ihatemySOST
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Introduction:
I have previously created a post on this forum in a format that mimics systematic reviews, and it seems it received some appreciation to some extent, so I decided to conduct another systematic review about the effectiveness of jumping to increase height.
Jumping has always been promoted as a way to increase height, although people’s explanation of how it works is illogical, as they rely on anecdotal evidence such as the Massai tribe, or by referring to “Wolff’s Law” to prove the effectiveness of their methods. But this is illogical. Wolff’s Law states that bones increase in density according to mechanical stress and does not mention longitudinal bone growth (1).
Thus, it is clear, or at least to the author’s knowledge, that no one has previously provided evidence supporting the claim that jumping can actually increase height.
Therefore, in this review, we decided to discuss all the evidence supporting the effectiveness of these methods for increasing height, first in humans, then in animals, and finally the possible scientific explanation of how it might be effective.
In a study conducted by Xing Wang and his team, the effect of jumping exercises on children’s growth was studied over 24 weeks on three groups: Group 1 (15 short-stature children) underwent jumping exercises and their height increased by an average of 4.32 cm, Group 2 (20 normally growing children) were under natural observation and their height increased by 0.93 cm, and Group 3 (27 short-stature children under natural observation) grew 1.84 cm. The results showed that jumping exercises significantly enhanced the growth of short-stature children compared to natural observation (p < 0.01), and interestingly, the group that underwent the intervention grew in six months what a normal child would grow in about a year (as reported by the researchers) {2}
In another study supervised by researcher Liu Liu and conducted in Quanzhou City, Fujian Province, China, an experimental design was used to compare height before and after intervention in children. The study included two groups: the intervention group of 96 short-stature children who underwent jumping exercises once a week for three months, and the control group of 100 children under natural observation without intervention. The results showed that the height increase in the intervention group was very significant after the intervention compared to before (t = 2.03, P = 0.04 < 0.05) and was greater than the average natural increase for Chinese children of the same age group for boys (t = 2.98, P < 0.01) and girls (t = 2.59, P = 0.01 < 0.05). The experimental group also recorded a greater height increase compared to the control group (P = 0.05) {3}
In another study conducted under the supervision of researcher Jeong-Hoon, but this time on children with growth hormone deficiency, the children were divided into two groups of 12 children each: one group received growth hormone only, and the other group received growth hormone and performed jumping exercises three times a week. After 12 weeks, or approximately three months, they found that the group that performed jumping grew 1.26 cm more than the group that did not. Interestingly, most of the growth was in the legs, and the scientists reported that jumping the spine is considered effective enough to be called a “growth plate stimulator” {4}
In another study in Japan, a comparison was made between adolescents aged 15-19 who performed high-intensity exercises and adolescents of the same age group. They found that the group that performed the exercises was significantly taller than the group that did not, although these were not jumping exercises, they were high-intensity exercises following the same principle {5}
To the author’s knowledge, these are the only studies that have tested the effectiveness of jumping to increase height. Interestingly, they involved children with growth hormone deficiency, children with idiopathic short stature, and normal children, and there is no other drug or method that has been proven effective for these three groups, which frankly supports the effectiveness of jumping.
Now let’s talk about studies on animals. Mice were divided into four groups: control, swimming, jumping, and running. We will, of course, focus only on the results of jumping. The femur length increased very significantly (9.5%) and the tibia length also increased very significantly (9%). Interestingly, there was a marked hypertrophy of the cartilage layer, which increased by 70%, the growth plate length increased by 25%, and the mRNA expression of BMP2 and SMAD pathways rose by 62-96% {7}
It seems that all the evidence indicates that jumping is effective in children or young animals, while there is no evidence in older mice, right? No, and here comes the shock. In a study conducted by Ishiko and his research team on mice aged 3 and 6 months, they were exercised with jumping 100 times, five times a week. Very interestingly, they reported that the tibia and femur lengths increased significantly compared to the control. These results are exceptional, especially since mice at this age have already completed skeletal maturity, yet jumping still significantly promoted growth. It is important to mention that mice growth plates never close but become inactive after sexual maturity (after 8 weeks), where structural growth is then limited. Nevertheless, daily jumping for several minutes was able to clearly stimulate longitudinal growth of the tibia and femur, which is remarkable {8}
Discussion:
Despite the limited evidence, and although all of it reports the same results, a clear stimulation of longitudinal bone growth, these studies support, at least for the time being, that daily jumping is very effective for increasing height.
