How can I manage hair loss whilst on aromatase inhibitors?

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chopped_guy

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After being on aromatase inhibitors; for heightmaxxing, I've started to notice hair loss. According to the all-knowing members of this community, over suppression of estrogen is "bad" even though literally all RCTs done on humans have used full oncology dose of AIs. I switched from letrozole to anastrozole this week, exemestane is kinda hard to find.

Even before adding AIs my forehead way massive, males of both sides of my family are bald before the age of 30.

Blood work on anastrozole 1mg E3D
Estradiol 11.2 pg/mL
Test (total) 783 ng/dL (this is lower than what i had on letrozole)
DHT 68.3 ng/dL



Urea (Urease/GLDH): 15 mg/dL
Creatinine (Jaffe compensated): 0.8 mg/dL

eGFR (CKD-EPI): 134 mL/min

Uric Acid (Uricase Colorimetric): 5.4 mg/dL
Calcium (5-Nitro-5'-methyl-BAPTA): 9.8 mg/dL
Phosphate (Phosphomolybdate Reduction): 3.3 mg/dL
Sodium (ISE, indirect): 142 mmol/L
Potassium (ISE, indirect): 3.8 mmol/L
Chloride (ISE, indirect): 105 mmol/L
Bilirubin Total (Colorimetric diazo): 0.24 mg/dL
Bilirubin Direct (Diazo Gen.2 Jendrassik-Grof): 0.08 mg/dL
Bilirubin Indirect (Calculated): 0.16 mg/dL
ALT (IFCC without pyridoxal phosphate): 13 U/L
AST (IFCC without pyridoxal phosphate): 18 U/L
ALP (PNPP, AMP Buffer – IFCC): 111 U/L
Total Protein (Biuret Method): 7.1 g/dL
Albumin (Bromocresol Green, BCG): 4.6 g/dL
Globulin (Calculated): 2.5 g/dL
A/G Ratio (Calculated): 1.9
Complement C3 (Immunoturbidimetric assay): 115 mg/dL
Complement C4 (Immunoturbidimetric assay): 26 mg/dL


hematocrit: 44%

TSH (Ultrasensitive) (ECLIA): 3.58 µIU/mL
T3 (ECLIA): 146 ng/dL
T4 (ECLIA): 6.3 µg/dL


IGF-1 test is so damn expensive!

I recently turned 15, 54 kg (Ganied 4kg in <2 months) and 171 cm ( Or 172 cm in morning).

Should I start taking finasteride Or topical minoxidil ???????? assume all drugs are OTC for me (Yesss pharma grade)
 
Get of your AI immediately

you tanked your E2 during peak development and that is extremely unhealthy and will cause all sorts of problems with bone structure, libido, etc

You need estrogen
 
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Reactions: Micrognathic, savage21 and currybot
Get of your AI immediately

you tanked your E2 during peak development and that is extremely unhealthy and will cause all sorts of problems with bone structure, libido, etc

You need estrogen
Acceptable at this point, Worst case I have osteoperosis, zero sexual desire and +2.3 cm vs placebo (from a one year double blind RCT)
 
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Reactions: starborn3995
Get of your AI immediately

you tanked your E2 during peak development and that is extremely unhealthy and will cause all sorts of problems with bone structure, libido, etc

You need estrogen
Acceptable at this point, Worst case I have osteoperosis, zero sexual desire and +2.3 cm vs placebo (from a one year double blind RCT)
 
  • JFL
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Reactions: Micrognathic and BR32
The hair loss mechanism is obvious as fuck

Estradiol at 11pg/mL is crashed

Estrogen is protective for hair follicles

Low E2 with high androgen senseitvy at the folicle accelerate your genetic male pattern baldness

This happen even without supraphysiological DHT

Your hair loss isn't bad luck you gave yourself accelerated male pattern baldness

nice job
 
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Reactions: Micrognathic, savage21, FemboyLover1 and 1 other person
Finasteride or dutasertide is an awful idea

You need DHT for genital maturation, deepening your voice, neurodevelopment and proper libido function

Blocking your 5-AR on top of estrogen suppression is destroying your endocrine system and development

You are 15

this is how you get incomplete virilizaiton, long term sexual dysfunction, possibly neurological defects
 
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Reactions: Micrognathic
You took adult oncology RCTs and said yeah that will apply to me a healthy 15 year old.

