Keep using SSRI or stop?

[GatoradeTRZ8]

Ive been on escitalopram 10mg for a few month because of ocd.

positive effects:
feeling calm even in stressful situations
not giving a fuck about what people think or other unrelevant stuff
Less overthinking
Less anxiety

Negative effects:
Slight weight gain/more hunger (3kg)
Needing more sleep and getting tired earlier than usual
E2 increase according to blood test (not sure if it was because of the ssri or just an e2 spike)

My baseline total t was 650, e2 was 25

I did a blood test after quitting test e cold turkey:
Total t 580 and e2 34

the increase in e2 was either due to the ssri or maybe it was an e2 spike


Overall a good drug for those who truly needed, no sexual side effects so far

But i would rather try to learn how to not give a fuck myself instead of having to rely on a drug with side effects

I also take Attentin (dextroamphetamine) and according to leo & longevity fluvoxamine is good in combination with attentin because its the strongest sigma 1 receptor agonist among all ssris. Which means that attentin would feel stronger with the same dosage and would cause less side effects than if taken alone

So I have 3 options now:
1. escitalopram + attentin
2. attentin alone
3. attentin + fluvoxamine

I think 2 or 3 makes the most sense, what would you do in my case?


Tagging high iq people:
@User28823
@Keylozz
@aids
@TsarTsar444

 

[nullandvoid]

Ive been on escitalopram 10mg for a few month because of ocd.

positive effects:
feeling calm even in stressful situations
not giving a fuck about what people think or other unrelevant stuff
Less overthinking
Less anxiety

Negative effects:
Slight weight gain/more hunger (3kg)
Needing more sleep and getting tired earlier than usual
E2 increase according to blood test (not sure if it was because of the ssri or just an e2 spike)

My baseline total t was 650, e2 was 25

I did a blood test after quitting test e cold turkey:
Total t 580 and e2 34

the increase in e2 was either due to the ssri or maybe it was an e2 spike


Overall a good drug for those who truly needed, no sexual side effects so far

But i would rather try to learn how to not give a fuck myself instead of having to rely on a drug with side effects

I also take Attentin (dextroamphetamine) and according to leo & longevity fluvoxamine is good in combination with attentin because its the strongest sigma 1 receptor agonist among all ssris. Which means that attentin would feel stronger with the same dosage and would cause less side effects than if taken alone

So I have 3 options now:
1. escitalopram + attentin
2. attentin alone
3. attentin + fluvoxamine

I think 2 or 3 makes the most sense, what would you do in my case?


Tagging high iq people:
@User28823
@Keylozz
@aids
@TsarTsar444

I personally take around 50mg of zoloft a day and the pros heavily outweigh the cons, yeah it's jew medicine but it works. In my opinion stay on SSRIs while putting in effort to mitigate or at least reduce the negatives.

Please rep if you found this post helpful.

 

[O'bhai]

are you prescribed?

 

[tomahawk]

Fuck ssris unless prescribed
Even when prescribed kinda shit and hella dangerous

 

[SoundnVision]

Poison

 

[ivan.kuk]

SSRIs have the same rate of effect as placebos. https://pmc.ncbi.nlm.nih.gov/articles/PMC4592645/

 

[aids]

SSRIs are a great bandaid fix to provide you with some cognisance and motivation to fix things in your life.

If you are depressed because of external variables, then stay on them until you fix said problems, then taper off.

If you have clinical depression, then maybe you should look into some psychedelics. I'm not too knowledgeable on this but I'd like to think that effectively managing an acute period of extremely-high neuroplasticity will enable you to address clinical depression and perhaps give you a better outlook on life after your trip.

 

[aids]

Just want to clarify that I DNR'd your entire thread because I'm so tired.
I will come back to it in the morning, just mention me again or quote a post so I get the notification.
Thanks

 

[Nexom]

SSRIs are a great bandaid fix to provide you with some cognisance and motivation to fix things in your life.

If you are depressed because of external variables, then stay on them until you fix said problems, then taper off.