There may be more than one scientific explanation for these results. First, increased activity of the growth hormone (GH) and IGF-1 axis, as it has been previously reported that jumping exercises are effective in increasing GH/IGF-1 axis activity in a study conducted on adolescents and children {9}. However, this is probably not the reason, as in the study by Xing Wang and his team, a significant increase in height was reported even without any clear effect on the GH axis {2}. Therefore, increased GH/IGF-1 axis activity is not the cause, or at least not the main cause
So what is the reason? In reality, it comes down to two causes: the first is the internal stimulation of periosteal cells, and the second is the direct stimulation of chondrocyte cells.
During jumping, the bone matrix undergoes mechanical deformation. As a result of this deformation, the periosteum secretes a protein called OSTN {10}. When OSTN is secreted from periosteal cells, it enters the growth plates through the metaphyseal artery. Upon entering the growth plate, it binds to NPC-C, which increases the bioavailability of CNP and allows it to bind to NPR-B, activating cyclic guanosine monophosphate (cGMP). This leads to inhibition of the FGFR3C pathway in chondrocytes, allowing better proliferation and hypertrophy of chondrocyte cells. This is the most well-known classical theory in the scientific community and has been discussed and validated by researchers {11}.
(A figure illustrating how mechanical stress leads to increased OSTN, then its entry into the growth plate, followed by inhibition of NPR-C and increased longitudinal bone growth)
To test this classical hypothesis, mice were produced that expressed higher levels of OSTN than normal mice. Interestingly, the body length of these mice was about 12% longer compared to wild-type mice, which is quite significant, especially for a protein that was not expected to have a role in longitudinal growth. Interestingly, they also observed that cGMP levels increased by 77% compared to wild-type mice, further supporting the classical theory we have already presented {28}
(Another figure illustrating the classical theory)
Another mechanism by which jumping increases height (and the most likely one) is through applying intermittent cyclic compression on chondrocyte cells. It has already been proven that jumping applies compressive force, as demonstrated in a clinical study {14}. Although the measurement was taken at the mid-tibia, it is very logical that chondrocytes experience compressive force upon impact with the ground. In reality, this type of compression is very effective in increasing the expression of pathways important for longitudinal growth. For example, in an in vivo study on mice, the effect of intermittent cyclic compression on tibial growth was tested, and the results showed a significant increase in tibial length compared to the control group, with nearly a twofold increase in PTHrP gene expression. Although this study did not directly test jumping, it follows the same principle as jumping, which is cyclic compression {12}.
In another study, it was observed that applying the expected mechanical compression led to a clear increase in longitudinal bone growth, with a noticeable increase in PTGS2 (a protein important for regulating longitudinal bone growth) {13}.
It has also been reported in vitro that intermittent mechanical compression is effective in increasing IGF-1 and other important growth factors in chondrocyte cells {15}, and it also significantly enhances the proliferation of human chondrocyte cells in the laboratory {16}.
It has also been reported that jumping indeed generates tensile force approximately comparable to the compressive force on the bone axis. During the jump, while the person is airborne, gravity applies tensile force, and it is very likely that chondrocytes in the growth plate are exposed to the same tensile force {14}. According to the Hueter-Volkmann law, and as demonstrated in many animal models, moderate intermittent tension is an effective stimulator of chondrocyte proliferation and longitudinal bone growth {17,18}. Interestingly, it has been reported that tensile force on chondrocytes increases PTHrP gene expression by approximately fivefold {19}, and mechanical stress on chondrocytes also significantly enhances the IHH pathway {20}.
