed micro-CT analysis of the bone structure. Enhanced cortical density and volume were measured via 3D micro-CT analysis in the femur, whereas in both L4 and the femur, trabecular density was higher in this group than in the Orx rats based on 2D micro-CT analysis. In the femur, the effect was more pronounced than in L4, with additionally elevated trabecular thickness and number of nodes in the Ostarine Proph. group. In contrast, mineral content in the Orx rats was maintained under Ostarine Proph. in L4, whereas in the femur, it was at the lower level seen in Orx rats. This could be explained by the heterogenous changes that occur in various skeletal parts during osteoporosis [36–39]. Bone loss during osteoporosis depends on bone localization, and even anti-osteoporotic treatment varies between femora and vertebrae samples [37, 40]. Ostarine applied as a therapeutic treatment for 6 weeks was effective solely in improving the cortical density of the femur. Perhaps, a prolonged treatment could have a stronger effect on osteoporotic bone tissue. The osteoanabolic effects of SARMs have been previously described in the literature; e.g., studies on SARM drugs such as S-4 or LGD-3303 have shown their positive effects on bone tissue. Kearbey et al. [41, 42] showed that S-4 treatment maintained trabecular BMD, cortical content, and increased bone strength after 120 days of treatment in ovariectomized rats. Vajda et al. [43] used another SARM, LGD-3303, which was orally administered for 14 days in osteopenic female rats, and found increased bone density at cortical and cancellous bone sites [43].”
For the people that think the Sarm/ Sarm is cope.
“In sum, Ostarine Proph. treatment showed positive effects in terms of preventing osteoporotic changes in cortical and trabecular bone. Ostarine Therapy treatment had less effect, solely improving the cortical density of femur. Thus, in monotherapy, the effect of ostarine does not appear to be sufficient to significantly reduce the development and progression of osteoporosis. Combination therapies of SARM and SERM could be considered in future studies, e.g., a combination of ostarine and raloxifene [23]. By applying this combination therapy, the anabolic influence on musculoskeletal tissue is maintained, whereas the androgenic effect on the prostate is reduced”
https://pmc.ncbi.nlm.nih.gov/articles/PMC10403398/
For those who say where the cortical growth here it is. Click on the studies from above and go through them.I’d say S4 and Lgd is ur best bet. For height but for other bone growth they basically all work.
If you made it here thanks for reading; instead of working on my college classes I made this and I hope u enjoyed. I know everything’s not very obvious and it’s kinda messy, but I figured I’d get this info down bc I’ve seen lots of ppl ask if Sarms are cope and if they go to the studies then they will learn that they arnt. Yes they are suppressive, however there are methods to getting around this as discussed.
As a little treat to ppl who stayed to read I’ll give u some places to get it.
Just Sarms
Chemyo
Swiss chems
Actual gear and Sarms
Napsgear
In this guide I prove that Sarm give gains and bone density. Ostarine actually has documented data about BMD and Volume being greater after giving rats osteoporosis and treatment.
TLDR: Sarm = muscle growth and bone density.
I had ChatGpt make me this cute little graph. I would say it’s kinda accurate but everybody’s body responds differently. Go ahead and pick out ur candy teenage Sarm goblin. Take the lbs with a grain of salt.
| Compound | Bulk Muscle Gain | Cut/Recomp Retention | Typical Lean Gain Range (8–12 wks) | Suppression | Notes |
| LGD-4033 |  (High) | (Good) | ~4–8 lbs (some water possible) | (Mod) | Best “bulk SARM” overall |
| RAD-140 | (High) | (Very Good) | ~4–8 lbs (denser, leaner) | (Mod–High) | Strong but harsher sides |
| Ostarine (MK-2866) | (Modest) | (Very Good) | ~2–5 lbs (clean recomp) | (Low–Mod) | Best cutting/recomp option |
| AC-262 | (Modest) | (Good) | ~2–4 lbs (subtle lean gain) | (Low–Mod) | “Natty+” mild choice |
| S4 (Andarine) | (Modest) | (Good) | ~2–5 lbs (hardening) | (Mod) | Vision sides are the issue |
| S23 | (High) | (Very Good) | ~5–10 lbs (but risky) | (Severe) | Shutdown territory, basically gear atp |
The difference between rat bones and human bones. Taken from rad-140 study.
