HEIGHTMAXX HGH growth hormone increasing part 1

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Introduction


Growth hormone is a peptide hormone primarily secreted by somatotropic cells in the anterior pituitary gland.
The hypothalamus regulates this process through the release of somatostatin (an inhibitor) and growth hormone-releasing hormone (a stimulator)

FACTORS AFFECTING THE INCREASE IN GH

1. Sex hormones
Testosterone increases growth hormone through an estrogen-dependent mechanism, estrogens increase growth hormone by positive regulation of somatocrinin.

Increased activity of 5a-reductase can reduce growth hormone through a competitive mechanism with aromatase, thereby lowering the level of estrogen and growth hormone as a result.

Research indicates that DHT has a complex relationship with growth hormone (GH) secretion. In studies involving adolescent males undergoing treatment for conditions such as constitutional delay in growth and adolescence, it was observed that DHT administration did not significantly increase GH levels. For instance, one study reported that integrated concentrations of GH decreased in subjects treated with DHT compared to those treated with testosterone. Specifically, the integrated concentration of GH (ICGH) decreased from 4.32 +/- 0.61 to 2.39 +/- 0.42 micrograms/L after treatment with DHT (P < 0.025). This suggests that while testosterone stimulates GH secretion through an estrogen-dependent mechanism, DHT may have a suppressive effect on GH levels. (https://www.sciencedirect.com/science/article/abs/pii/S0026049596901821)
2. Amino acids
Amino acids such as leucine, arginine, lysine, ornithine, tryptophan, increase the level of growth hormone mainly by inhibiting somatostatin.
It is not worth focusing on them, as when used alone, they increase the level of growth hormone only for a short time, resulting in lower levels than other methods.

Glycine, an amino acid that increases growth hormone by 400% or more for several hours, appears to be more effective (https://academic.oup.com/ejendo/article-abstract/93/3/283/6803525?redirectedFrom=PDF&login=false).

Creatine also has a long-term effect on growth hormone levels, but only by 80% (https://www.researchgate.net/public...ading_enhances_human_growth_hormone_secretion), but there is a study on the effects of creatine on children's diets and their adult growth.

Every additional 0.1 g of creatine consumed per day increases height by 0.60 cm (simple model) or 0.30 cm (adjusted model). (https://pubmed.ncbi.nlm.nih.gov/33806719/)

3. GABA-B agonists

GABA-B receptor agonism strongly inhibits somatostatin.
Agonist drugs, from weak to strong:

Taurine
GABA
Picamilon (GABA + nicotinic acid)
Phenibut
Baclofen (addictive)
GHB, also known as sodium oxybutyrate.
(GHB is banned in the Russian Federation and is included in the list of narcotic drugs)

GABA or GABA-amino acid, which provides a short-term increase in growth hormone levels by 400% (for no more than an hour) (https://pubmed.ncbi.nlm.nih.gov/18091016/).

Pikamilon, like GABA, also increases the level of growth hormone, but in a more effective way, as nicotinic acid allows it to penetrate the BBB more efficiently (https://www.sciencedirect.com/science/article/abs/pii/S1570023210001479).

Phenibut, a GABA molecule + a phenyl ring, has a similar effect on growth hormone, but even more potent.

It has been shown that baclofen, a phenibut + chlorine molecule, increases IGF1 levels even when it is present in milk.

Baclofen, phenibut+chlorine molecule, there are stages for increasing even IGF1 with baclofen, which is a fact of a strong and persistent increase in GH, stage 1 (https://academic.oup.com/jcem/article-abstract/48/6/1038/2679186?login=false), stage 2 (https://pubmed.ncbi.nlm.nih.gov/16554457/).

Oxybutyrate has been used in sports and bodybuilding to increase growth hormone even before it was widely available on the market, not to mention ibutamoren.
Structurally, it also resembles GABA, but in addition to GABA agonism, it also has its own GABAA receptor. It has been reported to increase growth hormone by up to 30 times (https://pubmed.ncbi.nlm.nih.gov/27744373/) within an hour.

END OF PART 1

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