How to prevent maturation of the growth plate- senolytics

[smaxx01]

So you have chondrocytes, MSCs, and osteoblasts.

MSCs-
Stem cells that differentiate into chondrocytes and osteoblasts

Osteoblasts-
Osteoblasts are bone forming cells that increase bone formation and mineralization

Chondrocytes-
Cartilage forming cells in the discs of your spine and joints

So how bones mature Is through these three maturing and going through hypertrophy until the point they become senescent.
How do we fix this?


Senolytics
Senolytics are compounds that cause apoptosis of these inactive senescent cells and flush them out.
Which can we use and how often?

Fox04Dri-
This is probably going to be the safest strongest senolytic you can get and it’s pretty expensive but given the time window we’re using it it’s not that bad at all, I would reccomend using 5-10mg eod for 6 days so 5-10mg 3 days in total with 1 day in between each so that there is time for the apoptotic senescent cells to clear but you can honestly use it days in a row too it doesn’t matter too much. I would only do this every 12-16 weeks.

Fisetin-
This is going to be the strongest natural senolytic supplement you could use and it’s often sold in 100mg pills so what you should do is buy the raw powder in a bag of like 50g and do 20-30mg/kg daily for 3 days every 3-4 weeks, I would pair this eith the same dose of the next compound

Quercetin
Also a flavonoid similar to fisetin but not as strong, still synergistic with fisetin so I would use them together

Now after the senolytic process you want to prolong the life of the healthy live bone cells
What can we use to do this?

Epithalon-
This peptide lengthens telomeres and can prolong the life of your live MSCs and chondrocytes and osteoblasts, it will also prolong the life of senescent cells so it’s crucial to use the fox04 before using this, I would suggest 10mg for 10 days following the fox04

Abaloparatide-
PTH analogue that has a very short half life so it works well with the bones responsiveness to pulsation in bone growth, it also decreases chondrocyte hypertrophy and increases osteoblast and chondrocyte differentiation.

Kartogenin-
Godsend for increasing chondrogenesis which is when MSCs turn into chondrocytes, I’d take 50mg a day and I might get some but you have to buy the raw powder in bulk

Cartalax
Similar to Kartogenin also promotes chondrogenesis but also has different mechanisms to keep the cartilage healthy, going to be using 2mg a day

Other things that might help but are risky

Roxadustat
Increases HIF-1a causing a less hypoxic environment at the plate but it also increases VEGF which can close plates so I’m still looking into it

Vesugen
Increases the number of MSCs and is great when paired with cartalax and Kartogenin and epitalon but it can increase VEGF too

Hopefully someone gets something out of this

 

[birthdefect]

So you have chondrocytes, MSCs, and osteoblasts.

MSCs-
Stem cells that differentiate into chondrocytes and osteoblasts

Osteoblasts-
Osteoblasts are bone forming cells that increase bone formation and mineralization

Chondrocytes-
Cartilage forming cells in the discs of your spine and joints

So how bones mature Is through these three maturing and going through hypertrophy until the point they become senescent.
How do we fix this?


Senolytics
Senolytics are compounds that cause apoptosis of these inactive senescent cells and flush them out.
Which can we use and how often?

Fox04Dri-
This is probably going to be the safest strongest senolytic you can get and it’s pretty expensive but given the time window we’re using it it’s not that bad at all, I would reccomend using 5-10mg eod for 6 days so 5-10mg 3 days in total with 1 day in between each so that there is time for the apoptotic senescent cells to clear but you can honestly use it days in a row too it doesn’t matter too much. I would only do this every 12-16 weeks.

Fisetin-
This is going to be the strongest natural senolytic supplement you could use and it’s often sold in 100mg pills so what you should do is buy the raw powder in a bag of like 50g and do 20-30mg/kg daily for 3 days every 3-4 weeks, I would pair this eith the same dose of the next compound

Quercetin
Also a flavonoid similar to fisetin but not as strong, still synergistic with fisetin so I would use them together

Now after the senolytic process you want to prolong the life of the healthy live bone cells
What can we use to do this?

Epithalon-
This peptide lengthens telomeres and can prolong the life of your live MSCs and chondrocytes and osteoblasts, it will also prolong the life of senescent cells so it’s crucial to use the fox04 before using this, I would suggest 10mg for 10 days following the fox04

Abaloparatide-
PTH analogue that has a very short half life so it works well with the bones responsiveness to pulsation in bone growth, it also decreases chondrocyte hypertrophy and increases osteoblast and chondrocyte differentiation.

Kartogenin-
Godsend for increasing chondrogenesis which is when MSCs turn into chondrocytes, I’d take 50mg a day and I might get some but you have to buy the raw powder in bulk

Cartalax
Similar to Kartogenin also promotes chondrogenesis but also has different mechanisms to keep the cartilage healthy, going to be using 2mg a day

Other things that might help but are risky

Roxadustat
Increases HIF-1a causing a less hypoxic environment at the plate but it also increases VEGF which can close plates so I’m still looking into it

Vesugen
Increases the number of MSCs and is great when paired with cartalax and Kartogenin and epitalon but it can increase VEGF too

Hopefully someone gets something out of this

quercetin (and even metformin for that matter) are senomorphics

 

[tomahawk]

good thread will research