This isn't evidence based its fucking retarded

The doses used in oncology are used because the disease burden justified the use not because it was healthy.
 
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Reactions: Micrognathic and FemboyLover1
Finasteride or dutasertide is an awful idea

You need DHT for genital maturation, deepening your voice, neurodevelopment and proper libido function

Blocking your 5-AR on top of estrogen suppression is destroying your endocrine system and development

You are 15

this is how you get incomplete virilizaiton, long term sexual dysfunction, possibly neurological defects
Agreed, But my dick is 16cm, voice pretty deep But after taking AI i literally lost all sexual desire. Im probably tanner 4 Or 5
 
Agreed, But my dick is 16cm, voice pretty deep But after taking AI i literally lost all sexual desire. Im probably tanner 4 Or 5
Your dick length and deep voice are totally irrelevant

You lost your sex drive because you tanked your E2 taking extreme doses of letrozole.
 
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Reactions: legsflexxx
Agreed, But my dick is 16cm, voice pretty deep But after taking AI i literally lost all sexual desire. Im probably tanner 4 Or 5
tanner staging doesn't matter it doesn't equate to endrocein safety or brain maturity and it doesnt' justify the use of AIs recklessly
 
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Reactions: legsflexxx
You took adult oncology RCTs
Nah fuck No im not that dumb

Yackobovitch-Gavan et al. 2025 (Israel) - POSITIVE RESULTS​

Study Design:

  • Retrospective real-world matched cohort study

  • Published in Journal of Clinical Endocrinology & Metabolism 2025
Group 1: AI Monotherapy (Advanced Bone Age)

Population:

  • 27 midpubertal boys with fast puberty and advanced bone age

  • Mean age at treatment start: 12.4 years

  • Bone age: 14.0 years (median)

  • Pubertal stages 2-5, mostly stages 3-4
Treatment:

  • Anastrozole 1 mg/day

  • Duration: 2.8 years (median)
Final Adult Height Results:

  • AI group: 166.6 ± 3.1 cm

  • Controls: 163.4 ± 4.3 cm

  • Difference: +3.2 cm (p=0.003) - Statisticcally SIGNIFICANT!!!!!!!!!!!!!!

    Rohani et al. 2019 (CDGP) - POSITIVE RESULTS​

    Study Design:
    • Controlled trial (letrozole vs. no treatment)

    • 8 patients each group with CDGP
      Treatment:
    • Letrozole 2.5 mg/day for 1 year


      Final Height Results:
    • Letrozole: 171.0 ± 4.5 cm

    • Control: 168.8 ± 4.1 cm

    • Difference: +2.2 cm (p=0.04) - SiGNIFICANT!!!


      Height Gain Over PAH:
    • Letrozole: +1.9 cm above baseline PAH - Diff even more than PAH!!!

    • Control: +0.1 cm


 
tanner staging doesn't matter it doesn't equate to endrocein safety or brain maturity and it doesnt' justify the use of AIs recklessly
Most AI RCTs are not on 18 yo retards thinking they'll grow If they stack exemestane and IGF-1 LR3 with tren, Most are on 12-15yo retards using full oncology dose
 
Nah fuck No im not that dumb

Yackobovitch-Gavan et al. 2025 (Israel) - POSITIVE RESULTS​

Study Design:

  • Retrospective real-world matched cohort study

  • Published in Journal of Clinical Endocrinology & Metabolism 2025
Group 1: AI Monotherapy (Advanced Bone Age)

Population:

  • 27 midpubertal boys with fast puberty and advanced bone age

  • Mean age at treatment start: 12.4 years

  • Bone age: 14.0 years (median)

  • Pubertal stages 2-5, mostly stages 3-4
Treatment:

  • Anastrozole 1 mg/day

  • Duration: 2.8 years (median)
Final Adult Height Results:

  • AI group: 166.6 ± 3.1 cm

  • Controls: 163.4 ± 4.3 cm

  • Difference: +3.2 cm (p=0.003) - Statisticcally SIGNIFICANT!!!!!!!!!!!!!!

