How people with acromegaly dont stop growing?

[goat2x]

They only stop growing when the tumor in their pituitary gland is removed.
Some of them are 30-40 and still grow in height
how the fuck? growth plates arent closed or what the fuck happens

 

[Deleted member 3832]

idk. There was this guy apparently who was 145 cm at 18 because of dwarfism and when he got acromegaly he grew up to be 205 cm.

 

[Mateusz74]

idk. There was this guy apparently who was 145 cm at 18 because of dwarfism and when he got acromegaly he grew up to be 205 cm.

I think he took mk677

 

[goat2x]

idk. There was this guy apparently who was 145 cm at 18 because of dwarfism and when he got acromegaly he grew up to be 205 cm.

ive read that a women in her 40s was still growing before the tumor removal

 

[Alexanderr]

idk. There was this guy apparently who was 145 cm at 18 because of dwarfism and when he got acromegaly he grew up to be 205 cm.

You mean gigantism.

 

[Deleted member 3270]

I think he took mk677

Way different from my stack lmao

 

[AutisticBeaner]

idk. There was this guy apparently who was 145 cm at 18 because of dwarfism and when he got acromegaly he grew up to be 205 cm.

i dont know if we're talking about the same person but this is much more extreme:

Adam Rainer - Wikipedia

en.wikipedia.org

at 19 he was 111cm/3'8, he later died at 51 measuring 234cm/7'8

 

[Deleted member 3832]

i dont know if we're talking about the same person but this is much more extreme:

Adam Rainer - Wikipedia

en.wikipedia.org

at 19 he was 111cm/3'8, he later died at 51 measuring 234cm/7'8

Jesus Christ wtf lmao. 111 cm?

 

[PubertyMaxxer]

Would like to hear @Strike_Poseidon opinion on this

 

[AutisticBeaner]

Jesus Christ wtf lmao. 111 cm?

it's absolutely crazy. the article also says that he went from shoe size 10 to size 20 in only three years

 

[Deleted member 2661]

Fuarrrk I need acromegaly immediately
Reminder that such robust concrete skulls await you if you are ever blessed with it

 

[AutisticBeaner]

You mean gigantism.

acromegaly is gigantism

 

[goat2x]

Would like to hear @Strike_Poseidon opinion on this

i would rather not
fuck that 10 yr old autist

 

[Deleted member 3832]

Fuarrrk I need acromegaly immediately
Reminder that such robust concrete skulls await you if you are ever blessed with it
View attachment 357026

Sorry fam but that's a bit too much don't you think? I mean if your goal is pure intimidation then I agree but your goal is attracting women so I don't think that would help.

 

[AutisticBeaner]

Fuarrrk I need acromegaly immediately
Reminder that such robust concrete skulls await you if you are ever blessed with it
View attachment 357026

 

[Deleted member 2661]

Sorry fam but that's a bit too much don't you think? I mean if your goal is pure intimidation then I agree but your goal is attracting women so I don't think that would help.

Chin bigger than forehead = life on godmode

 

[Greeicy]

idk. There was this guy apparently who was 145 cm at 18 because of dwarfism and when he got acromegaly he grew up to be 205 cm.

Every manletcel’s wet dream

 

[Alexanderr]

acromegaly is gigantism

It is not.
Gigantism refers to abnormally high linear growth due to excess IGF-1/GH while the epiphyseal plates are open. People with acromegaly basically suffer from the same thing (excessive secretion of IGF-1/GH) but when the growth plates are fused, so they can’t grow taller, instead the bones thicken. Acromegaly therefore only happens in adults.

 

[AutisticBeaner]

It is not.
Gigantism refers to abnormally high linear growth due to excess IGF-1/GH while the epiphyseal plates are open. People with acromegaly basically suffer from the same thing (excessive secretion of IGF-1/GH) but when the growth plates are fused, so they can’t grow taller, instead the bones thicken. Acromegaly therefore only happens in adults.

found the exact sentence that you got from google lol

 

[Alexanderr]

found the exact sentence that you got from google lol

How does that disprove my point?

 

[goat2x]

It is not.
Gigantism refers to abnormally high linear growth due to excess IGF-1/GH while the epiphyseal plates are open. People with acromegaly basically suffer from the same thing (excessive secretion of IGF-1/GH) but when the growth plates are fused, so they can’t grow taller, instead the bones thicken. Acromegaly therefore only happens in adults.

