bloodymanor
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FIRST PART
1. Other worth mentioning hormones are also involved in regulation.
1. Other worth mentioning hormones are also involved in regulation.
GLUCOCORTICOIDS
Glucocorticoids modulate growth hormone (GH) secretion through persistent and competing effects on the hypothalamus and pituitary gland. The final effect of this modulation depends on the structure of the hormones and the duration of exposure. The traditional hypothesis is that chronically elevated glucocorticoid levels suppress GH secretion. However, functional impairment of reserve GH can also be observed in patients with low glucocorticoid levels, such as secondary hypoadrenalism, which is consistent with the biphasic dose-dependent effect of glucocorticoids on the somatotropic axis.Chronic stress leads to chronic elevation of glucocorticoid levels, which also chronically decreases GH levels.
In such cases, ashwagandha may be helpful by reducing cortisol levels and accelerating GH.
THYROID HORMONES
Thyroid hormones are regulators of the synthesis and secretion of growth hormones. In this study (https://joe.bioscientifica.com/view/journals/joe/112/3/joe_112_3_018.xml)....there is no continuation beyond the character limits.
2. Somatocrinin receptor agonists.
The drugs are listed in order, from the most powerful to the weakest*
CJC-1295 is the strongest representative of this class with a long-term effect. But there is a catch, the trials are taking place at stage 3, at stage 1, quite frequent side effects were identified, and a drop in the base level of secretion is also possible after discontinuation of the drug. At the second stage, almost all the scientists at the previous stage were removed, and the results were much better) well, and at the end, the death of one of the 192 (https://web.archive.org/web/20170131114951/http://www.natap.org/2006/newsUpdates/081106_02.htm), subjects due to a heart attack)
Theoresamlin
Theoresamlin is also a more powerful, weaker 1295, but it has a docking station and approval for human use.
Mod GRF (1-29)
There is a modified category of sermorelin (GRF (1-29)) with a longer half-life, 6 times longer than sermorelin.
Sermorelin (GRF(1-29))
The first 29 amino acids of GHRH have been found to be as effective as its full 44 amino acid structure. Sermorelin was approved (FDA) in 1997 for the treatment of children with growth hormone deficiency or growth retardation. Review period 5 minutes.
3. Ghrelin receptor agonists.
All drugs in this class stimulate hunger as well as actually stimulating the receptors of the "hunger hormone".
Hexarelin\Examorelin
The most potent in its class, but has a short half-life, is a derivative of GHRP-6.
GHRP-6
Less abrupt than hexarelin, but has a half-life of 3 times the normal (3 hours)
GHRP-2
GHRP-2 was the first drug of this class, which is very effective, was not approved due to the weakness of children with growth hormone deficiency, officially sold only as a diagnostic drug to reduce the deficiency of GH secretion.
Ipamorelin
Ipamorelin was developed on the basis of GHRP-1, clinical trials were carried out continuously due to insufficient effectiveness, half-life of 2 hours.
Ibutamoren, MK677
Ibutamoren is beyond competition due to its ease of administration, low cost and favorable doc-base, the period of action of "hunger" (strong hunger from the effects of ghrelin) lasts 8-9 hours (on high-quality sources), contrary to the popular opinion about rapid addiction to these testimonies based only on the growth of hormones, IGF1 and butamoren are used with daily intake and year-round, according to a study of year-round daily intake by choice of 60 years. people gave a stable 50% increase in IGF1.
(https://www.sciencedirect.com/science/article/abs/pii/S0167494310002530#preview-section-references)
[B]End of the first part, wait for the second..[/B]
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