Is anyone running peptides here?

[karbo]

I'm going to be running Ipamorelin + CJC no DAC, Semax and Selank (not all at once) and will add many more later on just to experiment

Tbh i've gotten so used to posting to offtopic, i think with the amount of rotters here, even if the topic is looksmaxxing it's better to post in this section to reach wider audience

 

[kaligula567]

i m running mk 677 (25mg ed) + cjc 1295 dac (5mg per week) but I consider switching to generic hgh from qsc

 

[n9wiff]

CJC no DAC

Isn't DAC better due to higher half-life?

 

[SubhumanForever]

No peptides for your height, my man.

 

[karbo]

Isn't DAC better due to higher half-life?

That's true, its half life is a week as opposed to the no DAC version which is just 30 minutes, but according to multiple personal anectodes from different forums, the general consensus is that no DAC is superior (or more like, healthier/more sustainable for long-term usage) because it triggers GH release rapidly, essentially mimicking a more natural release of GH.

CJC Dac triggers a very long, sustained release of GH, where DNA damage could occur by prolonged stimulation of the pituitary gland. Interestingly, CJC Dac is the one that costs more, for some reason.

 

[karbo]

i m running mk 677 (25mg ed) + cjc 1295 dac (5mg per week) but I consider switching to generic hgh from qsc

Nigga that sounds like extreme overkill. Although I don't know your height and weight, but 25mg mk on it's own is a pretty decent dosage, 5mg per week of CJC DAC on top of that sounds like unhealthy levels and prolonged time of GH release
People usually take 2mg per week

Like at this point, if GH release is your goal just cut these shit research chemical combinations out and pin real GH. I'd stop that protocol immediately and just get real HGH. Turns out it's not that expensive afterall, especially if you order from China, but there are even a few trusted european sites that lab-test their batches and sell legit, branded HGH

 

[n9wiff]

That's true, its half life is a week as opposed to the no DAC version which is just 30 minutes, but according to multiple personal anectodes from different forums, the general consensus is that no DAC is superior (or more like, healthier/more sustainable for long-term usage) because it triggers GH release rapidly, essentially mimicking a more natural release of GH.

CJC Dac triggers a very long, sustained release of GH, where DNA damage could occur by prolonged stimulation of the pituitary gland. Interestingly, CJC Dac is the one that costs more, for some reason.

Yeah it decreases the chances of acromgelay-like symptoms of appearing too die to the lack of chronic elevation.

CJC Dac probably coats more due to demand, because of the less frequent pinning advantage.

 

[kaligula567]

Nigga that sounds like extreme overkill. Although I don't know your height and weight, but 25mg mk on it's own is a pretty decent dosage, 5mg per week of CJC DAC on top of that sounds like unhealthy levels and prolonged time of GH release
People usually take 2mg per week

it combines ghrp (mk677) and ghrh (cjc dac) witch according to literature can replicate a moderate dose of hgh. 5mg is a moderate dose. I m injecting 2.5 mg 2x per week. 5'11 , 16.6 y/o btw

 

[karbo]

CJC Dac probably coats more due to demand, because of the less frequent pinning advantage.

Yeah, you are probably correct on that although I don't really get this 'wanting to pin less frequently' mentality, I think pinning multiple times a day sounds fun as fuck

 

[karbo]

No peptides for your height, my man.

Actually, peptides are the ONLY thing for your height, in general. For me at age 21 tho you are right. It's over

 

[SubhumanForever]

Actually, peptides are the ONLY thing for your height, in general. For me at age 21 tho you are right. It's over

Did you ascend btw or are you still incel?

 

[karbo]

Did you ascend btw or are you still incel?

Nigga how do you even know who tf I am. probably alt accountmaxxing
Depends on your definition of 'ascension'
If it's NT-tier extroversion and ability to regularly pull decent looking bitches and JBs then sure I've ascended years ago
Otherwise I've never felt worse mentally. I wanna die everyday

 

[karbo]

it combines ghrp (mk677) and ghrh (cjc dac) witch according to literature can replicate a moderate dose of hgh. 5mg is a moderate dose. I m injecting 2.5 mg 2x per week. 5'11 , 16.6 y/o btw

when did you start this protocol and what improvements have you noticed? any sides?

 

[kaligula567]

when did you start this protocol and what improvements have you noticed? any sides?

3 months ago I used this and aromasin 6.25 mg. I went from 5'10 (178cm) to almost 5'11 (180cm) sides were only in the first couple weeks (lethargy, bad sleep...)

 

[karbo]

3 months ago I used this and aromasin 6.25 mg. I went from 5'10 (178cm) to almost 5'11 (180cm) sides were only in the first couple weeks (lethargy, bad sleep...)

mirin dedication

 

[kaligula567]

mirin dedication

yes, here in the balkans 5'11 is 5'9 in america

 

[balding17yomanletcel]

Caging hard rn

 

[Cyrus]

That's true, its half life is a week as opposed to the no DAC version which is just 30 minutes, but according to multiple personal anectodes from different forums, the general consensus is that no DAC is superior (or more like, healthier/more sustainable for long-term usage) because it triggers GH release rapidly, essentially mimicking a more natural release of GH.

CJC Dac triggers a very long, sustained release of GH, where DNA damage could occur by prolonged stimulation of the pituitary gland. Interestingly, CJC Dac is the one that costs more, for some reason.

yeah if u want 5 needles up your ass ed go for it

 

[karbo]

yeah if u want 5 needles up your ass ed go for it

people with severe diabetes have been injecting insulin up to 4-5 times every single day, bitch nigger

 

[Cyrus]

people with severe diabetes have been injecting insulin up to 4-5 times every single day, bitch nigger

so?

 

[jattlife]

peptides are a waste of money ngl. u can fap around with bromantane and semax if u want but who rly gives a fuck

bpc is based tho i hear

 

[IntelligentCel]

I have used GHRPs in the past. Now I'm using direct HGH, 5 IUs a day.

 

[Dyorotic]

Semax is very good. Try Dihexa if you can source it, it's like if cerebrolysin and Semax made a baby and then injected it with TREN

 

[chincel11]

I'm going to be running Ipamorelin + CJC no DAC, Semax and Selank (not all at once) and will add many more later on just to experiment

Tbh i've gotten so used to posting to offtopic, i think with the amount of rotters here, even if the topic is looksmaxxing it's better to post in this section to reach wider audience

Any update

 

[balding17yomanletcel]

another banger by karb

 

[TsarTsar444]

another banger by karb

Sweet kerbo

 

[balding17yomanletcel]

Sweet kerbo

fuck are you still rotting

 

[karbo]

Semax is very good. Try Dihexa if you can source it, it's like if cerebrolysin and Semax made a baby and then injected it with TREN

For enhanced brain function and cognitive effects? What's your experience with it? My vendor has it for pretty cheap, I might look into it and get some

Any update

Pinning 2-3 times a day, indirectly helps mental well-being by improved sleep quality, and significant noticeable changes in exercise output and energy levels in general

 

[Dyorotic]

For enhanced brain function and cognitive effects? What's your experience with it? My vendor has it for pretty cheap, I might look into it and get some

Pinning 2-3 times a day, indirectly helps mental well-being by improved sleep quality, and significant noticeable changes in exercise output and energy levels in general

We probably have the same vendor, 400mg for like 85USD

It's a really subtle drug but infinitely better than any nootropic slop that isn't a pharmaceutical. It synergises well with stimulants and makes you feel very awake and happy. It works via global BDNF upregulation

Dihexa though, absolutely life-changing indescribable drug.

 

[karbo]

400mg for like 85USD

I assume you are talking about the very high dose vials? I've seen 40mg/vial (10vial/kit) Semax go for 100 USD but I opted for the 10mg ones. I doubt I will use them all up anyway
Have you tried both subq and nasal? Currently experimenting with subq selank, in a few days I will try subq semax.
Haven't really dug too deep in the topic but read something about their cognitive beneficts being more significant when applied nasally?

Also, I have lots of different vendors, but the one who offers 400mg Semax for 100 USD doesn't offer Dihexa

Can you tell more about your experiences with Dihexa? Currently looking into it as well as P21. My brain could definitely use them, after some time of drug abuse and prolonged sleep deprivation

 

[Dyorotic]

I assume you are talking about the very high dose vials? I've seen 40mg/vial (10vial/kit) Semax go for 100 USD but I opted for the 10mg ones. I doubt I will use them all up anyway
Have you tried both subq and nasal? Currently experimenting with subq selank, in a few days I will try subq semax.
Haven't really dug too deep in the topic but read something about their cognitive beneficts being more significant when applied nasally?

