hej1377
Chad-affirming care is a right, not a privilege
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How to achieve mental wellbeing & satisfaction
song of this thread
I feel in discussions about pharmacology and such I believe many people misunderstand what metrics and aspects are actually worth focusing on, so today I'll talk about what I would interpret the literature says about what you should focus on. I wanna see everyone in here acend (with exceptions) so it pains me to go on here and all day see niggas with no purpose and abused dog syndrome, but fortionally its no match for chinese research chemicals.
stability and balance
i wrote about lithium a few days ago as its gold standard for stability so ima cope paste
Lithium
i think when most people get into and learn about pharmacology regarding the brain people very easily and with good reason get obsessed with trying to increase different neurotransmitters and/or agonise certain receptors with amphetamines or pregabalin for example, and those drugs can be great, they definitely have their place as they work so good so acutely
This study looked at the correlation between autistic traits and metabolite levels of neurotransmitters as well as glutamate/gaba ratio and they found “In cross‑correlation analyses, the Glx/GABA ratio was significantly associated with both autistic traits and sensory responsivity, whereas Glx alone showed fewer associations. Clustering analyses further grouped autistic traits with the Glx/GABA ratio, rather than with the individual metabolite concentrations, suggesting that the ratio may be more behaviorally relevant than either metabolite alone.” so basically stability is law. Its also in pretty much every study linked to depression very very closely as well as well as almost any mental problem while absolute levels of any given compound is poor as an indicator. This is a straight waterfall for anyone who even does slight research so im not gonna write pages and pages of text arguing for why stability is the important metric as if you do not agree you are either not knowledgeable on the subject which is fine but im not gonna practically debate you or you're just an anti intellectualist, and jfl at that.
lithium is also pretty much as good as it gets when it comes to stability, this fucking huge meta analysis shows that lithium fucking terra mogs, manic episode risk fuckign sliced in half and depression reduced by about a fourth
anti/psychotics undoubtedly deserves a place here, but theres just so much to write about and i couldnt be fucked honestly, if this thread gets good engagement maybe ill write a seperate thread because i belive they will eventually revolutionize drugs for normal and normalish people, they mog but it would take hours
cortexin
cortexin acts as a bunch of peptide hormones, its super neuroprotective so it stops toxicity from glutamate and stabilizes the gaba.glutamate relationship which is really important like with lithium, and just in general it acts as a regulator and an antioxidants for many parts so it also helps to build synapses and supports efficient pruning, so its quite complex but that's the general gist of it in short, shares a lot in common with lithium and cerebrolysin, but its more focused towards mood and nt-maxxing than cere and a bit worse for building structure but its a bit like the best of both worlds if you wanna keep it cheap and simple and only get 1 compound
gb-115, i have a link to my review here
https://looksmax.org/threads/gb-115-unifiram-update-review-damn-near-miracles.1651560/
Also a copy paste as cortisol is a very impactfull hormone
relacorilant
relacorilant is a glucocorticoid receptor antagonist, so basically it blocks cortisol. This is of course great as cortisol is something most people are gonna have too much of rather than too little which makes you feel stressed and fatigued, but you probably know that as it's known as the stress hormone. Cortisol also is the main cause behind hormone induced loss of elastin and it's also of course a catabolic hormone and tren’s GR antagonism is also the reason it's so anti catabolic and therefore good for cutting. I do not believe it replaces tren or makes tren obsolete but i do think it could be an option to run instead of tren if you might be a beginner, high inhib, super risk adverse, really really need sleep or dread any other tren side etc etc then i think you could pair this with some test maybe and still be well off.
