PharmaPhaggot
Hedonism final boss
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- Oct 14, 2024
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gb115
gb-115 is a dug that has been talked about here for quite some time mainly due to its spectacular early performance in studies.
the was it works is by antagonizing the cck1 receptor. This is due to cholecystokinin causing more of an excitatory activity in stress and fear circuits and giving very much a panic-like feeling. This is good as we don't actually want to stop glutaminergic signaling as glutamate provides essential effects fro things such as academic performance. This is why many nootropics use glutamate and why many anxiety drugs that interact with glutamate can be problematic. But gb-115 just stops glutamate from favouring those anxiety circuits as we don't need them since we are not cavemen running from lions. It allows glutamate to work more stably and not be forced to act like its on steroids in certain parts of the brain. This is especially valuable if you are positively modulating glutamate with nootropics.
Back to the studies part this study showed that gb-115 was able to quickly and effectively help general anxiety with no side effects . This monkey study also showed it to have good anxiolytic effects
rapastininel
rapastinel works by modulating the glycin part of the nmda receptor, it leads to a stable way of enhancing glutamate activity, this may sound weird since glutamate is the main exitatory neurotransmitter and exitatory activity can cause anxiety. But the reason for why it might be good is due to its stability
rapastinel isnt even mainly for anxiety, an even bigger benefit is the enchanced ltp and synaptic plasticity and also its amazing anti depressive benefits, i suspect the structural aspect of the drug could help over time with the anxiety relief seen in preclinicals, like this study that concluded this “Rapastinel also produced an anxiolytic effect in the open field, as indexed by increased center time [F(1, 20) = 19.2, P < .05] without altering locomotor activity as measured by line crosses [F(1, 20) = 0.0, P > .05].” among many other benefits, id rec taking a read
buspirone
buspirone work by sending negative serotonergic feedback by agonising the presynaptic receptors, but they desensitise quick which allows for serotonin levels to increase in a controlled way in a few weeks, the post synaptic receptors are the opposite and buspirone activates them a bit so they are inhibited from being overexited, a little bit similar to gb-115 mechanism but with serotonin instead
vortioxetine
The drug that puts classical ssri’s to shame, it is like other pharma mentioned a drug that works in multiple ways, it does inhibit serotonin reuptake which in a sense makes it an ssri but it also works as an agonist against the 5-ht1a and b receptor while antagonizing the 5ht3 and 7 receptors. It also helps glutamate-gaba balance a bit. This all combined gives you the giga-nt feel good effects of an ssri on steroids without the fucked sides most ssri’s come with, this barely shows the common ssri sides more than the placebo group
gb-115 is a dug that has been talked about here for quite some time mainly due to its spectacular early performance in studies.
the was it works is by antagonizing the cck1 receptor. This is due to cholecystokinin causing more of an excitatory activity in stress and fear circuits and giving very much a panic-like feeling. This is good as we don't actually want to stop glutaminergic signaling as glutamate provides essential effects fro things such as academic performance. This is why many nootropics use glutamate and why many anxiety drugs that interact with glutamate can be problematic. But gb-115 just stops glutamate from favouring those anxiety circuits as we don't need them since we are not cavemen running from lions. It allows glutamate to work more stably and not be forced to act like its on steroids in certain parts of the brain. This is especially valuable if you are positively modulating glutamate with nootropics.
Back to the studies part this study showed that gb-115 was able to quickly and effectively help general anxiety with no side effects . This monkey study also showed it to have good anxiolytic effects
rapastininel
rapastinel works by modulating the glycin part of the nmda receptor, it leads to a stable way of enhancing glutamate activity, this may sound weird since glutamate is the main exitatory neurotransmitter and exitatory activity can cause anxiety. But the reason for why it might be good is due to its stability
rapastinel isnt even mainly for anxiety, an even bigger benefit is the enchanced ltp and synaptic plasticity and also its amazing anti depressive benefits, i suspect the structural aspect of the drug could help over time with the anxiety relief seen in preclinicals, like this study that concluded this “Rapastinel also produced an anxiolytic effect in the open field, as indexed by increased center time [F(1, 20) = 19.2, P < .05] without altering locomotor activity as measured by line crosses [F(1, 20) = 0.0, P > .05].” among many other benefits, id rec taking a read
buspirone
buspirone work by sending negative serotonergic feedback by agonising the presynaptic receptors, but they desensitise quick which allows for serotonin levels to increase in a controlled way in a few weeks, the post synaptic receptors are the opposite and buspirone activates them a bit so they are inhibited from being overexited, a little bit similar to gb-115 mechanism but with serotonin instead
vortioxetine
The drug that puts classical ssri’s to shame, it is like other pharma mentioned a drug that works in multiple ways, it does inhibit serotonin reuptake which in a sense makes it an ssri but it also works as an agonist against the 5-ht1a and b receptor while antagonizing the 5ht3 and 7 receptors. It also helps glutamate-gaba balance a bit. This all combined gives you the giga-nt feel good effects of an ssri on steroids without the fucked sides most ssri’s come with, this barely shows the common ssri sides more than the placebo group
