Mk677 is overhated

[xela2008]

Sure mk677 won't do much but for most people it has zero bad side effects if you want to gain weight. "You'll get diabetes!" I've never even heard anyone get diabetes on mk677 even though it's so known and you can easily counter it if you have to. I had like 3.6mmol/L while on it

 

[Mushroom]

Sure mk677 won't do much but for most people it has zero bad side effects if you want to gain weight. "You'll get diabetes!" I've never even heard anyone get diabetes on mk677 even though it's so known and you can easily counter it if you have to. I had like 3.6mmol/L while on it

it's good during PCT

 

[Zeekie]

Sure mk677 won't do much but for most people it has zero bad side effects if you want to gain weight. "You'll get diabetes!" I've never even heard anyone get diabetes on mk677 even though it's so known and you can easily counter it if you have to. I had like 3.6mmol/L while on it

I agree with you that Mk-677 gets too much hate, it does what it claims to do, minimal increase in appetite, sleep quality and HGH production.

However the fact that you've never heard of anyone getting diabetes from it, doesn't mean it isn't possible, it is a FACT that Mk-677 causes insulin resistance and hence must be paired with an insulin modulator to avoid it potentially turning into diabetes.

Furthermore, it's not only the insulin resistance but also the increase in blood pressure.

I don't use Mk and don't plan to, but it can be potentially dangerous when not dosed, cycled and paired with an insulin resistance modulator. Useful compound for bulkers and teens, but you should never take your health lightly.

 

[xela2008]

I agree with you that Mk-677 gets too much hate, it does what it claims to do, minimal increase in appetite, sleep quality and HGH production.

However the fact that you've never heard of anyone getting diabetes from it, doesn't mean it isn't possible, it is a FACT that Mk-677 causes insulin resistance and hence must be paired with an insulin modulator to avoid it potentially turning into diabetes.

Furthermore, it's not only the insulin resistance but also the increase in blood pressure.

I don't use Mk and don't plan to, but it can be potentially dangerous when not dosed, cycled and paired with an insulin resistance modulator. Useful compound for bulkers and teens, but you should never take your health lightly.

It does not have to be paired with some insulin resistance shit. I had great blood sugar while on it and so will many others.

 

[i14bytes]

I agree with you that Mk-677 gets too much hate, it does what it claims to do, minimal increase in appetite, sleep quality and HGH production.

However the fact that you've never heard of anyone getting diabetes from it, doesn't mean it isn't possible, it is a FACT that Mk-677 causes insulin resistance and hence must be paired with an insulin modulator to avoid it potentially turning into diabetes.

Furthermore, it's not only the insulin resistance but also the increase in blood pressure.

I don't use Mk and don't plan to, but it can be potentially dangerous when not dosed, cycled and paired with an insulin resistance modulator. Useful compound for bulkers and teens, but you should never take your health lightly.

u need to manage cortisol on it. cortisol causes diabetes

 

[Zeekie]

It does not have to be paired with some insulin resistance shit. I had great blood sugar while on it and so will many others.

I'm sorry, but this is not a debate or opinion-based discussion, Mk-677 has been PROVEN to decrease insulin sensitivity in clinical trials. If you want to gamble with your health, then do it, but recommending it to others is idiotic. Even if you don't actually believe it does anything, does it really hurt to do it just in case? Better be safe than sorry.

"Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial" (PMID: 18981485)

 

[xela2008]

I'm sorry, but this is not a debate or opinion-based discussion, Mk-677 has been PROVEN to decrease insulin sensitivity in clinical trials. If you want to gamble with your health, then do it, but recommending it to others is idiotic. Even if you don't actually believe it does anything, does it really hurt to do it just in case? Better be safe than sorry.

"Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial" (PMID: 18981485)

View attachment 3772538

calm down G

 

[Zeekie]

calm down G

I'm pretty calm, but what you're suggesting is inherently dangerous and isn't in line with what the research clearly shows.

You do you though, I'm just informing.

 

[aids]

I'm sorry, but this is not a debate or opinion-based discussion, Mk-677 has been PROVEN to decrease insulin sensitivity in clinical trials. If you want to gamble with your health, then do it, but recommending it to others is idiotic. Even if you don't actually believe it does anything, does it really hurt to do it just in case? Better be safe than sorry.

"Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial" (PMID: 18981485)

View attachment 3772538

Caging. Clinically insignificant over two years for individuals aged 60-81. Old, shitty study that is not at all relevant for anybody on this forum.
I wholeheartedly believe none of you cunts actually read the shit you recite, and simply ask ChatGPT for something that backs your dumbass claims.

 

[bonelessvirgin]

"Zero bad side effects" is a ridiculous claim

 

[xela2008]

"Zero bad side effects" is a ridiculous claim

Not really. No significant side effects.

 

[Zeekie]

Caging. Clinically insignificant over two years for individuals aged 60-81. Old, shitty study that is not at all relevant for anybody on this forum.

Lmao. First, he study is far from "irrelevant". It was a randomized, double-blind, placebo-controlled trial, basically the gold standard of clinical research. It demonstrated a statistically significant decrease in insulin sensitivity with Mk-677.

Second, the way a compound works does not change drastically in such a way that insulin resistance would be only present in older individuals.

The age of the participants on it is pretty irrelevant, given that other studies using different population samples widely corroborate the findings. And the fact that the study itself is old doesn't mean shit either, considering that no modern studies have come out to disprove this claim.

I can keep quoting more studies if you'd like.

 

[Zeekie]

I wholeheartedly believe none of you cunts actually read the shit you recite, and simply ask ChatGPT for something that backs your dumbass claims.

Forgot to add:
+ I've tried that and ChatGPT is pretty shitty at scrapping and citing research.
+ Yes, I read the shit I recite. You just don't understand pharmacodynamics or how study relevance or accuracy functions.
+ "Dumbass" claims corroborated by many studies and anecdotal claims by the way

Regardless, what do you even gain from any of this? You lose nothing by using an insulin resistance modulator, given the body of evidence to support that it does negatively impact insulin sensitivity. You're giving yourself a completely avoidable negative health outcome for absolutely no reason. And again, even if you truly don't believe it could cause insulin sensitivy or an increase in blood pressure, does it hurt to do it just in fucking case?

Gambling with your health is completely idiotic, imaging having even the slightest risk of diabetes because you didn't wanna take an extra pill. Is it worth it?

 

[aids]

Lmao. First, he study is far from "irrelevant". It was a randomized, double-blind, placebo-controlled trial, basically the gold standard of clinical research. It demonstrated a statistically significant decrease in insulin sensitivity with Mk-677.

Wow, nice! What does that mean?
I said it was irrelevant, not inaccurate, fucknuts.

Second, the way a compound works does not change drastically in such a way that insulin resistance would be only present in older individuals.

Clinically insignificant change like I mentioned, which is going to be exacerbated in older individuals.

The age of the participants on it is pretty irrelevant, given that other studies using different population samples widely corroborate the findings. And the fact that the study itself is old doesn't mean shit either, considering that no modern studies have come out to disprove this claim.

Nobody is saying MK677 doesn't affect your blood sugar you fucking moronic nut-loving squirrel cunt.
It is a NEGLIGIBLE change. Taking an "insulin resistance modulator" is REDUNDANT.

I can keep quoting more studies if you'd like.

Yes, quote every study ever.

Forgot to add:
+ I've tried that and ChatGPT is pretty shitty at scrapping and citing research.

Cool.

+ Yes, I read the shit I recite. You just don't understand pharmacodynamics or how study relevance or accuracy functions.

Epic.

+ "Dumbass" claims corroborated by many studies and anecdotal claims by the way

I bet the findings also show that the change in blood sugar is clinically insignificant.
Two-years, 60-81 year olds, 25mg/day, only a 0.3mmol/L difference.

Regardless, what do you even gain from any of this? You lose nothing by using an insulin resistance modulator, given the body of evidence to support that it does negatively impact insulin sensitivity. You're giving yourself a completely avoidable negative health outcome for absolutely no reason. And again, even if you truly don't believe it could cause insulin sensitivy or an increase in blood pressure, does it hurt to do it just in fucking case?