Most gr antagonists throughout the years have like tren also had hormonal effects but relacorilant does not and has been specifically made for that. In both vivo and vitro it has showed effectiveness consistently like a vitro article here . This drug i cant really be fucked to write much about as the effects of cortisol is common knowledge and theres tons of studies to be found on this drug so i think the most valuable thing i can provide is just bringing it into discourse.
neural structure
The reason why you're here to begin with and why you've been an outcast your entire life is not due to being subhuman the vast majority of the time but instead but because you got subhuman genes in every aspect of your brain and this is quite a significant one
neural plasticity
dihexa
basically what dihexa does is that it mimics hepatocyte growth factor which is a growth factor in your brain you need to build stuff, kind of like the hcg for your brain, this is fast as shit which gives people some worries which is reasonable but its seriously potent and therefore good at what it does, the synapse build speed is insane, quite expensive tho but if you got some money to be able to use this for a while then pick it up, you need to use this for a while as this causes no up or down regulation of anything so there's so acute results
cerebrolysin
cerebrolysin is the gold standard of nootropics pretty much, its a mix of a fuck ton of peptides so it doesnt have 1 mechanism but instead many but the main one is upregulating different factors needed for neuronal signaling most importantly bdnf but also ngf gdnf etc, this causes the growth pathways pi3k/akt and mapk/erk to get brutally ran through at all times, its also giga neuroprotective among other benefits, its expensive but worth every penny.
TLQP-62, a highly theoreticall compound i wrote about a while ago but its to promising to not mention, it woyld revolutionize the noots and pharma scene if my theory is correct do ima cope and paste
What is TLQP-62?
TLQP is a peptide which comes from vgf protein, TLQP then stimulates bdnf release
The full procces is TLQP gets to the hippocampus, stimulates bdnf to be released and then act on the PI3K/AKT,MAPK/ERK and PLCy pathways and it does all this by first binding to the trkb receptor and requires glutamate and ndma signaling to do this
Now all this leads to neural survival more,stronger and stable synapses. Now i bet this doesnt seem revolutionairy because it seems very similar to the bdnf part of cerebrolysin but the diffrence is that cerebrolysin just contains a similar compound to mimic bdnf so this will have huge effect on damaged brains that are unable to replenish these neurotrophic factors
But somewhat healthy brains most likely can produce these somewhat close to the max of what you can use. The diffrence between the max and what youre likely to be able to produce is still there which is why cerebrolysin shows great results but youll still have a "celling". This could possibly be better due to it directly stimulating bdnf to actually be released and not just sit there
What are the limitations?
This peptide has only been in preclinicals and never been tested by humans, atleast from what we know since all the studies are on mice and i couldnt find anyone talking about this anywhere.
What would dosing look like?
This is a bit speculative but if we adjust it for humans its about 0,2-0,5mg that what we want in the hypocampus and when its in lyophilized form even tho its fucking huge(≈kda) i think its fair to eatimate that about 5% gets into the brain which would be 4-10mg intranasaly
pubmed.ncbi.nlm.nih.gov
According to this effects can last a week
www.nature.com
And according to this changes start happening very quick,just minutes 10-30,but it still seems unknown when noticeable effects start happening and not just an observable increase in vgf and cgb proteins
Sourcing?
Surprisingly this seems petty easy to source,found 20mg lyophilized for ish 60$ and another lab selling it in higher quantities,this may indicate a pretty low price per mg but ill see how much it is when they answer my enquiry
Is it better than cerebrolysin? Final verdict
I think that i cant say thats it definitely better even if it is as good as its promising since cerebrolysin is more broad and helps with creating veins,GDNF,CNTF,NGF and a few more but bdnf seems most responsible for the effects that most people use cere for. And TLQP-62 seems better strictly for BDNF which is the biggest reason for the massive increase in memory and learning and if cerebrolysin already can have such drastic effects im very interested in what TLQP can do
But imo it seems atleast very very interesting, more interesting than cerebrolysin for me atleast. I also feel very inclined to just take for the team and try this out but its still a bit scary since no one has tried it so i hope someone is low inhib enough to try it before me
Also a cope paste, use ideally with cerebrolysin
vorinostat/crebinostat/neurinostat
These 3 are all hdac inhibitors, they all work, neuroinostat is ideal but unrealistic to actually source most of the time, crebinostat is definitely doable but might run you a few hundred so it's a bit expensive. Vorinostat is slightly worse than both but the easiest and cheapest to source
What histone deacetylase like the name implies removes acetyl. This tightens DNA which makes transcription harder to accomplish. Therefore when hdac is inhibited more transcription is allowed so genes become expressed more strongly. Hdac does not act everywhere but it does act in the hippocampus which is the part most nootropics revolve around. This is of course theoretically but this study tested it and at least in rats it had significant effects on memory and long term plasticity which is in line with what's been theorized. this studyalso showed vorinostat was able to reverse cognitively declining mice brains.
