noodlelover
Kraken
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This is a reponse to a question on my profile page. I don't want to break it up into a bunch of little chunks so I'm posting it here. This is only my current understanding based on the studies I've read, and subject to change as I encounter new information.
That's a good question.
The evidence that high meat leads to arterial plaque
Pretty much every longitudinal study ever done shows that higher meat consumption is associated higher rates of arterial plaque and heart disease.
Not only this, but interventions such as low or no meat reverse this arterial plaque.
The proponents of the Carnivore diet, will say that's only because those populations were eating meat and carbs, and if you only eat meat you're safe from arterial plaque formation. They often point to the carnivore eskimos who ate only meat, mostly fish, and "lived long healthy lives."
But when you look at an actual study on the carnivore eskimos, you see that both the men and women die on average in their 40s and when their hearts are cut open post mortem, extensive arterial plaque is found.
There's some African population of carnivores as well, but again they all die in their 40s. No post mortem studies on them that I could find but it wouldn't surprise me if there arteries were like that of the carnivore eskimos.
The causal mechanisms
Many studies show that long term application of statins reduces coronary heart disease, so his theory has evidence supporting it.
But I have worries of possible unintended consequences. If you have to take a drug to stay alive on your diet, maybe it's not the greatest diet?
Statins are prescription only medicine, so you'd need to get your doctor on board if you want to try Peter Attia's strategy.
In theory there's another way. Supplementing with Berberine to reduce arterial plaque. Berberine is an over the counter supplement meaning you can get it without a doctor's prescription.
How much plaque can it reverse, with what dosages, and under what conditions? You'd have to do your own research to find out.
Now, berberine also decreases protein synthesis, and increases protein breakdown leading to smaller muscles. Essentially the body has two modes: BUILD and REPAIR. (These are modulated by IGF-1 and the MTOR pathways) And if you're always in Build mode, you will look good and then die early. If you're always in repair mode you'll live a long time but look scrawny.
Which is why I think some kind of mixture or cycling of the two modes is ideal.
That's a good question.
The evidence that high meat leads to arterial plaque
Pretty much every longitudinal study ever done shows that higher meat consumption is associated higher rates of arterial plaque and heart disease.
Not only this, but interventions such as low or no meat reverse this arterial plaque.
The proponents of the Carnivore diet, will say that's only because those populations were eating meat and carbs, and if you only eat meat you're safe from arterial plaque formation. They often point to the carnivore eskimos who ate only meat, mostly fish, and "lived long healthy lives."
But when you look at an actual study on the carnivore eskimos, you see that both the men and women die on average in their 40s and when their hearts are cut open post mortem, extensive arterial plaque is found.
There's some African population of carnivores as well, but again they all die in their 40s. No post mortem studies on them that I could find but it wouldn't surprise me if there arteries were like that of the carnivore eskimos.
The causal mechanisms
- High LDL Cholesterol penetrates the walls of the blood vessels
- The LDL Cholesterol Oxidizes triggering an inflammatory response attracting immune cells to the area.
- These immune cells crowd around the oxidize LDL and together all of it hardens into plaque.
Many studies show that long term application of statins reduces coronary heart disease, so his theory has evidence supporting it.
But I have worries of possible unintended consequences. If you have to take a drug to stay alive on your diet, maybe it's not the greatest diet?
Statins are prescription only medicine, so you'd need to get your doctor on board if you want to try Peter Attia's strategy.
In theory there's another way. Supplementing with Berberine to reduce arterial plaque. Berberine is an over the counter supplement meaning you can get it without a doctor's prescription.
How much plaque can it reverse, with what dosages, and under what conditions? You'd have to do your own research to find out.
Now, berberine also decreases protein synthesis, and increases protein breakdown leading to smaller muscles. Essentially the body has two modes: BUILD and REPAIR. (These are modulated by IGF-1 and the MTOR pathways) And if you're always in Build mode, you will look good and then die early. If you're always in repair mode you'll live a long time but look scrawny.
Which is why I think some kind of mixture or cycling of the two modes is ideal.
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