TLDR you can come back to this later when I mention it in the article but tbh u don’t have to read it.
“These rates are also affected by age and growth stage. The rats used in the present study were ~400 g at the beginning of the study, which corresponds to ~9–10 weeks of age, which represents an age of continued growth. Bone formation rates normalized to bone volume (BFR/BV) have been reported to be several times higher in rats compared to humans (Rubin et al., 2001; Taguchi & Lopez, 2021; Tanizawa et al., 1999). Bone remodeling periods, which is the average total duration of a single cycle of bone remodeling at any point on a bone surface, have been reported to be ~6 days for rats and 6–9 months for humans (Taguchi & Lopez, 2021). These differences have an important role in the study design and interpretation of the study data”
https://pmc.ncbi.nlm.nih.gov/articles/PMC12274021/
3 Sarms that do put on more serious gains but more suppression: Lgd-4033, Rad-140, S23
Lgd-4033
Will it give me bigger muscles and bone growth?
Some report a much more watery muscle gain while other report lean. Some attribute watery gain to be from electrolyte imbalance. So increase potassium a lot. Also they say it’s like Dball
The phase 1 clinical trial shows promise,
(I linked it a bunch of hyperlinks, so that it can take u to where it says it in the articles. But I think it only works for 1 of the hyperlinks)
“In animal models, LGD-4033 has demonstrated anabolic activity in the muscle, anti-resorptive and anabolic activity in bone, and robust selectivity for muscle versus prostate.”
https://pmc.ncbi.nlm.nih.gov/articles/PMC4111291/
Breaking that down further I went to the linked study’s abstract which says,
“We demonstrated that LGD2226 is fully active in cell-based models of bone and muscle. LGD2226 exhibited anabolic activity on muscle and bone with reduced impact on prostate growth in rodent models. Biomechanical testing of bones from animals treated with LGD2226 showed strong enhancement of bone strength above sham levels.”
They say it again here in phase 1
“LGD-4033 is a novel nonsteroidal, oral SARM that binds to androgen receptor with high affinity (Ki of ∼1 nM) and selectivity. In animal models, LGD-4033 has demonstrated anabolic activity in the muscle, anti-resorptive and anabolic activity in bone, and robust selectivity for muscle versus prostate.”
https://pmc.ncbi.nlm.nih.gov/articles/PMC4111291/#:~:text=LGD-4033 is a novel,selectivity for muscle versus prostate.
Suppression at 1mg
“LGD-4033 administration was associated with dose-dependent suppression of total testosterone, sex hormone–binding globulin, high density lipoprotein cholesterol, and triglyceride levels. follicle-stimulating hormone and free testosterone showed significant suppression at 1.0-mg dose only. Lean body mass increased dose dependently, but fat mass did not change significantly. Hormone levels and lipids returned to baseline after treatment discontinuation”
(https://pmc.ncbi.nlm.nih.gov/articles/PMC4111291/)
So does that mean it’s not safe?
Well in the exact same study they say this it’s safe up to 22 mgs.
“We also evaluated the effects of graded doses of LGD-4033 on lean body mass (LBM), muscle strength, and physical function. LGD-4033 doses of 0.1, 0.3, and 1.0 mg were selected for multiple dosing over 21 days because a previous phase I single ascending-dose study had established the safety of up to 22 mg LGD-4033”
Was that dosed everyday over the 21 day study? Was it gradual as they infer in the study? How gradual was it? They really don’t say but many users who run minimal-no pct say they are fine at the 5-10mg dose. I personally do not take their word for it. They may feel better after 1-2 months off cycle after they have recovered a bit but please run pct if u care abt ur health if u don’t y are u here go blast tren.