During jumping, chondrocytes in the growth plate are also exposed to shear force {14,21}. The effect of shear force on chondrocytes is very important and directly supports longitudinal growth, as it activates COX2 through the Rac/MEKK1/MKK7/JNK2/c-Jun-C/EBPβ-dependent pathway {21}, and also leads to a significant increase in SOX9 through activation of the MAPK/ERK-AGG pathway {22,23}. Additionally, fluid shear stress on chondrocytes greatly enhances PI3K/AKT activity {24}, a crucial pathway for protecting chondrocytes from apoptosis by increasing BCL-2 and reducing BAX {25}, and it also increases IGF-1 gene expression in chondrocytes {26}. There are many other pathways activated by fluid shear stress on chondrocytes; if you are interested, I recommend further research to learn more.
There is one more thing I wanted to include, honestly, which is a comparison with KY19382, a drug widely promoted on this forum as a “miracle” for increasing height. Interestingly, when this compound was administered to mice for ten weeks, from 3 weeks to 13 weeks of age, it led to an average femur length increase of about 3%. In contrast, jumping exercises from 4 weeks to 12 weeks of age resulted in an average increase of approximately 9.5% in femur length, a overwhelming superiority of jumping over this compound. It is amusing how a simple physical activity can so clearly outperform even the most heavily promoted chemical drugs for height increase {7,27}.
Conclusion:
Jumping exercises lead to increased longitudinal bone growth by applying tensile, compressive, and shear forces on chondrocytes and by increasing the gene expression of genes that stimulate chondrocyte proliferation and hypertrophy, making it, at least according to the currently available data, one of the most effective methods for increasing height.
Note : everything have written by user @ihatemySOST , thanks for reading !
References :
1. Wolff’s law in action: a mechanism for early knee osteoarthritis
Andrew J Teichtahl 1,2, Anita E Wluka 2, Pushpika Wijethilake 2, Yuanyuan Wang 2, Ali Ghasem-Zadeh 3, Flavia M Cicuttini 2
2. 24-Week jumping exercise influence on growth speed and GH-IGF-1-IGFBP-3 axis among short-stature children
Huiming Wang et al. BMC Pediatr. 2025.
3. More Jump More Health: Vertical Jumping Learning of Chinese Children and Health Promotion
Liu Liu et al. Front Psychiatry. 2022.
4. Effectiveness of complex exercise programs to promote growth in children undergoing growth hormone therapy
Jeong-Hoon Lee', Chang-Sik An', Won-Jong Yu**, Chang-Ryeol Lee', Jeong-Lae Kim*
1, Department of Phvsical Therany. Bulu University. Songnam. 18186. Kore: wivu@ cumackr/W..Yal
*Department of Physical Therapy, Korea Nazarene University, Cheonan, 31172, Korea,
*Department of Biomedical Engineering, Eulji University, Seongnam, 18155, Korea.
5. Relationships between exercise customs and height growth of the boys
who are in the latter half of puberty
桑原 伸弘 1）
Kuwabara Nobuhiro
1）
6. Effects of different types of exercise on TGFβ/BMP signaling pathway and bone growth in growing rats
2021-04-06 Zhao Changhong Li Shichang Hu Xiaopan
7. Effects of different types of exercise on TGFβ/BMP signaling pathway and bone growth in growing rats
2021-04-06 Zhao Changhong Li Shichang Hu Xiaopan
8. 364 Physiology and Biochemistry Effects of Jump Training on Bone Hypertrophy in Young and Old Rats V, Umemura', T. Ishiko', H. Tsujimoto', H. Miura', N. Mokushi', H. Suzuk? School of Physical Education
9. Effects of Music Rope-Skipping exercise on health fitness, blood lipids and growth-related factors in male middle school Boys
10. Mechanical Load Increases in Bone Formation via a Sclerostin-Independent Pathway
