L-ARGININE QUESTIONS

[igniteisbad]

I've been taking an L-Arginine supplement (powder) for a little while now (I can't remember that well maybe 6 months?) I want to know everyone's opinions on it.

I talked with AI and I've only heard good things from it:

Spoiler: AI on L-Arginine

L-Arginine and Skin Health​

L-Arginine plays a crucial role in skin health and appearance through multiple mechanisms:

1. Collagen Synthesis:
   L-Arginine is a key precursor in the biosynthesis of collagen, the most abundant protein in the skin. It serves as a substrate for proline and hydroxyproline, which constitute approximately 23% of collagen molecules. Studies have shown that L-Arginine supplementation can increase collagen deposition in wound healing models by up to 35%
   https://www.webmd.com/vitamins/ai/ingredientmono-875/l-arginine

The conversion of L-Arginine to proline involves several enzymatic steps:
a) Arginase converts L-Arginine to ornithine
b) Ornithine aminotransferase converts ornithine to pyrroline-5-carboxylate (P5C)
c) P5C reductase then converts P5C to prolineFurthermore, L-Arginine enhances the activity of prolyl hydroxylase, a key enzyme in collagen stability. In vitro studies have demonstrated that L-Arginine can increase prolyl hydroxylase activity by up to 50% in fibroblast cultures

1. Nitric Oxide Production and Microcirculation:
   L-Arginine is the primary substrate for nitric oxide synthase (NOS), which produces nitric oxide (NO). NO is a potent vasodilator that improves microcirculation in the skin. A study on healthy volunteers showed that oral supplementation with 6g of L-Arginine daily for 4 weeks increased cutaneous microcirculation by 29% as measured by laser Doppler flowmetry
   https://www.healthline.com/nutrition/l-arginine

The improved microcirculation has several benefits for skin appearance:
a) Enhanced nutrient delivery to skin cells
b) Improved removal of metabolic waste products
c) Increased oxygen supply, promoting a healthy skin glow

1. Antioxidant Effects:
   L-Arginine exhibits both direct and indirect antioxidant properties in the skin:

a) Direct scavenging of reactive oxygen species (ROS): L-Arginine can directly neutralize superoxide anions and hydroxyl radicals. In vitro studies have shown that L-Arginine at physiological concentrations can reduce ROS levels by up to 20% in keratinocyte cultures
.b) Enhancement of antioxidant enzyme activity: L-Arginine supplementation has been shown to increase the activity of superoxide dismutase (SOD) and catalase in skin tissue. A study in aged rats demonstrated that L-Arginine supplementation (2.25g/kg body weight) increased SOD activity by 37% and catalase activity by 43% in skin tissue

1. Skin Hydration and Barrier Function:
   L-Arginine contributes to skin hydration and barrier function through multiple mechanisms:

a) Natural Moisturizing Factor (NMF) production: L-Arginine is a component of NMF, contributing to skin hydration. Studies have shown that topical application of 2.5% L-Arginine can increase skin hydration by up to 16% after 4 weeks of use .b) Aquaporin regulation: L-Arginine modulates the expression of aquaporin-3 (AQP3), a water channel protein in the skin. In vitro studies have demonstrated that L-Arginine can increase AQP3 expression by up to 45% in keratinocyte cultures, potentially enhancing skin hydration .c) Filaggrin metabolism: L-Arginine is involved in the metabolism of filaggrin, a key protein in skin barrier function. A study on atopic dermatitis patients showed that oral supplementation with 3g of L-Arginine daily for 8 weeks improved skin barrier function, as measured by transepidermal water loss (TEWL), by 27%.