If you have clinical depression, then maybe you should look into some psychedelics. I'm not too knowledgeable on this but I'd like to think that effectively managing an acute period of extremely-high neuroplasticity will enable you to address clinical depression and perhaps give you a better outlook on life after your trip.

Yes, psilocybin is really good at getting you out of a rut in my experience (and tons of other people I've talked to). DMT can change your life if you're a good candidate. I'll make threads on my experiences with all of them, but it's really interesting to see you mention them here.

 

[aids]

Yes, psilocybin is really good at getting you out of a rut in my experience (and tons of other people I've talked to). DMT can change your life if you're a good candidate. I'll make threads on my experiences with all of them, but it's really interesting to see you mention them here.

I have wanted to micro-dose Psilocybin for a little while.
But I've decided I will likely try a controlled trip under supervision of somebody I trust, to cause behavioural changes and perhaps make me more efficient/patient/kind and so on.

 

[Nexom]

I have wanted to micro-dose Psilocybin for a little while.
But I've decided I will likely try a controlled trip under supervision of somebody I trust, to cause behavioural changes and perhaps make me more efficient/patient/kind and so on.

That's honestly the best approach, I always tell people to be careful when dabbling into anything like this despite having done everything on my own (with tons of precautions and the right measures). If done right, it has benefits for most people and recently I've even seen talks about longevity but haven't looked much into it. For anyone reading this in the future, I highly discourage anyone try anything like this without proper knowledge (and of course technically necessary "don't do illegal shit")

 

[4ever]

Unrelated but how long after quitting test e did you get bloodwork?

 

[GatoradeTRZ8]

Just want to clarify that I DNR'd your entire thread because I'm so tired.
I will come back to it in the morning, just mention me again or quote a post so I get the notification.
Thanks

Alright, heres a tldr, you can answer whenever you want

• Been on escitalopram 10 mg for OCD for a few months → big mental benefits (calm, less anxiety/overthinking, less caring about others’ opinions), no sexual side effects.
• Downsides: ~3 kg weight gain/increased hunger, slightly more fatigue/sleep need, E2 rose (baseline T 650 / E2 25 → after stopping test E: T 580 / E2 34; unclear if SSRI-related or natural spike).
• I prefer to learn these mental skills without relying on an SSRI long-term. (And think I can)
• I also take Attentin (dextroamphetamine).
• Based on Leo & Longevity: fluvoxamine (another SSRI) + Attentin may be synergistic (sigma-1 agonism → stronger stimulant effect at same dose, fewer sides).
• Options:
  1. Escitalopram + Attentin
  2. Attentin alone
  3. Attentin + fluvoxamine
• Im leaning toward 2 or 3 and asking what makes most sense.

 

[aids]

Alright, heres a tldr, you can answer whenever you want

• Been on escitalopram 10 mg for OCD for a few months → big mental benefits (calm, less anxiety/overthinking, less caring about others’ opinions), no sexual side effects.
• Downsides: ~3 kg weight gain/increased hunger, slightly more fatigue/sleep need, E2 rose (baseline T 650 / E2 25 → after stopping test E: T 580 / E2 34; unclear if SSRI-related or natural spike).
• I prefer to learn these mental skills without relying on an SSRI long-term. (And think I can)
• I also take Attentin (dextroamphetamine).
• Based on Leo & Longevity: fluvoxamine (another SSRI) + Attentin may be synergistic (sigma-1 agonism → stronger stimulant effect at same dose, fewer sides).
• Options:
  1. Escitalopram + Attentin
  2. Attentin alone
  3. Attentin + fluvoxamine
• Im leaning toward 2 or 3 and asking what makes most sense.

I’m gonna mark this as unread and reply in morning or evening tomorrow (today but after I sleep).

 

[GatoradeTRZ8]

Unrelated but how long after quitting test e did you get bloodwork?

