amir_syr
Iron
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- Feb 18, 2025
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trestolone (MENT): what is it?
trestolone(MENT) was originally developed to be a contraceptive, because of how strong it is in suppressing spermatogenesis (production of sperm), it's about 7 to almost 10 times stronger than testosterone, unlike testosterone MENT or trestolone doesn't need to convert to dht for its effects, it aromatises to a form of estrogen called 7a-methyl-estradiol, which is actually estimated to be about 10 times more potent at the estrogen receptor level than normal estradiol, but it also strongly binds to the androgen receptors approximately 2-3 times the strength of testosterone.
Potential in heightmaxxing:
MENT significantly enhances IGF-1 sensitivity, mostly because of its dual activation of androgen receptors and estrogen receptors. The conversion to 7α-methyl-estradiol amplifies IGF-1 signaling through ER pathways, which stimulates IGF-1 receptor expression and increases its activity. This estrogenic action synergizes with AR activation to boost mTOR and PI3K/AKT pathways which are both crutial for growth, also great for cellular proliferation, and general tissue growth. MENT not only increases IGF-1 levels but also improves cellular responsiveness (better igf1 sensitivty), potentially making it more effective than Tren in general bone growth, but honestly most of its effects come from the specific estrogen that comes with it and it's insane activation in those ERs and everyone's running an AI so it might just counter it jfl.
MENT vs TREN:
Most roidcels here mostly use tren for its igf1 sensitivity increase and overall androgenicity, but ment comes with almost the same androgenicity though less ar activation, tren is known to at least 1.5x or 2.5 igf1 sensitivity. Ment is roughly 3x times stronger than tren in this matter, it upregulates igf1 receptor expression and enhances general sensitivity to igf1, MENT overall outperforms Tren in cellular responsiveness. mTOR PathwayPotently activated through AR and ER synergy, enhancing protein synthesis and growth. Unlike tren which has very strong AR-driven mTOR activation but lacks the added ER-driven boost.Slight edge to MENT due to ER contribution. PI3K/AKT pathway is strongly activated through AR + ER, enhancing cell survival, growth, and hypertrophy. Tren has strong activation but only through AR; lacks ER-mediated benefits.MENT has the advantage in PI3K/AKT modulation.
but you have to keep in mind that most of ments benefits come because of the type of estrogen that comes with it, which might be contradicting to height, estrogen = bad for growth plates. Even if one lowers estrogen on MENT it'll still be risky since the type of estrogen that comes with it binds strongly to the ERs, which would be a good thing for overall growth but bad for the general growth window.
this thread wasn't really meant to be high iq nor high effort just a thought that I had while reviewing studies about it.
pubmed.ncbi.nlm.nih.gov
pmc.ncbi.nlm.nih.gov
en.m.wikipedia.org
trestolone(MENT) was originally developed to be a contraceptive, because of how strong it is in suppressing spermatogenesis (production of sperm), it's about 7 to almost 10 times stronger than testosterone, unlike testosterone MENT or trestolone doesn't need to convert to dht for its effects, it aromatises to a form of estrogen called 7a-methyl-estradiol, which is actually estimated to be about 10 times more potent at the estrogen receptor level than normal estradiol, but it also strongly binds to the androgen receptors approximately 2-3 times the strength of testosterone.
Potential in heightmaxxing:
MENT significantly enhances IGF-1 sensitivity, mostly because of its dual activation of androgen receptors and estrogen receptors. The conversion to 7α-methyl-estradiol amplifies IGF-1 signaling through ER pathways, which stimulates IGF-1 receptor expression and increases its activity. This estrogenic action synergizes with AR activation to boost mTOR and PI3K/AKT pathways which are both crutial for growth, also great for cellular proliferation, and general tissue growth. MENT not only increases IGF-1 levels but also improves cellular responsiveness (better igf1 sensitivty), potentially making it more effective than Tren in general bone growth, but honestly most of its effects come from the specific estrogen that comes with it and it's insane activation in those ERs and everyone's running an AI so it might just counter it jfl.
MENT vs TREN:
Most roidcels here mostly use tren for its igf1 sensitivity increase and overall androgenicity, but ment comes with almost the same androgenicity though less ar activation, tren is known to at least 1.5x or 2.5 igf1 sensitivity. Ment is roughly 3x times stronger than tren in this matter, it upregulates igf1 receptor expression and enhances general sensitivity to igf1, MENT overall outperforms Tren in cellular responsiveness. mTOR PathwayPotently activated through AR and ER synergy, enhancing protein synthesis and growth. Unlike tren which has very strong AR-driven mTOR activation but lacks the added ER-driven boost.Slight edge to MENT due to ER contribution. PI3K/AKT pathway is strongly activated through AR + ER, enhancing cell survival, growth, and hypertrophy. Tren has strong activation but only through AR; lacks ER-mediated benefits.MENT has the advantage in PI3K/AKT modulation.
but you have to keep in mind that most of ments benefits come because of the type of estrogen that comes with it, which might be contradicting to height, estrogen = bad for growth plates. Even if one lowers estrogen on MENT it'll still be risky since the type of estrogen that comes with it binds strongly to the ERs, which would be a good thing for overall growth but bad for the general growth window.
this thread wasn't really meant to be high iq nor high effort just a thought that I had while reviewing studies about it.
Comparison of 7α-methyl-19-nortestosterone effectiveness alone or combined with progestins on androgen receptor mediated-transactivation - PubMed
7α-methyl-19-nortestosterone (MENT) is an androgen with potent gonadotropin inhibitory activity and prostate-sparing effects. These attributes give MENT advantages over testosterone as a male contraceptive, but, as in the case of testosterone, a partial dose-dependent suppression of...
pubmed.ncbi.nlm.nih.gov
7α-Methyl-19-Nortestosterone (MENT) vs. Testosterone Implants for Hypogonadal Osteoporosis: a Preclinical Study in the Aged Male Orchidectomized Rat Model - PMC
Overt male hypogonadism induces not only osteoporosis but also unfavorable changes in body composition, which can be prevented by testosterone (T) replacement. In this preclinical study, the potential of synthetic androgen ...
pmc.ncbi.nlm.nih.gov