L-Arginine and Hair Growth​

L-Arginine's effects on hair growth and quality are multifaceted:

1. Vasodilation and Follicular Blood Flow:
   L-Arginine-derived NO improves blood flow to hair follicles. A study using laser Doppler flowmetry demonstrated that topical application of a 2% L-Arginine solution increased scalp blood flow by 35% within 30 minutes of application.
2. Modulation of Hair Growth Cycle:
   L-Arginine influences the hair growth cycle through several mechanisms:

a) Prolongation of anagen phase: In vitro studies on human hair follicle organ cultures have shown that L-Arginine (1mM) can extend the anagen phase by up to 26% compared to controls .b) Inhibition of ornithine decarboxylase (ODC): L-Arginine competitively inhibits ODC, an enzyme involved in hair follicle regression. A study on mouse models demonstrated that L-Arginine supplementation (2% in drinking water) reduced ODC activity in hair follicles by 42%, potentially delaying the onset of the catagen phase.

1. Protein Synthesis in Hair Follicles:
   L-Arginine is crucial for the synthesis of hair proteins:

a) Keratin production: L-Arginine is a precursor for proline and histidine, key amino acids in hair keratin. In vitro studies have shown that L-Arginine supplementation (2mM) can increase keratin production in hair follicle cultures by up to 35% .b) Hair shaft strength: A clinical study on 100 women with thinning hair showed that oral supplementation with 1g of L-Arginine daily for 6 months increased hair tensile strength by 12.5% and reduced hair breakage by 35%.

L-Arginine and Body Composition​

L-Arginine's effects on body composition are particularly relevant for aesthetic enhancement:

1. Muscle Protein Synthesis:
   L-Arginine stimulates muscle protein synthesis through multiple pathways:

a) mTOR activation: L-Arginine activates the mTOR pathway, a key regulator of protein synthesis. A study on young adults showed that ingestion of 6g of L-Arginine increased muscle protein synthesis rates by 56% compared to placebo .b) Growth hormone secretion: L-Arginine stimulates growth hormone (GH) release. A meta-analysis of 17 studies found that L-Arginine supplementation (5-9g) increased GH levels by an average of 100% compared to baseline .c) Insulin sensitivity: L-Arginine improves insulin sensitivity in skeletal muscle. A study on type 2 diabetic patients showed that L-Arginine supplementation (8.3g daily) improved insulin sensitivity by 34% after 4 weeks.

1. Fat Metabolism:
   L-Arginine influences fat metabolism through several mechanisms:

a) Lipolysis: L-Arginine stimulates the release of growth hormone, which promotes lipolysis. A study on obese subjects showed that L-Arginine supplementation (9g daily) increased 24-hour growth hormone secretion by 60%, leading to a 7% reduction in fat mass after 12 weeks .b) Brown adipose tissue (BAT) activation: L-Arginine may activate BAT, increasing energy expenditure. An animal study demonstrated that L-Arginine supplementation (1.51% of diet) increased BAT mass by 34% and UCP1 expression (a marker of BAT activity) by 98% .c) Adiponectin production: L-Arginine stimulates the production of adiponectin, a hormone that enhances fat oxidation. A clinical trial on obese type 2 diabetic patients showed that L-Arginine supplementation (8.3g daily) increased plasma adiponectin levels by 35% after 21 days.

1. Exercise Performance:
   L-Arginine can enhance exercise performance, indirectly contributing to improved body composition:

a) Nitric oxide production: L-Arginine increases NO production during exercise. A study on cyclists showed that L-Arginine supplementation (6g daily) increased plasma nitrate levels by 100% and improved time to exhaustion by 26% during high-intensity exercise .b) Lactate metabolism: L-Arginine may improve lactate clearance during exercise. A study on trained athletes demonstrated that acute L-Arginine supplementation (6g) reduced blood lactate levels by 23% during high-intensity exercise. In conclusion, L-Arginine's multifaceted effects on skin health, hair growth, and body composition make it a potentially valuable compound for aesthetic enhancement. However, it's important to note that individual responses may vary, and more research is needed to fully elucidate the optimal dosages and long-term effects of L-Arginine supplementation for these purposes.

sorry if the spoiler thing didn't work I haven't done that before

But I've heard people say it's cope and to take something else, what would that be? does it have a good bio-availability?
if I SHOULD take it, how much should I take? is my dosage good?