So running this with pct is required. To what degree is up to you, some people also run lower doses (5-10mgs) which has lower suppression compared to the 20-50mgs taken for bodybuilding.
Recommend Pct
Hcg on cycle 500-1200mcg per week would be good to synthetically increase ur LH. (Get ur balls producing some test) and will act as our pct. Enclomiphene for 4 weeks pct as well.
Minimal pct
Serm of choice.
Enclomiphene 4-6 weeks pct.
Enclomiphene as “test base”
To get around injections some users will use anywhere from 6mgs-100mgs of Enclomiphene on cycle to keep test levels up. 6-12mgs is reportedly enough for some users taking 5-10mgs lgd ED.
Some have reported taking 25mg Enclomiphene ED on cycle with 10-20mgs lgd.
You can see how it exponentially increases from there.
Taking the Enclomiphene “test base” route comes with risks and effects. The most common being feeling like ur on your period everyday and gyno. The worst being Eye damage/blindness, and or eye floaters. Users report these effects around 50mgs ED.
Rad-140: muscle hardener, increase strength. Mega dose tested on grandmas with cancer?
This Sarm is more suppressive than lgd-4033. But u said it was tested on grandmas with cancer. Yes and they all survived. By suppressive I mean less suppressive than typical roids. To put it into perspective ostarine could be compared to 1-2 drinks of alcohol a day. Rad is more similar to “binge drinking” 4-6 drinks.
Cool. What abt the mega dosed grandmas man? Here’s the study.
https://www.annalsofoncology.org/article/S0923-7534(19)58565-9/fulltext
They gave these bitches 50-150mg of RAD for an avg of 8 weeks. And these woman had to be inoperable meaning stage 4 breast cancer to be apart of the study. And none of them died. Maybe Sarms arnt as bad as we thought.
Also these are woman their body’s respond differently than men. I just thought this shit was a crazy tolerance study so I included it.
Now here’s a study on something much more similar to the male bipedal Homosapien; rats and monkeys. shows how selective rad is on rats and monkeys at what would be 0.8mg per day for a 170lbs man. TLDR
“Clinical chemistry indicated the expected lowering of lipids (LDL, HDL, triglycerides).28 Despite the rather dramatic increases in body weight over such a short time, there was no elevation of liver enzyme transaminase levels in any animal at any dose >2 fold over its baseline value.29,30 Given the well-established relationship between oral androgen use and liver stress indicators, we were quite pleased that at a dose 10-fold greater than the fully effective dose we saw minimal liver enzyme elevations.31Taken in sum, RAD140 has all the hallmarks of a SARM. It is potency selective, since it stimulates muscle weight increases at a lower dose than that required to stimulate prostate weight increases. Moreover, it is also efficacy selective, because it is fully anabolic on muscle but demonstrates less than complete efficacy on the prostate and seminal vesicles and, in fact, can partially antagonize the stimulation of the seminal vesicles induced by testosterone.”
Whats funny is how set up to succeed this study was.
“One area of interest for the clinical use of SARMs involves the combination of their pharmaceutical use with resistance exercise aimed at increasing skeletal muscle size and strength. The current research sought to determine if RAD140 improves muscle growth and bone mineral density/microarchitecture in combination with a resistance exercise model. These results may serve as a basis for this approach to be applied in a clinical setting to combine a training program with RAD140 supplementation treatments (e.g., prehabilitation and rehabilitation). In preclinical models, FO is a resistance training model that induces animal muscular hypertrophy. This model works to achieve mechanical overload by chronically increasing the load on an animal's muscle group(s) by surgical intervention through removing critical synergist muscle(s) (or distal portions of muscle(s)), leaving the remaining muscle(s) to maintain the animal's posture and mobility (Terada et al., 2012; Terena et al., 2017). The FO model, combined with testosterone treatments, has been proven to significantly increase muscle mass and the cross‐sectional area of myofibers. Previous research has reported that the SARMs MK‐0773, GTx‐024, and LGD‐4033 can increase lean body mass and bone mineral density (BMD). There is also a link between resistance training and the FO model to bone remodeling. Resistance training in humans and FO in rodents are known to cause increases in various circulating factors, including IGF‐I, growth hormone, and testosterone (Zouhal et al., 2022).”