Also, I have lots of different vendors, but the one who offers 400mg Semax for 100 USD doesn't offer Dihexa

Can you tell more about your experiences with Dihexa? Currently looking into it as well as P21. My brain could definitely use them, after some time of drug abuse and prolonged sleep deprivation

Yeah we're talking about Tracy lmfao

The thing with Semax and Selank is that in their base form they have really short half-lives and don't have the BBB penetrability that the N-acetylated and amidated versions have. Na-Semax(& Selank)-Amidate is the strongest variant, it has a longer half life and way better occupancy rates at the receptors as well as hightened permeation of the blood brain barrier. With these versions subq administration is fine

Tracy sells n-acetyl amidate versions of both but they're out of stock at the moment

Dihexa is a whole other beast in terms of it's effect on neurogenesis. It is infinitely more neurogeneic than cerebrolysin, Semax and P21. It works via hepatocyte growth factor (HGF) where it acts as a positive allosteric modulator for c-met. It penetrates the blood brain barrier easily. Supposedly it's seven orders of magnitude stronger than BDNF at inducing neurogenesis

The way I'd describe Dihexa is pure serenity, it's like everything becomes more pronounced. Colors are almost double as vibrant and it can get scary at times because it feels so surreal. Reaction speed is up, reflexes are up, cognitive processing is way up. I just don't care about anything, nothing that use to be cortisol inducing scares me anymore. It's the best thing I've ever tried

the caveat is that it is isanely tedious to administer. It has borderline zero oral bioavailability, it isn't water soluble at all so it doesn't really work intranasally and it won't work sublingually too. It's only soluble in DMSO and it needs to either be injected (that'd hurt bad) or applied topically. I do about 20mg/ml of dmso and apply about .5 ml on my ballsack daily (no joke ballsack has the highest rate of absorbance via transdermal drug delivery). It's annoying but worth it imo

What I do nowadays is 1.5mg NA-Semax-amidate in the morning subq and the Dihexa solution on my nuts. DMSO eviscerates all the hair on my nutsack so it's always clean shaven JFL

Ideally a stack for healing the brain would be a combination of GH, BPC157 (.75 - 1mg range) and Dihexa with Semax and if you can be assed cerebrolysin and P21. I can't find p21 so if you have sources that are cheap please drop em

 

[karbo]

Yeah we're talking about Tracy lmfao

The thing with Semax and Selank is that in their base form they have really short half-lives and don't have the BBB penetrability that the N-acetylated and amidated versions have. Na-Semax(& Selank)-Amidate is the strongest variant, it has a longer half life and way better occupancy rates at the receptors as well as hightened permeation of the blood brain barrier. With these versions subq administration is fine

Tracy sells n-acetyl amidate versions of both but they're out of stock at the moment

Dihexa is a whole other beast in terms of it's effect on neurogenesis. It is infinitely more neurogeneic than cerebrolysin, Semax and P21. It works via hepatocyte growth factor (HGF) where it acts as a positive allosteric modulator for c-met. It penetrates the blood brain barrier easily. Supposedly it's seven orders of magnitude stronger than BDNF at inducing neurogenesis

The way I'd describe Dihexa is pure serenity, it's like everything becomes more pronounced. Colors are almost double as vibrant and it can get scary at times because it feels so surreal. Reaction speed is up, reflexes are up, cognitive processing is way up. I just don't care about anything, nothing that use to be cortisol inducing scares me anymore. It's the best thing I've ever tried

the caveat is that it is isanely tedious to administer. It has borderline zero oral bioavailability, it isn't water soluble at all so it doesn't really work intranasally and it won't work sublingually too. It's only soluble in DMSO and it needs to either be injected (that'd hurt bad) or applied topically. I do about 20mg/ml of dmso and apply about .5 ml on my ballsack daily (no joke ballsack has the highest rate of absorbance via transdermal drug delivery). It's annoying but worth it imo

What I do nowadays is 1.5mg NA-Semax-amidate in the morning subq and the Dihexa solution on my nuts. DMSO eviscerates all the hair on my nutsack so it's always clean shaven JFL

Ideally a stack for healing the brain would be a combination of GH, BPC157 (.75 - 1mg range) and Dihexa with Semax and if you can be assed cerebrolysin and P21. I can't find p21 so if you have sources that are cheap please drop em

Thanks for the extremely detailed response, you've given me some great insights. Although there are some worrying informations about Dihexa, specifically its ability to potentially accelerate already-existing cancerous cells

About the N-Acetyl-Amidate forms of Semax/Selank, I have heard mixed opinions whether which ones are better suited for these purposes, however my research is definitely not up to date, I can't comment on it but I will look into it further. I have a vendor that has both forms in stock at the moment for a pretty good price (10 vials), I will share it with you later, I just have to deal with some stuff urgently now

What you shared about Dihexa sounds pretty fascinating, you've got me very interested, and I might just go and pick up some. I've read many anecdotes, both positive and neutral.
May I ask how much have you paid for your Dihexa, and how often do you apply the solution? I've read reports of people using it just once a week, or even daily, so just curious about your own protocol.
I've just messaged a bunch of vendors an hour ago and already got a quotation for 90 USD per gram of Dihexa, which sounds pretty decent

Since I'm already running GH secretagogues (Ipa/Mod GRF) I am not going to be using GH, trying to negate potential side effects that could arose by using straight GH, as opposed to the secretagogues I've just listed

As for the BPC, I've read some worrying side effects regarding anhedonia, worsening of certain autoimmune disorders (of which I probably have a few, specifically histamine related, as well as gut dysbiosis called SIBO) so at this time I am taking it slow and only introducing one new compound at a time

I see you didn't really mention Selank, I suppose that's because your experiences with Dihexa have been so good it's useless to even bother with it? In that case, should I even bother with the NA Amidate forms of Semax and Selank if I am also going to try Dihexa?

 

[balding17yomanletcel]

should i inject ketamine

yes

 

[Dyorotic]

The person in that first image you posted doesn't know what he's talking about. Dihexa doesn't work via TrKB. Dihexa is a positive allosteric modulator at c-met. It makes HGF bind at a higher and more consistent rate. Benzodiazepines work the same way, they attach to BZD receptors and increase GABA's affinity for GABAa

Technically Dihexa should be potently carcinogenic because we know aberrant expression of HGF is correlated with cancer but there hasn't been a single shed of evidence to suggest it causes cancer. It never ended up inducing a clinically signifcant amount of neoplasia in any of the studies. t's all speculative, that doesn't mean the risk isn't there, it absolutely is. It depends on your risk tolerance

About the N-Acetyl-Amidate forms of Semax/Selank, I have heard mixed opinions whether which ones are better suited for these purposes

You can try all of them. I've read anecdotes of people who think there are substantial differences between all the iterations but that isn't the case, you just need less of the NA-Amidate versions to get the same result as the original ones.

I've just messaged a bunch of vendors an hour ago and already got a quotation for 90 USD per gram of Dihexa, which sounds pretty decent

yep that's the exact price I buy mine from. 90USD is what the legitimate vendors charge

Since I'm already running GH secretagogues (Ipa/Mod GRF) I am not going to be using GH, trying to negate potential side effects that could arose by using straight GH, as opposed to the secretagogues I've just listed

GH nowadays is actually cheaper than CJC dac and other GHRH/GHRP analogues, it's wild. I prefer GH over peptides simply because it isn't affected by eating food.

But yeah if you want to use peptides go for it, they're just as good as GH.

As for the BPC, I've read some worrying side effects regarding anhedonia, worsening of certain autoimmune disorders (of which I probably have a few, specifically histamine related, as well as gut dysbiosis called SIBO)

Dude, get LL37. It's an endogenously produced anitmicrobial peptide that bacteria essentially cannot build tolerance/resistance to. It is the most potent biofilm distrupter which means it will eviscerate any overgrowth in your small intestines. On top of it's antimicrobial activity it is potently antifungal, I've seen/read multiple anecdotes of people who have cleared all of their candida/fungus with just a couple dosages. It is probably the most anti-inflammatory peptide because it downregulates almost all interleukins.

So it's antimicrobial, antinflammator, anti-fungus, anti-mold, anti-tumour. It kills almost all p.acnes bacteria (so it's good for acne).

I had severe digestive issues and on LL37 I can eat whatever the fuck I want and never have any problems. I had methane dominant SIBO, which is all gone now. BPC157 is mandatory too because it's so fucking potent at healing the gut. Tracy sells LL37 for cheap.
100-200mcg a day for 8 weeks and you'll be cured.

I see you didn't really mention Selank, I suppose that's because your experiences with Dihexa have been so good it's useless to even bother with it?

Selank is great. It's very good at modulating inflammation within the brain specfically. Selank is supposedly equipotent at inducing anxiolysis as benzos, I find that difficut to believe but that's what the research suggests.

In that case, should I even bother with the NA Amidate forms of Semax and Selank if I am also going to try Dihexa?

Stil get them, they're so cheap it doesn't even matter. Dihexa is just operating in a realm way beyond them.

Another good drug you should look into is ISRIB. In people with brain damage or those who have experienced traumatic brain injuries a process called the integrated stress response is hyperactive. It essentially halts protein synthesis globally, which is speculated to be one of the reasons why cognitive decline is so prominant with these injuries. The integrated stress response is also responsible for fighting viruses because by inhibting protein synthesis it stops the replication of viruses but if you've got something like HIV, Epstein-bar or long covid, ISR is chronically activated leading to severe cognitive deficits. Inhibting ISR leads to a massive induction of protein synthesis and almost completely reverts cognitive deficts in people with TBI.

They gave old rats ISRIB and they basically performed as though they were adolescent rats, there was no discernable difference between the two groups. It is the most powerful tool for cognitive enhancement and can help reset the brain after damage/drug abuse etc etc.

I'll be getting ISRIB soon because I have an essential tremour after abusing the absolute fuck out of baclofen and pregabalin (multiple grams of PG a day)

Anyway get Dihexa for sure it's fucking beautiful

 

[karbo]

Sorry it took so long to get back to you, I actually had a brutal SIBO flare-up after consuming a fuckload of carbs and was bedridden for a while

The person in that first image you posted doesn't know what he's talking about. Dihexa doesn't work via TrKB. Dihexa is a positive allosteric modulator at c-met. It makes HGF bind at a higher and more consistent rate. Benzodiazepines work the same way, they attach to BZD receptors and increase GABA's affinity for GABAa

Technically Dihexa should be potently carcinogenic because we know aberrant expression of HGF is correlated with cancer but there hasn't been a single shed of evidence to suggest it causes cancer. It never ended up inducing a clinically signifcant amount of neoplasia in any of the studies. t's all speculative, that doesn't mean the risk isn't there, it absolutely is. It depends on your risk tolerance

Thanks for the info. Sounds like you did your homework. Between all the available compounds out there + this debiliating chronic gut disorder I've been battling for a rather long time, it gets exhausting to not only do the research, but also memorize it all so in the end you actually can come up with a final protocol on how to proceed

GH nowadays is actually cheaper than CJC dac and other GHRH/GHRP analogues, it's wild. I prefer GH over peptides simply because it isn't affected by eating food.

But yeah if you want to use peptides go for it, they're just as good as GH.