 

[Jonas2k7]

But I've heard people say it's cope and to take something else, what would that be?

dnr

Take clenbuterol and anavar

 

[igniteisbad]

dnr

Take clenbuterol and anavar

what do they do

 

[Jonas2k7]

what do they do

no rep no help

 

[igniteisbad]

bump

 

[autistic_tendencies]

Citrulline is better

 

[PolishSlayer0]

bump

 

[Huge غرور]

Cope waste of money

 

[igniteisbad]

bump

I follow u on tiktok

 

[igniteisbad]

Cope waste of money

how come

 

[igniteisbad]

Citrulline is better

how come

 

[autistic_tendencies]

how come

I’ve read things arginine converts to citrulline in the body anyways

 

[Goonerholocaust]

I’ve read things arginine converts to citrulline in the body anyways

But why would you want citruline?

 

[autistic_tendencies]

But why would you want citruline?

Correction
Citrulline is then captured by the kidneys. Eighty per cent of citrulline synthesised by the intestine is converted into arginine,6 which is released into the blood stream for use by other tissues for protein synthesis and other purposes.


Arginine has a host of recovery and anti aging benefits

 

[Deleted member 100156]

Correction
Citrulline is then captured by the kidneys. Eighty per cent of citrulline synthesised by the intestine is converted into arginine,6 which is released into the blood stream for use by other tissues for protein synthesis and other purposes.


Arginine has a host of recovery and anti aging benefits

Shut up bitch

 

[autistic_tendencies]

Shut up bitch

I’m trying to help your subhuman ass

 

[igniteisbad]

Correction
Citrulline is then captured by the kidneys. Eighty per cent of citrulline synthesised by the intestine is converted into arginine,6 which is released into the blood stream for use by other tissues for protein synthesis and other purposes.


Arginine has a host of recovery and anti aging benefits

So it doesn’t matter if I get arginine or citrulline because the arginine will convert to citrulline which will then convert 80% back to arginine? I’m a bit confused

 

[Deleted member 59811]

I've been taking an L-Arginine supplement (powder) for a little while now (I can't remember that well maybe 6 months?) I want to know everyone's opinions on it.
View attachment 3231951

I talked with AI and I've only heard good things from it:

Spoiler: AI on L-Arginine

L-Arginine and Skin Health​

L-Arginine plays a crucial role in skin health and appearance through multiple mechanisms:

1. Collagen Synthesis:
   L-Arginine is a key precursor in the biosynthesis of collagen, the most abundant protein in the skin. It serves as a substrate for proline and hydroxyproline, which constitute approximately 23% of collagen molecules. Studies have shown that L-Arginine supplementation can increase collagen deposition in wound healing models by up to 35%
   https://www.webmd.com/vitamins/ai/ingredientmono-875/l-arginine

The conversion of L-Arginine to proline involves several enzymatic steps:
a) Arginase converts L-Arginine to ornithine
b) Ornithine aminotransferase converts ornithine to pyrroline-5-carboxylate (P5C)
c) P5C reductase then converts P5C to prolineFurthermore, L-Arginine enhances the activity of prolyl hydroxylase, a key enzyme in collagen stability. In vitro studies have demonstrated that L-Arginine can increase prolyl hydroxylase activity by up to 50% in fibroblast cultures

1. Nitric Oxide Production and Microcirculation:
   L-Arginine is the primary substrate for nitric oxide synthase (NOS), which produces nitric oxide (NO). NO is a potent vasodilator that improves microcirculation in the skin. A study on healthy volunteers showed that oral supplementation with 6g of L-Arginine daily for 4 weeks increased cutaneous microcirculation by 29% as measured by laser Doppler flowmetry
   https://www.healthline.com/nutrition/l-arginine

The improved microcirculation has several benefits for skin appearance:
a) Enhanced nutrient delivery to skin cells
b) Improved removal of metabolic waste products
c) Increased oxygen supply, promoting a healthy skin glow