Alyson Morse 1,2, Michelle Maree McDonald 3, Natalie H Kelly 4,5, Katherine M Melville 4,5, Aaron Schindeler 1,2, Ina Kramer 6, Michaela Kneissel 6, Marjolein CH van der Meulen 4,7, David Graham Little 1,2
11. Mechanical Load Increases in Bone Formation via a Sclerostin-Independent Pathway
Alyson Morse 1,2, Michelle Maree McDonald 3, Natalie H Kelly 4,5, Katherine M Melville 4,5, Aaron Schindeler 1,2, Ina Kramer 6, Michaela Kneissel 6, Marjolein CH van der Meulen 4,7, David Graham Little 1,2
12. Intermittent mechanical loading on mouse tibia accelerates longitudinal bone growth by inducing PTHrP expression in the female tibial growth plate
Sarah McGarry 1,2, Karen Kover 1,2, Daniel P Heruth 1,2, Mark Dallas 3, Xinxin Jin 4, Shufang Wu 5, Francesco De Luca 1,2
13. Effects of mechanical load/stress on bone growth
AUTHOR: Z Zhang; Department Of Women's And Children's Health (kbh); []
KEYWORDS: ;
14. Understanding the etiology of the posteromedial tibial stress fracture
Charles Milgrom et al. Bone. 2015 Sep
15. Effect of Cyclic Dynamic Compressive Loading on Chondrocytes and Adipose-Derived Stem Cells Co-Cultured in Highly Elastic Cryogel Scaffolds
by Chih-Hao Chen 1,2ORCID, Chang-Yi Kuo 1,2 and Jyh-Ping Chen 1,2,3,4,*ORCID
16. Mechanical Compression of Articular Cartilage Induces Chondrocyte Proliferation and Inhibits Proteoglycan Synthesis by Activation of the Erk Pathway: Implications for Tissue Engineering and Regenerative Medicine
James A Ryan 1,2, Eric A Eisner 1,3, Grayson DuRaine 1, Zongbing You 1,4, A Hari Reddi 1
17. Mechanical stimulation of growth plate chondrocytes: Previous approaches and future directions
D Lee 1,a, A Erickson 2, A T Dudley 2,*, S Ryu 1,3,*
18. The true history of the Hueter-Volkmann law
Jan Bartoníček 1,2, Ondřej Naňka 2,✉
19. Regulation of PTHrP expression by cyclic mechanical strain in postnatal growth plate chondrocytes
Tao Xu et al. Bone. 2013 Oct
20. Indian hedgehog is an essential component of mechanotransduction complex to stimulate chondrocyte proliferation
Q Wu et al. J Biol Chem. 2001
21. Plyometric training increases thickness and volume of knee articular cartilage in mice
Marco Chiaberge, Neelima Thottappillil, …Chen-Ming Fan
22. Elucidation of the signaling network of COX-2 induction in sheared chondrocytes: COX-2 is induced via a Rac/MEKK1/MKK7/JNK2/c-Jun-C/EBPβ- dependent pathway
Zachary R. Healy, Fei Zhu, Joshua D. Stull, Konstantinos Konstantopoulos
Whiting School of Engineering
23. Complex deformation of cartilage micropellets following mechanical stimulation promotes chondrocyte gene expression
Noémie Petitjean 1,2, Patrick Canadas 2, Christian Jorgensen 1,3, Pascale Royer 2, Simon Le Floc’h 2,#, Danièle Noël
24. Shear- and Compression-induced Chondrocyte Transcription Requires MAPK Activation in Cartilage Explants*
Author links open overlay panel
Jonathan B. Fitzgerald ‡ 1 2
, Moonsoo Jin § 1 3,
Diana H. Chai ‡
,
Patrick Siparsky ‡
,
Paul Fanning ¶
, Alan J. Grodzinsky ‡ § ∥
25. Protection of carboxymethylated chitosan on chondrocytes from nitric oxide-induced apoptosis by regulating phosphatidylinositol 3-kinase/Akt signaling pathway
Author links open overlay panel
Bin He
,
Haiying Tao
,
Ailin Wei
, Shiqing Liu,
Xiaohai Li
,
Ren Chen
26. IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK
Bela G Starkman *, John D Cravero *, Marcello DelCarlo Jr, Richard F Loeser
27. CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth
28. Circulating osteocrin stimulates bone growth by limiting C-type natriuretic peptide clearance
October 2017The Journal of clinical investigation 127(11)
I have previously created a post on this forum in a format that mimics systematic reviews, and it seems it received some appreciation to some extent, so I decided to conduct another systematic review about the effectiveness of jumping to increase height.