https://pmc.ncbi.nlm.nih.gov/articles/PMC12274021/
This study goes over how rad increases muscle growth in rats and bone growth.
https://pmc.ncbi.nlm.nih.gov/articles/PMC12274021/
TLDR:
That shit was depressing to read all of it just to find out what I knew already. Rad can grow muscle but failed to show promise in bones. However they do say they didn’t get the rats the 3mg/per/day and only 1.8-2.whatever it was. And that rats bones are vastly different than humans. The rat bone stuff said at the beginning is from this study.
Also they do say,
“Previous research has reported that the SARMs MK‐0773, GTx‐024, and LGD‐4033 can increase lean body mass and bone mineral density (BMD).”
So I’m glad I don’t have to go research that and put it down here for yall.
With what we already know about Sarms it’s still quite possible that rad does increase bone density in humans. According to the next studies.
https://cellbiopharm.com/ojs/index.php/MCBS/article/view/536#:~:text=SARM%20Rad140%20Increases%20Osteoblasts%2C%20Muscle,Molecular%20and%20Cellular%20Biomedical%20Sciences
https://pdfs.semanticscholar.org/5787/e5815292beba3f3ff294a3730f00ce08cb63.pdf
SARM Rad140 significantly increased the number of osteoblasts, muscle fiber CSA, and gastrocnemius muscle myonuclei, as well as decreased the number of osteoclasts.
SARM Rad140 may offer potential benefits as a therapy for osteoporosis and muscle weakening due to ADT, as the treatment has been shown to increase bone density.
TLDR
Bone density and lean muscle increase.
How does it feel
Many say they feel aggressive on it. Huh, weird I thought it was a Sarm, not riods. Sarms are not exactly what they are on paper. They are still being researched but this alone is proof they are not as selective as the Name Sarm interprets.
I would also like you to run this with a test base but if you don’t want to the same can be done as lgd to mitigate while on cycle and pct to get u back on the rail road .
S23
If your thinking about taking this you should have already tried a few others Sarms. As this one take more experience to deal with and honestly I don’t even think ima do it justice here this thread is more of an intro/guild into the Sarm world trying to make less ppl hate them.
This shit was developed as a male contraceptive. Many of u have never heard of male contraception due to the fact u don’t get hoes.
Is this an effective contraceptive; yes. But I still wouldn’t bet 18 years of pay checks on it. (Jfl I’m a pull and pray type of guy tbh I wish I ran this in hs would have saved me so many cortisol spikes and boosted growth)
“four of six animals showed no sperm in the testis and zero pregnancies (none of six) in mating trials. After termination of treatment, infertility was fully reversible, with a 100% pregnancy rate observed after 100 d of recovery”
“In intact male rats treated for 14 d, S-23 alone suppressed LH levels by greater than 50% at doses greater than 0.1 mg/d, with corresponding decreases in the size of the prostate but increases in the size of levator ani muscle.” Suppression is 100% going to happen on this shit it is reported by users to basically be a riod.
“S-23 increased bone mineral density and lean mass but reduced fat mass in a dose-dependent manner. This is the first study to show that a selective androgen receptor modulator combined with EB is an effective and reversible regimen for hormonal male contraception in rats.”
https://pmc.ncbi.nlm.nih.gov/articles/PMC2630904/#:~:text=S-23 increased bone mineral,hormonal male contraception in rats.
- Effects: Described as one of the strongest SARMs available, it is often utilized for cutting cycles due to its ability to harden muscles and increase strength.
