IGF-1 and Aging

[Deleted member 2268]

According to Vigorous Steve taking Metformin can reduce IGF-1 levels which can slow down aging. However lowering IGF-1 can slow down hypertrophy. So he says it’s a trade off between building muscle and anti aging.

Using test can increase IGF-1 but I’m wondering what role this plays in accelerating aging? Is it worth it to run Metformin for anti aging?

@Thomas DOM @Germania @softlysoftly @JFLateating

 

[Deleted member 2268]

Study showing test increases IGF-1

Testosterone increases insulin-like growth factor-1 and insulin-like growth factor-binding protein - PubMed

Growth of the male external genitalia is primarily regulated by androgens; however, several observations suggest growth hormone (GH) or a GH dependent factor, such as insulin-like growth factor-1 (IGF-1), might also be involved. It is hypothesized that testosterone (T) might induce the synthesis...

pubmed.ncbi.nlm.nih.gov

 

[Deleted member 20652]

I remember RealRob saying that the reason Testosteron increases collagen is because Testosteron increases IGF1 and IGF1 then in return increases collagen.

//Thomas MACHO

 

[thereallegend]

Is it worth it to run Metformin for anti aging?

Not it's not. Dr Rhonda Patrick said exercise is way more effective for aging and muscle building and diabetes. Taking metformin with exercise blunts muscle building and anti aging effect of exercise.

 

[Deleted member 20652]

High IGF 1 = high collagen.

//Thomas MACHO

 

[Dystopian]

Study showing test increases IGF-1

Testosterone increases insulin-like growth factor-1 and insulin-like growth factor-binding protein - PubMed

Growth of the male external genitalia is primarily regulated by androgens; however, several observations suggest growth hormone (GH) or a GH dependent factor, such as insulin-like growth factor-1 (IGF-1), might also be involved. It is hypothesized that testosterone (T) might induce the synthesis...

pubmed.ncbi.nlm.nih.gov

Lifefuel for pubberty

 

[Deleted member 2268]

High IGF 1 = high collagen.

//Thomas MACHO

So why does Vigorous Steve say IGF-1 accelerates aging? I was confused on this as well because I thought traditionally GH is used for anti aging

 

[Jerryterry129]

Hgh is aging

I’ve never once in my life seen someone on HGH look younger than their age

Hell I don’t even think I’ve seen someone on hgh look there age lmfao (always look older)

 

[Deleted member 20652]

So why does Vigorous Steve say IGF-1 accelerates aging? I was confused on this as well because I thought traditionally GH is used for anti aging

No idea bro.

GH and IGF1 is usually known as anti aging in most studies

//Thomas MACHO

 

[Deleted member 2268]

Hgh is aging

I’ve never once in my life seen someone on HGH look younger than their age

Hell I don’t even think I’ve seen someone on hgh look there age lmfao (always look older)

That’s my point. I think it may have to do with dosage? Maybe 1-2 iu is good for anti aging

 

[Jerryterry129]

That’s my point. I think it may have to do with dosage? Maybe 1-2 iu is good for anti aging

I don’t think hgh is good for anti aging at all lmao

There’s not a single person on hgh that I know of that looks younger than there age

 

[Deleted member 2268]

Not it's not. Dr Rhonda Patrick said exercise is way more effective for aging and muscle building and diabetes. Taking metformin with exercise blunts muscle building and anti aging effect of exercise.

So cardio?

 

[thereallegend]

So cardio?

Ideally HIIT

 

[Deleted member 2268]

Ideally HIIT

Does elliptical count as HIIT? Or sled push?

 

[thereallegend]

Does elliptical count as HIIT? Or sled push?

You're asking questions outside my knowledge

 

[ascension!]

Not it's not. Dr Rhonda Patrick said exercise is way more effective for aging and muscle building and diabetes. Taking metformin with exercise blunts muscle building and anti aging effect of exercise.

I will recommend to my mama a good diet+HIIT+red light therapy w/ tret for Aging, what about weight loss?

I’m Looksmaxing my parents

 

[thereallegend]

I will recommend to my mama a good diet+HIIT+red light therapy w/ tret for Aging, what about weight loss?

I’m Looksmaxing my parents

chromium picolinate and alpha lipoic acid

 

[ascension!]

chromium picolinate and alpha lipoic acid

For what use?

 

[thereallegend]

For what use?

weight loss

 

[Germania]

I also listened to his episode.
The question is always how drastic the effects are. For example, it is also said not to eat antioxidants (vitamin C, even fruits and so on) around exercise. What difference does that make? I dunno, but I don't think either metforim, berberine, antioxidants will be the reason for having a good body or not. But no one can prove it with numbers. Metformin and berberine should simply not be taken around training, as some german BB coaches on YouTube recommend.

 

[Deleted member 2268]

I also listened to his episode.
The question is always how drastic the effects are. For example, it is also said not to eat antioxidants (vitamin C, even fruits and so on) around exercise. What difference does that make? I dunno, but I don't think either metforim, berberine, antioxidants will be the reason for having a good body or not. But no one can prove it with numbers. Metformin and berberine should simply not be taken around training, as some german BB coaches on YouTube recommend.

Are you taking Metformin?

 

[Dystopian]

HGH is a stress hormone, stress ages you, but hgh stimulates collagen,muscle, hair and even bone remodeling

Personally I would use just for anti aging , there are other peptides that mog it to death

 

[Germania]

Are you taking Metformin?

Only Berberine, but i am thinking about taking Metformin. Need to educate myself a bit more about it.

 

[Deleted member 23558]

Not it's not. Dr Rhonda Patrick said exercise is way more effective for aging and muscle building and diabetes. Taking metformin with exercise blunts muscle building and anti aging effect of exercise.

Rhonda Patrick is extremely retarded but she’s right on this one

 

[damnit]

there are knowledgeable people here on aging (not just skin aging) , but Metformin suppresses mTOR by activating AMPK so it's indirect , and ramapycin directly supresses mTOR . Rapamycin wins for increasing lifespan, it's the most promising drug today to delay aging/age related diseases. But metformin isn't bad of course (aside from likeliness of b12 deficiency). Some studies pointed testosterone decrease while on it. Metformin has health like benefits that come somewhat close to everyday exercise.

You can also restrict mTOR with caloric restriction, so building muscle is a struggle with those drugs and caloric restriction. I guess the restriction falls between BMR and TDEE.

users like seth walsh are very well knowledgeable on this subject.

I regularly use metformin since a year now (1 gram ) , got diarrhea in the beginning , also tommy gets bloated form time to time.