1. Antioxidant Effects:
   L-Arginine exhibits both direct and indirect antioxidant properties in the skin:

a) Direct scavenging of reactive oxygen species (ROS): L-Arginine can directly neutralize superoxide anions and hydroxyl radicals. In vitro studies have shown that L-Arginine at physiological concentrations can reduce ROS levels by up to 20% in keratinocyte cultures
.b) Enhancement of antioxidant enzyme activity: L-Arginine supplementation has been shown to increase the activity of superoxide dismutase (SOD) and catalase in skin tissue. A study in aged rats demonstrated that L-Arginine supplementation (2.25g/kg body weight) increased SOD activity by 37% and catalase activity by 43% in skin tissue

1. Skin Hydration and Barrier Function:
   L-Arginine contributes to skin hydration and barrier function through multiple mechanisms:

a) Natural Moisturizing Factor (NMF) production: L-Arginine is a component of NMF, contributing to skin hydration. Studies have shown that topical application of 2.5% L-Arginine can increase skin hydration by up to 16% after 4 weeks of use .b) Aquaporin regulation: L-Arginine modulates the expression of aquaporin-3 (AQP3), a water channel protein in the skin. In vitro studies have demonstrated that L-Arginine can increase AQP3 expression by up to 45% in keratinocyte cultures, potentially enhancing skin hydration .c) Filaggrin metabolism: L-Arginine is involved in the metabolism of filaggrin, a key protein in skin barrier function. A study on atopic dermatitis patients showed that oral supplementation with 3g of L-Arginine daily for 8 weeks improved skin barrier function, as measured by transepidermal water loss (TEWL), by 27%.

L-Arginine and Hair Growth​

L-Arginine's effects on hair growth and quality are multifaceted:

1. Vasodilation and Follicular Blood Flow:
   L-Arginine-derived NO improves blood flow to hair follicles. A study using laser Doppler flowmetry demonstrated that topical application of a 2% L-Arginine solution increased scalp blood flow by 35% within 30 minutes of application.
2. Modulation of Hair Growth Cycle:
   L-Arginine influences the hair growth cycle through several mechanisms:

a) Prolongation of anagen phase: In vitro studies on human hair follicle organ cultures have shown that L-Arginine (1mM) can extend the anagen phase by up to 26% compared to controls .b) Inhibition of ornithine decarboxylase (ODC): L-Arginine competitively inhibits ODC, an enzyme involved in hair follicle regression. A study on mouse models demonstrated that L-Arginine supplementation (2% in drinking water) reduced ODC activity in hair follicles by 42%, potentially delaying the onset of the catagen phase.

1. Protein Synthesis in Hair Follicles:
   L-Arginine is crucial for the synthesis of hair proteins:

a) Keratin production: L-Arginine is a precursor for proline and histidine, key amino acids in hair keratin. In vitro studies have shown that L-Arginine supplementation (2mM) can increase keratin production in hair follicle cultures by up to 35% .b) Hair shaft strength: A clinical study on 100 women with thinning hair showed that oral supplementation with 1g of L-Arginine daily for 6 months increased hair tensile strength by 12.5% and reduced hair breakage by 35%.

L-Arginine and Body Composition​

L-Arginine's effects on body composition are particularly relevant for aesthetic enhancement:

1. Muscle Protein Synthesis:
   L-Arginine stimulates muscle protein synthesis through multiple pathways:

a) mTOR activation: L-Arginine activates the mTOR pathway, a key regulator of protein synthesis. A study on young adults showed that ingestion of 6g of L-Arginine increased muscle protein synthesis rates by 56% compared to placebo .b) Growth hormone secretion: L-Arginine stimulates growth hormone (GH) release. A meta-analysis of 17 studies found that L-Arginine supplementation (5-9g) increased GH levels by an average of 100% compared to baseline .c) Insulin sensitivity: L-Arginine improves insulin sensitivity in skeletal muscle. A study on type 2 diabetic patients showed that L-Arginine supplementation (8.3g daily) improved insulin sensitivity by 34% after 4 weeks.