Jumping has always been promoted as a way to increase height, although people’s explanation of how it works is illogical, as they rely on anecdotal evidence such as the Massai tribe, or by referring to “Wolff’s Law” to prove the effectiveness of their methods. But this is illogical. Wolff’s Law states that bones increase in density according to mechanical stress and does not mention longitudinal bone growth (1).
Thus, it is clear, or at least to the author’s knowledge, that no one has previously provided evidence supporting the claim that jumping can actually increase height.
Therefore, in this review, we decided to discuss all the evidence supporting the effectiveness of these methods for increasing height, first in humans, then in animals, and finally the possible scientific explanation of how it might be effective.
In a study conducted by Xing Wang and his team, the effect of jumping exercises on children’s growth was studied over 24 weeks on three groups: Group 1 (15 short-stature children) underwent jumping exercises and their height increased by an average of 4.32 cm, Group 2 (20 normally growing children) were under natural observation and their height increased by 0.93 cm, and Group 3 (27 short-stature children under natural observation) grew 1.84 cm. The results showed that jumping exercises significantly enhanced the growth of short-stature children compared to natural observation (p < 0.01), and interestingly, the group that underwent the intervention grew in six months what a normal child would grow in about a year (as reported by the researchers) {2}
In another study supervised by researcher Liu Liu and conducted in Quanzhou City, Fujian Province, China, an experimental design was used to compare height before and after intervention in children. The study included two groups: the intervention group of 96 short-stature children who underwent jumping exercises once a week for three months, and the control group of 100 children under natural observation without intervention. The results showed that the height increase in the intervention group was very significant after the intervention compared to before (t = 2.03, P = 0.04 < 0.05) and was greater than the average natural increase for Chinese children of the same age group for boys (t = 2.98, P < 0.01) and girls (t = 2.59, P = 0.01 < 0.05). The experimental group also recorded a greater height increase compared to the control group (P = 0.05) {3}
In another study conducted under the supervision of researcher Jeong-Hoon, but this time on children with growth hormone deficiency, the children were divided into two groups of 12 children each: one group received growth hormone only, and the other group received growth hormone and performed jumping exercises three times a week. After 12 weeks, or approximately three months, they found that the group that performed jumping grew 1.26 cm more than the group that did not. Interestingly, most of the growth was in the legs, and the scientists reported that jumping the spine is considered effective enough to be called a “growth plate stimulator” {4}
In another study in Japan, a comparison was made between adolescents aged 15-19 who performed high-intensity exercises and adolescents of the same age group. They found that the group that performed the exercises was significantly taller than the group that did not, although these were not jumping exercises, they were high-intensity exercises following the same principle {5}
To the author’s knowledge, these are the only studies that have tested the effectiveness of jumping to increase height. Interestingly, they involved children with growth hormone deficiency, children with idiopathic short stature, and normal children, and there is no other drug or method that has been proven effective for these three groups, which frankly supports the effectiveness of jumping.
Now let’s talk about studies on animals. Mice were divided into four groups: control, swimming, jumping, and running. We will, of course, focus only on the results of jumping. The femur length increased very significantly (9.5%) and the tibia length also increased very significantly (9%). Interestingly, there was a marked hypertrophy of the cartilage layer, which increased by 70%, the growth plate length increased by 25%, and the mRNA expression of BMP2 and SMAD pathways rose by 62-96% {7}
It seems that all the evidence indicates that jumping is effective in children or young animals, while there is no evidence in older mice, right? No, and here comes the shock. In a study conducted by Ishiko and his research team on mice aged 3 and 6 months, they were exercised with jumping 100 times, five times a week. Very interestingly, they reported that the tibia and femur lengths increased significantly compared to the control. These results are exceptional, especially since mice at this age have already completed skeletal maturity, yet jumping still significantly promoted growth. It is important to mention that mice growth plates never close but become inactive after sexual maturity (after 8 weeks), where structural growth is then limited. Nevertheless, daily jumping for several minutes was able to clearly stimulate longitudinal growth of the tibia and femur, which is remarkable {8}
Discussion:
Despite the limited evidence, and although all of it reports the same results, a clear stimulation of longitudinal bone growth, these studies support, at least for the time being, that daily jumping is very effective for increasing height.