Imo this is the most promising group of drugs out there, I think a very important suggestion wouls be to not use this alone but with other stuff as this could very well synergize with anything that causes neuronal signaling, directly or indirectly like cerebrolysin or any compound meant to cause synaptogenesis at some point, as a rule of thumb if its used for memory or learning directly and not just focus it probably gets amplified by hdaci, at least in theory. Because all it does is enhance signaling it doesn't cause it on its own.
synaptic pruning
synaptic pruning is how effectively your brain is set up. I'm going to simplify with a pic
this is an incel brain
this is a chad brain
You want cleanly and effectively, this decides how well something can be executed. Neural plasticity is like the engine while pruning is like the tires, if you have fucked traction youre not getting anywhere no matter how much hp you have under the hood. This is why so many smart people are so bad socially while it's a strength for some, because the more synapses the harder it is to organize
nmda receptor
the main way and the easiest way to achieve good pruning is through ndma activation, this has some nuance but it going to seem very non-nuanced as i think the clear winner for this metric is unifiram, unifiram makes the ampa receptor sensitive as shit which then sends ions around which switches on the nmda receptor, activation of nmda receptor then cleans up synapses and organizes them
socialmaxxing and meaning
serotonin and dopamine
2 very important neurotransmitters, people on here often focus on dopamine which is important dont get me wrong but it does not compare to the sociability and feel good effects from serotonin, but at the end of the day come with all of it or don't come at all so you have to prioritize everything.
vortioxetine
The drug that puts classical ssri’s to shame, it is like other pharma mentioned a drug that works in multiple ways, it does inhibit serotonin reuptake which in a sense makes it an ssri but it also works as an agonist against the 5-ht1a and b receptor while antagonizing the 5ht3 and 7 receptors. It also helps glutamate-gaba balance a bit. This all combined gives you the giga-nt feel good effects of an ssri on steroids without the fucked sides most ssri’s come with, this barely shows the common ssri sides more than the placebo group
tranylcypromine, mao-b and buspirone
tranylcypromine is the main drug i want to talk about here, it inhibits both mao-b and mao-a, mao-b breaks down dopamine while mao-a breaks down serotonin, and it also just stops the breakdown of all monoamines, this also makes it significantly stronger than any drug only breaking down a single type of mao, it also has a million downstream effects we could sit and talk about for hours but basically it raises and stabilizes neurotransmitters globally, this can give adhd like side effects tho according to this study, this is due to having too much of all these transmitters, if you're towards the adhd type already you're likely deficient so you might actually benefit from this while average people might be better of with other drugs, selegiline and rasagiline only inhibit mao-b, the difference is that selegiline breaks down into amphetamine and meth while rasa doesn't. Buspirone is also an option for normal people as its an agonist for serotonin and dopamine receptors, it's quite weak but that's actually beneficial as it also has a short half life so we avoid too many unstable levels and you're less open to neural adaptation.
oxytoxin, i wrote about this a while ago, seriously underrated, expensive tho but both of us know your ltn ass is not getting oxytocin from anywhere else than a chineae lab
Oxytocin is greatly involved in social bonding and feelings of love and attachment. Its very involved in social awareness, an oxytocin deifiency shows up in autism very commonly and seems to be one of the main reasons for the social aspects of ASD, therefore i think this thread is more widely applicable than most of you think. Oxytocin is also a big contributor to hightened feelings of well being and reduced anxiety, so if you're a high inhibcell but don't wanna deal with the withdrawl symptoms of gaba drugs then definitely take a look at the drugs listed below.
Spoiler: Why its so neglected despite its effects
The reason for it being so impactfull yet so ignored in pharmacology mainly boils down to big challenges for the drug developers. Just the fact that is so impactfull makes it difficult to work with, it also affects shit like cardiovascular function and the entire system a lot of the female reproduction system which makes these drugs often marketed for pregnancy and labour.