    Rohani et al. 2019 (CDGP) - POSITIVE RESULTS​

    Study Design:
    • Controlled trial (letrozole vs. no treatment)

    • 8 patients each group with CDGP
      Treatment:
    • Letrozole 2.5 mg/day for 1 year


      Final Height Results:
    • Letrozole: 171.0 ± 4.5 cm

    • Control: 168.8 ± 4.1 cm

    • Difference: +2.2 cm (p=0.04) - SiGNIFICANT!!!


      Height Gain Over PAH:
    • Letrozole: +1.9 cm above baseline PAH - Diff even more than PAH!!!

    • Control: +0.1 cm
These RCTs are irrelvant in your case as you're experiencing severe side effects

Also you are dumb these boys in yackobovitch were predicted to end up shorter than their genetic target AIs were used to normal growth trajectory not to exceed it. they were preventing loss not creating extra height.

This is fundamentally different from you who had normal puberty (until now) normal bone age.

Your second study is even worse.

This study was done on kids who had late puberty (not you) their growth plates stay open longer than yours naturally.

The error your making is this (Ai helped boys with abnormal puberty and growth patterns--> therefore AI is good for me)

Also youre exopeeincig side effects and you are hurting yourself.

full stop you gotta get off the AIs
 
Nah fuck No im not that dumb

Yackobovitch-Gavan et al. 2025 (Israel) - POSITIVE RESULTS​

Study Design:

  • Retrospective real-world matched cohort study

  • Published in Journal of Clinical Endocrinology & Metabolism 2025
Group 1: AI Monotherapy (Advanced Bone Age)

Population:

  • 27 midpubertal boys with fast puberty and advanced bone age

  • Mean age at treatment start: 12.4 years

  • Bone age: 14.0 years (median)

  • Pubertal stages 2-5, mostly stages 3-4
Treatment:

  • Anastrozole 1 mg/day

  • Duration: 2.8 years (median)
Final Adult Height Results:

  • AI group: 166.6 ± 3.1 cm

  • Controls: 163.4 ± 4.3 cm

  • Difference: +3.2 cm (p=0.003) - Statisticcally SIGNIFICANT!!!!!!!!!!!!!!

    Rohani et al. 2019 (CDGP) - POSITIVE RESULTS​

    Study Design:
    • Controlled trial (letrozole vs. no treatment)

    • 8 patients each group with CDGP
      Treatment:
    • Letrozole 2.5 mg/day for 1 year


      Final Height Results:
    • Letrozole: 171.0 ± 4.5 cm

    • Control: 168.8 ± 4.1 cm

    • Difference: +2.2 cm (p=0.04) - SiGNIFICANT!!!


      Height Gain Over PAH:
    • Letrozole: +1.9 cm above baseline PAH - Diff even more than PAH!!!

    • Control: +0.1 cm

Furthermore the sample groups for each study are tiny 27 for Yackobovitch-Gavan et al and its not randomized

Rohani et al is worthless you have 8 patents per group thats not even small thats pilot data
 
This is what happens when you don't understand endocrinology and make stupid rash decisions

You failed to understand feedback loops.

You failed to udnestadn puberty development timing.

Libido suppression as a 15 year old is not a discussion you need to stop now before you do permanent damage

You could permenantly destroy your libodo
 
If i don't i probably miss my peak growth window. If i agree with what ur saying, ill have to ask if potentially getting 3 cm vs placebo + side effects is better than nothing. Yeah i could height fraud 3cm quite easily.




