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"Melatonin downregulated the gene expression of the two major specific aromatase promoter regions, pII and pI.3, and also that of the aromatase promoter region pI.4. Melatonin 1 nm was able to counteract the stimulatory effect of tetradecanoyl phorbol acetate on PGE2 production and inhibit COX-2 and COX-1 mRNA expression. Melatonin 1 nm elicited a parallel time-dependent decrease in both cyclic AMP formation and aromatase mRNA expression. "
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www.ncbi.nlm.nih.gov
@wasted
Melatonin inhibits aromatase promoter expression by regulating cyclooxygenases expression and activity in breast cancer cells
Melatonin reduces the development of breast cancer interfering with oestrogen-signalling pathways, and also inhibits aromatase activity and expression. Our objective was to study the promoters through which melatonin modifies aromatase expression, evaluate ...
www.ncbi.nlm.nih.gov