Vassopressin receptors
Vasopressin is a hormone that basically bloats you and at the same time gives that "toxic boyfriend" effect so its involved in setting of signals in your brain that someone is about to steal your bitch so you become angry, jealous and territorial. Oxytocin and vasopressin are very similar on a molecular level which causes cross activation of eachothers receptors. The v1a receptor is mostly what gives aggression and a disturbed cardiovascular system, v1b is really what causes the kind of "panic" symptoms or an increase in anxiety or paranoia and the v2 receptor just makes you a bloatcell and is the reason largely for the physical issues like cardiovascular ones.
Oxytocin agonists
Spoiler: Regular bioidentical exogenous oxytocin
This has been getting talked about more and more on here which worries me a bit. Theres of course studies showing very positive cognetive benefits from exogenous oxytocin. But they almost unanimously uses intraneural administration. This is since oxytocin only has a half life of about 3-5 minutes in plasma, it also has trouble crossing he blood-brain-barrier. This in combination just makes the oxytocin useless if its used intranasaly which seems most common here. So basically its just a gimick and straight copium, overall 2/10
Spoiler: WAY-267464
Way-267464
This is an oxytocin agonist that is not a peptide. This is good since peptides generally have short half lives. I havent found any statistics about it's half life but simply it not being a peptide indicates that it probably is a lot more stable than other similar drugs.
this study(link) tried this drug on rats
Which seemed to cause a decrease in anxiety. This indicates that it succesfully is able to selectively stimulate oxytocin receptors selectively and not simultaneously affect the vassopressin receptors. It also confirms my speculation on stability since it worked systemically and didn't just get degraded.
More stats on it and a direct relevant quote is "WAY-267464 acts as a high-affinity and potent agonist at both human and mouse OTR. In a whole-cell binding assay, we determined the affinity (Ki, nM) of WAY-267464 at human and mouse OTR to be 58.4 ± 11.3 and 51.6 ± 5.9 respectively (Fig. 1A,B). In a cell-based functional assay measuring changes in [Ca2+]i in response to compound challenge, we determined the potency (EC50, nM) of WAY-267464 at human and mouse OTR to be 61.3 ± 4.5 and 29.0 ± 14.3 respectively (Fig. 1C,D). The maximal intrinsic"
Spoiler: LIT-001
LIT-001: the possible improvement of WAY
This is also a non-peptude oxytoxin agonist in preclinicals but on this drug we actually have quantified stats on how good it actually is and it seems better than the stats of wall WAY which is quoted above. A study you can read on nature.com (link) said "have shown that LIT-001 is a specific oxytocin receptor agonist with high affinity (EC50 = 25 nM and EC50 = 18 nM) and efficacy (Emax = 96% and 95%) for human and mouse receptors, respectively. Furthermore, the compound poorly antagonized vasopressin induced calcium release on V1aR (IC50 = 5900 nM) and was devoid of agonist or antagonist effect on V1bR." So it basically seems to fullfill all the requirements for a good oxytocin receptor agonist. Since its so effective and super selective.
Now if youre planning on using trenbolone or youre a bit autistic i think this is especially applicable to you but everyone can benefit from these it seems
Maybe oxytocinace inhibitors deserved atleast a mention but they dont seem that great imo and i doubt this thread will get significant engagement so i cant be asked to include likely obsolete compounds
If anyone even dares too mention bonemass your entire family will be murdered in cold blood
avoid damage and sleep
these are gonna be the only normie tips here but they are actually really important, you're probably a degenerate like me so minimize damage from stims with sleep, melatonin megdose and mexidol
and sleep is SO IMPORTANT people still underestimate it. Most important normiemax by far, if you have trouble sleeping use melatonin, if that fails use trazodone or hydroxyzine ad if that fails use zolpidem
i would elaborate more on the last section but im hungry and tired so im going to make something to eat
Holy unemployment
song of this thread
I feel in discussions about pharmacology and such I believe many people misunderstand what metrics and aspects are actually worth focusing on, so today I'll talk about what I would interpret the literature says about what you should focus on. I wanna see everyone in here acend (with exceptions) so it pains me to go on here and all day see niggas with no purpose and abused dog syndrome, but fortionally its no match for chinese research chemicals.