There may be more than one scientific explanation for these results. First, increased activity of the growth hormone (GH) and IGF-1 axis, as it has been previously reported that jumping exercises are effective in increasing GH/IGF-1 axis activity in a study conducted on adolescents and children {9}. However, this is probably not the reason, as in the study by Xing Wang and his team, a significant increase in height was reported even without any clear effect on the GH axis {2}. Therefore, increased GH/IGF-1 axis activity is not the cause, or at least not the main cause
So what is the reason? In reality, it comes down to two causes: the first is the internal stimulation of periosteal cells, and the second is the direct stimulation of chondrocyte cells.
During jumping, the bone matrix undergoes mechanical deformation. As a result of this deformation, the periosteum secretes a protein called OSTN {10}. When OSTN is secreted from periosteal cells, it enters the growth plates through the metaphyseal artery. Upon entering the growth plate, it binds to NPC-C, which increases the bioavailability of CNP and allows it to bind to NPR-B, activating cyclic guanosine monophosphate (cGMP). This leads to inhibition of the FGFR3C pathway in chondrocytes, allowing better proliferation and hypertrophy of chondrocyte cells. This is the most well-known classical theory in the scientific community and has been discussed and validated by researchers {11}.
(A figure illustrating how mechanical stress leads to increased OSTN, then its entry into the growth plate, followed by inhibition of NPR-C and increased longitudinal bone growth)
To test this classical hypothesis, mice were produced that expressed higher levels of OSTN than normal mice. Interestingly, the body length of these mice was about 12% longer compared to wild-type mice, which is quite significant, especially for a protein that was not expected to have a role in longitudinal growth. Interestingly, they also observed that cGMP levels increased by 77% compared to wild-type mice, further supporting the classical theory we have already presented {28}
(Another figure illustrating the classical theory)
Another mechanism by which jumping increases height (and the most likely one) is through applying intermittent cyclic compression on chondrocyte cells. It has already been proven that jumping applies compressive force, as demonstrated in a clinical study {14}. Although the measurement was taken at the mid-tibia, it is very logical that chondrocytes experience compressive force upon impact with the ground. In reality, this type of compression is very effective in increasing the expression of pathways important for longitudinal growth. For example, in an in vivo study on mice, the effect of intermittent cyclic compression on tibial growth was tested, and the results showed a significant increase in tibial length compared to the control group, with nearly a twofold increase in PTHrP gene expression. Although this study did not directly test jumping, it follows the same principle as jumping, which is cyclic compression {12}.
In another study, it was observed that applying the expected mechanical compression led to a clear increase in longitudinal bone growth, with a noticeable increase in PTGS2 (a protein important for regulating longitudinal bone growth) {13}.
It has also been reported in vitro that intermittent mechanical compression is effective in increasing IGF-1 and other important growth factors in chondrocyte cells {15}, and it also significantly enhances the proliferation of human chondrocyte cells in the laboratory {16}.
It has also been reported that jumping indeed generates tensile force approximately comparable to the compressive force on the bone axis. During the jump, while the person is airborne, gravity applies tensile force, and it is very likely that chondrocytes in the growth plate are exposed to the same tensile force {14}. According to the Hueter-Volkmann law, and as demonstrated in many animal models, moderate intermittent tension is an effective stimulator of chondrocyte proliferation and longitudinal bone growth {17,18}. Interestingly, it has been reported that tensile force on chondrocytes increases PTHrP gene expression by approximately fivefold {19}, and mechanical stress on chondrocytes also significantly enhances the IHH pathway {20}.
