Is increasing DNA Methylation worth it?

[Deleted member 1973]

Increasing DNA Methylation will illicit epigenetic changes to stimuli but the question is what can we do to tell the genes to up bone mass?

"A National Institutes of Health (NIH) study cites DNA methylation—a process that can interfere with the activation of certain genes—as a possible reason for increased risk with age. When genes designed to suppress tumors fail to turn on, that may promote cancer growth. DNA methylation may increase with age. “You can think of methylation as dust settling on an unused switch, which then prevents the cell from turning on certain genes,” NIH researcher Dr. Jack Taylor says in a news release. "If a cell can no longer turn on critical developmental programs, it might be easier for it to become a cancer cell."

gigantism is fucked up DNA methylation for the most part inducing mutations and silencing tumor suppressor genes giving pituitary tumors and GH avoiding negative feedback loops. Inducing hypermethylation is enough to increase your height alone like regular puberty kids do, HGH is just a final nail in the coffin to make those giant niggas grow super fast quickly

inhibiting DNA methylation is a treatment taught by many med schools to treat cancer, gradual hypermethylation is associated with growth plate senscene (increasing bone age and biological age), even the current owner of naturalheightgrowth.com Tyler agrees that if hypermethylation can reverse senscnet changes enough that we can trick the body in thinking the MSC's are in an earlier chondrocyte differentiation state then height growth can potentially be unlimited or at least same as gigantism patients...

GH isn't the only thing which causes gigantism, hypermethylation is an important factor in all those pituitary giants as well https://jmg.bmj.com/content/38/5/285- epigenetic factors on human height: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208652/

And guess what you know how they say nutrition deficiency can lead to stunted growth well take a look at this:

DNA methylation changes related to nutritional deprivation: a genome-wide analysis of population and in vitro data - Clinical Epigenetics

Background DNA methylation has recently been identified as a mediator between in utero famine exposure and a range of metabolic and psychiatric traits. However, genome-wide analyses are scarce and cross-sectional analyses are hampered by many potential confounding factors. Moreover, causal...

clinicalepigeneticsjournal.biomedcentral.com

keep in mind increased DNA methylation will increase cancer risk just like gigantism, anyway tall people have higher risk of cancer than normal people anyway

 

[Deleted member 5258]

 

[Deleted member 1973]

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t (Table 1). For the ALPL locus, an increase in 1% methylation at birth was related to a 0.15% decrease in height at age 9 years for an average person at an average age (within the study cohort analysed).

 

[Deleted member 5875]

It's worth it if you don't have a high risk of cancer.

 

[Deleted member 4946]

Increasing DNA Methylation will illicit epigenetic changes to stimuli but the question is what can we do to tell the genes to up bone mass?

Yes.... and no

 

[Chintuck22]

Increasing DNA Methylation will illicit epigenetic changes to stimuli but the question is what can we do to tell the genes to up bone mass?

In mild dosages not harmful (1g). It is used to extract harmful chemicals in your body through glutathione. SAMe can alter epigenetic clock, so i don't see why it's bad unless you're megadosing it.