stability and balance
i wrote about lithium a few days ago as its gold standard for stability so ima cope paste
Lithium
i think when most people get into and learn about pharmacology regarding the brain people very easily and with good reason get obsessed with trying to increase different neurotransmitters and/or agonise certain receptors with amphetamines or pregabalin for example, and those drugs can be great, they definitely have their place as they work so good so acutely
This study looked at the correlation between autistic traits and metabolite levels of neurotransmitters as well as glutamate/gaba ratio and they found “In cross‑correlation analyses, the Glx/GABA ratio was significantly associated with both autistic traits and sensory responsivity, whereas Glx alone showed fewer associations. Clustering analyses further grouped autistic traits with the Glx/GABA ratio, rather than with the individual metabolite concentrations, suggesting that the ratio may be more behaviorally relevant than either metabolite alone.” so basically stability is law. Its also in pretty much every study linked to depression very very closely as well as well as almost any mental problem while absolute levels of any given compound is poor as an indicator. This is a straight waterfall for anyone who even does slight research so im not gonna write pages and pages of text arguing for why stability is the important metric as if you do not agree you are either not knowledgeable on the subject which is fine but im not gonna practically debate you or you're just an anti intellectualist, and jfl at that.
lithium is also pretty much as good as it gets when it comes to stability, this fucking huge meta analysis shows that lithium fucking terra mogs, manic episode risk fuckign sliced in half and depression reduced by about a fourth
anti/psychotics undoubtedly deserves a place here, but theres just so much to write about and i couldnt be fucked honestly, if this thread gets good engagement maybe ill write a seperate thread because i belive they will eventually revolutionize drugs for normal and normalish people, they mog but it would take hours
cortexin
cortexin acts as a bunch of peptide hormones, its super neuroprotective so it stops toxicity from glutamate and stabilizes the gaba.glutamate relationship which is really important like with lithium, and just in general it acts as a regulator and an antioxidants for many parts so it also helps to build synapses and supports efficient pruning, so its quite complex but that's the general gist of it in short, shares a lot in common with lithium and cerebrolysin, but its more focused towards mood and nt-maxxing than cere and a bit worse for building structure but its a bit like the best of both worlds if you wanna keep it cheap and simple and only get 1 compound
gb-115, i have a link to my review here
https://looksmax.org/threads/gb-115-unifiram-update-review-damn-near-miracles.1651560/
Also a copy paste as cortisol is a very impactfull hormone
relacorilant
relacorilant is a glucocorticoid receptor antagonist, so basically it blocks cortisol. This is of course great as cortisol is something most people are gonna have too much of rather than too little which makes you feel stressed and fatigued, but you probably know that as it's known as the stress hormone. Cortisol also is the main cause behind hormone induced loss of elastin and it's also of course a catabolic hormone and tren’s GR antagonism is also the reason it's so anti catabolic and therefore good for cutting. I do not believe it replaces tren or makes tren obsolete but i do think it could be an option to run instead of tren if you might be a beginner, high inhib, super risk adverse, really really need sleep or dread any other tren side etc etc then i think you could pair this with some test maybe and still be well off.
Most gr antagonists throughout the years have like tren also had hormonal effects but relacorilant does not and has been specifically made for that. In both vivo and vitro it has showed effectiveness consistently like a vitro article here . This drug i cant really be fucked to write much about as the effects of cortisol is common knowledge and theres tons of studies to be found on this drug so i think the most valuable thing i can provide is just bringing it into discourse.
neural structure
The reason why you're here to begin with and why you've been an outcast your entire life is not due to being subhuman the vast majority of the time but instead but because you got subhuman genes in every aspect of your brain and this is quite a significant one
neural plasticity
dihexa
basically what dihexa does is that it mimics hepatocyte growth factor which is a growth factor in your brain you need to build stuff, kind of like the hcg for your brain, this is fast as shit which gives people some worries which is reasonable but its seriously potent and therefore good at what it does, the synapse build speed is insane, quite expensive tho but if you got some money to be able to use this for a while then pick it up, you need to use this for a while as this causes no up or down regulation of anything so there's so acute results
cerebrolysin
cerebrolysin is the gold standard of nootropics pretty much, its a mix of a fuck ton of peptides so it doesnt have 1 mechanism but instead many but the main one is upregulating different factors needed for neuronal signaling most importantly bdnf but also ngf gdnf etc, this causes the growth pathways pi3k/akt and mapk/erk to get brutally ran through at all times, its also giga neuroprotective among other benefits, its expensive but worth every penny.