- Mechanism: As a SARM that increases lean muscle and reduces fat, S23 acts similarly to dihydrotestosterone (DHT) in certain tissues, which can lead to the miniaturization of hair follicles, leading to hair loss.
S4
This is the Sarm known for scary vision coloring; a yellow or at high doses green tint. Not that scary after stopping people report vision returning to normal. Night blindness starts around 50mgs some people take this up to 200mg
100mgs of S4 is still more hair safe than 10mg of rad-140.
A guy named Alek.performance took 175mg everyday for like a year or 2 and after he stopped taking it his green vision stopped.
Anyways bone density
“S-4 treatment caused a significantly larger increase in total body bone mineral density than DHT. S-4 (3 and 10 mg/kg) also demonstrated agonist activity in the pituitary and significantly decreased plasma LH and FSH levels in castrated animals in a dose-dependent manner. In summary, the strong anabolic effects of S-4 in skeletal muscle, bone, and pituitary were achieved with minimal pharmacologic effect in the prostate. The tissue-selective pharmacologic activity of SARMs provides obvious advantages over steroidal androgen therapy and demonstrates the promising therapeutic utility that this new class of drugs may hold.”
https://pmc.ncbi.nlm.nih.gov/articles/PMC2039881/#:~:text=Furthermore, S-4 treatment caused,class of drugs may hold.
S-4 does not interact with the ER and cannot be aromatized. Thus, the effects of S-4 on bone should be mediated only by direct action on the AR, providing a valid and direct comparison to DHT.
Considering the fact that both muscle and bone are DHT-independent tissues, we hypothesized that S-4 would have similar anabolic activity to DHT in these tissues, and both treatments would improve muscle strength and body composition and restore ORX-caused bone loss.
Total body BMD and BMC (n = 7–8) in different treatment groups. A, Total body BMD and BMC measured at 12 wk (before S-4 and DHT treatment) and 20 wk (after S-4 and DHT treatment). B, Changes in total body BMD and BMC during 8 wk treatment with S-4 and DHT (between 12 and 20 wk after ORX). Data are presented as mean ± sem. *, P < 0.05, compared with the intact control group. #, P< 0.05, compared with the vehicle (Veh)-treated ORX group.
“S-4 (3 or 10 mg/kg) treatment did not affect IGF-I levels. However, DHT (3 mg/kg) significantly decreased plasma IGF-I concentrations to 271 ng/ml, approximately 70% of the level observed in intact animals.”
I assume this igf suppression doesn’t really matter. Yall prolly run HGH with dht.
Ac-262:
Less data on this one
“Conclusion
Given AC-262's properties as a SARM, AC-262 holds potential for a range of medical applications. One of the most promising uses is in treating conditions like sarcopenia (age-related muscle loss) and osteoporosis, where patients could benefit from increased
muscle mass and bone density without the risks associated with traditional androgen therapy.”
Note worthy
“In prostate cancer cells, AC-262
was able to antagonize the effects of DHT, a strong natural androgen. The cancer cells react to DHT by multiplying and thus AC-262 was able to inhibit cancer growth in the presence of DHT.”
https://umbrellalabs.is/wp-content/uploads/2025/06/ULB-Article-10_2024-02-AC_262536-WMlinked.pdf
Ostarine (MK-2866)
This one is pretty much in stone it will grow ur bones. Not only fixed damage but actually made the bones BMD higher than what it was before making these rats have osteoporosis.
Bone analyses
In vivo pQCT of L4
Twelve weeks after Orx, total BMD was significantly lower in the Orx group as compared to the Non-Orx group, whereas ostarine and testosterone prophylaxis treatments prevented this bone loss and showed increased total BMD as compared with the Orx, Ostarine Therapy, and Test. Therapy groups (Table 1).
