LY3866288 (LOXO-435)

[Asoka]

this topic on fgfr3 inhibitors is not usually talked about but there is promising research showing that they could definitely lead to increased bone growth for height and craniofacial bone mass. Unlike the mild effects of HGH and GH secretagogues this could actually show extremely promising results. There haven't been any studies on healthy humans regarding fgfr3 inhibitors but they could come with potential risks which I would advise to definitely look into and research. however could just be hype like pth analogs. But they aren't as expensive and hard to source.

 

[Bryce]

there is promising research showing that they could definitely lead to increased bone growth for height and craniofacial bone mass

 

[niggacum492139]

.

 

[Asoka]

Savarirayan, R. et al. "Once-daily, subcutaneous vosoritide therapy in children with achondroplasia: a randomised, double-blind, phase 3, placebo-controlled, multicentre trial." The Lancet, 2020.
Savarirayan, R. et al. "Sustained growth-promoting effects of vosoritide in children with achondroplasia from an ongoing phase 3 extension study." Genetics in Medicine, 2024.
Infigratinib (BridgeBio):
Hébert, E. et al. "Oral Infigratinib Therapy in Children with Achondroplasia." The New England Journal of Medicine, 2024.
Dabogratinib (formerly TYRA-300):
Starrett, J. H. et al. "TYRA-300, an FGFR3-selective inhibitor, promotes bone growth in two FGFR3-driven models of chondrodysplasia." JCI Insight, 2025.
ClinicalTrials.gov: NCT06842355

 

[Zagro]

But they aren't as expensive and hard to source.

If you can source fgfr3 inhibitors you surely can find pth analogues and they are ten fold cheaper.

 

[Asoka]

Not Loxo-435 specifically as even I can't find a source but there are some really cheap and easy to buy fgfr3 inhibitors

 

[jeoyw9192]

Not Loxo-435 specifically as even I can't find a source but there are some really cheap and easy to buy fgfr3 inhibitors

Source?

 

[Zagro]

Not Loxo-435 specifically as even I can't find a source but there are some really cheap and easy to buy fgfr3 inhibitors

Meclizine is not even comparable if you meant that as the cheap and easy option, mild inhibition of fgfr3 and you need high doses and daily use for that which will make you feel like shit on the daily.

 

[Asoka]

Meclizine is not even comparable if you meant that as the cheap and easy option, mild inhibition of fgfr3 and you need high doses and daily use for that which will make you feel like shit on the daily.

Yh meclizine doesn't look as promising and I've heard people feel so run down and tired on them at long periods of time, I think one that people should look into for the time being is Erdafitinib

 

[Asoka]

Source?

gatekeeping my main source but Indiamart basically has anything. You just might receive random low quality shit instead of the real deal

 

[Zagro]

Yh meclizine doesn't look as promising and I've heard people feel so run down and tired on them at long periods of time, I think one that people should look into for the time being is Erdafitinib

Thats pretty damn expensive how do you plan to get it cheap? And also it does have a pretty worrying side effect profile.

You could try Infigratinib it has a similar side effect profile which is still bad but much more available imo.

 

[Asoka]

Thats pretty damn expensive how do you plan to get it cheap? And also it does have a pretty worrying side effect profile.

You could try Infigratinib it has a similar side effect profile which is still bad but much more available imo.

because dosing for it in normal healthy people hasn't been determined, if I were to try it I would start low and build it up. Maybe start at 100mcg daily. So it runs around roughly 100$ a month. In my opinion that's not too good expensive considering the pros. The side effects can be terrible though which is why I was previously talking about LoXo-435 due to potentially less side effects, however extremely hard to source. So Imma probably just wait for more research to come out unless I find a source for more fgfr3 inhibitors, but by then it would be too late 🫩

 

[aids]

Savarirayan, R. et al. "Once-daily, subcutaneous vosoritide therapy in children with achondroplasia: a randomised, double-blind, phase 3, placebo-controlled, multicentre trial." The Lancet, 2020.
Savarirayan, R. et al. "Sustained growth-promoting effects of vosoritide in children with achondroplasia from an ongoing phase 3 extension study." Genetics in Medicine, 2024.
Infigratinib (BridgeBio):
Hébert, E. et al. "Oral Infigratinib Therapy in Children with Achondroplasia." The New England Journal of Medicine, 2024.
Dabogratinib (formerly TYRA-300):
Starrett, J. H. et al. "TYRA-300, an FGFR3-selective inhibitor, promotes bone growth in two FGFR3-driven models of chondrodysplasia." JCI Insight, 2025.
ClinicalTrials.gov: NCT06842355

Note that every study is regarding children, we have already established that exogenous hormones from a very early age will affect craniofacial development. This is nothing new.
The point is, no 10 year old is going to be using this shit off-label, nor should they.

 

[Asoka]

Note that every study is regarding children, we have already established that exogenous hormones from a very early age will affect craniofacial development. This is nothing new.
The point is, no 10 year old is going to be using this shit off-label, nor should they.

Exogenous hormones at early ages (starting around 8-10) will most likely yield same results for someone who takes a good fgfr3 inhibitor starting at 15. Just saying that it will prove to give better results, obviously still have to deal with side effects

 

[Copercel]

Stawp laughing at me