Infigratinib vs Erdafitinib

[eugenicsarebased]

id like your takes on this topic but here is mine: infigratib is more selective for FGFR1-3 and less FGFR4 activity, in theory which means it could lead to more targeted growth plate activity and less sides, whislt erdafitinib is pan a FGFR1-4 inhbitor meaning a stronger FGFR4 hit. In theory Erdafitinib would be stronger for height but there is real risks with it. Also in my case for Erdafitinib there is real clinical evidence, doctors report rapid overgrowth in teens who take it and in one case a teen reached a state of 19cm a year growth also all these pacients are normal non androcrolopasia unlike the studies for Infigratinib

 

[AtrophicPyra]

id like your takes on this topic but here is mine: infigratib is more selective for FGFR1-3 and less FGFR4 activity, in theory which means it could lead to more targeted growth plate activity and less sides, whislt erdafitinib is pan a FGFR1-4 inhbitor meaning a stronger FGFR4 hit. In theory Erdafitinib would be stronger for height but there is real risks with it. Also in my case for Erdafitinib there is real clinical evidence, doctors report rapid overgrowth in teens who take it and in one case a teen reached a state of 19cm a year growth also all these pacients are normal non androcrolopasia unlike the studies for Infigratinib

what do you think abt tyra300?

 

[eugenicsarebased]

what do you think abt tyra300?

mid num 1 is erdafitinib number 2 inigratib number and below those two comes tyra 300

 

[AtrophicPyra]

mid num 1 is erdafitinib number 2 inigratib number and below those two comes tyra 300

but erdafitinib inhibits fgfr4 too which is useless to inhibit for bone growth however erdafitinib is more concentrated on fgfr1-3

 

[i_blamegamertag]

Cjc and ipa mogs brootal

 

[eugenicsarebased]

but erdafitinib inhibits fgfr4 too which is useless to inhibit for bone growth however erdafitinib is more concentrated on fgfr1-3

true

 

[exsttttt]

id like your takes on this topic but here is mine: infigratib is more selective for FGFR1-3 and less FGFR4 activity, in theory which means it could lead to more targeted growth plate activity and less sides, whislt erdafitinib is pan a FGFR1-4 inhbitor meaning a stronger FGFR4 hit. In theory Erdafitinib would be stronger for height but there is real risks with it. Also in my case for Erdafitinib there is real clinical evidence, doctors report rapid overgrowth in teens who take it and in one case a teen reached a state of 19cm a year growth also all these pacients are normal non androcrolopasia unlike the studies for Infigratinib

ye i think erda is better, more studies and cases of pediatric growth in non achondroplasia kids, and cheaper per gram+ stronger per mg meaning daily cost is even lower, and signficantly more potent than infig regardless of what in vitro binding assays and EC50 say.

 

[exsttttt]

mid num 1 is erdafitinib number 2 inigratib number and below those two comes tyra 300

tyra prolly best but expensive and needs high ass dosing, if u could afford 100mg daily it would be better than both, but thats far from today.

 

[exsttttt]

Cjc and ipa mogs brootal

dnr nigga

 

[fraudster#1]

erda is better, but wnver no one here is touching it

id like your takes on this topic but here is mine: infigratib is more selective for FGFR1-3 and less FGFR4 activity, in theory which means it could lead to more targeted growth plate activity and less sides, whislt erdafitinib is pan a FGFR1-4 inhbitor meaning a stronger FGFR4 hit. In theory Erdafitinib would be stronger for height but there is real risks with it. Also in my case for Erdafitinib there is real clinical evidence, doctors report rapid overgrowth in teens who take it and in one case a teen reached a state of 19cm a year growth also all these pacients are normal non androcrolopasia unlike the studies for Infigratinib

 

[fraudster#1]

id like your takes on this topic but here is mine: infigratib is more selective for FGFR1-3 and less FGFR4 activity, in theory which means it could lead to more targeted growth plate activity and less sides, whislt erdafitinib is pan a FGFR1-4 inhbitor meaning a stronger FGFR4 hit. In theory Erdafitinib would be stronger for height but there is real risks with it. Also in my case for Erdafitinib there is real clinical evidence, doctors report rapid overgrowth in teens who take it and in one case a teen reached a state of 19cm a year growth also all these pacients are normal non androcrolopasia unlike the studies for Infigratinib

hm, i also heard from a guy reporting clavicles growth with infragatinib. what do u think?

 

[exsttttt]

hm, i also heard from a guy reporting clavicles growth with infragatinib. what do u think?

unless he was dosing atleast more than 30mg id say its bs cuz infig isnt that potent at lower dosages but it still would have an effect; an fgfr3 inhibitor would affect all primary and even secondary growth plates.