Yeah but sometimes someone with acromegaly grows in height too

Tanya Angus, Who Inspired Those With Gigantism, Dies

A Las Vegas woman with acromegaly had uncontrolled growth -- to 7 feet tall and 400 pounds.

abcnews.go.com

This women was only 5'7 at 21 and she was a woman so high estrogen levels
she grew more than 1 feet after 21

 

[Alexanderr]

Yeah but sometimes someone with acromegaly grows in height too

Tanya Angus, Who Inspired Those With Gigantism, Dies

A Las Vegas woman with acromegaly had uncontrolled growth -- to 7 feet tall and 400 pounds.

abcnews.go.com

This women was only 5'7 at 21 and she was a woman so high estrogen levels
she grew more than 1 feet after 21

“Her gigantism was caused by a tumor on her pituitary gland but radiation and three surgeries”
They mention she had acromegaly and then mention she had gigantism not much later, lol

 

[AutisticBeaner]

How does that disprove my point?

did i say it does?

 

[Alexanderr]

did i say it does?

No, but good to know you learned something today.

 

[goat2x]

“Her gigantism was caused by a tumor on her pituitary gland but radiation and three surgeries”
They mention she had acromegaly and then mention she had gigantism not much later, lol

at 21 especially she was a woman
idk

 

[Alexanderr]

at 21 especially she was a woman
idk

Only people with gigantism experience linear growth, since they’ve still got growth plates allowing them to.
She must’ve had gigantism if she grew vertically.

at 21 especially she was a woman
idk

People with gigantism also often experience a delay in puberty.

 

[shortretrudedchin]

As far as I've understood:
1)the tumor and/or the extreme release of gh cause the sex hormones to go near 0
2)their production of gh/igf-1 is not blunted by somatostin/glucose like a normal person

 

[goat2x]

As far as I've understood:
1)the tumor and/or the extreme release of gh cause the sex hormones to go near 0
2)their production of gh/igf-1 is not blunted by somatostin/glucose like a normal person

idk about the first but the second is wrong
the gh/igf1 levels are elavted because of the tumor

 

[Theonewhowillascend]

As far as I've understood:
1)the tumor and/or the extreme release of gh cause the sex hormones to go near 0
2)their production of gh/igf-1 is not blunted by somatostin/glucose like a normal person

Is the first true true?

 

[shortretrudedchin]

idk about the first but the second is wrong
the gh/igf1 levels are elavted because of the tumor

Is high,but it's not neutralized by those factors i mentioned,like it would be in a normal person,so it results in a lot more growth than normal

Is the first true true?

There is a correlation between acromegaly and hypogoniadism,so it's very likely

 

[goat2x]

Is high,but it's not neutralized by those factors i mentioned,like it would be in a normal person,so it results in a lot more growth than normal

There is a correlation between acromegaly and hypogoniadism,so it's very likely

but thats not the main reason lmao

 

[shortretrudedchin]

It

but thats not the main reason lmao

It contributes a lot,otherwise every professional bodybuilder and their dogs would look like Nikolaj Valuev

 

[goat2x]

It

It contributes a lot,otherwise every professional bodybuilder and their dogs would look like Nikolaj Valuev

wtf are u talkin about lmao
pro bodybuilders doesnt take that much hgh as these guys got,they also have closed plates
"Pituitary GH-secreting adenomas are responsible for 98% of acromegaly and almost exclusively are benign "

 

[Mr.cope]

The pituitary gland is what secretes hormones
Acromegaly is continuous hgh in their system
So they are gonna keep growing until that organ is removed

 

[goat2x]

The pituitary gland is what secretes hormones
Acromegaly is continuous hgh in their system
So they are gonna keep growing until that organ is removed

ywah i know that
but how do they grow vertically
one user said that their puberty is delayed it might be that

 

[shortretrudedchin]

wtf are u talkin about lmao
pro bodybuilders doesnt take that much hgh as these guys got,they also have closed plates
"Pituitary GH-secreting adenomas are responsible for 98% of acromegaly and almost exclusively are benign "

1)People can get in pseudo acromegaly range with 3 iu of pharma grade hgh,pros use at the very least 10 iu daily,this without considering the exogenous igf-1 and insulin
2)Even with closed growth plates,they should experience changes in thickness

Anyway,i'm not an expert on the subject,I think @Dyorotic2 can give the answer to this question better than most people on this site

 

[Theonewhowillascend]

1)People can get in pseudo acromegaly range with 3 iu of pharma grade hgh,pros use at the very least 10 iu daily,this without considering the exogenous igf-1 and insulin
2)Even with closed growth plates,they should experience changes in thickness