Fuck no i found a RCT showing it does nothing

Varimo et al. 2019 (ISS) - NEGATIVE RESULTS​

Study Design:

  • Double-blind, placebo-controlled (Hero et al. 2005 follow-up)

  • Long-term follow-up to final adult heightpmc.ncbi.nlm.nih+1
Population:

  • Pre- and early-pubertal boys with ISS

  • Letrozole n=10, Placebo n=10

  • Mean bone age at treatment cessation: 10.2-10.8 years
Treatment:

  • Letrozole 2.5 mg/day vs. Placebo

  • Duration: 2 years
Final Adult Height:

  • Letrozole: 164.8 ± 4.0 cm

  • Placebo: 163.7 ± 3.7 cm
Difference: +1.1 cm (p=0.49) - NOT SIGNIFICANT


This wasy double blind.
But with AIs i can atleast cope with the fact im short
 
Another negative trial, AIs probably are cope, this was literally 3 years!!!!!!!
Zegarra W, Ranadive S, Toulan D, Neely EK. Anastrozole vs Letrozole to Augment Height in Pubertal Males With Idiopathic Short Stature: A 3-Year Randomized Trial. J Endocr Soc. 2024 Aug 27;8(10):bvae141. doi: 10.1210/jendso/bvae141. PMID: 39262574; PMCID: PMC11388000.
 
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Reactions: BR32
You don't understand male puberty.

Growth is not a single narrow window

Artificially suppressing your estrogen does not guarantee preserved growth potential

endocrinology doesn't work like "intervene now or lose everything forever"

This RCT destroys your argument dumbass

Varimo et al 2019 is the strongest paper you shared and it supports my position,

Double blind

placebo controleled

long term follow up

result

+1.1 cm

p=0.49

no meaningful benefit

when properly controlled and followed to adulthood Ai heigh gains often disappear,.

You are assuming 3cm is guaranteed , side effects are temporary, libido will recover,, brain development will be unaffected

You already told me you have lost your libido, started balding tanked your E2. what benefits have you seen?
 
You don't understand male puberty.

Growth is not a single narrow window

Artificially suppressing your estrogen does not guarantee preserved growth potential

endocrinology doesn't work like "intervene now or lose everything forever"

This RCT destroys your argument dumbass

Varimo et al 2019 is the strongest paper you shared and it supports my position,

Double blind

placebo controleled

long term follow up

result

+1.1 cm

p=0.49

no meaningful benefit

when properly controlled and followed to adulthood Ai heigh gains often disappear,.

You are assuming 3cm is guaranteed , side effects are temporary, libido will recover,, brain development will be unaffected

You already told me you have lost your libido, started balding tanked your E2. what benefits have you seen?
Bruh even tho im retarded you kinda convinced me, Should have read RCTs before blasting AIs, imagine i found Varimo et al before taking AI, should have read more RCTs before arguing on a incel forum, then coming to the conclusion; Why am i so dumb.
 
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Reactions: BR32
Bruh even tho im retarded you kinda convinced me, Should have read RCTs before blasting AIs, imagine i found Varimo et al before taking AI, should have read more RCTs before arguing on a incel forum, then coming to the conclusion; Why am i so dumb.
Its ok man

the science is complicated and this forum gives dogshit advice all the time

if you hop off the AIs now you'll prolly be ok

Take HGH for height
 
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Reactions: chopped_guy
Bruh even tho im retarded you kinda convinced me, Should have read RCTs before blasting AIs, imagine i found Varimo et al before taking AI, should have read more RCTs before arguing on a incel forum, then coming to the conclusion; Why am i so dumb.
Bruh, your serum E2 IS within reference range, AIs alone probably won't increase height alone but other RCTs show AI+ rhGH OUTPERFORMED HGH alone. And yes hair loss is brutal, but you should ask a doctor not incels for advice, and yes 5a inhibitors should not be used during puberty. Use rhGH (idiopathic short stature dose, NOT replacement), maybe use exemestane 6.25 mg E3D Or LOWER ur damn anastrozole dose 0.5 mg (half a pill) E3D. Use tropical minoxidil
 
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Reactions: chopped_guy
Bruh, your serum E2 IS within reference range, AIs alone probably won't increase height alone but other RCTs show AI+ rhGH OUTPERFORMED HGH alone. And yes hair loss is brutal, but you should ask a doctor not incels for advice, and yes 5a inhibitors should not be used during puberty. Use rhGH (idiopathic short stature dose, NOT replacement), maybe use exemestane 6.25 mg E3D Or LOWER ur damn anastrozole dose 0.5 mg (half a pill) E3D. Use tropical minoxidil