REDUNDANT. The change in blood sugar is NOTHINGGGGGGGGGGG.
Pissing money down the toilet and just introducing unnecessary compounds that also have the potential for sides.

Gambling with your health is completely idiotic, imaging having even the slightest risk of diabetes because you didn't wanna take an extra pill. Is it worth it?

We can go back and forth about this argument, debating the relevance of the studies, but if you unironically believe that a 0.3mmol/L change in blood sugar of the MK677 group relative to placebo, given the duration that the participants took MK677, as well as their already-old age, is going to RISK DIABETES, then you are a FAT FUCK THAT WOULD HAVE GOTTEN T2D ANYWAY.

 

[copercel123]

Sure mk677 won't do much but for most people it has zero bad side effects if you want to gain weight. "You'll get diabetes!" I've never even heard anyone get diabetes on mk677 even though it's so known and you can easily counter it if you have to. I had like 3.6mmol/L while on it

Underhated *

 

[Zeekie]

Wow, nice! What does that mean?
I said it was irrelevant, not inaccurate, fucknuts.


Clinically insignificant change like I mentioned, which is going to be exacerbated in older individuals.


Nobody is saying MK677 doesn't affect your blood sugar you fucking moronic nut-loving squirrel cunt.
It is a NEGLIGIBLE change. Taking an "insulin resistance modulator" is REDUNDANT.


Yes, quote every study ever.


Cool.


Epic.


I bet the findings also show that the change in blood sugar is clinically insignificant.
Two-years, 60-81 year olds, 25mg/day, only a 0.3mmol/L difference.


REDUNDANT. The change in blood sugar is NOTHINGGGGGGGGGGG.
Pissing money down the toilet and just introducing unnecessary compounds that also have the potential for sides.


We can go back and forth about this argument, debating the relevance of the studies, but if you unironically believe that a 0.3mmol/L change in blood sugar of the MK677 group relative to placebo, given the duration that the participants took MK677, as well as their already-old age, is going to RISK DIABETES, then you are a FAT FUCK THAT WOULD HAVE GOTTEN T2D ANYWAY.

"Old shitty study":
I quote from what you said "Old, shitty study", the reason why I said that was because your comment implies two things, that the fact that the study is "old" makes the findings any less valuable, which is false, and "shitty study" implies that the study is of low quality. That was the point I was addressing.

"Clinical relevance":
If the change is truly negligible, and insulin sensitizers like berberine are also known to have negligible side effects and additional benefits (improved lipid profile for example), then calling them "unnecessary" is wrong. If small changes do matter enough to be concerned about extra compounds, then small negative effects from MK-677 also matter. “0.3 mmol/L is negligible, so I won’t counteract it,” and then also say “Taking a benign insulin sensitizer is dangerous overkill.” Either small physiological changes matter or they don’t.

Also, a change of 0.3 mmol/L is small, but it isn't irrelevant. That can easily move someone from normoglycemia into prediabetic territory and it can also increase the glucose curve over time. I'm sorry, but I just don't see how there's not an inherent danger if we consider that Mk-677 is usually taken chronically (daily and for months at a time) and if we consider that most people lack ideal metabolic health to begin with.

Mk-677 is "decent" at best, it offers small gains, if these are worth it for you then why not accept small preventatives with other small benefits? My argument is simple, if a cheap, safe insulin sensitizer can offset a known and measurable negative effect, even if minor, and on top of that improve other health markers, why not take it?

 

[xela2008]

Underhated *

no

 

[slaters]

Lmao. First, he study is far from "irrelevant". It was a randomized, double-blind, placebo-controlled trial, basically the gold standard of clinical research. It demonstrated a statistically significant decrease in insulin sensitivity with Mk-677.

Second, the way a compound works does not change drastically in such a way that insulin resistance would be only present in older individuals.

The age of the participants on it is pretty irrelevant, given that other studies using different population samples widely corroborate the findings. And the fact that the study itself is old doesn't mean shit either, considering that no modern studies have come out to disprove this claim.

I can keep quoting more studies if you'd like.

Ngl anyone that gets diabetes from mk deserves it
If they decide to take some chemical without spending 30 minutes looking up what else they need then