Yeah, it's actually pretty fucking wild to me how the prices significantly went down in the past few years. I remember being 16 and on this forum, and barely any threads were talking about HGH, and if they were, it was incompetent people spewing the usual bullshit about "chinese sources being ratpiss", no mentions about any chinese chemical supply sites other than alibaba (come on), meanwhile China, among some other asian territories are literally the biggest exporters of chemical compounds globally, and it's pretty likely that some of the medications (or their precursors) these schizos are taking on the daily were synthesized by such chinese superlabs.

This combined with the fact that at 15-16 I didn't have much money, I ended giving up about all this GH shit and just went on my way growing up like a normal person. Youngcels on this site are lucky as fuck, since the site has now massively knowledgeable users with personal anecdotes, who are willing to spoonfeed them on how to purchase and administer dirt cheap growth hormone at the age where it will actually make a difference to their height

Dude, get LL37. It's an endogenously produced anitmicrobial peptide that bacteria essentially cannot build tolerance/resistance to. It is the most potent biofilm distrupter which means it will eviscerate any overgrowth in your small intestines. On top of it's antimicrobial activity it is potently antifungal, I've seen/read multiple anecdotes of people who have cleared all of their candida/fungus with just a couple dosages. It is probably the most anti-inflammatory peptide because it downregulates almost all interleukins.

So it's antimicrobial, antinflammator, anti-fungus, anti-mold, anti-tumour. It kills almost all p.acnes bacteria (so it's good for acne).

Yes, I've read about LL37, but again, the information (or lack thereof) about these peptides is really making it extremely hard to ultimately make the decision whether you will be taking them or not. Not because of financial reasons, rather than health, as many such cases have demonstrated that some people royally fucked themselves further by introducing some compound into their system that wasn't supposed to be there (including me, done that in the past and needed months to recover)

I will definitely be ordering LL37 because it's cheap and to be honest my SIBO/gut symptoms at times are unbearable and make life not worth living, but I am really not sure what to expect. I've read anecdotes on reddit, some guy talking about how a few doses completely ruined his life (JFL, didn't read much further tho, not sure what that one was about), and an other guy saying LL37 worsens SIBO. Obviously my research is barely scratching surface level, so not really sure, but at this point I am ready to throw off different compounds at my body in hopes of getting better.

It would probably also help if I had an actual understanding of this field, so I wouldn't have to lean onto personal anecdotes on reddit, and actually understand and interpret all the biochemical terms correctly they mention in the various available scientific articles.

I had severe digestive issues and on LL37 I can eat whatever the fuck I want and never have any problems. I had methane dominant SIBO, which is all gone now. BPC157 is mandatory too because it's so fucking potent at healing the gut. Tracy sells LL37 for cheap.
100-200mcg a day for 8 weeks and you'll be cured.

My protocol currently, is that I have a 100g bag of Rifaximin on the way to me from China.

High dosage rifaximin for the treatment of small intestinal bacterial overgrowth - PubMed

Rifaximin 1600 mg/day showed a significantly higher efficacy for small intestinal bacterial overgrowth treatment with respect to 1200 mg with similar compliance and side-effect profile.

pubmed.ncbi.nlm.nih.gov

The usage of Rifaximin in treatment of SIBO and other similar gut disorders is almost globally approved, even in my shit poor east european country a private gastroenterologist prescribed it once (although, despite trying to sweet talk, they refused not going according to the protocol, which in my country is a fucking ridiculous SIX DAY TREATMENT OF 800MG DAILY. While american studies are using not only DOUBLE of that dose, but also instead of 6 days, it's 14.
And even then, people need to repeat the courses even up to 3 or 4 times.

Those 6 days of taking pharma rifaximin actually gave my life back for a few days, so since it's clearly a much more researched compound, I am giving this a go first. Not sure if I should just order LL37 right now in case I am not satisfied with the Rifaximin results, but I think I will, since due to your post, I want to try the NA version of Selank, so why not order these peptides all at once.

BPC I am not sure about, there have been reports about it causing issues with histamine?
And for some unknown reason, I have a feeling I have histamine intolerance, although I have not been tested for it

Selank is great. It's very good at modulating inflammation within the brain specfically. Selank is supposedly equipotent at inducing anxiolysis as benzos, I find that difficut to believe but that's what the research suggests.

Dude, selank is something fucking else. I injected 500mcg in the morning and 500mcg just half an hour ago, and the feeling of it is something indescribable. I am a fan of all compounds that modulate GABA in some way, used to love Phenibut until it obliterated my stomach, benzos, alcohol, whatever. But injected Selank? You don't feel "high" on it. People call Phenibut 'subtle' but this feels like an improved version of "being normal".
It's like, my tolerance for anxiety inducing events is WAY higher. Socialization and speech abilities just simply go up in a manner you don't even actively notice. And the simple mental well-being just feels very relaxing.

But according to the simple rules of the universe, something that gives this much of a boost cannot be taken indefinitely. In fact, 3 days ago I had such a fucking amazing experience when injecting 300mcg Selank in the morning I still keep thinking about how good I felt that day. Now it's day 3 and I can already tell the effects are less pronounced.

I am not interested in trying NA-Semax, because it is my understanding that semax is more used for its cognitive repairing effects, which is going to be rather useless for me, since in my 100g Rifaximin order, in the last minute I managed to ask the vendor to include a gram of Dihexa (paid 100 USD for it).

Thanks for bringing my attention to this compound, I don't think I would have ordered Dihexa if it weren't for you, since it is very rarely discussed

However, NA-Selank definitely has my attention, as I have read that it not only is more potent but lasts longer. I really feel like Selank is something like you should only take every once in a while, but I guess experimentation will show me what's the ideal dosing frequency

Another good drug you should look into is ISRIB. In people with brain damage or those who have experienced traumatic brain injuries a process called the integrated stress response is hyperactive. It essentially halts protein synthesis globally, which is speculated to be one of the reasons why cognitive decline is so prominant with these injuries. The integrated stress response is also responsible for fighting viruses because by inhibting protein synthesis it stops the replication of viruses but if you've got something like HIV, Epstein-bar or long covid, ISR is chronically activated leading to severe cognitive deficits. Inhibting ISR leads to a massive induction of protein synthesis and almost completely reverts cognitive deficts in people with TBI.

They gave old rats ISRIB and they basically performed as though they were adolescent rats, there was no discernable difference between the two groups. It is the most powerful tool for cognitive enhancement and can help reset the brain after damage/drug abuse etc etc.

I'll be getting ISRIB soon because I have an essential tremour after abusing the absolute fuck out of baclofen and pregabalin (multiple grams of PG a day)

Hahaha, thanks for this recommendation, aswell as the information, it was very informative! I wouldn't want to mess around with compounds though that are very under-researched, when my conditions simply do not justify it.
It's understandable you are researching it, GABA-related brain damage is no fucking joke, but my type of possible brain damage is stimulant induced

 

[Dyorotic]

chinese sources being ratpiss

This made me cage IRL because I'm literally dyorotic2 and this is what everyone said to me when I talked about GH from china

the information (or lack thereof) about these peptides is really making it extremely hard to ultimately make the decision whether you will be taking them or not. Not because of financial reasons, rather than health

I can totally understand the apprehension. LL37 in particular scares the fuck out of me because we literally don't know whether it becomes pro-inflammatory at higher dosages or retains it's antiinflammatory profile. It's also potentially implicated in alzheimers so yeah not ideal at all. The thing is, nothing has healed my SIBO/SIFO/gut issues like LL37 and BPC. They're just so powerful.

some guy talking about how a few doses completely ruined his life (JFL, didn't read much further tho, not sure what that one was about), and an other guy saying LL37 worsens SIBO

Don't listen to this garbage tbh. These types of people are also the same group who end up with permanently numb penises after discontinuing finasteride. In other words they're schizophrenics who are incredibly susceptible to psychosomatic afflictions.

LL37 is an endogenous peptide, it functions as one of many antimicrobial peptides. It's part of the cathelicidin family

My protocol currently, is that I have a 100g bag of Rifaximin on the way to me from China.

Very good choice. Rifa is very selective to the gut microbiome IIRC, meaning less antibiotic action throughout the rest of the body.

Those 6 days of taking pharma rifaximin actually gave my life back for a few days

This is actually an incredible sign, you understand that right?

Not sure if I should just order LL37 right now in case I am not satisfied with the Rifaximin results, but I think I will, since due to your post, I want to try the NA version of Selank, so why not order these peptides all at once.

LL37 in conjunction with a antibiotic is probably the most powerful tool we currently have against antibiotic resistance. LL37 at just 150mcg with the combined therapy of Rifa will ensure that the bacteria don't gain resistance.

If you have the time/energy (I know the brainfog/fatigue is unforgiving with SIBO) read this study

Dude, selank is something fucking else

This is probably indicative of neuroinflammation. Selank is derived from tufstin which is an endogenous neuromodulating peptide that is specifically quite good at abating inflammation within the brain. Selank is obviously altered to be a LOT stronger than tufstin. In multiple studies it has been proven to be AS effective as benzos and upregulates the expression of a shit tonne of GABA genes.

Thanks for bringing my attention to this compound, I don't think I would have ordered Dihexa if it weren't for you, since it is very rarely discussed

Oh by the way our source just started selling Dihexa (on the 15th of August) but I missed it because finding the pricelist is a behemoth task nowadays. Anyway they charge 70usd per gram, which is the best price I've seen yet.

Dihexa is probably the most healing substance I've come across. I can't stress enough the importance of transdermal delivery though, this thing won't be absorbed any other way. I fucking reel with cringe when people on r/Nootropics and other gay subreddits take it orally or snort it and say some aids shit like "didn't do a thing don't waste your money". Whatever, less people experiencing pure bliss is better for us anyway

However, NA-Selank definitely has my attention, as I have read that it not only is more potent but lasts longer. I really feel like Selank is something like you should only take every once in a while, but I guess experimentation will show me what's the ideal dosing frequency

NA-Selank is better and far more sustainable. You can push the dose higher btw, there are tonnes of ADHD protocols that implement 3mg+ of Selank and apparently reverse all of their issues with attention/focus etc etc.