Its ok man

the science is complicated and this forum gives dogshit advice all the time

if you hop off the AIs now you'll prolly be ok

Take HGH for height
Agreed, probably not touching AIs for now, but ill keep E2 tests frequent
 
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Reactions: BR32
The hair loss mechanism is obvious as fuck

Estradiol at 11pg/mL is crashed

Estrogen is protective for hair follicles

Low E2 with high androgen senseitvy at the folicle accelerate your genetic male pattern baldness

This happen even without supraphysiological DHT

Your hair loss isn't bad luck you gave yourself accelerated male pattern baldness

nice job
Eh, the increase in hairloss is really just telogen effluvium.

I messed around with AIs in my teens aswell and was shedding hair all over my body. Came back as soon as i hopped off
 
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Reactions: Micrognathic, poopjeet, BR32 and 1 other person
Eh, the increase in hairloss is really just telogen effluvium.

I messed around with AIs in my teens aswell and was shedding hair all over my body. Came back as soon as i hopped off
Bruh this is huge, if you're comfortable could you share:
Which AI did you use?
What dose did you use?
Did it help? (Acc to you)
Did you stack it with other hormones or peptides, e.g. anamorelin, MK-677, hGH etc.?
How long did you use them?
What side effects did you notice (which you attribute to AI)?
 
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Reactions: Bitchwhipper2
Bruh this is huge, if you're comfortable could you share:
Which AI did you use?
What dose did you use?
Did it help? (Acc to you)
I was using aromasin at lower doses from 17-19 and stopped growing around the time I stopped
Did you stack it with other hormones or peptides, e.g. anamorelin, MK-677, hGH etc.?
How long did you use them?
Used a bit of mk 677 on n off
What side effects did you notice (which you attribute to AI)?
I used aromasin at 25mg daily. I didnt notice the usual libido feeling like shit sides, so I just kept going until i was getting like 3 asshairs per piece of toilet paper when wiping

This is how much my eyebrows recovered by hopping off
IMG 20251225 085110
IMG 20251225 085127
 
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Reactions: Micrognathic, chopped_guy and poopjeet
I was using aromasin at lower doses from 17-19 and stopped growing around the time I stopped

Used a bit of mk 677 on n off

I used aromasin at 25mg daily. I didnt notice the usual libido feeling like shit sides, so I just kept going until i was getting like 3 asshairs per piece of toilet paper when wiping

This is how much my eyebrows recovered by hopping off
View attachment 4461543View attachment 4461544
Interesting, because my eyebrows became very thick and low set on AI
 
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Reactions: Bitchwhipper2
After being on aromatase inhibitors; for heightmaxxing, I've started to notice hair loss. According to the all-knowing members of this community, over suppression of estrogen is "bad" even though literally all RCTs done on humans have used full oncology dose of AIs. I switched from letrozole to anastrozole this week, exemestane is kinda hard to find.

Even before adding AIs my forehead way massive, males of both sides of my family are bald before the age of 30.

Blood work on anastrozole 1mg E3D
Estradiol 11.2 pg/mL
Test (total) 783 ng/dL (this is lower than what i had on letrozole)
DHT 68.3 ng/dL