TLQP-62, a highly theoreticall compound i wrote about a while ago but its to promising to not mention, it woyld revolutionize the noots and pharma scene if my theory is correct do ima cope and paste
What is TLQP-62?
TLQP is a peptide which comes from vgf protein, TLQP then stimulates bdnf release
The full procces is TLQP gets to the hippocampus, stimulates bdnf to be released and then act on the PI3K/AKT,MAPK/ERK and PLCy pathways and it does all this by first binding to the trkb receptor and requires glutamate and ndma signaling to do this
Now all this leads to neural survival more,stronger and stable synapses. Now i bet this doesnt seem revolutionairy because it seems very similar to the bdnf part of cerebrolysin but the diffrence is that cerebrolysin just contains a similar compound to mimic bdnf so this will have huge effect on damaged brains that are unable to replenish these neurotrophic factors
But somewhat healthy brains most likely can produce these somewhat close to the max of what you can use. The diffrence between the max and what youre likely to be able to produce is still there which is why cerebrolysin shows great results but youll still have a "celling". This could possibly be better due to it directly stimulating bdnf to actually be released and not just sit there
What are the limitations?
This peptide has only been in preclinicals and never been tested by humans, atleast from what we know since all the studies are on mice and i couldnt find anyone talking about this anywhere.
What would dosing look like?
This is a bit speculative but if we adjust it for humans its about 0,2-0,5mg that what we want in the hypocampus and when its in lyophilized form even tho its fucking huge(≈kda) i think its fair to eatimate that about 5% gets into the brain which would be 4-10mg intranasaly
VGF and its C-terminal peptide TLQP-62 in ventromedial prefrontal cortex regulate depression-related behaviors and the response to ketamine - PubMed
Patients with major depressive disorder (MDD) often have structural and functional deficits in the ventromedial prefrontal cortex (vmPFC), but the underlying molecular pathways are incompletely understood. The neuropeptide precursor VGF (non-acronymic) plays a critical role in depression and...
According to this effects can last a week
An increase in VGF expression through a rapid, transcription-independent, autofeedback mechanism improves cognitive function - Translational Psychiatry
The release of neuropeptides from dense core vesicles (DCVs) modulates neuronal activity and plays a critical role in cognitive function and emotion. The granin family is considered a master regulator of DCV biogenesis and the release of DCV cargo molecules. The expression of the VGF protein...
And according to this changes start happening very quick,just minutes 10-30,but it still seems unknown when noticeable effects start happening and not just an observable increase in vgf and cgb proteins
Sourcing?
Surprisingly this seems petty easy to source,found 20mg lyophilized for ish 60$ and another lab selling it in higher quantities,this may indicate a pretty low price per mg but ill see how much it is when they answer my enquiry
Is it better than cerebrolysin? Final verdict
I think that i cant say thats it definitely better even if it is as good as its promising since cerebrolysin is more broad and helps with creating veins,GDNF,CNTF,NGF and a few more but bdnf seems most responsible for the effects that most people use cere for. And TLQP-62 seems better strictly for BDNF which is the biggest reason for the massive increase in memory and learning and if cerebrolysin already can have such drastic effects im very interested in what TLQP can do
But imo it seems atleast very very interesting, more interesting than cerebrolysin for me atleast. I also feel very inclined to just take for the team and try this out but its still a bit scary since no one has tried it so i hope someone is low inhib enough to try it before me
Also a cope paste, use ideally with cerebrolysin
vorinostat/crebinostat/neurinostat
These 3 are all hdac inhibitors, they all work, neuroinostat is ideal but unrealistic to actually source most of the time, crebinostat is definitely doable but might run you a few hundred so it's a bit expensive. Vorinostat is slightly worse than both but the easiest and cheapest to source
What histone deacetylase like the name implies removes acetyl. This tightens DNA which makes transcription harder to accomplish. Therefore when hdac is inhibited more transcription is allowed so genes become expressed more strongly. Hdac does not act everywhere but it does act in the hippocampus which is the part most nootropics revolve around. This is of course theoretically but this study tested it and at least in rats it had significant effects on memory and long term plasticity which is in line with what's been theorized. this studyalso showed vorinostat was able to reverse cognitively declining mice brains.
