cmazstereo
Iron
- Joined
- Feb 2, 2021
- Posts
- 76
- Reputation
- 203
An high IGF1/IGFBP-3 ratio is predictive of baldness. Estrogen increases IGF-1 and inhibits IGFBP-3.
Increasing IGF-1 by a single standard deviation increases balding risks by 31%. Increasing IGFBP-3 by a single standard deviation decreases balding risks by 38%.
https://www.mcgill.ca/pollak-lab/fi...ing_plasma_insulin_like_growth_factor_1_0.pdf
Estradiol, progesterone, and transforming growth factor alpha regulate insulin-like growth factor binding protein-3 (IGFBP3) expression in mouse en... - PubMed - NCBI
In these two studies, they find High Estrogen and Cortisol in balding men :
Hormonal basis of male and female androgenic alopecia: clinical relevance. - PubMed - NCBI
Hormonal parameters in androgenetic hair loss in the male. - PubMed - NCBI
The cascade often starts before Estrogen. Endotoxins and/or Serotonin promote chronically high Cortisol which promotes Estrogen synthesis. Cortisol promotes DHT. DHEA-S which is significantly higher in balding men is a marker of stress. Inflammatory cytokines and prostaglandins also induce aromatase expression and estrogen synthesis.
Serum elevation of dehydroepiandrosterone sulfate associated with male pattern baldness in young men. - PubMed - NCBI
Acute and chronic stress increase DHEAS concentrations in rhesus monkeys
Zinc, which is anti-estrogenic is significantly lower in all types of hair loss, including male pattern baldness.
Analysis of Serum Zinc and Copper Concentrations in Hair Loss
Increasing IGF-1 by a single standard deviation increases balding risks by 31%. Increasing IGFBP-3 by a single standard deviation decreases balding risks by 38%.
https://www.mcgill.ca/pollak-lab/fi...ing_plasma_insulin_like_growth_factor_1_0.pdf
Estradiol, progesterone, and transforming growth factor alpha regulate insulin-like growth factor binding protein-3 (IGFBP3) expression in mouse en... - PubMed - NCBI
In these two studies, they find High Estrogen and Cortisol in balding men :
Hormonal basis of male and female androgenic alopecia: clinical relevance. - PubMed - NCBI
Hormonal parameters in androgenetic hair loss in the male. - PubMed - NCBI
The cascade often starts before Estrogen. Endotoxins and/or Serotonin promote chronically high Cortisol which promotes Estrogen synthesis. Cortisol promotes DHT. DHEA-S which is significantly higher in balding men is a marker of stress. Inflammatory cytokines and prostaglandins also induce aromatase expression and estrogen synthesis.
Serum elevation of dehydroepiandrosterone sulfate associated with male pattern baldness in young men. - PubMed - NCBI
Acute and chronic stress increase DHEAS concentrations in rhesus monkeys
Zinc, which is anti-estrogenic is significantly lower in all types of hair loss, including male pattern baldness.
Analysis of Serum Zinc and Copper Concentrations in Hair Loss