Anyway,i'm not an expert on the subject,I think @Dyorotic2 can give the answer to this question better than most people on this site

I agree and also want to hear dyorotic2 opinion about why some people grow vertically at 21

 

[Xander578]

Fuarrrk I need acromegaly immediately
Reminder that such robust concrete skulls await you if you are ever blessed with it
View attachment 357026

one lefort 3 away from being unmoggable

 

[Alexanderr]

2)their production of gh/igf-1 is not blunted by somatostin/glucose like a normal person

Yeah, that’s how they test whether someone has gigantism/acromegaly as well.

ywah i know that
but how do they grow vertically
one user said that their puberty is delayed it might be that

They grow vertically because the GH/IGF-1 stimulates proliferation of the chondrocytes in your epiphyseal plates (growth plates) which allows them to grow vertically. (Basically the bone/cartilage just expands vertically, lengthening it).

If the epiphyseal plates are fused, it isn’t possible for the bones to grow taller so they just thicken instead.
The pituitary disorder seems to affect puberty by delaying it, which would allow for a greater time period of bone growth and ultimately increase adult height.

Reminder: only people with gigantism experience an increase in height, not people with acromegaly.

I agree and also want to hear dyorotic2 opinion about why some people grow vertically at 21

Because their fucking growth plates are still open and active? The answer is simple guys. They wouldn’t be able to grow taller if it wasn’t.

 

[Deleted member 4946]

It is not.
Gigantism refers to abnormally high linear growth due to excess IGF-1/GH while the epiphyseal plates are open. People with acromegaly basically suffer from the same thing (excessive secretion of IGF-1/GH) but when the growth plates are fused, so they can’t grow taller, instead the bones thicken. Acromegaly therefore only happens in adults.

that ain't how it works, taking HGH well only make you as tall as DNA will allow (cell cycle counter from DNA methyltransferase) that's why I say, people with gigantism have no form of regulation in their DNA methylation, they have hypermethylation which is why their growth plates pretty much never become inactive (senescence) and fuse, I will repeat this once last time to you all, you want to get taller than your DNA's cell cycle limit (loss of DNA methyltransferase in the resting zone), stop taking all of this HGH and IGF-1, all it'll do is stimulate proliferation which is good as long as your keeping your DNA methylation in check (not excessive to point of cancer), you don't need fucking 800ng/dl of IGF-1 to get taller, if that was true it should be IMPOSSIBLE to grow during puberty unless you have gigantism. I'm sure you all get the jist of what I am saying now.

I am studying biochemistry now as well for all u who are interested (even tho im still 15) it's too bad they didn't know about shit like this back then: http://genesdev.cshlp.org/content/18/9/1035.full.pdf. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0019503

telomere lengths don't change significantly in the growth plate wth age, however DNA methylation does!

 

[Deleted member 2968]

They only stop growing when the tumor in their pituitary gland is removed.
Some of them are 30-40 and still grow in height
how the fuck? growth plates arent closed or what the fuck happens

Jesus acromegaly would benefit me so much.I am already having acromegalic pheno.Gotta blast hgh and T even more now.Pull ups,push ups and lots of hgh from now

 

[goat2x]

that ain't how it works, taking HGH well only make you as tall as DNA will allow (cell cycle counter from DNA methyltransferase) that's why I say, people with gigantism have no form of regulation in their DNA methylation, they have hypermethylation which is why their growth plates pretty much never become inactive (senescence) and fuse, I will repeat this once last time to you all, you want to get taller than your DNA's cell cycle limit (loss of DNA methyltransferase in the resting zone), stop taking all of this HGH and IGF-1, all it'll do is stimulate proliferation which is good as long as your keeping your DNA methylation in check (not excessive to point of cancer), you don't need fucking 800ng/dl of IGF-1 to get taller, if that was true it should be IMPOSSIBLE to grow during puberty unless you have gigantism. I'm sure you all get the jist of what I am saying now.

I am studying biochemistry now as well for all u who are interested (even tho im still 15) it's too bad they didn't know about shit like this back then: http://genesdev.cshlp.org/content/18/9/1035.full.pdf. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0019503

telomere lengths don't change significantly in the growth plate wth age, however DNA methylation does!

so you need igf1 hgh and what to keep methylation in check ?

 

[Deleted member 4946]

so you need igf1 hgh and what to keep methylation in check ?

do your own 0 IQ research, i ain't helping you

 

[goat2x]

do your own 0 IQ research, i ain't helping you

Then why you replying to my thread jfl
You are my obedient dog