Hahaha, thanks for this recommendation, aswell as the information, it was very informative! I wouldn't want to mess around with compounds though that are very under-researched, when my conditions simply do not justify it.

Yeah that's fair. I have a retarded risk tolerance and I do experiment a lot.

 

[karbo]

This made me cage IRL because I'm literally dyorotic2 and this is what everyone said to me when I talked about GH from china

Holy FUCK nigga. Now that is some news; I haven't heard your name in a while but it doesn't surprise me you kept this passion of biochemistry of yours. May I ask, did you go on to formally study such a field? I settled for cybersecurity engineering (starting this sept) but fear that it won't invoke enough passion to keep me studying

I used to be much more up to date on biochemistry terms and expressions but my knowledge is now shit-tier due to memory problems

I can totally understand the apprehension. LL37 in particular scares the fuck out of me because we literally don't know whether it becomes pro-inflammatory at higher dosages or retains it's antiinflammatory profile. It's also potentially implicated in alzheimers so yeah not ideal at all. The thing is, nothing has healed my SIBO/SIFO/gut issues like LL37 and BPC. They're just so powerful.

Yeah, it is some extremely powerful stuff. Anyway, I was just about to impulsively order from BPC, LL37, N-A Selank Amidate and GHKcu powder, when I noticed, that the new price catalog that you mentioned, has N-A Selank out of stock.

Fuck, I shouldn't have waited at all. It was probably in stock just a few days ago, now it's vendor searching all over again, thing is, NA Selank Amidate is such a specific product, zero vendors on my list have it atm.

Don't listen to this garbage tbh. These types of people are also the same group who end up with permanently numb penises after discontinuing finasteride. In other words they're schizophrenics who are incredibly susceptible to psychosomatic afflictions.

That's actually the exact theory I had in mind. You know I follow a broad range of communities online to get a little insight into people's minds who are different from me, among many, one is PSSD (that's just one example)
Since I myself had psychosomatic symptoms at one point (which disappeared after I further educated myself on the topic of distress) I came to the conclusion that the mind is a powerful tool.

Didn't take seriously the "few doses of LL37 ruined my life" guy, however the one that was all about spewing shit about how it worsens SIBO worried me a bit, because I just cannot afford the time to try another compound, potentially get a flare up/worsening of symptoms that lasts weeks and requires further weeks to correct.
Uni is starting in 10 days, and with this condition + the fact that I am tapering from benzos, I can't risk being royally fucked by brain fog.
(I use a substance called norflurazepam for tapering, it's got triple digit hours long half life, but I am not out of the woods yet and still have to take it daily to not experience withdrawal

Very good choice. Rifa is very selective to the gut microbiome IIRC, meaning less antibiotic action throughout the rest of the body.

This is actually an incredible sign, you understand that right?

Sure I do, it's just, after almost a year of this shit you start to lose hope. I mean, the chemical properties (specifically the color) match the color of the product I am going to receive, but other than that I can't confirm whether it's truly rifaximin, and if so how what purity. Then there is the problem of actually getting the package; since it's not on my name and address it will be tricky and will have to do some social engineering with the delivery person, which although have a 0% failure rate in my case, in times like this my confidence drops

LL37 in conjunction with a antibiotic is probably the most powerful tool we currently have against antibiotic resistance. LL37 at just 150mcg with the combined therapy of Rifa will ensure that the bacteria don't gain resistance.

If you have the time/energy (I know the brainfog/fatigue is unforgiving with SIBO) read this study

I stumbled upon that actually, but haven't taken the time to read it all. Will do, thanks.
You think they should be used together?

This is probably indicative of neuroinflammation. Selank is derived from tufstin which is an endogenous neuromodulating peptide that is specifically quite good at abating inflammation within the brain. Selank is obviously altered to be a LOT stronger than tufstin. In multiple studies it has been proven to be AS effective as benzos and upregulates the expression of a shit tonne of GABA genes.

That is interesting. Could you elaborate on what neuroinflammation pertains exactly?
I know that there is a direct correlation between my gut state and brain; the worse flare-up I get, the more my mood and cognitive capabilities get obliterated, in LITERALLY real time.
I could give a well-articulated eloquent speech, have a meal that triggers something bad and within 30 minutes I start to be unable to remember words, stutter more, and so on.

Also, it's confusing to me that it UPREGULATES gaba? What's the catch? Sounds too good to be true

Oh by the way our source just started selling Dihexa (on the 15th of August) but I missed it because finding the pricelist is a behemoth task nowadays. Anyway they charge 70usd per gram, which is the best price I've seen yet.

Dihexa is probably the most healing substance I've come across. I can't stress enough the importance of transdermal delivery though, this thing won't be absorbed any other way. I fucking reel with cringe when people on r/Nootropics and other gay subreddits take it orally or snort it and say some aids shit like "didn't do a thing don't waste your money". Whatever, less people experiencing pure bliss is better for us anyway

Yeah, I am aware, it's a pretty good price, and given the fact how trustworthy the vendor is, I am pissed as fuck that I couldn't manage to come to a decision sooner and pull the plug on NA-Selank.

Anyway, yeah, I already have a 100ml DMSO liquid bottle at home, I read about its transdermal efficiency, so obviously I am doing that way. I can understand (actually can't really) people's excessive want to avoid self-administering using needles, but why the fuck would you not do transdermal when it's confirmed to be bioavailably superior?

NA-Selank is better and far more sustainable. You can push the dose higher btw, there are tonnes of ADHD protocols that implement 3mg+ of Selank and apparently reverse all of their issues with attention/focus etc etc.

Fuck this shit. Really hope NA Selank will be in stock soon again. Brb injecting 1mg Selank + 1mg Semax
Jokes aside, could you show me some protocols that do use such high dosages? I mean, I thought 1mg (divided into two doses) in a day was rather high

I have a retarded risk tolerance

I wouldn't say that at all. A retarded risk tolerance would be, for example, the youngcel who posted about injecting 4 peptides at the same time into himself, without having a single clue (surface level understanding at most) of what they are actually doing.

What you do is extensive research, assess as best based on your judgement, then execute your potentially risky plans, in hopes of directly attaining superior biochemical functions in your body, something that other people never even consider, let alone be able to conceptualize what the fuck that is, as they were led to believe simply eating well and exercising is the creme de la creme of health.
I respect the fuck out of that, and if my conditions justified it, I wouldn't draw any lines on where I would stop with the experiments

 

[6PSLcel]

I'm going to be running Ipamorelin + CJC no DAC, Semax and Selank (not all at once) and will add many more later on just to experiment

Tbh i've gotten so used to posting to offtopic, i think with the amount of rotters here, even if the topic is looksmaxxing it's better to post in this section to reach wider audience

What do all those things do bhai ? I don’t know much about peptides

 

[Dyorotic]

I settled for cybersecurity engineering (starting this sept) but fear that it won't invoke enough passion to keep me studying

Mining engineering is what I did, never cared for pharmacology or anything like that professionally

Fuck, I shouldn't have waited at all. It was probably in stock just a few days ago, now it's vendor searching all over again, thing is, NA Selank Amidate is such a specific product, zero vendors on my list have it atm.

Yeah no one really sells it. But definitely do buy the NA versions they're a lot better.

one is PSSD (that's just one example)

PSSD is one I wholeheartedly believe in because it changes the expression of SERT over time, leading to a massive, negative shift in neurotransmission. With 5ar inhibitors they're only removing an enzyme.

Didn't take seriously the "few doses of LL37 ruined my life" guy, however the one that was all about spewing shit about how it worsens SIBO worried me a bit, because I just cannot afford the time to try another compound, potentially get a flare up/worsening of symptoms that lasts weeks and requires further weeks to correct.

Yes do your due diligence and read as much as you can about it. It's a gamble obviously but I had combined methane and hydrogen SIBO and after doing a round of LL37 (didn't touch antibiotics) I was cleared completely

BPC in general is just incredibly potent and healing any and all aliments in the gut, no point not using it.

Uni is starting in 10 days, and with this condition + the fact that I am tapering from benzos

Fuck, condolences for the benzo taper. Some brutal stuff no doubt. I had a massive pregabalin issue where I was using multiple GRAMS of it daily to function (therapeutic dosage is around 75-600mg), I was on about 1.5-2g. Tapered in about a month and jumped off with baclofen 50mg and then dropped the baclofen rapidly. I've got an essential tremor now which is what I'm attempting to heal with Dihexa and ISRIB.

Okay I've got some amazing tips for you in terms of benzo withdrawal. If you can get your hands on memantine, GET IT. It's so powerful at abating benzo withdrawals because the main reason withdrawal is so unforgiving is due to the dysregulation of glutamate in response to the deprival of GABA transmission. GABA(a) receptors downregulate rapidly on benzodiazepines and after the discontinuation you're basically in hyper-glutamatergic state, whereby glutmate is rampant; this is where all the symptoms derive from

Memantine is a non-competitive antagonist at NDMA receptors which means it won't cause dissociation like ketamine (a full antagonist) but it will completely normalise abarant activation of the receptors by glutamate

Next is BPC157, yep, it heals the GABAergic system by upregulating GABA(b) receptors allowing for a greater deal of gaba transmission. It also acts as a neurogenic so it's helpful in that regard as well.

Seroquel: this'll make sure you actually sleep. It's not really habit forming so you can taper very rapidly and still sleep correctly.

GH/GH peptides: Growth hormone sensitizes the brain to GABA and also increases rem sleep by 50% (astounding number) and deep sleep also goes up, the onset of sleep hastens and sleep maintenance improves drastically. GH also synergises well with growth factors like BDNF. So Semax + GH/peptides will work fantastically for brain issues/tapering off neuropsychiatric drugs.

The last is clonidine, this will normalise norepinephrine signalling in the brain because by agonising a2 receptors in the brain it downregulates the release of noradrenaline and adrenaline.