4-5 months

 

[Keylozz]

Yes, as aids said, look into psychedelics for a permanent fix to the problem, especially LSD/Shrooms and S-Ketamine (I’ve done both and do them sometimes)

Also some neurogenic/experimental nootropics that I’m using and people report benefits for depression and OCD (And they are/were being developed for depression)

ACD-856
Usmarapride
NSI-189
TAK-653
AF710b (since you mentioned s1 receptor)

My stack is a bit longer than that but those work as intended for OCD/depression, even though I’m using them as cognitive enhancers

I don’t really like SSRIs unless a low dose for a slight mood uplift on a certain period of time, not for depression

 

[greedpsl]

I personally take around 50mg of zoloft a day and the pros heavily outweigh the cons, yeah it's jew medicine but it works. In my opinion stay on SSRIs while putting in effort to mitigate or at least reduce the negatives.

Please rep if you found this post helpful.

im on zoloft too

 

[greedpsl]

Ive been on escitalopram 10mg for a few month because of ocd.

positive effects:
feeling calm even in stressful situations
not giving a fuck about what people think or other unrelevant stuff
Less overthinking
Less anxiety

Negative effects:
Slight weight gain/more hunger (3kg)
Needing more sleep and getting tired earlier than usual
E2 increase according to blood test (not sure if it was because of the ssri or just an e2 spike)

My baseline total t was 650, e2 was 25

I did a blood test after quitting test e cold turkey:
Total t 580 and e2 34

the increase in e2 was either due to the ssri or maybe it was an e2 spike


Overall a good drug for those who truly needed, no sexual side effects so far

But i would rather try to learn how to not give a fuck myself instead of having to rely on a drug with side effects

I also take Attentin (dextroamphetamine) and according to leo & longevity fluvoxamine is good in combination with attentin because its the strongest sigma 1 receptor agonist among all ssris. Which means that attentin would feel stronger with the same dosage and would cause less side effects than if taken alone

So I have 3 options now:
1. escitalopram + attentin
2. attentin alone
3. attentin + fluvoxamine

I think 2 or 3 makes the most sense, what would you do in my case?


Tagging high iq people:
@User28823
@Keylozz
@aids
@TsarTsar444

I'm a tiny bit less horny, but it makes u feel very slight relief. It helped me leanmaxx bc It made me not want to binge eat while depressed.

 

[hej1377]

They absolutely work but still gets mogged by other anti depressants that should be used over ssri's first as they dont come with the same sides

Imo try desvenflaxamine, if that doesnt work go for venflaxamine

Youcould also midigate ssri sides if you like, buprupione which is another better anti depressant can act as a counterweight, testosterone can kind of also act as counterweight although strictly for counteracting sides bup prob mogs, altough you dont have to pick and can just cruise on test and take bup

As mentioned above i think psychadelucs can be a great thing to try as it ofter can help depression. Ketamine is probably as good if not better, id try both and do a couple trips and see how it makes you feel

 

[DonkChewbert]

Flip a coin every day to choose whether you take your SSRIs so you become crazy and women will like you because you're unpredictable.

 

[TsarTsar444]

Escitalopram is the probably the most gentle (least side effects) and most legit (in terms of possitives) ssri currently. I don't consider it a cuck pill like the older generation ones like Zoloftstein or Prozacberg. It has no to mild sexual sides which is the biggest win for males especially. Even if it does its only during the first 2 months or less and then it goes away. This here is from reading papers on it and from personal irl anecdotes of people that take it.

Most important tho and what people seem to miss is that ssri's like escitalopram are best for GADcels and OCDcels, not for externally induced depression or a dysphoric and anhedonic individual (it can even worsen the later although mildly most definitely).

Also the weight thing with SSRI is one of the topics that gring my gears everytime i see mentioned because people seem to have a misunderstanding on what happens. Its just simply makes you either eat more or less as well depending on what relationship you have with food when in a stressed-dysphoric-anxious state. Some people lose weight because they dont feel like binge eating as much anymore to cope with problems for example. If you gain weight then honestly its probably a looksmax because depressed anorexiacels are usually frail, gaunt and pale looking when in a depressive episode not just from undereating calories but also in general nutrients.

Yeah Escitalopram and Attentin are a S tier combo indeed, amazing synergy and they help eachothers sides as well.

 

[Nexom]

I’m gonna mark this as unread and reply in morning or evening tomorrow (today but after I sleep).

