IGF-1 spikes multiple times a day

[addalinnerlight]

Here is why Spiking your glucose blood sugar levels more than once a day might be bad. High IQcels please debate.

Your body ramps up IGFBPs in response to high free IGF‑1 so most of your IGF‑1 becomes nactive. More total IGF‑1 no longer equals more bioactive IGF‑1 at the tissue level. Chronically elevated IGF‑1 (from constant insulin) on the hypothalamus/pituitary to suppress Growth Hormone pulses. Less GH less IGF‑1 production in the next cycle. You end up throttling your own anabolic axis.
Every big glucose hit drives a big insulin release. Do that 3×/day and your cells start down regulating insulin receptors. Over weeks you’ll develop insulin resistance, which means your liver and muscle stop responding as well and your planned IGF‑1 bump from insulin falls flat.

 

[truelurker]

very few high iqcels here and most are inactive

 

[Inosebreathonly]

Here is why Spiking your glucose blood sugar levels more than once a day might be bad. High IQcels please debate.

Your body ramps up IGFBPs in response to high free IGF‑1 so most of your IGF‑1 becomes nactive. More total IGF‑1 no longer equals more bioactive IGF‑1 at the tissue level. Chronically elevated IGF‑1 (from constant insulin) on the hypothalamus/pituitary to suppress Growth Hormone pulses. Less GH less IGF‑1 production in the next cycle. You end up throttling your own anabolic axis.
Every big glucose hit drives a big insulin release. Do that 3×/day and your cells start down regulating insulin receptors. Over weeks you’ll develop insulin resistance, which means your liver and muscle stop responding as well and your planned IGF‑1 bump from insulin falls flat.

Insulin suppresses gh-igf-1 axis yeah but it actually increases free igf-1 by lowering igfbp-1 and 2 production in the liver and also by binding to them

Also igf-1 doesn't "spike" like gh it experiences some elevation occasional but not that big of an increase compared to baseline so I'd say total igf-1 levels are pretty consistent during the day.

Free igf-1 levels fluctuate more during the day and are almost proportionate with insulin levels

And more frequent elevations/spikes in gh and igf-1=wider and more prominent growth window periods
For example gh secretagogues increase the frequency of spikes in gh which is good for growth plate stimulation

Obviously you'd still want to keep gh-igf-1 axis intact and prevent insulin resistance so take insulin sensitizing supplements like ALA, cinnamon, fish oil etc. and exercise

 

[addalinnerlight]

Insulin suppresses gh-igf-1 axis yeah but it actually increases free igf-1 by lowering igfbp-1 and 2 production in the liver and also by binding to them

Also igf-1 doesn't "spike" like gh it experiences some elevation occasional but not that big of an increase compared to baseline so I'd say total igf-1 levels are pretty consistent during the day.

Free igf-1 levels fluctuate more during the day and are almost proportionate with insulin levels

And more frequent elevations/spikes in gh and igf-1=wider and more prominent growth window periods
For example gh secretagogues increase the frequency of spikes in gh which is good for growth plate stimulation

Obviously you'd still want to keep gh-igf-1 axis intact and prevent insulin resistance so take insulin sensitizing supplements like ALA, cinnamon, fish oil etc. and exercise

Yea but Spiking 1x is ideal with cinnamon after no? Spike ir right after exercise with leucine

 

[Inosebreathonly]

Yea but Spiking 1x is ideal with cinnamon after no? Spike ir right after exercise with leucine

I'd say 3 times is ideal
In the morning when igf-1 is already at its highest during the day
After exercise
And 3 hours before bed

 

[addalinnerlight]

I'd say 3 times is ideal
In the morning when igf-1 is already at its highest during the day
After exercise
And 3 hours before bed

Three big insulin jolts daily lead cells to down‑regulate receptors, causing insulin resistance.
Constant high insulin blunts GH pulses via feedback, cutting your liver’s IGF‑1 output.
Elevated IGF‑1 ramps up binding proteins, so most of it stays locked up and inactive.
Nutrient transporters (GLUT4, amino‑acid channels) max out quickly extra spikes add almost nothing. No? I would say one is ideal post workout

 

[Inosebreathonly]

Three big insulin jolts daily lead cells to down‑regulate receptors, causing insulin resistance.
Constant high insulin blunts GH pulses via feedback, cutting your liver’s IGF‑1 output.
Elevated IGF‑1 ramps up binding proteins, so most of it stays locked up and inactive.
Nutrient transporters (GLUT4, amino‑acid channels) max out quickly extra spikes add almost nothing. No? I would say one is ideal post workout

I already talked about how you should perform insulin sensitizing strategies besides 3 big insulin spikes within 24 hour is unlikely to cause insulin resistance if u r otherwise healthy

I literally said insulin lowers igfbp and increases free igf-1 drastically, it doesn't stay "inactive"

 

[addalinnerlight]

Insulin suppresses gh-igf-1 axis yeah but it actually increases free igf-1 by lowering igfbp-1 and 2 production in the liver and also by binding to them

Also igf-1 doesn't "spike" like gh it experiences some elevation occasional but not that big of an increase compared to baseline so I'd say total igf-1 levels are pretty consistent during the day.

Free igf-1 levels fluctuate more during the day and are almost proportionate with insulin levels

And more frequent elevations/spikes in gh and igf-1=wider and more prominent growth window periods
For example gh secretagogues increase the frequency of spikes in gh which is good for growth plate stimulation

Obviously you'd still want to keep gh-igf-1 axis intact and prevent insulin resistance so take insulin sensitizing supplements like ALA, cinnamon, fish oil etc. and exercise

Cinnamon and omega‑3s might improve your sensitivity by ~10–15 %, but that doesn’t completely neutralize three giant spikes.