Imo this is the most promising group of drugs out there, I think a very important suggestion wouls be to not use this alone but with other stuff as this could very well synergize with anything that causes neuronal signaling, directly or indirectly like cerebrolysin or any compound meant to cause synaptogenesis at some point, as a rule of thumb if its used for memory or learning directly and not just focus it probably gets amplified by hdaci, at least in theory. Because all it does is enhance signaling it doesn't cause it on its own.
synaptic pruning
synaptic pruning is how effectively your brain is set up. I'm going to simplify with a pic
this is an incel brain
this is a chad brain
You want cleanly and effectively, this decides how well something can be executed. Neural plasticity is like the engine while pruning is like the tires, if you have fucked traction youre not getting anywhere no matter how much hp you have under the hood. This is why so many smart people are so bad socially while it's a strength for some, because the more synapses the harder it is to organize
nmda receptor
the main way and the easiest way to achieve good pruning is through ndma activation, this has some nuance but it going to seem very non-nuanced as i think the clear winner for this metric is unifiram, unifiram makes the ampa receptor sensitive as shit which then sends ions around which switches on the nmda receptor, activation of nmda receptor then cleans up synapses and organizes them
socialmaxxing and meaning
serotonin and dopamine
2 very important neurotransmitters, people on here often focus on dopamine which is important dont get me wrong but it does not compare to the sociability and feel good effects from serotonin, but at the end of the day come with all of it or don't come at all so you have to prioritize everything.
vortioxetine
The drug that puts classical ssri’s to shame, it is like other pharma mentioned a drug that works in multiple ways, it does inhibit serotonin reuptake which in a sense makes it an ssri but it also works as an agonist against the 5-ht1a and b receptor while antagonizing the 5ht3 and 7 receptors. It also helps glutamate-gaba balance a bit. This all combined gives you the giga-nt feel good effects of an ssri on steroids without the fucked sides most ssri’s come with, this barely shows the common ssri sides more than the placebo group
tranylcypromine, mao-b and buspirone
tranylcypromine is the main drug i want to talk about here, it inhibits both mao-b and mao-a, mao-b breaks down dopamine while mao-a breaks down serotonin, and it also just stops the breakdown of all monoamines, this also makes it significantly stronger than any drug only breaking down a single type of mao, it also has a million downstream effects we could sit and talk about for hours but basically it raises and stabilizes neurotransmitters globally, this can give adhd like side effects tho according to this study, this is due to having too much of all these transmitters, if you're towards the adhd type already you're likely deficient so you might actually benefit from this while average people might be better of with other drugs, selegiline and rasagiline only inhibit mao-b, the difference is that selegiline breaks down into amphetamine and meth while rasa doesn't. Buspirone is also an option for normal people as its an agonist for serotonin and dopamine receptors, it's quite weak but that's actually beneficial as it also has a short half life so we avoid too many unstable levels and you're less open to neural adaptation.
oxytoxin, i wrote about this a while ago, seriously underrated, expensive tho but both of us know your ltn ass is not getting oxytocin from anywhere else than a chineae lab
Oxytocin is greatly involved in social bonding and feelings of love and attachment. Its very involved in social awareness, an oxytocin deifiency shows up in autism very commonly and seems to be one of the main reasons for the social aspects of ASD, therefore i think this thread is more widely applicable than most of you think. Oxytocin is also a big contributor to hightened feelings of well being and reduced anxiety, so if you're a high inhibcell but don't wanna deal with the withdrawl symptoms of gaba drugs then definitely take a look at the drugs listed below.