Hey, reminder for this.
Curious what you have to say

 

[aids]

Alright, heres a tldr, you can answer whenever you want

• Been on escitalopram 10 mg for OCD for a few months → big mental benefits (calm, less anxiety/overthinking, less caring about others’ opinions), no sexual side effects.
• Downsides: ~3 kg weight gain/increased hunger, slightly more fatigue/sleep need, E2 rose (baseline T 650 / E2 25 → after stopping test E: T 580 / E2 34; unclear if SSRI-related or natural spike).
• I prefer to learn these mental skills without relying on an SSRI long-term. (And think I can)
• I also take Attentin (dextroamphetamine).
• Based on Leo & Longevity: fluvoxamine (another SSRI) + Attentin may be synergistic (sigma-1 agonism → stronger stimulant effect at same dose, fewer sides).
• Options:
  1. Escitalopram + Attentin
  2. Attentin alone
  3. Attentin + fluvoxamine
• Im leaning toward 2 or 3 and asking what makes most sense.

Again, take what you need until you fix the cause of your depression.
So, take SSRIs and dextroamphetamine, then taper off the SSRI, then you’re good.

 

[GatoradeTRZ8]

Escitalopram is the probably the most gentle (least side effects) and most legit (in terms of possitives) ssri currently. I don't consider it a cuck pill like the older generation ones like Zoloftstein or Prozacberg. It has no to mild sexual sides which is the biggest win for males especially. Even if it does its only during the first 2 months or less and then it goes away. This here is from reading papers on it and from personal irl anecdotes of people that take it.

Most important tho and what people seem to miss is that ssri's like escitalopram are best for GADcels and OCDcels, not for externally induced depression or a dysphoric and anhedonic individual (it can even worsen the later although mildly most definitely).

Also the weight thing with SSRI is one of the topics that gring my gears everytime i see mentioned because people seem to have a misunderstanding on what happens. Its just simply makes you either eat more or less as well depending on what relationship you have with food when in a stressed-dysphoric-anxious state. Some people lose weight because they dont feel like binge eating as much anymore to cope with problems for example. If you gain weight then honestly its probably a looksmax because depressed anorexiacels are usually frail, gaunt and pale looking when in a depressive episode not just from undereating calories but also in general nutrients.

Yeah Escitalopram and Attentin are a S tier combo indeed, amazing synergy and they help eachothers sides as well.

Yes it mogs
The side effects dont really bother me a lot but it still makes me think if i should taper off and try to learn to not overthink myself. Especially the e2 increase bothers me, but I only did one blood test on escitalopram so cant really say for sure if it was the cause or if it was an e2 spike.
Also it helped me to see that worrying too much is retarded, so I think that I would be in a lot better situation even after tapering off than before taking escitalopram.
But if it goes well with attentin I would consider to keep taking it. What do you think about fluvoxamine? Because its the strongest sigma-1 agonist among ssris and that should mean it would synergize with attentin even better than escitalopram right?

Again, take what you need until you fix the cause of your depression.
So, take SSRIs and dextroamphetamine, then taper off the SSRI, then you’re good.

But its not depression, it’s overthinking unnecessary things and past events.
I don’t know if it’s completely fixable, but reducing it to the point where it no longer has a meaningful impact on my life is possible.

 

[aids]

Yes it mogs
The side effects dont really bother me a lot but it still makes me think if i should taper off and try to learn to not overthink myself. Especially the e2 increase bothers me, but I only did one blood test on escitalopram so cant really say for sure if it was the cause or if it was an e2 spike.
Also it helped me to see that worrying too much is retarded, so I think that I would be in a lot better situation even after tapering off than before taking escitalopram.
But if it goes well with attentin I would consider to keep taking it. What do you think about fluvoxamine? Because its the strongest sigma-1 agonist among ssris and that should mean it would synergize with attentin even better than escitalopram right?


But its not depression, it’s overthinking unnecessary things and past events.
I don’t know if it’s completely fixable, but reducing it to the point where it no longer has a meaningful impact on my life is possible.

Then psychedelics, @Nexom will make a thread, I believe?

 

[Nexom]

Then psychedelics, @Nexom will make a thread, I believe?

I'll be making a series of threads on my experiences, but in January probably.