 

[benal22]

whats the correct dosing for Erdafitinib

 

[Zorbital]

id like your takes on this topic but here is mine: infigratib is more selective for FGFR1-3 and less FGFR4 activity, in theory which means it could lead to more targeted growth plate activity and less sides, whislt erdafitinib is pan a FGFR1-4 inhbitor meaning a stronger FGFR4 hit. In theory Erdafitinib would be stronger for height but there is real risks with it. Also in my case for Erdafitinib there is real clinical evidence, doctors report rapid overgrowth in teens who take it and in one case a teen reached a state of 19cm a year growth also all these pacients are normal non androcrolopasia unlike the studies for Infigratinib

Is Erdafitinib not extremly risky for your sight?

 

[antx]

id like your takes on this topic but here is mine: infigratib is more selective for FGFR1-3 and less FGFR4 activity, in theory which means it could lead to more targeted growth plate activity and less sides, whislt erdafitinib is pan a FGFR1-4 inhbitor meaning a stronger FGFR4 hit. In theory Erdafitinib would be stronger for height but there is real risks with it. Also in my case for Erdafitinib there is real clinical evidence, doctors report rapid overgrowth in teens who take it and in one case a teen reached a state of 19cm a year growth also all these pacients are normal non androcrolopasia unlike the studies for Infigratinib

Source for any of those two?

 

[HubertSkeletrix]

type shit

 

[eugenicsarebased]

whats the correct dosing for Erdafitinib

5mg a day is good id say

 

[eugenicsarebased]

Source for any of those two?

i have a source for both dm me brah

 

[eugenicsarebased]

Is Erdafitinib not extremly risky for your sight?

it is lol but better than roping

 

[hypnotixx]

Source for any of those two?

indiamart

 

[Zorbital]

indiamart

wich vendor ?

 

[hypnotixx]

https://m.indiamart.com/proddetail/erdafitinib-5mg-tablet-2854654717433.html or https://m.indiamart.com/proddetail/erdafitinib-5mg-2854855409333.html

 

[manuel355335]

id like your takes on this topic but here is mine: infigratib is more selective for FGFR1-3 and less FGFR4 activity, in theory which means it could lead to more targeted growth plate activity and less sides, whislt erdafitinib is pan a FGFR1-4 inhbitor meaning a stronger FGFR4 hit. In theory Erdafitinib would be stronger for height but there is real risks with it. Also in my case for Erdafitinib there is real clinical evidence, doctors report rapid overgrowth in teens who take it and in one case a teen reached a state of 19cm a year growth also all these pacients are normal non androcrolopasia unlike the studies for Infigratinib

Can you link the study

 

[Zorbital]

https://m.indiamart.com/proddetail/erdafitinib-5mg-tablet-2854654717433.html or https://m.indiamart.com/proddetail/erdafitinib-5mg-2854855409333.html

both under 100reviews , ts will probably kill you

 

[hypnotixx]

both under 100reviews , ts will probably kill you

erdafitinib will also kill you too lmao

 

[Zorbital]

erdafitinib will also kill you too lmao

yes but atleast the corpse is 6'5

 

[Zorbital]

i have a source for both dm me brah

look in dms

 

[ascendrx]

id like your takes on this topic but here is mine: infigratib is more selective for FGFR1-3 and less FGFR4 activity, in theory which means it could lead to more targeted growth plate activity and less sides, whislt erdafitinib is pan a FGFR1-4 inhbitor meaning a stronger FGFR4 hit. In theory Erdafitinib would be stronger for height but there is real risks with it. Also in my case for Erdafitinib there is real clinical evidence, doctors report rapid overgrowth in teens who take it and in one case a teen reached a state of 19cm a year growth also all these pacients are normal non androcrolopasia unlike the studies for Infigratinib

Just take what u want

 

[johnlarp1639]

Can someone pm me source for erd bro

 

[TakaTeo]

id like your takes on this topic but here is mine: infigratib is more selective for FGFR1-3 and less FGFR4 activity, in theory which means it could lead to more targeted growth plate activity and less sides, whislt erdafitinib is pan a FGFR1-4 inhbitor meaning a stronger FGFR4 hit. In theory Erdafitinib would be stronger for height but there is real risks with it. Also in my case for Erdafitinib there is real clinical evidence, doctors report rapid overgrowth in teens who take it and in one case a teen reached a state of 19cm a year growth also all these pacients are normal non androcrolopasia unlike the studies for Infigratinib

Dog shit Vs cat shit

 

[TakaTeo]

id like your takes on this topic but here is mine: infigratib is more selective for FGFR1-3 and less FGFR4 activity, in theory which means it could lead to more targeted growth plate activity and less sides, whislt erdafitinib is pan a FGFR1-4 inhbitor meaning a stronger FGFR4 hit. In theory Erdafitinib would be stronger for height but there is real risks with it. Also in my case for Erdafitinib there is real clinical evidence, doctors report rapid overgrowth in teens who take it and in one case a teen reached a state of 19cm a year growth also all these pacients are normal non androcrolopasia unlike the studies for Infigratinib

Please send the studies so I can confirm which ones I'm comparing too and if im looking at the same one. If I'm not mistaken, the format in which the bone growth was expressed was quite unpleasant and not anywhere near the clean vertical growth that would be desired

 

[johnlarp1639]

