currycel67
Bronze
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- Dec 17, 2025
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I’ve never seen anyone talk about lgd3033
And while I was just researching SARMS
I found this holy grail
What it is :
LGD-3303 is a non-steroidal SARM that was researched primarily for bone and muscle preservation,It never went commercial and most data is preclinical And don’t confuse it with LGD-4033 both of em are different
Mechanism:
LGD-3303 activates androgen receptors on osteoblasts, the cells responsible for bone formation. This leads to
INCREASED OSTEOBLASTS ACTIVITY
INCREASED BONE MINERAL DENSITY (BMD)
INCREASED CORTICAL THICKNESS VIA PERIOSTEAL APPOSITION
Periosteal apposition means bone is laid down on the outer surface, making existing bones thicker and mechanically stronger.
What this means for bones :
Bones become denser and thicker shaft bones like (femur,tibia,humerus) showed increased strength this could be applicable to other bones too fracture resistance improves
Facial bones :
This can only do bone remodelling no
And it obv increases bone density and cortical thickness we can compare it with some mechanical loading like bone smashing to grow bones theoretically
And LGD-3033 has the same effect on BMD of tren or deca but better periosteal apposition
And for the high iqcles
Mechanism:
LGD-3033 binds the Androgen receptor with high affinity, induces a different AR-cofactor recruitment pattern than testosterone and favors gene transcription involved in osteoblast differentiation(osteoblast upregulation), bone matrix sythesis, cortical bone reinforcement
We can build muscle with this too it has strong anabolic effect on muscle too it builds the same amount of muscle lgd4033 builds much better than anavar and moderate dose test btw gains are dry dense controlled
And this doesn’t have the strong suppression risks like tren or other injectables it does suppress on level like lgd4033, or test alone that level suppression
And there is no human data tho everything here is theoretical and animal studies and you can check the studies on your own and before getting on do your own research I’m doing this just for educational purposes
And about the dosage LGD-3303 has no established human dose. All available data comes from animal models, and translating those doses to humans requires multiple assumptions (allometric scaling, safety factors, unknown pharmacokinetics). Any numeric claim should be treated as speculative rather than evidence-based but if I were to guess 10mg wouldn’t be bad
And about source I’ve seen some bodybuilding pharma selling them
And while I was just researching SARMS
I found this holy grail
What it is :
LGD-3303 is a non-steroidal SARM that was researched primarily for bone and muscle preservation,It never went commercial and most data is preclinical And don’t confuse it with LGD-4033 both of em are different
Mechanism:
LGD-3303 activates androgen receptors on osteoblasts, the cells responsible for bone formation. This leads to
INCREASED OSTEOBLASTS ACTIVITY
INCREASED BONE MINERAL DENSITY (BMD)
INCREASED CORTICAL THICKNESS VIA PERIOSTEAL APPOSITION
Periosteal apposition means bone is laid down on the outer surface, making existing bones thicker and mechanically stronger.
What this means for bones :
Bones become denser and thicker shaft bones like (femur,tibia,humerus) showed increased strength this could be applicable to other bones too fracture resistance improves
Facial bones :
This can only do bone remodelling no
And it obv increases bone density and cortical thickness we can compare it with some mechanical loading like bone smashing to grow bones theoretically
And LGD-3033 has the same effect on BMD of tren or deca but better periosteal apposition
And for the high iqcles
Mechanism:
LGD-3033 binds the Androgen receptor with high affinity, induces a different AR-cofactor recruitment pattern than testosterone and favors gene transcription involved in osteoblast differentiation(osteoblast upregulation), bone matrix sythesis, cortical bone reinforcement
We can build muscle with this too it has strong anabolic effect on muscle too it builds the same amount of muscle lgd4033 builds much better than anavar and moderate dose test btw gains are dry dense controlled
And this doesn’t have the strong suppression risks like tren or other injectables it does suppress on level like lgd4033, or test alone that level suppression
And there is no human data tho everything here is theoretical and animal studies and you can check the studies on your own and before getting on do your own research I’m doing this just for educational purposes
And about the dosage LGD-3303 has no established human dose. All available data comes from animal models, and translating those doses to humans requires multiple assumptions (allometric scaling, safety factors, unknown pharmacokinetics). Any numeric claim should be treated as speculative rather than evidence-based but if I were to guess 10mg wouldn’t be bad
And about source I’ve seen some bodybuilding pharma selling them
