MENT: potential tren dethroner?

amir_syr

amir_syr

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trestolone (MENT): what is it?
trestolone(MENT) was originally developed to be a contraceptive, because of how strong it is in suppressing spermatogenesis (production of sperm), it's about 7 to almost 10 times stronger than testosterone, unlike testosterone MENT or trestolone doesn't need to convert to dht for its effects, it aromatises to a form of estrogen called 7a-methyl-estradiol, which is actually estimated to be about 10 times more potent at the estrogen receptor level than normal estradiol, but it also strongly binds to the androgen receptors approximately 2-3 times the strength of testosterone.


Potential in heightmaxxing:

MENT significantly enhances IGF-1 sensitivity, mostly because of its dual activation of androgen receptors and estrogen receptors. The conversion to 7α-methyl-estradiol amplifies IGF-1 signaling through ER pathways, which stimulates IGF-1 receptor expression and increases its activity. This estrogenic action synergizes with AR activation to boost mTOR and PI3K/AKT pathways which are both crutial for growth, also great for cellular proliferation, and general tissue growth. MENT not only increases IGF-1 levels but also improves cellular responsiveness (better igf1 sensitivty), potentially making it more effective than Tren in general bone growth, but honestly most of its effects come from the specific estrogen that comes with it and it's insane activation in those ERs and everyone's running an AI so it might just counter it jfl.


MENT vs TREN:
Most roidcels here mostly use tren for its igf1 sensitivity increase and overall androgenicity, but ment comes with almost the same androgenicity though less ar activation, tren is known to at least 1.5x or 2.5 igf1 sensitivity. Ment is roughly 3x times stronger than tren in this matter, it upregulates igf1 receptor expression and enhances general sensitivity to igf1, MENT overall outperforms Tren in cellular responsiveness. mTOR PathwayPotently activated through AR and ER synergy, enhancing protein synthesis and growth. Unlike tren which has very strong AR-driven mTOR activation but lacks the added ER-driven boost.Slight edge to MENT due to ER contribution. PI3K/AKT pathway is strongly activated through AR + ER, enhancing cell survival, growth, and hypertrophy. Tren has strong activation but only through AR; lacks ER-mediated benefits.MENT has the advantage in PI3K/AKT modulation.

but you have to keep in mind that most of ments benefits come because of the type of estrogen that comes with it, which might be contradicting to height, estrogen = bad for growth plates. Even if one lowers estrogen on MENT it'll still be risky since the type of estrogen that comes with it binds strongly to the ERs, which would be a good thing for overall growth but bad for the general growth window.



this thread wasn't really meant to be high iq nor high effort just a thought that I had while reviewing studies about it.



 
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Holy fuck OP you are such a fucking pseudointellectual moron its laughable, never make a thread on pharmacology again you pathetic piece of shit.

I would wager my entire lineage you didnt even fucking open either of your citations you complete and utter clown.

MENT is one of the most diabolically dogshit compounds to ever be synthesized and your making threads saying its the "dethroner of tren".

Going to cage when you aromatize into fucking oblivion, fuck you.
 
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Dnr retard thanks for reply
 
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-potential in height maxing
-insane estrogen
🤔
 
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trestolone (MENT): what is it?
trestolone(MENT) was originally developed to be a contraceptive, because of how strong it is in suppressing spermatogenesis (production of sperm), it's about 7 to almost 10 times stronger than testosterone, unlike testosterone MENT or trestolone doesn't need to convert to dht for its effects, it aromatises to a form of estrogen called 7a-methyl-estradiol, which is actually estimated to be about 10 times more potent at the estrogen receptor level than normal estradiol, but it also strongly binds to the androgen receptors approximately 2-3 times the strength of testosterone.


Potential in heightmaxxing:

MENT significantly enhances IGF-1 sensitivity, mostly because of its dual activation of androgen receptors and estrogen receptors. The conversion to 7α-methyl-estradiol amplifies IGF-1 signaling through ER pathways, which stimulates IGF-1 receptor expression and increases its activity. This estrogenic action synergizes with AR activation to boost mTOR and PI3K/AKT pathways which are both crutial for growth, also great for cellular proliferation, and general tissue growth. MENT not only increases IGF-1 levels but also improves cellular responsiveness (better igf1 sensitivty), potentially making it more effective than Tren in general bone growth, but honestly most of its effects come from the specific estrogen that comes with it and it's insane activation in those ERs and everyone's running an AI so it might just counter it jfl.


MENT vs TREN:
Most roidcels here mostly use tren for its igf1 sensitivity increase and overall androgenicity, but ment comes with almost the same androgenicity though less ar activation, tren is known to at least 1.5x or 2.5 igf1 sensitivity. Ment is roughly 3x times stronger than tren in this matter, it upregulates igf1 receptor expression and enhances general sensitivity to igf1, MENT overall outperforms Tren in cellular responsiveness. mTOR PathwayPotently activated through AR and ER synergy, enhancing protein synthesis and growth. Unlike tren which has very strong AR-driven mTOR activation but lacks the added ER-driven boost.Slight edge to MENT due to ER contribution. PI3K/AKT pathway is strongly activated through AR + ER, enhancing cell survival, growth, and hypertrophy. Tren has strong activation but only through AR; lacks ER-mediated benefits.MENT has the advantage in PI3K/AKT modulation.

but you have to keep in mind that most of ments benefits come because of the type of estrogen that comes with it, which might be contradicting to height, estrogen = bad for growth plates. Even if one lowers estrogen on MENT it'll still be risky since the type of estrogen that comes with it binds strongly to the ERs, which would be a good thing for overall growth but bad for the general growth window.



this thread wasn't really meant to be high iq nor high effort just a thought that I had while reviewing studies about it.



Honestly shit thread and it's clear you know absolutely nothing that you're talking about but I'll still rep for effort :lul:
 
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Honestly shit thread and it's clear you know absolutely nothing that you're talking about but I'll still rep for effort :lul:
It literally wasn't intended to be high iq but just a thought and more of a question ment the only compound idk shit abt the title was just meant to be catchy
 
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shit thread
 
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