• Yes, insulin does drop IGFBP‑1/2 and free up IGF‑1. But if you chronically run insulin sky‑high, your pituitary will dial back GH, and your liver will start making more IGFBPs overall—so net “free” time in the long term can actually shrink.
• Short‑term vs. long‑term
  • Over a few weeks you’ll probably feel fine: energy will be good, pumps will be strong, IGF‑1 likely elevated after each spike.
  • Over months of non‑stop sugar bombs, though, even a “healthy” system starts to adapt by dampening receptor sensitivity.

 

[truelurker]

good thread free reps for everybody

 

[addalinnerlight]

Cinnamon and omega‑3s might improve your sensitivity by ~10–15 %, but that doesn’t completely neutralize three giant spikes.

• Yes, insulin does drop IGFBP‑1/2 and free up IGF‑1. But if you chronically run insulin sky‑high, your pituitary will dial back GH, and your liver will start making more IGFBPs overall—so net “free” time in the long term can actually shrink.
• Short‑term vs. long‑term
  • Over a few weeks you’ll probably feel fine: energy will be good, pumps will be strong, IGF‑1 likely elevated after each spike.
  • Over months of non‑stop sugar bombs, though, even a “healthy” system starts to adapt by dampening receptor sensitivity.

Ai btw so debate me. I dont know but ai says its bad

 

[addalinnerlight]

Insulin suppresses gh-igf-1 axis yeah but it actually increases free igf-1 by lowering igfbp-1 and 2 production in the liver and also by binding to them

Also igf-1 doesn't "spike" like gh it experiences some elevation occasional but not that big of an increase compared to baseline so I'd say total igf-1 levels are pretty consistent during the day.

Free igf-1 levels fluctuate more during the day and are almost proportionate with insulin levels

And more frequent elevations/spikes in gh and igf-1=wider and more prominent growth window periods
For example gh secretagogues increase the frequency of spikes in gh which is good for growth plate stimulation

Obviously you'd still want to keep gh-igf-1 axis intact and prevent insulin resistance so take insulin sensitizing supplements like ALA, cinnamon, fish oil etc. and exercise

Fish Oil is stupid because of the PUFAS Dawg thats asking for a descension

 

[Inosebreathonly]

Cinnamon and omega‑3s might improve your sensitivity by ~10–15 %, but that doesn’t completely neutralize three giant spikes.

• Yes, insulin does drop IGFBP‑1/2 and free up IGF‑1. But if you chronically run insulin sky‑high, your pituitary will dial back GH, and your liver will start making more IGFBPs overall—so net “free” time in the long term can actually shrink.
• Short‑term vs. long‑term
  • Over a few weeks you’ll probably feel fine: energy will be good, pumps will be strong, IGF‑1 likely elevated after each spike.
  • Over months of non‑stop sugar bombs, though, even a “healthy” system starts to adapt by dampening receptor sensitivity.

Chatgpt ahh
You wouldn't want to "neutralize" the spikes as this would kill the whole purpose of the method
A postprandial walk combined with those supplements and you should be fine if u have a healthy metabolism and body composition
And ofc u gotta cycle it off take some rest every few weeks, reduce the sugar intake..
Too much and too uncontrolled anything can be bad
This is kind of a short term growth accelerator

 

[addalinnerlight]

Chatgpt ahh
You wouldn't want to "neutralize" the spikes as this would kill the whole purpose of the method
A postprandial walk combined with those supplements and you should be fine if u have a healthy metabolism and body composition
And ofc u gotta cycle it off take some rest every few weeks, reduce the sugar intake..
Too much and too uncontrolled anything can be bad
This is kind of a short term growth accelerator

I literally Said it was ai Down below and fish Oil is literally PUFAS

 

[addalinnerlight]

Chatgpt ahh
You wouldn't want to "neutralize" the spikes as this would kill the whole purpose of the method
A postprandial walk combined with those supplements and you should be fine if u have a healthy metabolism and body composition
And ofc u gotta cycle it off take some rest every few weeks, reduce the sugar intake..
Too much and too uncontrolled anything can be bad
This is kind of a short term growth accelerator

Yeah but it takes weeks to reset insulin sensitivity so a 3 week on one week off wouldnt even be useful you would need 3-3 off on or something like that which is why u might as Well do one spike

 

[Inosebreathonly]

Ai btw so debate me. I dont know but ai says its bad

Why would u want to "debate" if u get ur arguments from chatgpt..
And do whatever u want it is just experimenting at the end

 

[addalinnerlight]

Why would u want to "debate" if u get ur arguments from chatgpt..
And do whatever u want it is just experimenting at the end

I wanted you to debate ? Because I literally Said I didnt know and askedn for your argument against it

 

[Enytraina]

very few high iqcels here and most are inactive

Here is why Spiking your glucose blood sugar levels more than once a day might be bad. High IQcels please debate.

Your body ramps up IGFBPs in response to high free IGF‑1 so most of your IGF‑1 becomes nactive. More total IGF‑1 no longer equals more bioactive IGF‑1 at the tissue level. Chronically elevated IGF‑1 (from constant insulin) on the hypothalamus/pituitary to suppress Growth Hormone pulses. Less GH less IGF‑1 production in the next cycle. You end up throttling your own anabolic axis.
Every big glucose hit drives a big insulin release. Do that 3×/day and your cells start down regulating insulin receptors. Over weeks you’ll develop insulin resistance, which means your liver and muscle stop responding as well and your planned IGF‑1 bump from insulin falls flat.

@TrueRamirez