Urea (Urease/GLDH): 15 mg/dL
Creatinine (Jaffe compensated): 0.8 mg/dL

eGFR (CKD-EPI): 134 mL/min

Uric Acid (Uricase Colorimetric): 5.4 mg/dL
Calcium (5-Nitro-5'-methyl-BAPTA): 9.8 mg/dL
Phosphate (Phosphomolybdate Reduction): 3.3 mg/dL
Sodium (ISE, indirect): 142 mmol/L
Potassium (ISE, indirect): 3.8 mmol/L
Chloride (ISE, indirect): 105 mmol/L
Bilirubin Total (Colorimetric diazo): 0.24 mg/dL
Bilirubin Direct (Diazo Gen.2 Jendrassik-Grof): 0.08 mg/dL
Bilirubin Indirect (Calculated): 0.16 mg/dL
ALT (IFCC without pyridoxal phosphate): 13 U/L
AST (IFCC without pyridoxal phosphate): 18 U/L
ALP (PNPP, AMP Buffer – IFCC): 111 U/L
Total Protein (Biuret Method): 7.1 g/dL
Albumin (Bromocresol Green, BCG): 4.6 g/dL
Globulin (Calculated): 2.5 g/dL
A/G Ratio (Calculated): 1.9
Complement C3 (Immunoturbidimetric assay): 115 mg/dL
Complement C4 (Immunoturbidimetric assay): 26 mg/dL


hematocrit: 44%

TSH (Ultrasensitive) (ECLIA): 3.58 µIU/mL
T3 (ECLIA): 146 ng/dL
T4 (ECLIA): 6.3 µg/dL


IGF-1 test is so damn expensive!

I recently turned 15, 54 kg (Ganied 4kg in <2 months) and 171 cm ( Or 172 cm in morning).

Should I start taking finasteride Or topical minoxidil ???????? assume all drugs are OTC for me (Yesss pharma grade)
Get the fuck off letrozole NOW. That shit is awful
 
  • +1
Reactions: BR32
After being on aromatase inhibitors; for heightmaxxing, I've started to notice hair loss. According to the all-knowing members of this community, over suppression of estrogen is "bad" even though literally all RCTs done on humans have used full oncology dose of AIs. I switched from letrozole to anastrozole this week, exemestane is kinda hard to find.

Even before adding AIs my forehead way massive, males of both sides of my family are bald before the age of 30.

Blood work on anastrozole 1mg E3D
Estradiol 11.2 pg/mL
Test (total) 783 ng/dL (this is lower than what i had on letrozole)
DHT 68.3 ng/dL



Urea (Urease/GLDH): 15 mg/dL
Creatinine (Jaffe compensated): 0.8 mg/dL

eGFR (CKD-EPI): 134 mL/min

Uric Acid (Uricase Colorimetric): 5.4 mg/dL
Calcium (5-Nitro-5'-methyl-BAPTA): 9.8 mg/dL
Phosphate (Phosphomolybdate Reduction): 3.3 mg/dL
Sodium (ISE, indirect): 142 mmol/L
Potassium (ISE, indirect): 3.8 mmol/L
Chloride (ISE, indirect): 105 mmol/L
Bilirubin Total (Colorimetric diazo): 0.24 mg/dL
Bilirubin Direct (Diazo Gen.2 Jendrassik-Grof): 0.08 mg/dL
Bilirubin Indirect (Calculated): 0.16 mg/dL
ALT (IFCC without pyridoxal phosphate): 13 U/L
AST (IFCC without pyridoxal phosphate): 18 U/L
ALP (PNPP, AMP Buffer – IFCC): 111 U/L
Total Protein (Biuret Method): 7.1 g/dL
Albumin (Bromocresol Green, BCG): 4.6 g/dL
Globulin (Calculated): 2.5 g/dL
A/G Ratio (Calculated): 1.9
Complement C3 (Immunoturbidimetric assay): 115 mg/dL
Complement C4 (Immunoturbidimetric assay): 26 mg/dL


hematocrit: 44%

TSH (Ultrasensitive) (ECLIA): 3.58 µIU/mL
T3 (ECLIA): 146 ng/dL
T4 (ECLIA): 6.3 µg/dL


IGF-1 test is so damn expensive!

I recently turned 15, 54 kg (Ganied 4kg in <2 months) and 171 cm ( Or 172 cm in morning).

Should I start taking finasteride Or topical minoxidil ???????? assume all drugs are OTC for me (Yesss pharma grade)
nigga what the fuck are you doing on letrozole 😭

cant grow without estrogen
youre fucking yourself
 
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Reactions: BR32
I know but why were you on it in the first place?
Easy to get (pharma grade), like used in infertility too, but it crashed my E2 so i switched to anastrozole, which kept my E2 >10 pg/mL (actually within the lab's ref for males)
 
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