H
Hahha
Iron
- Joined
- Jul 19, 2025
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(Sorry for bad formatting first high effort thread)
So many of you know igf-1 lr3 and say its cope for bonemass because it doesnt bind to the igfbps nearly as regular igf BUT igf-1 lr3 still can work for bones. Igf-1 lr3 still binds to igf receptors and affecting bones by different pathways like PI3K/Akt pathway causing osteoblast proliferation and Osteoblast differentiation from mesenchymal stem cells and upregulation of Runx2 and Osterix, transcription factors central to bone matrix production. Another pathway it affects bones by is the MAPK pathway this causes cell cycle progression, collagen synthesis, and osteoblast replication. It also Increases osteoprotegerin (OPG) and decreases RANKL expression in osteoblasts, indirectly suppressing osteoclast (bone-resorbing cell) activity (this causes a higher bone formation relative to reabsorption) igf-1 lr3 also has a much longer half life of 20-30 hrs so it can act on bones for longer and it is also 2-3x more potent (might not be for bones) Now let me explain how local injections might work way better then systemic injections even tho igf-1 lr3 acts systemically.
Systemic vs local
Systemic: it diffuses bodywide , desired receptor activation is short lived and low concentration , competes with circulating igfbps , half life at target is only minutes to hours , higher risk of organ growth
Local: its concentrated at injection site , High sustained activation in local osteoblasts/chondrocytes , half life at target is hours to days within extracellular matrix. Overall just mogs
In short: local delivery mimics natural IGF-1 physiology, where the molecule acts near its production site, rather than floating and having less desired concentration in target.
Now some more good stuff and benefits on why it mogs systemic injections
1) direct osteoblast activation (High receptor occupancy on local osteoblasts)
2) Recruitment of progenitor cell (Mesenchymal stem cells in periosteum migrate and differentiate into osteoblasts. This causes localized thickening or remodeling)
3) Potential synergism with mechanical stress ( bonesmashing or other procdures like mse , marpe etc)
Now how do i dose it or do it you may ask. Well my advice pick a dose between 100-200mcg then split it into multiple injections like 50mcg on each zygo or whatever place you want to grow.
You might also say “muhhh just pin hghhh muggh just take incralex” yes hgh and pure igf may be more effective in growing bones but the price is not something most users in this forum could afford thats why igf-1 lr3 comes to play.
(Thanks for reading)
So many of you know igf-1 lr3 and say its cope for bonemass because it doesnt bind to the igfbps nearly as regular igf BUT igf-1 lr3 still can work for bones. Igf-1 lr3 still binds to igf receptors and affecting bones by different pathways like PI3K/Akt pathway causing osteoblast proliferation and Osteoblast differentiation from mesenchymal stem cells and upregulation of Runx2 and Osterix, transcription factors central to bone matrix production. Another pathway it affects bones by is the MAPK pathway this causes cell cycle progression, collagen synthesis, and osteoblast replication. It also Increases osteoprotegerin (OPG) and decreases RANKL expression in osteoblasts, indirectly suppressing osteoclast (bone-resorbing cell) activity (this causes a higher bone formation relative to reabsorption) igf-1 lr3 also has a much longer half life of 20-30 hrs so it can act on bones for longer and it is also 2-3x more potent (might not be for bones) Now let me explain how local injections might work way better then systemic injections even tho igf-1 lr3 acts systemically.
Systemic vs local
Systemic: it diffuses bodywide , desired receptor activation is short lived and low concentration , competes with circulating igfbps , half life at target is only minutes to hours , higher risk of organ growth
Local: its concentrated at injection site , High sustained activation in local osteoblasts/chondrocytes , half life at target is hours to days within extracellular matrix. Overall just mogs
In short: local delivery mimics natural IGF-1 physiology, where the molecule acts near its production site, rather than floating and having less desired concentration in target.
Now some more good stuff and benefits on why it mogs systemic injections
1) direct osteoblast activation (High receptor occupancy on local osteoblasts)
2) Recruitment of progenitor cell (Mesenchymal stem cells in periosteum migrate and differentiate into osteoblasts. This causes localized thickening or remodeling)
3) Potential synergism with mechanical stress ( bonesmashing or other procdures like mse , marpe etc)
Now how do i dose it or do it you may ask. Well my advice pick a dose between 100-200mcg then split it into multiple injections like 50mcg on each zygo or whatever place you want to grow.
You might also say “muhhh just pin hghhh muggh just take incralex” yes hgh and pure igf may be more effective in growing bones but the price is not something most users in this forum could afford thats why igf-1 lr3 comes to play.
(Thanks for reading)