You may be able to do all this without these substances but if you don't want to suffer memantine helps a fuck tonne. All this helped me get off pregabalin which imo (I don't know what doses you're at) my predicament was probably worse than yours.

Sure I do, it's just, after almost a year of this shit you start to lose hope. I mean, the chemical properties (specifically the color) match the color of the product I am going to receive, but other than that I can't confirm whether it's truly rifaximin, and if so how what purity

You can always get it tested by Janoshik. Look it up.

I would order indian generics of antibiotics though, not from China. But if you did buy from QSC don't worry, there products are always legit.

That is interesting. Could you elaborate on what neuroinflammation pertains exactly?

SIBO causes global inflammation. You'll be inflammed everywhere, including your brain. This is why people with SIBO always complain about fatigue and brainfog. Selank downregulates interleukins in the brain by a huge margin.

Also, it's confusing to me that it UPREGULATES gaba? What's the catch? Sounds too good to be true

Yeah it changes the expression of a fuck tonne of genes, all the gaba genes, so GABBR2, GABRA1, GABRA2 etc, are all slightly upregulated. Overall it's quite positive, some things like gaba reuptake transporters are slightly upregulated which means less GABA transmission but that'd be offset mostly by the receptors being sensitized.

but why the fuck would you not do transdermal when it's confirmed to be bioavailably superior?

DMSO reeks like crazy and hurts a lot, but yeah no pain no gain + injecting is annoying and time consuming.

Fuck this shit. Really hope NA Selank will be in stock soon again. Brb injecting 1mg Selank + 1mg Semax

1mg of NA-Semax potentiates the fuck out of all my other drugs. Feels like low dose amphetamine almost but it isn't neurotoxic, quite the contrary (works by upregulating TrKB receptors and dumping the brain with BDNF)

Jokes aside, could you show me some protocols that do use such high dosages? I mean, I thought 1mg (divided into two doses) in a day was rather high

.6mg to 1mg of NA-Semax will have you flying. Selank can be dosed way higher, think 2-3mg. Obviously titrate never just blindly dose beyond a couple hundred mcg to start with.

What you do is extensive research, assess as best based on your judgement, then execute your potentially risky plans, in hopes of directly attaining superior biochemical functions in your body, something that other people never even consider, let alone be able to conceptualize what the fuck that is, as they were led to believe simply eating well and exercising is the creme de la creme of health

Yeah I suppose you're right. I spend thousands of dollars on drugs/substances/compounds though, I definitely need to relocate my funds aswell JFL. At the moment though my mission is to resolve this essential tremor I have going on.

I respect the fuck out of that, and if my conditions justified it, I wouldn't draw any lines on where I would stop with the experiments

Thanks dog. I used to talk to you a lot, fun to talk to an old user.

 

[karbo]

Mining engineering is what I did, never cared for pharmacology or anything like that professionally

Always found it very honorable when people study certain fields for the sake of studying and knowledge, not as a means to a specific end

Yeah no one really sells it. But definitely do buy the NA versions they're a lot better.

Just 2 weeks ago our mutual vendor had it in stock, but it seems I was able to find some more vendors who carry it. I already have normal Semax and Selank, and I've concluded that I will order both NA Semax + NA Selank, plus NA Semax Amidate + NA Selank Amidate aswell.
These compounds really intrigue me, it's extremely interesting how I can feel the bad/inflammation sensations from my stomach condition that are ALWAYS accompanied by corresponding mental issues, exactly proportional to how severe the inflammation is at the moment, and yet, when being on them, despite the physical issues persist, the more significant issues like speech, brain fog and mental fatigue improve overwhelmingly

PSSD is one I wholeheartedly believe in because it changes the expression of SERT over time, leading to a massive, negative shift in neurotransmission. With 5ar inhibitors they're only removing an enzyme.

So what you are saying is, there's no reason to be scared of hair loss meds, in case that time comes

I debated whether what PSSD people are reporting to be experiencing is truly based on reality or not, but some of their statements heavily lean towards hypochondriasis and other anxiety-related psychological conditions.
The same phenomenon can be witnessed on the absolute cesspool of a forum called "benzobuddies", where people genuinely use pill cutters for their 5mg Diazepam tablets to cut it into 1/8th of a piece. Many others reported 'forever withdrawal symptoms', in which they claimed they tapered and haven't touched a benzo in MULTIPLE YEARS, yet they are still suffering from "something" that they attribute to PAWS.
People with fundamental anxiety issues acting irrationally anxious about their anxiety medicine's effects. Quite the coincidence isn't it?

In fact, this ridiculousness in my vulnerable and paranoid state almost pulled me in, which is what originally led me to find such a retarded forum in the first place. Now with a tad more pharmacology knowledge I am not at all anxious in the mind, and despite having gone through active benzo withdrawal multiple times, I take it for what it is, and not for what I BELIEVE it is, which makes a monumental difference in how I experience it (both psychologically and physiologically)

Yes do your due diligence and read as much as you can about it. It's a gamble obviously but I had combined methane and hydrogen SIBO and after doing a round of LL37 (didn't touch antibiotics) I was cleared completely

BPC in general is just incredibly potent and healing any and all aliments in the gut, no point not using it.

Yeah, going to order both from our mutual vendor; just waiting for my Rifaximin and Dihexa to get shipped.

Even though it might make more sense to use LL-37 first due to its biofilm disruptor mechanism, that might reverse potential anti-biotic resistance, but given that my first (albeit low dose) Rifaximin treatment felt like a huge improvement, I will do that course first.

By the way, I hope you didn't dump your whole gram of Dihexa into DMSO, as according to this site that lists the chemical's properties (as for the solubility, only DMSO is stated) your solution would begin to lose potency at just a month of freezer temperature storage

Fuck, condolences for the benzo taper. Some brutal stuff no doubt. I had a massive pregabalin issue where I was using multiple GRAMS of it daily to function (therapeutic dosage is around 75-600mg), I was on about 1.5-2g. Tapered in about a month and jumped off with baclofen 50mg and then dropped the baclofen rapidly. I've got an essential tremor now which is what I'm attempting to heal with Dihexa and ISRIB.

I am somewhat familiar with Pregabalin, although didn't take it more than a handful of times. 300mg on my first time made me extremely dizzy, and that was with existing Phenibut tolerance! Multiple grams sound like a nightmare to come off. Sorry you are dealing with that

Okay I've got some amazing tips for you in terms of benzo withdrawal. If you can get your hands on memantine, GET IT. It's so powerful at abating benzo withdrawals because the main reason withdrawal is so unforgiving is due to the dysregulation of glutamate in response to the deprival of GABA transmission. GABA(a) receptors downregulate rapidly on benzodiazepines and after the discontinuation you're basically in hyper-glutamatergic state, whereby glutmate is rampant; this is where all the symptoms derive from

Memantine is a non-competitive antagonist at NDMA receptors which means it won't cause dissociation like ketamine (a full antagonist) but it will completely normalise abarant activation of the receptors by glutamate

Thanks for the tip, I'm actually going to utilize it tomorrow. I have had Memantine on hand for a few years now for this exact reason, but haven't really noticed any significant reductions in withdrawal, but maybe that's because it's been atleast a year since I've tried and the WDs weren't severe enough for me to pay enough attention to what extent Memantine does actually help

Also, I kind of had/have an on and off ketamine addiction, I justified using it for its NMDA antagonism mechanism that I assumed would have a similar extent of reducing overactive glutamate, like Memantine does

Seroquel: this'll make sure you actually sleep. It's not really habit forming so you can taper very rapidly and still sleep correctly.

It makes me wonder, how can you wholeheartedly believe that SSRI's potentially cause irreversible dysfunctions over-time, yet recommend an anti-psychotic, that (based on a whole lot of personal anecdotes on various forums) are supposedly the absolute devil compounds of all psychiatry?

I've read stories of people being injected with a single, or just a few doses worth of anti psychotics against their will, and never feeling the same again, which, based on their coherency and presentation of their experiences, seemed way more believable to me than PSSD

GH/GH peptides: Growth hormone sensitizes the brain to GABA and also increases rem sleep by 50% (astounding number) and deep sleep also goes up, the onset of sleep hastens and sleep maintenance improves drastically. GH also synergises well with growth factors like BDNF. So Semax + GH/peptides will work fantastically for brain issues/tapering off neuropsychiatric drugs.

Sounds fucking good. I definitely feel it, on the days I do all Mod GRF + IPA + Semax + Selank

The last is clonidine, this will normalise norepinephrine signalling in the brain because by agonising a2 receptors in the brain it downregulates the release of noradrenaline and adrenaline.

You may be able to do all this without these substances but if you don't want to suffer memantine helps a fuck tonne. All this helped me get off pregabalin which imo (I don't know what doses you're at) my predicament was probably worse than yours.

Sounds like a bit overkill to me though. I mean, it does make sense but at some point you have to draw the line of manually bio-engineering your body and let homeostasis do its work once you reach a healthy enough level.
I believe once I resolve my gut issues, I won't have to need a substance like clonidine.

You may be able to do all this without these substances but if you don't want to suffer memantine helps a fuck tonne. All this helped me get off pregabalin which imo (I don't know what doses you're at) my predicament was probably worse than yours.

Yeah, no doubt. I am not that fucked, although it hasn't been established what dose of this RC benzo (norflurazepam) is equivalent with in terms of pharma benzos, I am guessing I am in the ballpark of daily 1.5mg Alprazolam? I think especially with memantine/ket I can finish this taper in a few weeks

You can always get it tested by Janoshik. Look it up.