Spoiler: Why its so neglected despite its effects
The reason for it being so impactfull yet so ignored in pharmacology mainly boils down to big challenges for the drug developers. Just the fact that is so impactfull makes it difficult to work with, it also affects shit like cardiovascular function and the entire system a lot of the female reproduction system which makes these drugs often marketed for pregnancy and labour.
Vassopressin receptors
Vasopressin is a hormone that basically bloats you and at the same time gives that "toxic boyfriend" effect so its involved in setting of signals in your brain that someone is about to steal your bitch so you become angry, jealous and territorial. Oxytocin and vasopressin are very similar on a molecular level which causes cross activation of eachothers receptors. The v1a receptor is mostly what gives aggression and a disturbed cardiovascular system, v1b is really what causes the kind of "panic" symptoms or an increase in anxiety or paranoia and the v2 receptor just makes you a bloatcell and is the reason largely for the physical issues like cardiovascular ones.
Oxytocin agonists
Spoiler: Regular bioidentical exogenous oxytocin
This has been getting talked about more and more on here which worries me a bit. Theres of course studies showing very positive cognetive benefits from exogenous oxytocin. But they almost unanimously uses intraneural administration. This is since oxytocin only has a half life of about 3-5 minutes in plasma, it also has trouble crossing he blood-brain-barrier. This in combination just makes the oxytocin useless if its used intranasaly which seems most common here. So basically its just a gimick and straight copium, overall 2/10
Spoiler: WAY-267464
Way-267464
This is an oxytocin agonist that is not a peptide. This is good since peptides generally have short half lives. I havent found any statistics about it's half life but simply it not being a peptide indicates that it probably is a lot more stable than other similar drugs.
this study(link) tried this drug on rats
Which seemed to cause a decrease in anxiety. This indicates that it succesfully is able to selectively stimulate oxytocin receptors selectively and not simultaneously affect the vassopressin receptors. It also confirms my speculation on stability since it worked systemically and didn't just get degraded.
More stats on it and a direct relevant quote is "WAY-267464 acts as a high-affinity and potent agonist at both human and mouse OTR. In a whole-cell binding assay, we determined the affinity (Ki, nM) of WAY-267464 at human and mouse OTR to be 58.4 ± 11.3 and 51.6 ± 5.9 respectively (Fig. 1A,B). In a cell-based functional assay measuring changes in [Ca2+]i in response to compound challenge, we determined the potency (EC50, nM) of WAY-267464 at human and mouse OTR to be 61.3 ± 4.5 and 29.0 ± 14.3 respectively (Fig. 1C,D). The maximal intrinsic"
Spoiler: LIT-001
LIT-001: the possible improvement of WAY
This is also a non-peptude oxytoxin agonist in preclinicals but on this drug we actually have quantified stats on how good it actually is and it seems better than the stats of wall WAY which is quoted above. A study you can read on nature.com (link) said "have shown that LIT-001 is a specific oxytocin receptor agonist with high affinity (EC50 = 25 nM and EC50 = 18 nM) and efficacy (Emax = 96% and 95%) for human and mouse receptors, respectively. Furthermore, the compound poorly antagonized vasopressin induced calcium release on V1aR (IC50 = 5900 nM) and was devoid of agonist or antagonist effect on V1bR." So it basically seems to fullfill all the requirements for a good oxytocin receptor agonist. Since its so effective and super selective.
Now if youre planning on using trenbolone or youre a bit autistic i think this is especially applicable to you but everyone can benefit from these it seems
Maybe oxytocinace inhibitors deserved atleast a mention but they dont seem that great imo and i doubt this thread will get significant engagement so i cant be asked to include likely obsolete compounds
If anyone even dares too mention bonemass your entire family will be murdered in cold blood
avoid damage and sleep
these are gonna be the only normie tips here but they are actually really important, you're probably a degenerate like me so minimize damage from stims with sleep, melatonin megdose and mexidol
and sleep is SO IMPORTANT people still underestimate it. Most important normiemax by far, if you have trouble sleeping use melatonin, if that fails use trazodone or hydroxyzine ad if that fails use zolpidem
i would elaborate more on the last section but im hungry and tired so im going to make something to eat
Holy unemployment
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