During jumping, chondrocytes in the growth plate are also exposed to shear force {14,21}. The effect of shear force on chondrocytes is very important and directly supports longitudinal growth, as it activates COX2 through the Rac/MEKK1/MKK7/JNK2/c-Jun-C/EBPβ-dependent pathway {21}, and also leads to a significant increase in SOX9 through activation of the MAPK/ERK-AGG pathway {22,23}. Additionally, fluid shear stress on chondrocytes greatly enhances PI3K/AKT activity {24}, a crucial pathway for protecting chondrocytes from apoptosis by increasing BCL-2 and reducing BAX {25}, and it also increases IGF-1 gene expression in chondrocytes {26}. There are many other pathways activated by fluid shear stress on chondrocytes; if you are interested, I recommend further research to learn more.
There is one more thing I wanted to include, honestly, which is a comparison with KY19382, a drug widely promoted on this forum as a “miracle” for increasing height. Interestingly, when this compound was administered to mice for ten weeks, from 3 weeks to 13 weeks of age, it led to an average femur length increase of about 3%. In contrast, jumping exercises from 4 weeks to 12 weeks of age resulted in an average increase of approximately 9.5% in femur length, a overwhelming superiority of jumping over this compound. It is amusing how a simple physical activity can so clearly outperform even the most heavily promoted chemical drugs for height increase {7,27}.
Conclusion:
Jumping exercises lead to increased longitudinal bone growth by applying tensile, compressive, and shear forces on chondrocytes and by increasing the gene expression of genes that stimulate chondrocyte proliferation and hypertrophy, making it, at least according to the currently available data, one of the most effective methods for increasing height.
Note : everything have written by user @ihatemySOST , thanks for reading !
References :
1. Wolff’s law in action: a mechanism for early knee osteoarthritis
Andrew J Teichtahl 1,2, Anita E Wluka 2, Pushpika Wijethilake 2, Yuanyuan Wang 2, Ali Ghasem-Zadeh 3, Flavia M Cicuttini 2
2. 24-Week jumping exercise influence on growth speed and GH-IGF-1-IGFBP-3 axis among short-stature children
Huiming Wang et al. BMC Pediatr. 2025.
3. More Jump More Health: Vertical Jumping Learning of Chinese Children and Health Promotion
Liu Liu et al. Front Psychiatry. 2022.
4. Effectiveness of complex exercise programs to promote growth in children undergoing growth hormone therapy
Jeong-Hoon Lee', Chang-Sik An', Won-Jong Yu**, Chang-Ryeol Lee', Jeong-Lae Kim*
1, Department of Phvsical Therany. Bulu University. Songnam. 18186. Kore: wivu@ cumackr/W..Yal
*Department of Physical Therapy, Korea Nazarene University, Cheonan, 31172, Korea,
*Department of Biomedical Engineering, Eulji University, Seongnam, 18155, Korea.
5. Relationships between exercise customs and height growth of the boys
who are in the latter half of puberty
桑原 伸弘 1）
Kuwabara Nobuhiro
1）
6. Effects of different types of exercise on TGFβ/BMP signaling pathway and bone growth in growing rats
2021-04-06 Zhao Changhong Li Shichang Hu Xiaopan
7. Effects of different types of exercise on TGFβ/BMP signaling pathway and bone growth in growing rats
2021-04-06 Zhao Changhong Li Shichang Hu Xiaopan
8. 364 Physiology and Biochemistry Effects of Jump Training on Bone Hypertrophy in Young and Old Rats V, Umemura', T. Ishiko', H. Tsujimoto', H. Miura', N. Mokushi', H. Suzuk? School of Physical Education
9. Effects of Music Rope-Skipping exercise on health fitness, blood lipids and growth-related factors in male middle school Boys