Yes I am aware but I am a jew when it comes to money (which is ironic, as the amount I have put into drugs probably go past the 10K mark). Also, the fact that these are contraband products, it's not in my interest to mail a minuscule amount of prohibited substance abroad, and potentially get charged with distribution JFL.
In my experience, they are running a business and it is in their best interest to keep customers. I haven't really had a bad experience with chinese vendors (except when it comes to recreational compounds, those labs tend to be very shady and very often send a completely different, or even deadly compounds instead of the one promised)

Besides there are other ways of testing. I could look up the chemical's properties, see it's solubility in different solvents, I try it at home, and if it's wrong, then I know something's not right. That's the most length I'm willing to go for a test. But I might not even do that.
The fact that Rifaximin is red color and I am receiving red powder is enough for me, if I eat a capsule of 500mg and die immediately, so be it, jfl

I would order indian generics of antibiotics though, not from China.

Did exactly that in june with Rifaximin. I really didn't want to go the china raw powder way, but I am left with no choice.
India doesn't have that certain special shipping protocols like China vendors do, as they operate as fully legit businesses (China always avoids customs clearance, which is sort of a mystery to me that they are able to do this in literally any and all countries)

I was so desperate that I placed an 280 USD order for a huge amount of indian branded rifaximin capsules. Few days later, caught at customs, destroyed because indians claim to only have "export rights", so no refunds, 280 USD down the drain

injecting is annoying and time consuming.

Tbh I love it and was even a bit disappointed when I came to learn Dihexa is supposed to be applied topically rather than injected, JFL

1mg of NA-Semax potentiates the fuck out of all my other drugs. Feels like low dose amphetamine almost but it isn't neurotoxic, quite the contrary (works by upregulating TrKB receptors and dumping the brain with BDNF)

.6mg to 1mg of NA-Semax will have you flying. Selank can be dosed way higher, think 2-3mg. Obviously titrate never just blindly dose beyond a couple hundred mcg to start with.

Can't wait to try them out, as I already love the standard versions (Selank especially, still not sure whether Semax does anything perceptible for me)

At the moment though my mission is to resolve this essential tremor I have going on.

Thanks dog. I used to talk to you a lot, fun to talk to an old user.

With your knowledge and especially extreme dedication I'm sure it will be resolved if you just keep at it and not lose hope.
Also, if I may ask, what led you down this path of abusing GABA medications?
I've struggled with almost all types of anxiety (social especially) all my life, despite being (not feeling) more than competent than my peers at essentially anything (that might be an overexaggeration) I really put my mind to.

This, in particular is what perpetuates the toxic shame that induces further anxiety; the fact that I am objectively atleast DECENT in all sorts of fields and talents, not just from my perspective; have been told this numerous times, experienced much social, financial, sexual success, and yet this abused dog mentality doesn't seem to leave my system. Feels so fucking shameful.

 

[Dyorotic]

Just 2 weeks ago our mutual vendor had it in stock, but it seems I was able to find some more vendors who carry it

I would definitely wait for Tracy to have them back in stock. Other chinese vendors just sell regular Semax/Selank and market it as the NA versions.

it's extremely interesting how I can feel the bad/inflammation sensations from my stomach condition that are ALWAYS accompanied by corresponding mental issues, exactly proportional to how severe the inflammation is at the moment, and yet, when being on them, despite the physical issues persist, the more significant issues like speech, brain fog and mental fatigue improve

Yeah, inflammation is inflammation, it doesn't discriminate really. But because the brain is deeply contingent on the function of the gut, having the source of your inflammation derive from the stomach/gut/intestines really fucks everything else up too. Semax is increasing BDNF by a large margin and Selank is downregulating interleukins massively, they both also inhibit enkephalinase, the enzyme responsible for the degredation of endogenous opioid receptor ligands, so they both increase opioidergic signalling quite a bit.

Semax in particular is really interesting because on top of it's inhibitory effect on enkephalinase it also (via it's primary MOA) acts as an antagonist to the melanocortin system (the system that melanotan I/II & PT141 agonises). Supposedly the melanocortin system acts antagonistically to the opioidergic system, so when you block MCR1-5 you're globally upregulating MU, KAPPA etc. Melanotan is known to cause anhedonia with prolonged usage so that may be why. Semax is probably super ideal to run alongside either MT1 (better) or MT2.

So what you are saying is, there's no reason to be scared of hair loss meds, in case that time comes

I've been on 5ar inhibitors for at leas two years now. Finasteride stopped all hairloss even on steroids but dutasteride was the cherry on top that basically solved all my problems. Hair never gets oily, acne is essentially impossible (I finished accutane recently though) and hair loss obviously reverted entirely. I used finasteride natty and had zero problems, if anything I was paradoxically hornier and felt way more androgenic (oily skin, libido, etc). I actually don't think there was ever a time where my libido was so strong other than the time between 2022-2023.

So yes, don't be afraid of 5ar inhibitors they're glorious. DHT is a worthless hormone.

The same phenomenon can be witnessed on the absolute cesspool of a forum called "benzobuddies", where people genuinely use pill cutters for their 5mg Diazepam tablets to cut it into 1/8th of a piece. Many others reported 'forever withdrawal symptoms', in which they claimed they tapered and haven't touched a benzo in MULTIPLE YEARS, yet they are still suffering from "something" that they attribute to PAWS.

I know all about this. I've never used benzos so I can't chime in as to whether there is any merit to this phenomenon. Benzos are poisonous obviously and the GABAergic system is incredibly difficult to navigate.

If you end up having longterm issues I've seen some major success with people using Flumazenil, a benzodiazepine antagonist. Apparently it causes a rapid resensitization of the subunits/receptors.

People with fundamental anxiety issues acting irrationally anxious about their anxiety medicine's effects. Quite the coincidence isn't it?

Yeah mostly this.

Now with a tad more pharmacology knowledge I am not at all anxious in the mind, and despite having gone through active benzo withdrawal multiple times, I take it for what it is, and not for what I BELIEVE it is, which makes a monumental difference in how I experience it (both psychologically and physiologically)

There isn't any sound evidence of permanent damage. Once you're off you'll be back to normal relatively quickly, it's that last jump that brutalises you the hardest.

For healing you need to modulate glutamate (in a healthy way). NAC and memantine are fantastic for this. BPC obviously and Dihexa will make recovery super smooth.

Even though it might make more sense to use LL-37 first due to its biofilm disruptor mechanism, that might reverse potential anti-biotic resistance, but given that my first (albeit low dose) Rifaximin treatment felt like a huge improvement, I will do that course first.

Definitely do that. Rifa is way less risky and it's actually indicated for SIBO.

Also shit, I completely forgot to mention. Sibo is fundamentally an issue relating to the gut motility. People always focus on the bacterial overgrowth aspect but they never question why they have the overgrowth to begin with. If peristalsis isn't functioning as it normally does you end up with a slow transit of food, which gives the microbiome way more time to digest the carbohydrates and proliferate. Once this happens you're fucked essentially until you either erradicate the bacteria (which works for the short-term) or you increase gastric motlity, which just disallows the bacteria to proliferate at an unsual rate.

Increasing gut motlity is relatively easy. Endogenous compounds like ghrelin, motilin & acetylcholine increase the rate at which the stomach empties and also increase the strength of peristalsis. Dopamine negatively regulates motility and 5HT-4 receptor agonism increases the release of acetylcholine in the stomach, hence why drugs like metoclopramide are so powerful at inducing gastric emptying, it's a D2 antagonist and an agonist at 5HT4.

The problem is, no one wants to fucking inhibt the most important dopamine receptor. It'll suppress gonadotropins (via prolactin), cause lactation, mess with motivation and energy etc. 5HT-4 agonists are also unforgiving and cause insane headaches. Not worth it.

You can easily bypass these mechanisms and just increase acetylcholine globally, not just in the gut. Pyridostigmine, an acetylcholinesterase inhibitor majorly increases gastric emptying and is relatively side-effect free. Naltrexone, an opioid antagonist, used at low doses will temporarily block the opioidergic system and cause a massive increase in motility. Naltrexone in general is amazing for inflammation because what it does is shut down opioidergic signalling for a very short window, but long enough to induce mass receptor sensitization, once it dissociates from the receptor and clears from the body (a couple hours) you're left with a lot of opioid activity, which is super anti-inflammatory. Naltrexone downregulates a bunch of interleukins. I use it and I definitely recommend.

Combine naltrexone with Semax and selank and you've got yourself a lowgrade opioid with little to no dependence/withdrawal because you're always maintaing a homeostatic baseline (slightly raised).

Another thing you'll want to hit is the ghrelin receptor. MK677 is obviously the best option for this and will keep your stomach moving super fast.

Erythromycin (an antibiotic) is known for it's motilin receptor agonism which can be maintained at a low dosage, between 50-100mg everyday. It's not enough to cause much antibiotic activity but it's enough to stimulate motilin.

The next thing you will want to focus on is stomach acid. You need to increase the fuck out of your HCL. Take betaine HCL with apple cider vinegar extract. This will increase the acidity of your stomach, which is necessary to avoid overgrowth (bacteria hate acidity).

If you can't get your hands on the motility agents, 100% get Betaine HCL because there are people who have legitimately taken it for a couple days and reverted sibo entirely.

By the way, I hope you didn't dump your whole gram of Dihexa into DMSO, as according to this site that lists the chemical's properties (as for the solubility, only DMSO is stated) your solution would begin to lose potency at just a month of freezer temperature storage

No I didn't. I make little bottles at a time, they usually last a week or two.

It makes me wonder, how can you wholeheartedly believe that SSRI's potentially cause irreversible dysfunctions over-time, yet recommend an anti-psychotic, that (based on a whole lot of personal anecdotes on various forums) are supposedly the absolute devil compounds of all psychiatry?

I should have prefaced that seroquel is a very, very weak antipsychotic at low doses, probably next to zero activity as an AP at anything sub 400mg. It rapidly dissociates from dopamine and serotonin receptors even at therapeutic dosages and that's why it's so well tolerated in bipolar patients. People take up to a gram everyday.

The problem is, basically every single antipsychotic is digustingly potent at antagonising H1, which means it induces intense sleepiness/ somnolence.

At around 15-100 maybe even 200mg it is essentially just a very powerful antihistamine, that's it.