At the end of the experiment (week 18), the total BMD of Orx animals was lower as compared to those of the Non-Orx, Ostarine Proph., and Test. Proph. groups (Table 1). In ostarine prophylaxis animals, BMD was higher as compared to the ostarine therapy group, while testosterone-therapy animals had lower BMD as compared to ostarine-prophylaxis animals.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10403398/
“Short-term treatment of osteoporotic bone with ostarine leads to improvement of several microstructural bone indices.”
https://pubmed.ncbi.nlm.nih.gov/29785666/#:~:text=Short-term treatment of osteoporotic,of several microstructural bone indices.
TLDR: bone go big
“In our study, we present ostarine’s effects on structural and chemical parameters, biomechanical stability, and gene expression at two skeletal sites, the lumbar spine and femur. This study provides new insights into the important topic of male osteoporosis. In the present study, Ostarine Proph. treatment prevented bone deterioration in male rats after Orx by maintaining the BMD of L4 at a higher level than in Orx rats, as was determined via in vivo pQCT analysis at weeks 12 and 18 after Orx. After 18 weeks had passed since Orx, this treatment even improved BMD as comparing to Non-Orx rats. The favorable effect of Ostarine Proph. was supported by a detailed micro-CT analysis of the bone structure. Enhanced cortical density and volume were measured via 3D micro-CT analysis in the femur, whereas in both L4 and the femur, trabecular density was higher in this group than in the Orx rats based on 2D micro-CT analysis. In the femur, the effect was more pronounced than in L4, with additionally elevated trabecular thickness and number of nodes in the Ostarine Proph. group. In contrast, mineral content in the Orx rats was maintained under Ostarine Proph. in L4, whereas in the femur, it was at the lower level seen in Orx rats. This could be explained by the heterogenous changes that occur in various skeletal parts during osteoporosis [36–39]. Bone loss during osteoporosis depends on bone localization, and even anti-osteoporotic treatment varies between femora and vertebrae samples [37, 40]. Ostarine applied as a therapeutic treatment for 6 weeks was effective solely in improving the cortical density of the femur. Perhaps, a prolonged treatment could have a stronger effect on osteoporotic bone tissue. The osteoanabolic effects of SARMs have been previously described in the literature; e.g., studies on SARM drugs such as S-4 or LGD-3303 have shown their positive effects on bone tissue. Kearbey et al. [41, 42] showed that S-4 treatment maintained trabecular BMD, cortical content, and increased bone strength after 120 days of treatment in ovariectomized rats. Vajda et al. [43] used another SARM, LGD-3303, which was orally administered for 14 days in osteopenic female rats, and found increased bone density at cortical and cancellous bone sites [43].”
For the people that think the Sarm/ Sarm is cope.
“In sum, Ostarine Proph. treatment showed positive effects in terms of preventing osteoporotic changes in cortical and trabecular bone. Ostarine Therapy treatment had less effect, solely improving the cortical density of femur. Thus, in monotherapy, the effect of ostarine does not appear to be sufficient to significantly reduce the development and progression of osteoporosis. Combination therapies of SARM and SERM could be considered in future studies, e.g., a combination of ostarine and raloxifene [23]. By applying this combination therapy, the anabolic influence on musculoskeletal tissue is maintained, whereas the androgenic effect on the prostate is reduced”
https://pmc.ncbi.nlm.nih.gov/articles/PMC10403398/
For those who say where the cortical growth here it is. Click on the studies from above and go through them.I’d say S4 and Lgd is ur best bet. For height but for other bone growth they basically all work.
If you made it here thanks for reading; instead of working on my college classes I made this and I hope u enjoyed. I know everything’s not very obvious and it’s kinda messy, but I figured I’d get this info down bc I’ve seen lots of ppl ask if Sarms are cope and if they go to the studies then they will learn that they arnt. Yes they are suppressive, however there are methods to getting around this as discussed.
As a little treat to ppl who stayed to read I’ll give u some places to get it.
Just Sarms
Chemyo
Swiss chems
Actual gear and Sarms
Napsgear