1. Fat Metabolism:
   L-Arginine influences fat metabolism through several mechanisms:

a) Lipolysis: L-Arginine stimulates the release of growth hormone, which promotes lipolysis. A study on obese subjects showed that L-Arginine supplementation (9g daily) increased 24-hour growth hormone secretion by 60%, leading to a 7% reduction in fat mass after 12 weeks .b) Brown adipose tissue (BAT) activation: L-Arginine may activate BAT, increasing energy expenditure. An animal study demonstrated that L-Arginine supplementation (1.51% of diet) increased BAT mass by 34% and UCP1 expression (a marker of BAT activity) by 98% .c) Adiponectin production: L-Arginine stimulates the production of adiponectin, a hormone that enhances fat oxidation. A clinical trial on obese type 2 diabetic patients showed that L-Arginine supplementation (8.3g daily) increased plasma adiponectin levels by 35% after 21 days.

1. Exercise Performance:
   L-Arginine can enhance exercise performance, indirectly contributing to improved body composition:

a) Nitric oxide production: L-Arginine increases NO production during exercise. A study on cyclists showed that L-Arginine supplementation (6g daily) increased plasma nitrate levels by 100% and improved time to exhaustion by 26% during high-intensity exercise .b) Lactate metabolism: L-Arginine may improve lactate clearance during exercise. A study on trained athletes demonstrated that acute L-Arginine supplementation (6g) reduced blood lactate levels by 23% during high-intensity exercise. In conclusion, L-Arginine's multifaceted effects on skin health, hair growth, and body composition make it a potentially valuable compound for aesthetic enhancement. However, it's important to note that individual responses may vary, and more research is needed to fully elucidate the optimal dosages and long-term effects of L-Arginine supplementation for these purposes.

sorry if the spoiler thing didn't work I haven't done that before

But I've heard people say it's cope and to take something else, what would that be? does it have a good bio-availability?
if I SHOULD take it, how much should I take? is my dosage good?

L arginine gets absolutely raped throughout your digestive tract and you absorb none. L citrulline survives the whole trip unscathed and is then converted to l arginine

Tldr if you want to raise arginine you need to take citruline, taking arginine won't do anything.

 

[igniteisbad]

L arginine gets absolutely raped throughout your digestive tract and you absorb none. L citrulline survives the whole trip unscathed and is then converted to l arginine

Tldr if you want to raise arginine you need to take citruline, taking arginine won't do anything.

tysm for helping ppl like me bro

 

[univer]

L arginine gets absolutely raped throughout your digestive tract and you absorb none. L citrulline survives the whole trip unscathed and is then converted to l arginine

Tldr if you want to raise arginine you need to take citruline, taking arginine won't do anything.

What's the scientific literature supporting this? The bioavailability of amino acids like L-Arginine depends primarily on the form (ex. Whey protein) in which you take it... not the actual supplement itself.

 

[Deleted member 59811]

What's the scientific literature supporting this? The bioavailability of amino acids like L-Arginine depends primarily on the form (ex. Whey protein) in which you take it... not the actual supplement itself.

Nigga just google it jfl. L arginine gets raped by your body and you absorb none, l citrulline survives untill it gets converterd

 

[Deleted member 59811]

tysm for helping ppl like me bro

Cheers mogger

 

[univer]

Nigga just google it jfl. L arginine gets raped by your body and you absorb none, l citrulline survives untill it gets converterd

I'll admit, I researched a bit and you're right. Oral bioavailability of L-arginine is only 20% (Source below).

https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2125.1999.00883.x

L-Citrulline is a lot better if you wanna increase plasma L-arginine levels since it's more bioavailable.

 

[Deleted member 59811]

I'll admit, I researched a bit and you're right. Oral bioavailability of L-arginine is only 20% (Source below).

https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2125.1999.00883.x

L-Citrulline is a lot better if you wanna increase plasma L-arginine levels since it's more bioavailable.

Ik nigga I'm just regurgitating whatever I read online