The reason why I prefer it to other antihistamines is that it's basically devoid of any muscarinic acetylcholine receptor antagonism (this will slow gastric emptying and make you a complete drooling moron) and it also has a super short half life. Stuff like doxylamine stays in your system way too long and is a known potent antagonist of acetylcholine.

I believe once I resolve my gut issues, I won't have to need a substance like clonidine.

Yeah I 100% agree. If you can avoid drugs then yes take that path.

I was so desperate that I placed an 280 USD order for a huge amount of indian branded rifaximin capsules. Few days later, caught at customs, destroyed because indians claim to only have "export rights", so no refunds, 280 USD down the drain

That's brutal. Yeah indians are annoying as fuck when it comes to shpping

Tbh I love it and was even a bit disappointed when I came to learn Dihexa is supposed to be applied topically rather than injected, JFL

Yeah you gotta work for it lmfao.

Can't wait to try them out, as I already love the standard versions (Selank especially, still not sure whether Semax does anything perceptible for me)

Normally people say the inverse (Semax works and Selank doesn't). To me that seems like you've got a lot of inflammation going on.

Also, if I may ask, what led you down this path of abusing GABA medications?

OCD and insomnia mostly. Primarily insomnia. Pregabalin gave me the most orgasmic and fullfilling sleep I've ever had. It dropped by heart rate by like 40 points, I felt warm and fuzzy, I fell asleep within minutes after the peak, etc.

and yet this abused dog mentality doesn't seem to leave my system

I relate so hard. I think we're all abused dogs on this site tbh, I know multiple people in PSL who have the same mentalities.

 

[karbo]

I would definitely wait for Tracy to have them back in stock. Other chinese vendors just sell regular Semax/Selank and market it as the NA versions.

Mine's called Alissa actually Anyway, that is exactly what I am planning to do, however she only sells the amidated versions, not the simple N-acetylated ones, and since they are gigacheap and I like the original compounds a lot, I'll just order 2 kits of supposed NA semax/selanks. At worst I'll have an extra 2 kits of normal semax/selank

Today was a mindblowingly phenomenal experience. I've injected .5mg semax and 1mg Selank in the morning, and went to my first day of uni where I was placed into different groups with strangers and had to introduce myself and do all sorts of social interactions for 3 hours straight

Under normal circumstances in events such as this, this would have induced extreme anxiety due to trauma flashbacks, but today, for the first time ever I was able to keep my composure and do extremely well socially. No trembling in voice, significant reducement in overthinking, nice flow of eloquent conversation; just incredibly pleasant all-around.

If these compounds will continue to work, I can categorize them as life-changing, something that no other drug, prescription medication, research chemical or whatever else was able to produce before. This is fucking insane.

For healing you need to modulate glutamate (in a healthy way). NAC and memantine are fantastic for this. BPC obviously and Dihexa will make recovery super smooth.

Currently on both NAC and memantine, breezing through benzo WD's like they are not even there.

Semax in particular is really interesting because on top of it's inhibitory effect on enkephalinase it also (via it's primary MOA) acts as an antagonist to the melanocortin system (the system that melanotan I/II & PT141 agonises). Supposedly the melanocortin system acts antagonistically to the opioidergic system, so when you block MCR1-5 you're globally upregulating MU, KAPPA etc. Melanotan is known to cause anhedonia with prolonged usage so that may be why. Semax is probably super ideal to run alongside either MT1 (better) or MT2.

I've been on 5ar inhibitors for at leas two years now. Finasteride stopped all hairloss even on steroids but dutasteride was the cherry on top that basically solved all my problems. Hair never gets oily, acne is essentially impossible (I finished accutane recently though) and hair loss obviously reverted entirely. I used finasteride natty and had zero problems, if anything I was paradoxically hornier and felt way more androgenic (oily skin, libido, etc). I actually don't think there was ever a time where my libido was so strong other than the time between 2022-2023.

So yes, don't be afraid of 5ar inhibitors they're glorious. DHT is a worthless hormone.

Very interesting, thanks for the information. I am fascinated by Semax/Selank and keep reading studies about them to understand more.

I wonder, why did you end up doing Mining Mngineering when I can clearly detect you being passionate about biochemistry?
I myself am wondering a lot, if I made a mystake by going into Cybersecurity Engineering; medicine is just something you can be way more passionate about, you know.
Even if you might not be able to help/save yourself, you could use your knowledge to help others which would be a very honorable life goal on its own

Thoughts on constantly elevated BDNF levels causing acute hair loss? I am not worried about it, especially when running GH secretagogues alongside them, just interested on your input (i was born nw2 jfl, HT clinic diagnosed it as 'triangular alopecia', but besides my hairline being fucked from birth, I am not receding or losing hairs ever despite being naturally high T)

Also shit, I completely forgot to mention. Sibo is fundamentally an issue relating to the gut motility. People always focus on the bacterial overgrowth aspect but they never question why they have the overgrowth to begin with. If peristalsis isn't functioning as it normally does you end up with a slow transit of food, which gives the microbiome way more time to digest the carbohydrates and proliferate. Once this happens you're fucked essentially until you either erradicate the bacteria (which works for the short-term) or you increase gastric motlity, which just disallows the bacteria to proliferate at an unsual rate.

Increasing gut motlity is relatively easy. Endogenous compounds like ghrelin, motilin & acetylcholine increase the rate at which the stomach empties and also increase the strength of peristalsis. Dopamine negatively regulates motility and 5HT-4 receptor agonism increases the release of acetylcholine in the stomach, hence why drugs like metoclopramide are so powerful at inducing gastric emptying, it's a D2 antagonist and an agonist at 5HT4.

The problem is, no one wants to fucking inhibt the most important dopamine receptor. It'll suppress gonadotropins (via prolactin), cause lactation, mess with motivation and energy etc. 5HT-4 agonists are also unforgiving and cause insane headaches. Not worth it.

You can easily bypass these mechanisms and just increase acetylcholine globally, not just in the gut. Pyridostigmine, an acetylcholinesterase inhibitor majorly increases gastric emptying and is relatively side-effect free. Naltrexone, an opioid antagonist, used at low doses will temporarily block the opioidergic system and cause a massive increase in motility. Naltrexone in general is amazing for inflammation because what it does is shut down opioidergic signalling for a very short window, but long enough to induce mass receptor sensitization, once it dissociates from the receptor and clears from the body (a couple hours) you're left with a lot of opioid activity, which is super anti-inflammatory. Naltrexone downregulates a bunch of interleukins. I use it and I definitely recommend.

Combine naltrexone with Semax and selank and you've got yourself a lowgrade opioid with little to no dependence/withdrawal because you're always maintaing a homeostatic baseline (slightly raised).

Another thing you'll want to hit is the ghrelin receptor. MK677 is obviously the best option for this and will keep your stomach moving super fast.

I've had my eye on low dose naltrexone for a long time, in fact, that seized indian shipment of rifaximin actually contained some of that aswell.
Thanks for the tip, at the time I am just using two mainstream supplements for motility (ginger & artichoke extract)
Not sure if they do anything at all, I am hoping the Rifaximin will be enough to set things straight once and for all, but if that doesn't work out I will definitely look into these solutions you just offered.
Ipamorelin is a ghrelin agonist aswell

The next thing you will want to focus on is stomach acid. You need to increase the fuck out of your HCL. Take betaine HCL with apple cider vinegar extract. This will increase the acidity of your stomach, which is necessary to avoid overgrowth (bacteria hate acidity).

If you can't get your hands on the motility agents, 100% get Betaine HCL because there are people who have legitimately taken it for a couple days and reverted sibo entirely.

I've had Betaine HCl and used it here and there for half a year now, but honestly I cannot tell if it's an ideal supplement for me to use or not. Didn't notice any improvements, nor worsening of symptoms
The symptoms of both low and high stomach acid are more or less the same, and there is no easy at-home test to conlude which group you fit into

I should have prefaced that seroquel is a very, very weak antipsychotic at low doses, probably next to zero activity as an AP at anything sub 400mg. It rapidly dissociates from dopamine and serotonin receptors even at therapeutic dosages and that's why it's so well tolerated in bipolar patients. People take up to a gram everyday.

The problem is, basically every single antipsychotic is digustingly potent at antagonising H1, which means it induces intense sleepiness/ somnolence.

At around 15-100 maybe even 200mg it is essentially just a very powerful antihistamine, that's it.

The reason why I prefer it to other antihistamines is that it's basically devoid of any muscarinic acetylcholine receptor antagonism (this will slow gastric emptying and make you a complete drooling moron) and it also has a super short half life. Stuff like doxylamine stays in your system way too long and is a known potent antagonist of acetylcholine.

Damn, I had no idea. Regardless, the fear-mongering around anti psychotics make me steer clear of them. IMO, unless you have heavy psychotic symptoms, you have no business taking such compounds

OCD and insomnia mostly. Primarily insomnia. Pregabalin gave me the most orgasmic and fullfilling sleep I've ever had. It dropped by heart rate by like 40 points, I felt warm and fuzzy, I fell asleep within minutes after the peak, etc.

OCD and insomnia is fucking brutal. Probably a great correlation between the two aswell (pretty sure my near 2 year long insomnia was also anxiety/OCD induced, definitely not just drugs). Getting out of that mental hellhole takes insane strength and persistence

I relate so hard. I think we're all abused dogs on this site tbh, I know multiple people in PSL who have the same mentalities.

Brutal. Nevertheless, we can still live a content life by managing the mental dysfunctions as best we can, and most importantly, practice self-acceptance, because ultimately that is the thing that has the potential to bring true fulfillment, nothing else.

 

[evap0]

could one of u link dihexa source pls
@9898 @karbo

 

[karbo]

Tracy sells n-acetyl amidate versions of both but they're out of stock at the moment

By the way, Tracy just confirmed NA Semax/Selank are already in stock with lab tests pending, will be available to order in ~1 week.
I will be stocking the fuck up, and have multiple other shipments on the way aswell

A protocol of careful diet, 14 days course of Rifaximin, then on an "as needed" basis: BPC-157, KPV, Thymosin Alpha 1, LL-37, GHRH/GHRPs, NA Semax/Selank, and finally Dihexa

Really hoping I can finally cure my devastating autoimmune disorders and not only get my life back, but to run on 120% efficiacy.