10. Mechanical Load Increases in Bone Formation via a Sclerostin-Independent Pathway
Alyson Morse 1,2, Michelle Maree McDonald 3, Natalie H Kelly 4,5, Katherine M Melville 4,5, Aaron Schindeler 1,2, Ina Kramer 6, Michaela Kneissel 6, Marjolein CH van der Meulen 4,7, David Graham Little 1,2
11. Mechanical Load Increases in Bone Formation via a Sclerostin-Independent Pathway
Alyson Morse 1,2, Michelle Maree McDonald 3, Natalie H Kelly 4,5, Katherine M Melville 4,5, Aaron Schindeler 1,2, Ina Kramer 6, Michaela Kneissel 6, Marjolein CH van der Meulen 4,7, David Graham Little 1,2
12. Intermittent mechanical loading on mouse tibia accelerates longitudinal bone growth by inducing PTHrP expression in the female tibial growth plate
Sarah McGarry 1,2, Karen Kover 1,2, Daniel P Heruth 1,2, Mark Dallas 3, Xinxin Jin 4, Shufang Wu 5, Francesco De Luca 1,2
13. Effects of mechanical load/stress on bone growth
AUTHOR: Z Zhang; Department Of Women's And Children's Health (kbh); []
KEYWORDS: ;
14. Understanding the etiology of the posteromedial tibial stress fracture
Charles Milgrom et al. Bone. 2015 Sep
15. Effect of Cyclic Dynamic Compressive Loading on Chondrocytes and Adipose-Derived Stem Cells Co-Cultured in Highly Elastic Cryogel Scaffolds
by Chih-Hao Chen 1,2ORCID, Chang-Yi Kuo 1,2 and Jyh-Ping Chen 1,2,3,4,*ORCID
16. Mechanical Compression of Articular Cartilage Induces Chondrocyte Proliferation and Inhibits Proteoglycan Synthesis by Activation of the Erk Pathway: Implications for Tissue Engineering and Regenerative Medicine
James A Ryan 1,2, Eric A Eisner 1,3, Grayson DuRaine 1, Zongbing You 1,4, A Hari Reddi 1
17. Mechanical stimulation of growth plate chondrocytes: Previous approaches and future directions
D Lee 1,a, A Erickson 2, A T Dudley 2,*, S Ryu 1,3,*
18. The true history of the Hueter-Volkmann law
Jan Bartoníček 1,2, Ondřej Naňka 2,✉
19. Regulation of PTHrP expression by cyclic mechanical strain in postnatal growth plate chondrocytes
Tao Xu et al. Bone. 2013 Oct
20. Indian hedgehog is an essential component of mechanotransduction complex to stimulate chondrocyte proliferation
Q Wu et al. J Biol Chem. 2001
21. Plyometric training increases thickness and volume of knee articular cartilage in mice
Marco Chiaberge, Neelima Thottappillil, …Chen-Ming Fan
22. Elucidation of the signaling network of COX-2 induction in sheared chondrocytes: COX-2 is induced via a Rac/MEKK1/MKK7/JNK2/c-Jun-C/EBPβ- dependent pathway
Zachary R. Healy, Fei Zhu, Joshua D. Stull, Konstantinos Konstantopoulos
Whiting School of Engineering
23. Complex deformation of cartilage micropellets following mechanical stimulation promotes chondrocyte gene expression
Noémie Petitjean 1,2, Patrick Canadas 2, Christian Jorgensen 1,3, Pascale Royer 2, Simon Le Floc’h 2,#, Danièle Noël
24. Shear- and Compression-induced Chondrocyte Transcription Requires MAPK Activation in Cartilage Explants*
Author links open overlay panel
Jonathan B. Fitzgerald ‡ 1 2
, Moonsoo Jin § 1 3,
Diana H. Chai ‡
,
Patrick Siparsky ‡
,
Paul Fanning ¶
, Alan J. Grodzinsky ‡ § ∥
25. Protection of carboxymethylated chitosan on chondrocytes from nitric oxide-induced apoptosis by regulating phosphatidylinositol 3-kinase/Akt signaling pathway
Author links open overlay panel
Bin He
,
Haiying Tao
,
Ailin Wei
, Shiqing Liu,
Xiaohai Li
,
Ren Chen
26. IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK
Bela G Starkman *, John D Cravero *, Marcello DelCarlo Jr, Richard F Loeser
27. CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth
28. Circulating osteocrin stimulates bone growth by limiting C-type natriuretic peptide clearance
October 2017The Journal of clinical investigation 127(11)
