ascendrx
Ethnic Terraslayer
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Preface
Abstract
- 11-KDHT is a powerful androgen that demonstrates strong agonist activity on the androgen receptor (AR). It is also capable of regulating a wider range of AR-dependent proteins compared to DHT.
- A key advantage of 11-KDHT and 11-Ketotestosterone (11KT) is their slower metabolic breakdown, resulting in a significantly longer half-life than DHT and Testosterone (T). The half-life of 11-KDHT is approximately 36 hours. Studies show that while DHT is eliminated within 48 hours, over one-fifth (21%) of 11-KDHT remains in the body after 72 hours.
- Both 11KT and 11KDHT bind to the androgen receptor with an affinity comparable to T and DHT. They function as full agonists, effectively activating the AR to induce gene expression and stimulate the proliferation of androgen-dependent cells.
11-KDHT is critically important in the progression of castration-resistant prostate cancer. Interestingly, patients with this condition often present with low levels of prolactin.
Given that 11-KDHT is as potent as DHT-- a known suppressor of prolactin so it may offer a unique benefit. Its prolonged duration of action could allow for less frequent dosing while effectively managing prolactin levels. This makes it a potential substitute for other steroids that can raise prolactin. Furthermore, by mitigating prolactin's effects, it may also enhance sexual function by reducing the refractory period.
Moreover, 11-KDHT can also be used as an aromatase inhibitor with longer inter-dose intervals. Due to it being similar to DHT for its anti-estrogenic properties. This may be useful to pubertycels to keep their plates open while promoting cell proliferation and skipping the horrendous side effects of AIs like aromasin or letrozole.
11-KT and 11-KDHT are also non-aromatizable, meaning that they won't get converted into estrogen, meaning they have no gyno side effects like other steroids.
To add, there are also anecdotal evidence in DHT and 11-KDHT elimating bloat and promoting a "dry" look.
Finally, 11-KT has anti-cortisol properties, which promotes "alpha" personality and inhibition, less stress, and better motivation. And so does its anti-prolactin properties.[5] 11-KDHT also has this property
- 11-KDHT is a powerful androgen that demonstrates strong agonist activity on the androgen receptor (AR). It is also capable of regulating a wider range of AR-dependent proteins compared to DHT.
- A key advantage of 11-KDHT and 11-Ketotestosterone (11KT) is their slower metabolic breakdown, resulting in a significantly longer half-life than DHT and Testosterone (T). The half-life of 11-KDHT is approximately 36 hours. Studies show that while DHT is eliminated within 48 hours, over one-fifth (21%) of 11-KDHT remains in the body after 72 hours.
- Both 11KT and 11KDHT bind to the androgen receptor with an affinity comparable to T and DHT. They function as full agonists, effectively activating the AR to induce gene expression and stimulate the proliferation of androgen-dependent cells.
11-KDHT is critically important in the progression of castration-resistant prostate cancer. Interestingly, patients with this condition often present with low levels of prolactin.
Given that 11-KDHT is as potent as DHT-- a known suppressor of prolactin so it may offer a unique benefit. Its prolonged duration of action could allow for less frequent dosing while effectively managing prolactin levels. This makes it a potential substitute for other steroids that can raise prolactin. Furthermore, by mitigating prolactin's effects, it may also enhance sexual function by reducing the refractory period.
Moreover, 11-KDHT can also be used as an aromatase inhibitor with longer inter-dose intervals. Due to it being similar to DHT for its anti-estrogenic properties. This may be useful to pubertycels to keep their plates open while promoting cell proliferation and skipping the horrendous side effects of AIs like aromasin or letrozole.
11-KT and 11-KDHT are also non-aromatizable, meaning that they won't get converted into estrogen, meaning they have no gyno side effects like other steroids.
To add, there are also anecdotal evidence in DHT and 11-KDHT elimating bloat and promoting a "dry" look.
Finally, 11-KT has anti-cortisol properties, which promotes "alpha" personality and inhibition, less stress, and better motivation. And so does its anti-prolactin properties.[5] 11-KDHT also has this property
TLDR
11KDHT and 11KT do the following:
-Increase NT
-lower inhibition
-Increase aggression
-lower stress
-enhance sexual experience
-decrease refractory period (time it take for a male to recover after orgasm.)
-Decrease estrogen
-Build muscle
-Burn fat
-Increase height in open platecels
-doesn't need AI
-Increase energy
-Eliminate bloat
-Decrease fatigue
11KDHT and 11KT do the following:
-Increase NT
-lower inhibition
-Increase aggression
-lower stress
-enhance sexual experience
-decrease refractory period (time it take for a male to recover after orgasm.)
-Decrease estrogen
-Build muscle
-Burn fat
-Increase height in open platecels
-doesn't need AI
-Increase energy
-Eliminate bloat
-Decrease fatigue
FOR AUTISTS:
Biosynthesis from the precursor 11OHA4:
Binding of DHT, T, 11KDHT and 11KT to the human AR (A) and transactivation via an ARE (B and C).
Regulation of AR-regulated proteins by DHT, 11KDHT, T and 11KT in VCaP cells:
METABOLISM:
SOURCES:
https://www.researchgate.net/public...tent_Androgens_Which_Can_No_Longer_Be_Ignored
https://www.ncbi.nlm.nih.gov/pubmed/2775814
https://www.ncbi.nlm.nih.gov/pubmed/30763940
https://www.ncbi.nlm.nih.gov/pubmed/6645492
https://www.researchgate.net/public...tent_Androgens_Which_Can_No_Longer_Be_Ignored
https://academic.oup.com/jcem/article/101/10/3582/2764896
http://press.endocrine.org/doi/10.1210/endo-meetings.2015.NRSHA.6.SAT-276
https://www.ncbi.nlm.nih.gov/pubmed/2775814
https://www.ncbi.nlm.nih.gov/pubmed/30763940
https://www.ncbi.nlm.nih.gov/pubmed/6645492
https://www.researchgate.net/public...tent_Androgens_Which_Can_No_Longer_Be_Ignored
https://academic.oup.com/jcem/article/101/10/3582/2764896
http://press.endocrine.org/doi/10.1210/endo-meetings.2015.NRSHA.6.SAT-276
BOTB WORTHY?
THIS WAS VERY HIGH EFFORT SO SHOW SOME APPRECIATION (I KNOW THE IMAGE FORMAT SIZE'S ARE MESSED UP JFL)
Last edited:
. Do not take unless you want a visit from the norwood reaper and a prostate the size of a football.