I was wondering, did you ever use probiotics for your dysbiosis? Without a GI map it's literally gambling with your health, but with such powerful antibiotics, I wonder how and when my gut flora is going to start rebalancing itself

Btw, are you still running Dihexa? Still experiencing similar godly effects?

 

[Dyorotic]

By the way, Tracy just confirmed NA Semax/Selank are already in stock with lab tests pending, will be available to order in ~1 week.

Mog! I need more of it

A protocol of careful diet, 14 days course of Rifaximin, then on an "as needed" basis: BPC-157, KPV, Thymosin Alpha 1, LL-37, GHRH/GHRPs, NA Semax/Selank, and finally Dihexa

Sounds really good. LL37 will be the biggest needle mover here, behind Rifa.

TA1 is amazing because it'll help abate the histaminergic overload that SIBO produces, it'll also regulate immune function that is normally suppressed. GHRPs will also be amazing because they'll cause rapid clearing of the stomach. The growth hormone will help reset the GABAergic system after your benzo usage.

Semax/Selank, potent anitinflammatories, will obviously help a lot here. Dihexa will just help you recovery in general, it's quite subtle but powerful.

Really hoping I can finally cure my devastating autoimmune disorders and not only get my life back, but to run on 120% efficiacy.

I had the same mindset and I'm back to normal now basically.

In about a week I'll be trying trans-ISRIB for my tremor. I think this'll be the one tbh.

I was wondering, did you ever use probiotics for your dysbiosis? Without a GI map it's literally gambling with your health, but with such powerful antibiotics, I wonder how and when my gut flora is going to start rebalancing itself

Don't touch probiotics IMO they're poison. Gut dysbosis is just as bad if you tip the pendelum towards "good" bacteria. All you want is sufficient bacteria, not an overload of them.

Focus on HCL production + motlity enhancement and you'll be good to go after erradicating the bacteria with Rifa (and LL37)

I recommend about 100mcg twice daily for 8 weeks and then maybe maintain with 50mcg daily, also take D3 because LL37 is highly dependent on D3 to function

Btw, are you still running Dihexa? Still experiencing similar godly effects?

Of course. It's going great. Headaches are annoying and so are the nightmares but I feel so sharp and alive.

My stack is starting to come into play and within a week I'll have everything I need.

SR9009, ITPP and mots-c for fatigue/energy and then the Dihexa & ISRIB for healing the brain. I can't wait to try ITPP

Also taking istradefyline which is a selective A2A receptor antagonist (caffeine hits adenosine 1 & 2). It's suppose to decrease fatigue perception

 

[karbo]

Mog! I need more of it


Sounds really good. LL37 will be the biggest needle mover here, behind Rifa.

TA1 is amazing because it'll help abate the histaminergic overload that SIBO produces, it'll also regulate immune function that is normally suppressed. GHRPs will also be amazing because they'll cause rapid clearing of the stomach. The growth hormone will help reset the GABAergic system after your benzo usage.

Semax/Selank, potent anitinflammatories, will obviously help a lot here. Dihexa will just help you recovery in general, it's quite subtle but powerful.


I had the same mindset and I'm back to normal now basically.

In about a week I'll be trying trans-ISRIB for my tremor. I think this'll be the one tbh.


Don't touch probiotics IMO they're poison. Gut dysbosis is just as bad if you tip the pendelum towards "good" bacteria. All you want is sufficient bacteria, not an overload of them.

Focus on HCL production + motlity enhancement and you'll be good to go after erradicating the bacteria with Rifa (and LL37)

I recommend about 100mcg twice daily for 8 weeks and then maybe maintain with 50mcg daily, also take D3 because LL37 is highly dependent on D3 to function


Of course. It's going great. Headaches are annoying and so are the nightmares but I feel so sharp and alive.

My stack is starting to come into play and within a week I'll have everything I need.

SR9009, ITPP and mots-c for fatigue/energy and then the Dihexa & ISRIB for healing the brain. I can't wait to try ITPP

Also taking istradefyline which is a selective A2A receptor antagonist (caffeine hits adenosine 1 & 2). It's suppose to decrease fatigue perception

I am getting exhausted as fuck. I took the Rifaximin for 10 days, but I am not sure the desired effects were exerted properly, I am wondering if the efficacy of the compound was lowered by the fact that I took the raw powder in gelatin capsules, as opposed to pharma products that are intentionally made in pill form, most likely to be able to bypass the acidity of your stomach and actually make it to the intestines

I am also extremely confused by this stomach acidity thing, regarding the bacteria of SIBO. No conclusive answers, what cures someone makes others more ill. I experimented with Betaine for MONTHS, still cannot decide if it's good or bad but I am leaning towards bad, as I feel worse than ever, but when I do take Betaine I get insane upper stomach pain. Just fuck this shit.

My 500 euro shipment looks like was seized today. I am fucking angry and hopeless. I wasn't sure about the LL-37 protocol anyway, even if I were to order again I am not sure if I should just try it, and if I were to try it, would it be wise to stabilise my immune system inbefore with other compounds such as TA1

Out of curiosity, when you did LL-37 for 8 weeks, did you incorporate any other compounds (apart from D vit) specifically to make sure the protocol will do more good than harm? Were you taking other peptides alongside it (such as BPC), or prepared for the course for a certain amount of time with other compounds INBEFORE the LL-37?

Did you end up taking those new compounds you mentioned? How are they going so far?

I ended up trying Dihexa today for the first time (10mg in 0.5ml DMSO just like you said) and damn, it is indeed fucking interesting. Definitely worthwhile to explore, although the cancer growth side effects scare me. But at this point my gut is so fucked up, my risk tolerance is crazy.
What's your schedule for taking it? Or have you moved on to other compounds and don't currently pay much attention to Dihexa?
I could see myself using this on a regular basis

I am taking arginine salt of BPC-157 + KPV orally and also Larazotide but I am not sure they are the real deal (ordered them from biolabshop.com) It's a hit or miss, but with all these seized shipments and millions of supplement experiments I cannot afford to lab test them. Will keep taking them anyway, in hopes of getting atleast a bit of a relief for my gut

 

[DORIAN]

Currently on both NAC and memantine

How's that working out for you? Was on NAC and memantine for quite a while (several years on/off) with some cerebrolysin and semax/selank and a bunch of other stuff. Finally, taking a long break from memantine and going to be trying Cortexin and Dihexa (not removing NAC).

 

[DORIAN]

The thing with Semax and Selank is that in their base form they have really short half-lives and don't have the BBB penetrability that the N-acetylated and amidated versions have. Na-Semax(& Selank)-Amidate is the strongest variant, it has a longer half life and way better occupancy rates at the receptors as well as hightened permeation of the blood brain barrier. With these versions subq administration is fine

Semax: $0.25 per mg.
Na-Semax Amidate: $0.65 per mg.

Worth the price difference?

 

[Dyorotic]

Semax: $0.25 per mg.
Na-Semax Amidate: $0.65 per mg.

Worth the price difference?

yes

 

[karbo]

I had severe digestive issues and on LL37 I can eat whatever the fuck I want and never have any problems. I had methane dominant SIBO, which is all gone now. BPC157 is mandatory too because it's so fucking potent at healing the gut. Tracy sells LL37 for cheap.
100-200mcg a day for 8 weeks and you'll be cured.


Selank is great. It's very good at modulating inflammation within the brain specfically. Selank is supposedly equipotent at inducing anxiolysis as benzos, I find that difficut to believe but that's what the research suggests.

Turns out that my 500 EUR shipment wasn't seized in the end, it was just an extremely strange event where it was held up for 3 weeks at customs (despite tracking saying it has already gone through it, then the entries were deleted, package was called back a few hours later and then it was stuck for weeks)
It was obvious to me it's seized but they randomly decided to deliver it a few days ago.

Anyway, not sure if you remember my psychotic rant about peptides not working and everything being shit; all I wanna say is that I am, in terms of a psychiatric assessment, not competent enough to judge whether a compound is good or not. I am totally fucked up even when sober, so take whatever I say with a grain of salt, since my mood changes completely on a day-to-day basis

I wanted to try NA Semax Amidate standalone today, but something in me prevented doing so, as I was also really curious about the NA Selank Amidate.

Having done both of these, I can say that the difference is massive. In terms of cognitive and memory, it induces memory recall to a bit larger margin than the normal versions. I sat down at the piano, and was able to play a piece that I haven't played in over a year, because I forgot. Of course I didn't play it fast or perfect, but it was pretty crazy that I was just sitting there, and dormant memories were slowly coming back into my brain and I was able to use them

The major difference however, is the physical effects. For this, I think the the Selank might be the culprit, rather than the Semax but I will never know, as I can't be arsed to ever try dosing them individually.
With standard Semax/Selank, I never felt, not even A TINY BIT of physical effects. Having used them a few times, it was always a surprise to notice them working, it usually took a human interaction to understand that there has been indeed, a behavioral change induced by the compound.

However, NA Semax Amidate + NA Selank Amidate within about 1-2 hours of injection filled me with major relaxation, something that closely resembles opiates or benzos. So much that I actually forgot I'm still withdrawing from benzos, and forgot to take my daily taper dose
Although it's important to declare, that despite this relaxation did indeed feel good, it didn't scratch that "drug type of relaxation" type feeling. It's not a feeling that's efficient if you are looking for escapism, which is a bit paradoxic because it was indeed relaxing as fuck, to the point of me falling asleep.
I don't think I have experienced such a feeling before

Still hesitant on the LL-37, time and desperation will tell if I will ever end up using it.

Also got a gram of Naltrexone. What's your dose and schedule for taking it?