Yusu
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Hautalterung durch Infrarotstrahlung?
Auch infrarote Wärmestrahlung kann offenbar - ähnlich wie ultraviolette Strahlung - in Hautzellen Mechanismen auslösen, die zu einer beschleunigten
www.scinexx.de
Apparently, infrared heat radiation can also - similar to ultraviolet radiation - trigger mechanisms in skin cells that lead to accelerated skin aging and perhaps also to cancer development. This is shown in a new study by environmental physicians. The shorter-wave IR-A radiation is particularly harmful. So will we have to protect ourselves from the warming rays of the sun in the future?
The human skin is exposed to infrared radiation every day. The most important source of this infrared (IR) radiation is the sun. Sunlight at sea level contains about 50 percent infrared radiation in addition to the ultraviolet (UV) and visible portion. A large proportion of this is in turn made up of short-wave IRA radiation (700-1400 nm), which, in contrast to IRB and IRC radiation, penetrates deep into the skin.
In addition, humans are exposed to infrared radiation from other sources such as saunas, heaters and ovens. A targeted application of infrared radiation in the medical field must be distinguished from this. There, the heat-generating effect of infrared radiation is used in precisely dosed irradiation - for example in physiotherapy or in the treatment of cancer.
Collagen degradation after heat irradiation
However, while the negative effects of UV radiation on the skin are well known and warnings about them are repeatedly issued by the Radiation Protection Commission and in the media, very little has been known about the molecular effects of infrared radiation on human skin despite its everyday significance. For this reason, scientists at the Institute for Environmental Medical Research (IUF) at the Heinrich Heine University in Düsseldorf initially investigated the effect of IRA radiation on human skin cells (dermal fibroblasts) in cell culture experiments.
These experiments revealed that a mechanism is activated in these skin cells, similar to that known for UV radiation. Thus, after irradiation of the skin cells there was an increased expression of an enzyme collagenase, which is able to break down the protein collagen, an essential component of the connective tissue (e.g. skin).
IRA activates degradation enzyme
In further investigations, the scientists were able to prove that IRA radiation in a physiologically relevant dose range triggers a signaling pathway in cultured human skin cells as well as in healthy human skin, which leads to an increased expression of matrix metalloproteinase-1 (MMP-1). This enzyme breaks down the proteins collagen and elastin in the dermal matrix; increased activity of MMP-1 leads to increased breakdown of connective tissue fibres in the skin and thus to premature skin ageing.
Further work showed that the signal response triggered by IRA radiation is mediated by mitochondria: IRA radiation leads to the formation of reactive oxygen species in the mitochondria of the irradiated skin cells and thus to oxidative stress. This stress response to IRA radiation could be prevented by treatment with certain antioxidants that accumulate in the mitochondria. This finding provides for the first time possibilities for the prevention of skin damage caused by IRA radiation.
Translated with www.DeepL.com/Translator (free version)