Please send the studies so I can confirm which ones I'm comparing too and if im looking at the same one. If I'm not mistaken, the format in which the bone growth was expressed was quite unpleasant and not anywhere near the clean vertical growth that would be desired

Skeletal overgrowth in a pre-pubescent child treated with pan-FGFR inhibitor

Fibroblast growth factors and their receptors (FGFR) have major roles in both human growth and oncogenesis. In adults, therapeutic FGFR inhibitors hav…

www.sciencedirect.com

Looks like this one, about 14.3 cm real growth with 19.6 cm extrapolated to annual. Keep in mind tho that this was a 15 year old and regular annual growth is 10 cm per year so almost 2 times assuming the rate keeps but idk this is just for this study. Also yeah he got scoliosis but actually was probably taller than recorded because he got hip deformities that made him slightly shorter at final height but at least nonmembranous bones unaffected tho

 

[TakaTeo]

Skeletal overgrowth in a pre-pubescent child treated with pan-FGFR inhibitor

Fibroblast growth factors and their receptors (FGFR) have major roles in both human growth and oncogenesis. In adults, therapeutic FGFR inhibitors hav…

www.sciencedirect.com

Looks like this one, about 14.3 cm real growth with 19.6 cm extrapolated to annual. Keep in mind tho that this was a 15 year old and regular annual growth is 10 cm per year so almost 2 times assuming the rate keeps but idk this is just for this study. Also yeah he got scoliosis but actually was probably taller than recorded because he got hip deformities that made him slightly shorter at final height but at least nonmembranous bones unaffected tho

This is not healthy, which was the entire basis of me and that guys disagreement, I get the point made, however kyphoscoliosis, severe deformities, lifelong pain / semi ambulatory wheel chair user type lifestyle aren't a reasonable trade off imo

 

[johnlarp1639]

This is not healthy, which was the entire basis of me and that guys disagreement, I get the point made, however kyphoscoliosis, severe deformities, lifelong pain / semi ambulatory wheel chair user type lifestyle aren't a reasonable trade off imo

You're right anyone planning to dose at 4-5 mg is not safe at all if anyone were to take it for height in conjunction with anything else should probably half or split it even more than that dosage if you're desperate and even then its a risk. In your argument you're correct though it's very unhealthy growth just because the mechanism is just targeting all fgfr pathways. Theoretically I wonder if taking it with something like meclizine proven to reduce bone spurs and increase limb and overall skeletal proportionality at least in mice studies could work. Btw most doses for meclizine are far underdosed from what i've seen and mice are given 2mg/kg/day in these studies, which for an 80kg human would be 160mg meclizine. Not sure how this translates at all though and here's one of the studies https://pmc.ncbi.nlm.nih.gov/articles/PMC5547068/

 

[TakaTeo]

You're right anyone planning to dose at 4-5 mg is not safe at all if anyone were to take it for height in conjunction with anything else should probably half or split it even more than that dosage if you're desperate and even then its a risk. In your argument you're correct though it's very unhealthy growth just because the mechanism is just targeting all fgfr pathways. Theoretically I wonder if taking it with something like meclizine proven to reduce bone spurs and increase limb and overall skeletal proportionality at least in mice studies could work. Btw most doses for meclizine are far underdosed from what i've seen and mice are given 2mg/kg/day in these studies, which for an 80kg human would be 160mg meclizine. Not sure how this translates at all though and here's one of the studies https://pmc.ncbi.nlm.nih.gov/articles/PMC5547068/

I think it's one of the cases where taming cereberus (our unfriendly FGFR3) is not worth the effort, as compared to more simplistic and elegant methods (hgh pathways, estrogen modulation to prevent plate fusure, etc) that have a significantly lower rate of issues.

I have some issues from the rate at which I grew, including spinal overgrowth, I'm not describing it perfectly, if wanted ill re-read my old notes (it's a side effect noted in ISS subjects who used Letrozole for high dose in developmental years)
if I recall correctly the studies I replicated also noted blunted serotoninergic signalling, increase in sociopathic tendancy/ irritability and aggressive tendancies, and of course some bone density issues in people, which is similar to original castratos who would lose their gonads to preserve their vocal tone and typically grow unusually tall as a result but often be weak in constitution. Also completely crushed EST makes you insanely depressed, and if it's nuked like completely, then say goodbye to morning wood or even thinking of your dick as anything other than just for pissing , thankfully high enough androgens + low dose Cialis ensured that it was never an issue as my estrogen was kept low enough, I mostly avoided any aromatising compounds anabolics wise.

But honestly the main thing wasn't physical it was psychologically: I did not give a FUCK about the women I spoke or mostly anything at all very nihilistic but insanely low inhib which is likely connected to other types of substance abuse. I just didn't care about people, immediately tried to get two girlfriends at 16 a few months after staring my experimentation which did not sustain when they discovered eachother, I ended up getting with the one I cheated with then cheated again and so on so forth, I think that pattern i would definitely assess to be connected the lack of bonding to be from consistently low estrogen.