HGH Post (NOT MINE)

[Rigged]

Idk if its ever been posted on here its on a pretty big roiding server so thought id post it incase it hasnt been yet

 

[4lt.Real]

Holyyy, pm me the server bro

 

[Rigged]

Holyyy, pm me the server bro

The servers shit and dead with no info but trolls, its the same as looksmax after tiktok leak except it literally never had good info to begin with besides this and like 2 other pinned posts

I can pm u it if u still want tho lmk

 

[Krispitus]

Hi I want this. The fact that this was 3 years ago is insane. Super gold. I just wanna appreciate the evolution in knowledge.

 

[truecel12]

Idk if its ever been posted on here its on a pretty big roiding server so thought id post it incase it hasnt been yet

View attachment 2882762

water
anybody who was using less than 42ug/kg/d or 0.3mg/kg/week was going to get questionable efficacy from hgh

Effect of the Orally Active Growth Hormone Secretagogue MK-677 on Somatic Growth in Rats

Growth hormone secretagogues (GHSs) possess the ability to release growth hormone (GH) in the body. This study aimed to investigate the effects of MK-677, an orally active GHS, on somatic growth in rats.The serum levels of GH were measured after oral ...

www.ncbi.nlm.nih.gov

also
Oral administration of MK-677 at 4 mg/kg increased peak GH concentrations by 1.8-fold, compared to baseline. However, oral administration of MK-677 for 6 weeks did not increase body growth or serum levels of IGF-I.
in this study, stopped working after 6 weeks as well, gh being the same as control.
albiet dosage was really high, but a 80% increase is not that much compared to high dose hgh

In humans, daily oral administration of MK-677 in healthy older adults,8 GH-deficient adults,9 or GH-deficient children10 increases serum GH, IGF-I, and IGFBP-3 concentrations, suggesting that these GHSs are potential treatments for growth disorders. However, repeated administration of GHRP has been reported to desensitize its stimulatory effect on GH secretion, and there have been no studies of the growth promoting effect after its long-term use, thereby limiting clinical application.21

 

[truecel12]

Hi I want this. The fact that this was 3 years ago is insane. Super gold. I just wanna appreciate the evolution in knowledge.

what? this was always there to learn you fucking retard.

Effect of the Orally Active Growth Hormone Secretagogue MK-677 on Somatic Growth in Rats

Growth hormone secretagogues (GHSs) possess the ability to release growth hormone (GH) in the body. This study aimed to investigate the effects of MK-677, an orally active GHS, on somatic growth in rats.The serum levels of GH were measured after oral ...

www.ncbi.nlm.nih.gov

-2018

Marked increase of final height by long-term aromatase inhibition in a boy with idiopathic short stature - PubMed

Growth hormone (GH) is the most frequently used treatment in children with idiopathic short stature (ISS). Aromatase inhibitor (AI) therapy is still in an experimental state, and both final height (FH) and long-term efficacy data in ISS have not been published. We present a 14.5-year-old boy...

pubmed.ncbi.nlm.nih.gov

-2012

Randomized Trial of Aromatase Inhibitors, Growth Hormone, or Combination in Pubertal Boys with Idiopathic, Short Stature

Growth of short children in puberty is limited by the effect of estrogen on epiphyseal fusion.To compare: 1) the efficacy and safety of aromatase inhibitors (AIs) vs GH vs AI/GH on increasing adult height potential in pubertal boys with severe idiopathic ...

www.ncbi.nlm.nih.gov

-2016

all of this information was up to read. its just that nobody really applied it to themselves in a public way other than dyrotic

 

[Rigged]

water
anybody who was using less than 42ug/kg/d or 0.3mg/kg/week was going to get questionable efficacy from hgh

no nigga dose relationships in endo therapy is complex its influenced by shit like receptor sensitivity downstream signaling pathways like JAK-STAT, MAPK, and feedback mechanisms involve somatostatin and GHRH

Effect of the Orally Active Growth Hormone Secretagogue MK-677 on Somatic Growth in Rats

Growth hormone secretagogues (GHSs) possess the ability to release growth hormone (GH) in the body. This study aimed to investigate the effects of MK-677, an orally active GHS, on somatic growth in rats.The serum levels of GH were measured after oral ...

www.ncbi.nlm.nih.gov

also
Oral administration of MK-677 at 4 mg/kg increased peak GH concentrations by 1.8-fold, compared to baseline. However, oral administration of MK-677 for 6 weeks did not increase body growth or serum levels of IGF-I.

rat studies showed plateau in igf response after long mk use human pharmacokinetics differ due to metabolic and hormonal milieu, studies show maintained igf increase cause of longer activation of GHS-R1a receptors and ghrelin mimetic pathways, issue comes from species diffs in drug metabolism receptor density and feedback inhibition of endo gh release

in this study, stopped working after 6 weeks as well, gh being the same as control.
albiet dosage was really high, but a 80% increase is not that much.

gh and igf increase in rats after mk shows species specific receptor desensitization and metabolic clearances rate, while human studies show long endocrine adaptations, maintaining igf level cause sustained ghrelin receptor engagement and downstream signaling implications for PI3K/AKT pathway, the 80% increase should have context within pharmacodynamic parameters for each own species

In humans, daily oral administration of MK-677 in healthy older adults,8 GH-deficient adults,9 or GH-deficient children10 increases serum GH, IGF-I, and IGFBP-3 concentrations, suggesting that these GHSs are potential treatments for growth disorders. However, repeated administration of GHRP has been reported to desensitize its stimulatory effect on GH secretion, and there have been no studies of the growth promoting effect after its long-term use, thereby limiting clinical application.21

the issue with desensitization with ghrp use to receptor downregulation and feedback loops involving somatostatin upregulation, but clinical protocols involving cyclical ghrp use mitigates this desensitization keeping efficacy human trials show igf and igfbp-3 increases with long term use showing if u do it correctly u can prevent desensitization the problem with ghrh ghrp and somatostatin dynamics if u do it correctly u can optimize the outcome without compromising receptor sensitivity or endocrine function

 

[Rigged]

what? this was always there to learn you fucking retard.

Effect of the Orally Active Growth Hormone Secretagogue MK-677 on Somatic Growth in Rats

Growth hormone secretagogues (GHSs) possess the ability to release growth hormone (GH) in the body. This study aimed to investigate the effects of MK-677, an orally active GHS, on somatic growth in rats.The serum levels of GH were measured after oral ...

www.ncbi.nlm.nih.gov

-2018

Marked increase of final height by long-term aromatase inhibition in a boy with idiopathic short stature - PubMed

Growth hormone (GH) is the most frequently used treatment in children with idiopathic short stature (ISS). Aromatase inhibitor (AI) therapy is still in an experimental state, and both final height (FH) and long-term efficacy data in ISS have not been published. We present a 14.5-year-old boy...

pubmed.ncbi.nlm.nih.gov

-2012

Randomized Trial of Aromatase Inhibitors, Growth Hormone, or Combination in Pubertal Boys with Idiopathic, Short Stature

Growth of short children in puberty is limited by the effect of estrogen on epiphyseal fusion.To compare: 1) the efficacy and safety of aromatase inhibitors (AIs) vs GH vs AI/GH on increasing adult height potential in pubertal boys with severe idiopathic ...

www.ncbi.nlm.nih.gov

-2016

all of this information was up to read. its just that nobody really applied it to themselves in a public way other than dyrotic

nigga stop being a hater let low iq cels be low iq cels


#freedadumbniggas